{"id":"https://openalex.org/W3098031338","doi":"https://doi.org/10.3389/fimmu.2020.574276","title":"Immunomodulatory Role of the Extracellular Matrix Within the Liver Disease Microenvironment","display_name":"Immunomodulatory Role of the Extracellular Matrix Within the Liver Disease Microenvironment","publication_year":2020,"publication_date":"2020-11-11","ids":{"openalex":"https://openalex.org/W3098031338","doi":"https://doi.org/10.3389/fimmu.2020.574276","mag":"3098031338","pmid":"https://pubmed.ncbi.nlm.nih.gov/33262757","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7686550"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2020.574276","doi":"https://doi.org/10.3389/fimmu.2020.574276","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2020.574276","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2020.574276/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2020.574276/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081182203","display_name":"Claire McQuitty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I335284955","display_name":"Foundation for Liver Research","ror":"https://ror.org/0143pk141","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I335284955"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Claire E. McQuitty","raw_affiliation_strings":["Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom","Institute of Hepatology, Foundation for Liver Research, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom","institution_ids":["https://openalex.org/I183935753"]},{"raw_affiliation_string":"Institute of Hepatology, Foundation for Liver Research, London, United Kingdom","institution_ids":["https://openalex.org/I335284955"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022473461","display_name":"Roger L. Williams","orcid":"https://orcid.org/0000-0001-7754-4207","observed_orcids":["https://orcid.org/0000-0001-7754-4207","https://orcid.org/0000-0003-0840-9292","https://orcid.org/0000-0001-9349-2371","https://orcid.org/0000-0001-6094-3172"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I335284955","display_name":"Foundation for Liver Research","ror":"https://ror.org/0143pk141","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I335284955"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Roger Williams","raw_affiliation_strings":["Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom","Institute of Hepatology, Foundation for Liver Research, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom","institution_ids":["https://openalex.org/I183935753"]},{"raw_affiliation_string":"Institute of Hepatology, Foundation for Liver Research, London, United Kingdom","institution_ids":["https://openalex.org/I335284955"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038002101","display_name":"Shilpa Chokshi","orcid":"https://orcid.org/0000-0003-1735-8538","observed_orcids":["https://orcid.org/0000-0003-1735-8538"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I335284955","display_name":"Foundation for Liver Research","ror":"https://ror.org/0143pk141","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I335284955"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Shilpa Chokshi","raw_affiliation_strings":["Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom","Institute of Hepatology, Foundation for Liver Research, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom","institution_ids":["https://openalex.org/I183935753"]},{"raw_affiliation_string":"Institute of Hepatology, Foundation for Liver Research, London, United Kingdom","institution_ids":["https://openalex.org/I335284955"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033338213","display_name":"Luca Urbani","orcid":"https://orcid.org/0000-0002-4988-552X","observed_orcids":["https://orcid.org/0000-0002-4988-552X"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I335284955","display_name":"Foundation for Liver Research","ror":"https://ror.org/0143pk141","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I335284955"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Luca Urbani","raw_affiliation_strings":["Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom","Institute of Hepatology, Foundation for Liver Research, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom","institution_ids":["https://openalex.org/I183935753"]},{"raw_affiliation_string":"Institute of Hepatology, Foundation for Liver Research, London, United