{"id":"https://openalex.org/W3098005458","doi":"https://doi.org/10.1016/j.jad.2020.11.063","title":"The association between anti-inflammatory effects of long-term lithium treatment and illness course in Bipolar Disorder.","display_name":"The association between anti-inflammatory effects of long-term lithium treatment and illness course in Bipolar Disorder.","publication_year":2020,"publication_date":"2020-11-14","ids":{"openalex":"https://openalex.org/W3098005458","doi":"https://doi.org/10.1016/j.jad.2020.11.063","mag":"3098005458","pmid":"https://pubmed.ncbi.nlm.nih.gov/33338840"},"language":"en","primary_location":{"id":"doi:10.1016/j.jad.2020.11.063","doi":"https://doi.org/10.1016/j.jad.2020.11.063","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jad.2020.11.063","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0165032720329931/pdf","source":{"id":"https://openalex.org/S113871862","display_name":"Journal of Affective Disorders","issn_l":"0165-0327","issn":["0165-0327","1573-2517"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Affective Disorders","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0165032720329931/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055188969","display_name":"Robert Queissner","orcid":"https://orcid.org/0000-0001-6632-0902","observed_orcids":["https://orcid.org/0000-0001-6632-0902"]},"institutions":[{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"R. Queissner","raw_affiliation_strings":["Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria","institution_ids":["https://openalex.org/I202276237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053256414","display_name":"Melanie Lenger","orcid":"https://orcid.org/0000-0003-0638-5389","observed_orcids":["https://orcid.org/0000-0003-0638-5389"]},"institutions":[{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"M. Lenger","raw_affiliation_strings":["Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria","institution_ids":["https://openalex.org/I202276237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042437865","display_name":"Armin Birner","orcid":"https://orcid.org/0000-0002-5047-6264","observed_orcids":["https://orcid.org/0000-0002-5047-6264"]},"institutions":[{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"A. Birner","raw_affiliation_strings":["Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria. Electronic address: armin.birner@medunigraz.at","Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria. Electronic address: armin.birner@medunigraz.at","institution_ids":["https://openalex.org/I202276237"]},{"raw_affiliation_string":"Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria","institution_ids":["https://openalex.org/I202276237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029835725","display_name":"Nina Dalkner","orcid":"https://orcid.org/0000-0001-7716-3674","observed_orcids":["https://orcid.org/0000-0001-7716-3674","https://orcid.org/0000-0002-4419-3524"]},"institutions":[{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"N. Dalkner","raw_affiliation_strings":["Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria","institution_ids":["https://openalex.org/I202276237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056517698","display_name":"Frederike T. Fellendorf","orcid":"https://orcid.org/0000-0001-7215-3848","observed_orcids":["https://orcid.org/0000-0001-7215-3848"]},"institutions":[{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"F. Fellendorf","raw_affiliation_strings":["Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria","institution_ids":["https://openalex.org/I202276237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049569257","display_name":"Susanne Bengesser","orcid":"https://orcid.org/0000-0001-8012-908X","observed_orcids":["https://orcid.org/0000-0001-8012-908X"]},"institutions":[{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"S. Bengesser","raw_affiliation_strings":["Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria","institution_ids":["https://openalex.org/I202276237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013342842","display_name":"Martina Platzer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"M. Platzer","raw_affiliation_strings":["Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria","institution_ids":["https://openalex.org/I202276237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088723948","display_name":"Carlo Hamm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"C. Hamm","raw_affiliation_strings":["Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria","institution_ids":["https://openalex.org/I202276237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031834001","display_name":"Alexander Maget","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"A. Maget","raw_affiliation_strings":["Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria","institution_ids":["https://openalex.org/I202276237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079696232","display_name":"Bernd Reininghaus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"B. Reininghaus","raw_affiliation_strings":["Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria","institution_ids":["https://openalex.org/I202276237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011632749","display_name":"Michaela Ratzenhofer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"M. Ratzenhofer","raw_affiliation_strings":["Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria","institution_ids":["https://openalex.org/I202276237"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J. Schuller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"J. Schuller","raw_affiliation_strings":["Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria","institution_ids":["https://openalex.org/I202276237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054772233","display_name":"Harald Mangge","orcid":"https://orcid.org/0000-0003-4067-247X","observed_orcids":["https://orcid.org/0000-0003-4067-247X","https://orcid.org/0000-0002-5182-4558"]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]},{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"H. Mangge","raw_affiliation_strings":["Research Unit on Lifestyle and Inflammation-associated Risk Biomarkers, Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Unit on Lifestyle and Inflammation-associated Risk Biomarkers, Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Graz, Austria","institution_ids":["https://openalex.org/I15766117","https://openalex.org/I202276237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086062107","display_name":"Hans\u2010Peter