{"id":"https://openalex.org/W3098070531","doi":"https://doi.org/10.1161/circ.142.suppl_3.16758","title":"Abstract 16758: Presence of Left Atrial Fibrosis Contributes to Aberrant Hemodynamics and Increased Risk of Stroke in Atrial Fibrillation Patients","display_name":"Abstract 16758: Presence of Left Atrial Fibrosis Contributes to Aberrant Hemodynamics and Increased Risk of Stroke in Atrial Fibrillation Patients","publication_year":2020,"publication_date":"2020-11-12","ids":{"openalex":"https://openalex.org/W3098070531","doi":"https://doi.org/10.1161/circ.142.suppl_3.16758","mag":"3098070531"},"language":"en","primary_location":{"id":"doi:10.1161/circ.142.suppl_3.16758","doi":"https://doi.org/10.1161/circ.142.suppl_3.16758","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.142.suppl_3.16758","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083916488","display_name":"Nikhil Paliwal","orcid":"https://orcid.org/0000-0002-0396-4409","observed_orcids":["https://orcid.org/0000-0002-0396-4409"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikhil Paliwal","raw_affiliation_strings":["Johns Hopkins Univ, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Univ, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001602916","display_name":"Matteo Salvador","orcid":"https://orcid.org/0000-0002-4937-5538","observed_orcids":["https://orcid.org/0000-0002-4937-5538"]},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Matteo Salvador","raw_affiliation_strings":["Politecnico di Milano, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Politecnico di Milano, Milan, Italy","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015218943","display_name":"Ryan O\u2019Hara","orcid":"https://orcid.org/0000-0002-7636-1799","observed_orcids":["https://orcid.org/0000-0002-7636-1799"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan Ohara","raw_affiliation_strings":["Johns Hopkins Univ, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Univ, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087218413","display_name":"Rheeda L. Ali","orcid":"https://orcid.org/0000-0001-5853-8258","observed_orcids":["https://orcid.org/0000-0001-5853-8258"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rheeda Ali","raw_affiliation_strings":["JOHNS HOPKINS UNIVERSITY, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"JOHNS HOPKINS UNIVERSITY, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065329882","display_name":"Rebecca A. Yu","orcid":"https://orcid.org/0000-0003-1148-6977","observed_orcids":["https://orcid.org/0000-0003-1148-6977"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca Yu","raw_affiliation_strings":["Johns Hopkins Univ, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Univ, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082316876","display_name":"Usama A. Daimee","orcid":"https://orcid.org/0000-0002-2839-5564","observed_orcids":["https://orcid.org/0000-0002-2839-5564"]},"institutions":[{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Usama A Daimee","raw_affiliation_strings":["JOHNS HOPKINS HOSPITAL, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"JOHNS HOPKINS HOSPITAL, Baltimore, MD","institution_ids":["https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037928012","display_name":"Tauseef Akhtar","orcid":"https://orcid.org/0000-0003-3471-6704","observed_orcids":["https://orcid.org/0000-0003-3471-6704"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tauseef Akhtar","raw_affiliation_strings":["John Hopkins Univ, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"John Hopkins Univ, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084620884","display_name":"Pallavi Pandey","orcid":"https://orcid.org/0000-0003-0853-7892","observed_orcids":["https://orcid.org/0000-0003-0853-7892"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pallavi Pandey","raw_affiliation_strings":["Johns Hopkins Univ, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Univ, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005064274","display_name":"DAVID D. SPRAGG","orcid":"https://orcid.org/0000-0002-9190-9804","observed_orcids":["https://orcid.org/0000-0002-9190-9804"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David D Spragg","raw_affiliation_strings":["Johns Hopkins, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025889874","display_name":"Hugh G Calkins","orcid":"https://orcid.org/0000-0002-9262-9433","observed_orcids":["https://orcid.org/0000-0002-9262-9433"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hugh G Calkins","raw_affiliation_strings":["JOHNS HOPKINS UNIVERSITY SCHOOL MED, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"JOHNS HOPKINS UNIVERSITY SCHOOL MED, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070924694","display_name":"Natalia A. Trayanova","orcid":"https://orcid.org/0000-0002-8661-063X","observed_orcids":["https://orcid.org/0000-0002-8661-063X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalia Trayanova","raw_affiliation_strings":["JOHNS HOPKINS UNIVERSITY, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"JOHNS HOPKINS UNIVERSITY, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"142","issue":"Suppl_3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/left-atrial-fibrosis","display_name":"left atrial fibrosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/stroke-risk","display_name":"stroke risk","score":0.7889999747276306},{"id":"https://openalex.org/keywords/left-atrial-appendage","display_name":"left atrial