Kingdom","institution_ids":["https://openalex.org/I335284955"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5033338213"],"corresponding_institution_ids":["https://openalex.org/I183935753","https://openalex.org/I335284955"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.8215,"has_fulltext":true,"cited_by_count":148,"citation_normalized_percentile":{"value":0.87219344,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"11","issue":null,"first_page":"574276","last_page":"574276"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.8916000127792358,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.8916000127792358,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.014700000174343586,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":1.0},{"id":"https://openalex.org/keywords/chronic-liver-disease","display_name":"chronic liver disease","score":0.953000009059906},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/damage-associated-molecular-patterns","display_name":"damage-associated molecular patterns","score":0.843999981880188},{"id":"https://openalex.org/keywords/sterile-inflammation","display_name":"sterile inflammation","score":0.7599999904632568},{"id":"https://openalex.org/keywords/integrins","display_name":"integrins","score":0.7990000247955322},{"id":"https://openalex.org/keywords/tlrs","display_name":"TLRs","score":0.8059999942779541},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.7919999957084656},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"tissue engineering","score":0.8830000162124634},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.8471963405609131},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7300358414649963},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.6490565538406372},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5644243955612183},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5640818476676941},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.5142709612846375},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.48094600439071655},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4514441192150116},{"id":"https://openalex.org/C190672674","wikidata":"https://www.wikidata.org/wiki/Q3866591","display_name":"Decellularization","level":3,"score":0.41865861415863037},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4083392024040222},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2669038772583008},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2232455611228943},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.16489511728286743},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056747","descriptor_name":"Immunomodulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2020.574276","doi":"https://doi.org/10.3389/fimmu.2020.574276","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2020.574276","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2020.574276/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7686550","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7686550","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:33262757","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33262757","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:25bbdc8de3a34c04bee7af4159553911","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/25bbdc8de3a34c04bee7af4159553911","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 11 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2020.574276","doi":"https://doi.org/10.3389/fimmu.2020.574276","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2020.574276","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2020.574276/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3098031338.pdf","grobid_xml":"https://content.openalex.org/works/W3098031338.grobid-xml"},"referenced_works_count":444,"referenced_works":["https://openalex.org/W5970515","https://openalex.org/W35542602","https://openalex.org/W59410367","https://openalex.org/W126874934","https://openalex.org/W145716214","https://openalex.org/W232770196","https://openalex.org/W971709972","https://openalex.org/W1061628335","https://openalex.org/W1475256780","https://openalex.org/W1484403196","https://openalex.org/W1488554402","https://openalex.org/W1507468262","https://openalex.org/W1512800027","https://openalex.org/W1517312016","https://openalex.org/W1541649993","https://openalex.org/W1564583863","https://openalex.org/W1565388169","https://openalex.org/W1570233039","https://openalex.org/W1575754639","https://openalex.org/W1598280943","https://openalex.org/W1640772643","https://openalex.org/W1679604700","https://openalex.org/W1683802707","https://openalex.org/W1756401131","https://openalex.org/W1779418296","https://openalex.org/W1851942040","https://openalex.org/W1864762127","https://openalex.org/W1872026168","https://openalex.org/W1881544501","https://openalex.org/W1889353829","https://openalex.org/W1921991607","https://openalex.org/W1923528838","https://openalex.org/W1929807462","https://openalex.org/W1952903895","https://openalex.org/W1959298931","https://openalex.org/W1965637499","https://openalex.org/W1965977008","https://openalex.org/W1967092440","https://openalex.org/W1967161091","https://openalex.org/W1967314793","https://openalex.org/W1967518731","https://openalex.org/W1967872610","https://openalex.org/W1968712129","https://openalex.org/W1968958521","https://openalex.org/W1969497590","https://openalex.org/W1970365072","https://openalex.org/W1970924670","https://openalex.org/W1970951405","https://openalex.org/W1973143084","https://openalex.org/W1973895231","https://openalex.org/W1974167931","https://openalex.org/W1974895367","https://openalex.org/W1975491952","https://openalex.org/W1976711591","https://openalex.org/W1977689971","https://openalex.org/W1978855332","https://openalex.org/W1980209143","https://openalex.org/W1980534733","https://openalex.org/W1980690619","https://openalex.org/W1981285854","https://openalex.org/W1982654262","https://openalex.org/W1985091171","https://openalex.org/W1987277679","https://openalex.org/W1987383242","https://openalex.org/W1987960919","https://openalex.org/W1988063563","https://openalex.org/W1988673189","https://openalex.org/W1988759309","https://openalex.org/W1988973424","https://openalex.org/W1988973539","https://openalex.org/W1989653346","https://openalex.org/W1989846203","https://openalex.org/W1989897871","https://openalex.org/W1990364658","https://openalex.org/W1990458931","https://openalex.org/W1991246311","https://openalex.org/W1991264914","https://openalex.org/W1991309463","https://openalex.org/W1991731944","https://openalex.org/W1992308841","https://openalex.org/W1992874803","https://openalex.org/W1993177993","https://openalex.org/W1993629981","https://openalex.org/W1997450131","https://openalex.org/W1997527787","https://openalex.org/W1998059646","https://openalex.org/W1998507492","https://openalex.org/W1998947159","https://openalex.org/W1998975199","https://openalex.org/W1999483148","https://openalex.org/W1999885534","https://openalex.org/W2000069042","https://openalex.org/W2000287530","https://openalex.org/W2000369852","https://openalex.org/W2001244523","https://openalex.org/W2001602562","https://openalex.org/W2001915193","https://openalex.org/W2002220495","https://openalex.org/W2002969023","https://openalex.org/W2003380614","https://openalex.org/W2004505997","https://openalex.org/W2004908411","https://openalex.org/W2005603356","https://openalex.org/W2006061236","https://openalex.org/W2006227076","https://openalex.org/W2006827135","https://openalex.org/W2006877529","https://openalex.org/W2007274239","https://openalex.org/W2009061578","https://openalex.org/W2009789486","https://openalex.org/W2010169576","https://openalex.org/W2010427736","https://openalex.org/W2012180376","https://openalex.org/W2012511365","https://openalex.org/W2014415867","https://openalex.org/W2014484446","https://openalex.org/W2014634831","https://openalex.org/W2014779210","https://openalex.org/W2016014601","https://openalex.org/W2017096535","https://openalex.org/W2017105523","https://openalex.org/W2020425240","https://openalex.org/W2021100840","https://openalex.org/W2021328900","https://openalex.org/W2021701428","https://openalex.org/W2023130151","https://openalex.org/W2025785916","https://openalex.org/W2026550755","https://openalex.org/W2027069446","https://openalex.org/W2027402816","https://openalex.org/W2027440025","https://openalex.org/W2027557878","https://openalex.org/W2027559978","https://openalex.org/W2029560608","https://openalex.org/W2029710444","https://openalex.org/W2030434034","https://openalex.org/W2030438430","https://openalex.org/W2031188817","https://openalex.org/W2031304251","https://openalex.org/W2032110591","https://openalex.org/W2032265293","https://openalex.org/W2033161975","https://openalex.org/W2033533236","https://openalex.org/W2034568094","https://openalex.org/W2035195694","https://openalex.org/W2035347098","https://openalex.org/W2035385482","https://openalex.org/W2036286400","https://openalex.org/W2036575278","https://openalex.org/W2036645992","https://openalex.org/W2036917103","https://openalex