appendage","score":0.8420000076293945},{"id":"https://openalex.org/keywords/wall-shear-stress","display_name":"wall shear stress","score":0.8059999942779541},{"id":"https://openalex.org/keywords/oscillatory-shear-index","display_name":"oscillatory shear index","score":1.0},{"id":"https://openalex.org/keywords/computational-fluid-dynamics","display_name":"computational fluid dynamics","score":0.7519999742507935},{"id":"https://openalex.org/keywords/left-atrial-remodeling","display_name":"left atrial remodeling","score":0.6050000190734863},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.8539999723434448},{"id":"https://openalex.org/keywords/hemodynamics","display_name":"hemodynamics","score":0.5889999866485596},{"id":"https://openalex.org/keywords/late-gadolinium-enhancement-mri","display_name":"late gadolinium enhancement MRI","score":0.8899999856948853}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8992065191268921},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.8786716461181641},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7696447372436523},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.7140039205551147},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.7114101052284241},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7095697522163391},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.6499567031860352},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.5685369968414307},{"id":"https://openalex.org/C93038891","wikidata":"https://www.wikidata.org/wiki/Q1061524","display_name":"Intensity (physics)","level":2,"score":0.4135710597038269},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.142.suppl_3.16758","doi":"https://doi.org/10.1161/circ.142.suppl_3.16758","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.142.suppl_3.16758","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6000000238418579,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3166679106","https://openalex.org/W4411492864","https://openalex.org/W4399164350","https://openalex.org/W4404187274","https://openalex.org/W4410325658","https://openalex.org/W3094607301","https://openalex.org/W7214638584","https://openalex.org/W4353048092","https://openalex.org/W3212277254","https://openalex.org/W4377016241"],"abstract_inverted_index":{"Introduction:":[0],"Atrial":[1],"fibrillation":[2],"(AF)":[3],"patients":[4,46,95,263],"are":[5,51],"at":[6,130],"high":[7,223,265],"risk":[8,44,82],"of":[9,24,68,92,142,152,228,252],"stroke,":[10],"with":[11,34,47,109,250,264],"the":[12,20,39,76,116,131,173,190,226,229,280],"left":[13],"atrial":[14,28,48],"appendage":[15],"(LAA)":[16],"found":[17],"to":[18,56,72,79,178,195,259,276],"be":[19],"most":[21],"common":[22],"site":[23],"clot":[25,288],"formation.":[26,289],"Left":[27],"(LA)":[29],"fibrosis":[30,70,248,267],"is":[31],"also":[32],"associated":[33],"higher":[35,188],"stroke":[36,43,81],"risk.":[37],"However,":[38,202],"mechanisms":[40,60],"for":[41,181,198,208,243,285],"increased":[42,80],"in":[45,75,83,172,189,225,274,279],"fibrotic":[49,163,174,191,230],"remodeling":[50],"poorly":[52],"understood.":[53],"We":[54,87],"sought":[55],"explore":[57],"these":[58],"specific":[59],"using":[61],"fluid":[62,123],"dynamics":[63],"analysis.":[64],"Hypothesis:":[65],"The":[66],"presence":[67],"LA":[69,100,118,132,247,266],"leads":[71],"aberrant":[73,253],"hemodynamics":[74,129],"atria,":[77],"contributing":[78],"AF":[84,94,262,297],"patients.":[85],"Methods:":[86],"retrospectively":[88],"collected":[89],"LGE-MRI":[90],"images":[91],"3":[93,111,183,200],"and":[96,128,144,158,164,211,222,238,299],"reconstructed":[97],"their":[98],"3D":[99],"endocardial":[101],"surfaces.":[102],"Fibrotic":[103],"regions":[104,251],"were":[105,126,134,160],"identified":[106],"as":[107,176,193],"those":[108],"intensity":[110],"standard":[112],"deviations":[113],"greater":[114],"than":[115],"mean":[117],"blood-pool":[119],"intensity.":[120],"Personalized":[121],"computational":[122],"dynamic":[124],"simulations":[125],"performed,":[127],"wall":[133,137,231],"quantified":[135],"by":[136],"shear":[138,146],"stress":[139],"(WSS,":[140],"friction":[141],"blood)":[143],"oscillatory":[145],"index":[147],"(OSI,":[148],"temporal":[149],"directional":[150],"change":[151],"WSS).":[153],"For":[154],"each":[155],"case,":[156],"WSS":[157,168,221],"OSI":[159,186,224],"compared":[161,177,194],"between":[162],"normal":[165,179,196],"regions.":[166],"Results:":[167],"was":[169,187,205,215,236],"significantly":[170,218],"lower":[171],"region":[175,180,192,197],"all":[182,199],"cases.":[184,201],"Additionally,":[185],"this":[203],"different":[204],"statistically":[206,217],"significant":[207],"cases":[209],"1":[210],"3;":[212],"case":[213],"2":[214],"not":[216],"different.":[219],"Low":[220],"vicinity":[227],"suggest":[232],"that":[233],"local":[234],"blood-flow":[235],"slow":[237],"oscillating,":[239],"enabling":[240],"pro-thrombotic":[241,272],"conditions":[242,291],"circulating":[244],"blood.":[245],"Conclusion:":[246],"correlates":[249],"hemodynamics,":[254],"which":[255],"renders":[256],"it":[257],"susceptible":[258],"blood":[260],"thrombosis.":[261],"burden":[268],"will":[269],"have":[270],"more":[271,283],"regions,":[273],"addition":[275],"low":[277],"flow":[278],"LAA,":[281],"providing":[282],"sites":[284],"a":[286],"potential":[287],"These":[290],"might":[292],"get":[293],"exacerbated":[294],"during":[295],"an":[296],"event":[298],"cause":[300],"stroke.":[301]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2020-11-23T00:00:00"}