.org/W2037273983","https://openalex.org/W2038401636","https://openalex.org/W2038606974","https://openalex.org/W2039442213","https://openalex.org/W2039567228","https://openalex.org/W2039736385","https://openalex.org/W2040460288","https://openalex.org/W2040624227","https://openalex.org/W2040854254","https://openalex.org/W2041635943","https://openalex.org/W2041801047","https://openalex.org/W2042760078","https://openalex.org/W2044455641","https://openalex.org/W2044734165","https://openalex.org/W2044797498","https://openalex.org/W2045969462","https://openalex.org/W2046166693","https://openalex.org/W2046359424","https://openalex.org/W2046682881","https://openalex.org/W2047119143","https://openalex.org/W2048563910","https://openalex.org/W2049907045","https://openalex.org/W2051073305","https://openalex.org/W2051563649","https://openalex.org/W2051816002","https://openalex.org/W2053802748","https://openalex.org/W2053865773","https://openalex.org/W2054483829","https://openalex.org/W2054703329","https://openalex.org/W2055327883","https://openalex.org/W2056163657","https://openalex.org/W2056677725","https://openalex.org/W2057765165","https://openalex.org/W2058361955","https://openalex.org/W2058692868","https://openalex.org/W2059885558","https://openalex.org/W2061095488","https://openalex.org/W2061913778","https://openalex.org/W2062321035","https://openalex.org/W2062726330","https://openalex.org/W2063121650","https://openalex.org/W2063211029","https://openalex.org/W2065257841","https://openalex.org/W2065548757","https://openalex.org/W2066489069","https://openalex.org/W2068073506","https://openalex.org/W2069194720","https://openalex.org/W2069819211","https://openalex.org/W2069849035","https://openalex.org/W2070105244","https://openalex.org/W2070961669","https://openalex.org/W2071129130","https://openalex.org/W2073331000","https://openalex.org/W2074017212","https://openalex.org/W2076517608","https://openalex.org/W2077062607","https://openalex.org/W2077569218","https://openalex.org/W2078771695","https://openalex.org/W2080176520","https://openalex.org/W2080282300","https://openalex.org/W2081829534","https://openalex.org/W2083544543","https://openalex.org/W2083549154","https://openalex.org/W2084892018","https://openalex.org/W2087449202","https://openalex.org/W2087877540","https://openalex.org/W2088613706","https://openalex.org/W2090614253","https://openalex.org/W2092589546","https://openalex.org/W2094022594","https://openalex.org/W2094464744","https://openalex.org/W2095309118","https://openalex.org/W2095331812","https://openalex.org/W2095998281","https://openalex.org/W2096152109","https://openalex.org/W2096223977","https://openalex.org/W2097273361","https://openalex.org/W2097583511","https://openalex.org/W2098142645","https://openalex.org/W2099635702","https://openalex.org/W2101619182","https://openalex.org/W2104187124","https://openalex.org/W2105216609","https://openalex.org/W2105697133","https://openalex.org/W2106620894","https://openalex.org/W2107746364","https://openalex.org/W2107774642","https://openalex.org/W2108273756","https://openalex.org/W2108830789","https://openalex.org/W2110263673","https://openalex.org/W2110549425","https://openalex.org/W2111047324","https://openalex.org/W2111923806","https://openalex.org/W2113320375","https://openalex.org/W2114150480","https://openalex.org/W2114695060","https://openalex.org/W2114814207","https://openalex.org/W2114967662","https://openalex.org/W2115416944","https://openalex.org/W2115493961","https://openalex.org/W2115548241","https://openalex.org/W2115914792","https://openalex.org/W2116734097","https://openalex.org/W2117062936","https://openalex.org/W2117173160","https://openalex.org/W2118320694","https://openalex.org/W2118713387","https://openalex.org/W2122081319","https://openalex.org/W2122485317","https://openalex.org/W2122616632","https://openalex.org/W2124496335","https://openalex.org/W2125310843","https://openalex.org/W2126490617","https://openalex.org/W2126659405","https://openalex.org/W2129591536","https://openalex.org/W2129763311","https://openalex.org/W2130030207","https://openalex.org/W2130229338","https://openalex.org/W2131093431","https://openalex.org/W2131266963","https://openalex.org/W2131381643","https://openalex.org/W2131584053","https://openalex.org/W2131724226","https://openalex.org/W2134023627","https://openalex.org/W2134648443","https://openalex.org/W2134652066","https://openalex.org/W2136005024","https://openalex.org/W2137376744","https://openalex.org/W2137639228","https://openalex.org/W2137970334","https://openalex.org/W2138083101","https://openalex.org/W2138110431","https://openalex.org/W2138972371","https://openalex.org/W2140698023","https://openalex.org/W2140930678","https://openalex.org/W2141326785","https://openalex.org/W2141877739","https://openalex.org/W2142018793","https://openalex.org/W2142988890","https://openalex.org/W2143647993","https://openalex.org/W2144032514","https://openalex.org/W2144921016","https://openalex.org/W2146851359","https://openalex.org/W2146919918","https://openalex.org/W2147617210","https://openalex.org/W2148825865","https://openalex.org/W2149123553","https://openalex.org/W2149494021","https://openalex.org/W2150050975","https://openalex.org/W2153141062","https://openalex.org/W2154042778","https://openalex.org/W2154750687","https://openalex.org/W2155893315","https://openalex.org/W2156368000","https://openalex.org/W2159058635","https://openalex.org/W2159731793","https://openalex.org/W2160370983","https://openalex.org/W2161091841","https://openalex.org/W2161150914","https://openalex.org/W2162006722","https://openalex.org/W2162509998","https://openalex.org/W2162530232","https://openalex.org/W2162625088","https://openalex.org/W2164092307","https://openalex.org/W2164598272","https://openalex.org/W2164787467","https://openalex.org/W2165673838","https://openalex.org/W2166704790","https://openalex.org/W2166774670","https://openalex.org/W2167490424","https://openalex.org/W2170335992","https://openalex.org/W2171656980","https://openalex.org/W2172216752","https://openalex.org/W2177007785","https://openalex.org/W2185458851","https://openalex.org/W2190830971","https://openalex.org/W2225553364","https://openalex.org/W2239019329","https://openalex.org/W2241138445","https://openalex.org/W2268066121","https://openalex.org/W2269465056","https://openalex.org/W2307551625","https://openalex.org/W2329414459","https://openalex.org/W2329774418","https://openalex.org/W2340312001","https://openalex.org/W2345844730","https://openalex.org/W2395368163","https://openalex.org/W2397365606","https://openalex.org/W2405674616","https://openalex.org/W2408983074","https://openalex.org/W2412618262","https://openalex.org/W2416755733","https://openalex.org/W2418616153","https://openalex.org/W2431221622","https://openalex.org/W2476542314","https://openalex.org/W2490769112","https://openalex.org/W2510096447","https://openalex.org/W2517304629","https://openalex.org/W2530995434","https://openalex.org/W2537083947","https://openalex.org/W2537802380","https://openalex.org/W2548517585","https://openalex.org/W2548946619","https://openalex.org/W2550243513","https://openalex.org/W2554500207","https://openalex.org/W2560014600","https://openalex.org/W2562949639","https://openalex.org/W2578670173","https://openalex.org/W2586859855","https://openalex.org/W2587041385","https://openalex.org/W2594100081","https://openalex.org/W2594491387","https://openalex.org/W2596139865","https://openalex.org/W2613180696","https://openalex.org/W2613643891","https://openalex.org/W2738211982","https://openalex.org/W2742718825","https://openalex.org/W2746359565","https://openalex.org/W2746591356","https://openalex.org/W2758838459","https://openalex.org/W2759984881","https://openalex.org/W2766068933","https://openalex.org/W2769114174","https://openalex.org/W2770050579","https://openalex.org/W2770536443","https://openalex.org/W2770903823","https://openalex.org/W2773476769","https://openalex.org/W2779950914","https://openalex.org/W2782100994","https://openalex.org/W2782677925","https://openalex.org/W2782796034","https://openalex.org/W2782936472","https://openalex.org/W2783989380","https://openalex.org/W2784105613","https://openalex.org/W2790327151","https://openalex.org/W2790830382","https://openalex.org/W2792088252","https://openalex.org/W2794413691","https://openalex.org/W2797460017","https://openalex.org/W2799347062","https://openalex.org/W2801726808","https://openalex.org/W2803536345","https://openalex.org/W2806364231","https://openalex.org/W2809302144","https://openalex.org/W2883203008","https://openalex.org/W2887239495","https://openalex.org/W2887276938","https://openalex.org/W2890324251","https://openalex.org/W2895254819","https://openalex.org/W2895633654","https://openalex.org/W2896325654","https://openalex.org/W2897565061","https://openalex.org/W2899031631","https://openalex.org/W2900554213","https://openalex.org/W2902912681","https://openalex.org/W2904444744","https://openalex.org/W2905341752","https://openalex.org/W2906658161","https://openalex.org/W2911595899","https://openalex.org/W2912869261","https://openalex.org/W2914156600","https://openalex.org/W2921458707","https://openalex.org/W2923321302","https://openalex.org/W2944390245","https://openalex.org/W2964364140","https://openalex.org/W2965996124","https://openalex.org/W2972310443","https://openalex.org/W2972904585","https://openalex.org/W2975116744","https://openalex.org/W2978880851","https://openalex.org/W2980205244","https://openalex.org/W2997147409","https://openalex.org/W2998892996","https://openalex.org/W3004687495","https://openalex.org/W3005084307","https://openalex.org/W3010467346","https://openalex.org/W3017336344","https://openalex.org/W3023603061","https://openalex.org/W3031691268","https://openalex.org/W3033669843","https://openalex.org/W3040793371","https://openalex.org/W3043675621","https://openalex.org/W3044154681","https://openalex.org/W3044576199","https://openalex.org/W3073968329","https://openalex.org/W3112356895","https://openalex.org/W4206026069","https://openalex.org/W4210961984","https://openalex.org/W4210980460","https://openalex.org/W4211053760","https://openalex.org/W4233211689","https://openalex.org/W4313333745","https://openalex.org/W6676343355"],"related_works":["https://openalex.org/W4323659164","https://openalex.org/W2050739087","https://openalex.org/W1993557008","https://openalex.org/W4405073191","https://openalex.org/W4391946335","https://openalex.org/W3000114186","https://openalex.org/W3061783101","https://openalex.org/W7171644334","https://openalex.org/W2937267121","https://openalex.org/W3039317121"],"abstract_inverted_index":{"Chronic":[0],"liver":[1,147,163,232],"disease":[2,148],"when":[3],"accompanied":[4],"by":[5,10,171],"underlying":[6,162],"fibrosis,":[7,137],"is":[8,33],"characterised":[9],"an":[11],"accumulation":[12],"of":[13,40,55,62,66,74,83,91,114,145,168,213,221],"extracellular":[14],"matrix":[15],"(ECM)":[16],"proteins":[17,79,177],"and":[18,27,46,58,95,97,104,122,128,133,178,224,229],"chronic":[19,146],"inflammation.":[20,124],"Although":[21],"traditionally":[22],"considered":[23],"as":[24,37],"a":[25,38,53,88],"passive":[26],"largely":[28],"architectural":[29],"structure,":[30],"the":[31,50,68,126,143,159,173,219],"ECM":[32,51,78,102,127,175,208],"now":[34],"being":[35],"recognised":[36],"source":[39],"potent":[41],"DAMPs":[42],"with":[43,99,180],"immune-active":[44],"peptides":[45],"domains.":[47],"In":[48],"parallel,":[49],"anchors":[52],"range":[54,90],"cytokines,":[56],"chemokines":[57],"growth":[59],"factors,":[60],"all":[61],"which":[63,116],"are":[64,81,131,149],"capable":[65,82],"modulating":[67],"immune":[69,100,119,129,182],"responses.":[70],"A":[71,210],"growing":[72],"body":[73],"evidence":[75],"shows":[76],"that":[77],"themselves":[80],"interacting":[84],"both":[85],"directly,":[86],"via":[87],"wide":[89],"receptors":[92],"including":[93],"integrins":[94],"TLRs,":[96],"indirectly":[98],"cells.":[101],"deposition":[103],"remodelling":[105],"during":[106],"fibrosis":[107,167],"can":[108,117],"result":[109],"in":[110,135,142,165,200,218,231],"release":[111],"or":[112],"formation":[113],"ECM-DAMPs,":[115],"drive":[118],"cellular":[120],"infiltration":[121],"sterile":[123],"Both":[125],"response":[130],"interlinked":[132],"integral":[134],"driving":[136],"although":[138],"their":[139],"precise":[140],"interactions":[141,161,199,215],"context":[144],"poorly":[150],"understood.":[151],"This":[152],"review":[153],"aims":[154],"to":[155,195],"shed":[156],"light":[157],"on":[158],"ECM-immune":[160,197],"disease,":[164],"particular":[166],"different":[169],"aetiologies,":[170],"describing":[172],"main":[174],"intact":[176,206],"ECM-DAMPs":[179],"known":[181],"regulatory":[183],"activity.":[184],"We":[185],"also":[186],"discuss":[187],"how":[188],"tissue":[189],"engineering":[190],"could":[191],"provide":[192],"new":[193,222],"opportunities":[194],"explore":[196],"cell":[198],"bioreactor-based":[201],"dynamic":[202],"3D":[203],"models":[204],"containing":[205],"decellularized":[207],"scaffolds.":[209],"better":[211],"understanding":[212],"these":[214],"would":[216],"aid":[217],"identification":[220],"antifibrotic":[223],"immunomodulatory":[225],"targets":[226],"for":[227],"treatment":[228],"biomarkers":[230],"disease.":[233]},"counts_by_year":[{"year":2026,"cited_by_count":24},{"year":2025,"cited_by_count":24},{"year":2024,"cited_by_count":33},{"year":2023,"cited_by_count":31},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":17}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-11-23T00:00:00"}