Kapfhammer","orcid":"https://orcid.org/0000-0002-0808-462X","observed_orcids":["https://orcid.org/0000-0002-0808-462X"]},"institutions":[{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"H.P. Kapfhammer","raw_affiliation_strings":["Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria","institution_ids":["https://openalex.org/I202276237"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104105617","display_name":"EZ Reininghaus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"EZ. Reininghaus","raw_affiliation_strings":["Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria","institution_ids":["https://openalex.org/I202276237"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5042437865"],"corresponding_institution_ids":["https://openalex.org/I202276237"],"apc_list":{"value":3350,"currency":"USD","value_usd":3350},"apc_paid":{"value":3350,"currency":"USD","value_usd":3350},"fwci":0.9963,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.71814224,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"281","issue":null,"first_page":"228","last_page":"234"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":0.996999979019165},{"id":"https://openalex.org/keywords/lithium-treatment","display_name":"lithium therapy","score":0.8190000057220459},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.6940000057220459},{"id":"https://openalex.org/keywords/high-sensitivity-c-reactive-protein","display_name":"high-sensitivity C-reactive protein","score":0.8999999761581421},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.8389999866485596},{"id":"https://openalex.org/keywords/symptom-progression","display_name":"symptom progression","score":0.7590000033378601},{"id":"https://openalex.org/keywords/clinical-course","display_name":"clinical course","score":0.9670000076293945},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C2778541603","wikidata":"https://www.wikidata.org/wiki/Q152763","display_name":"Lithium (medication)","level":2,"score":0.7784824371337891},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6300042867660522},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5848288536071777},{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.5765345096588135},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3935413956642151}],"mesh":[{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008094","descriptor_name":"Lithium","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018020","descriptor_name":"Lithium Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jad.2020.11.063","doi":"https://doi.org/10.1016/j.jad.2020.11.063","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jad.2020.11.063","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0165032720329931/pdf","source":{"id":"https://openalex.org/S113871862","display_name":"Journal of Affective Disorders","issn_l":"0165-0327","issn":["0165-0327","1573-2517"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Affective Disorders","raw_type":"journal-article"},{"id":"pmid:33338840","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33338840","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of affective disorders","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.jad.2020.11.063","doi":"https://doi.org/10.1016/j.jad.2020.11.063","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jad.2020.11.063","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0165032720329931/pdf","source":{"id":"https://openalex.org/S113871862","display_name":"Journal of Affective Disorders","issn_l":"0165-0327","issn":["0165-0327","1573-2517"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Affective Disorders","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3098005458.pdf","grobid_xml":"https://content.openalex.org/works/W3098005458.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W3874376","https://openalex.org/W17446229","https://openalex.org/W143843505","https://openalex.org/W353307760","https://openalex.org/W1142790208","https://openalex.org/W1551831696","https://openalex.org/W1874748810","https://openalex.org/W1965636455","https://openalex.org/W1969114959","https://openalex.org/W1972616166","https://openalex.org/W1972926621","https://openalex.org/W1975110303","https://openalex.org/W1989764712","https://openalex.org/W1990223762","https://openalex.org/W1992284534","https://openalex.org/W1993856151","https://openalex.org/W2005350748","https://openalex.org/W2011092724","https://openalex.org/W2013106702","https://openalex.org/W2024886564","https://openalex.org/W2028751589","https://openalex.org/W2032657270","https://openalex.org/W2036257231","https://openalex.org/W2048873882","https://openalex.org/W2051189132","https://openalex.org/W2055476558","https://openalex.org/W2058077849","https://openalex.org/W2081459415","https://openalex.org/W2083294549","https://openalex.org/W2093499787","https://openalex.org/W2095417278","https://openalex.org/W2104658341","https://openalex.org/W2115086630","https://openalex.org/W2128629099","https://openalex.org/W2135757914","https://openalex.org/W2139276071","https://openalex.org/W2150123367","https://openalex.org/W2194924010","https://openalex.org/W2265848353","https://openalex.org/W2275840112","https://openalex.org/W2305240766","https://openalex.org/W2401642857","https://openalex.org/W2473956915","https://openalex.org/W2531435844","https://openalex.org/W2608092979","https://openalex.org/W2767282211","https://openalex.org/W2790759623","https://openalex.org/W2808473599","https://openalex.org/W2893851034","https://openalex.org/W2894763051","https://openalex.org/W2899587982","https://openalex.org/W3022013151","https://openalex.org/W3109338640","https://openalex.org/W4247665917","https://openalex.org/W6682190749"],"related_works":["https://openalex.org/W4394787458","https://openalex.org/W4248725940","https://openalex.org/W2790759623","https://openalex.org/W2333485767","https://openalex.org/W4304163337","https://openalex.org/W2213962598","https://openalex.org/W4286449136","https://openalex.org/W7219844277","https://openalex.org/W3026642021","https://openalex.org/W2025700197"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Altered":[1],"levels":[2,66,149,182],"of":[3,29,36,45,62,67,83,97,100,106,111,133,150,177,214,238,243],"acute-phase":[4],"proteins":[5],"are":[6,31],"often":[7],"described":[8],"in":[9,12,25,95,114,152,183,208,249],"different":[10],"conditions":[11],"BD.":[13,209,250],"Nevertheless,":[14],"data":[15],"on":[16],"the":[17,26,37,42,58,93,115,175,184],"association":[18,59,226],"between":[19,60,174,227],"lithium":[20,49,63,84,134,178,215,230,239],"treatment":[21,64,85,135,179,216,231],"and":[22,54,65,104,117,180,229],"inflammatory":[23,52,197],"markers":[24],"long-term":[27,43,48],"course":[28,44,207],"BD":[30,46,79],"still":[32],"missing.":[33],"The":[34,224],"aim":[35],"study":[38],"was":[39,69,169],"to":[40,137,159],"examine":[41],"concerning":[47],"treatment,":[50],"chronic":[51],"processes":[53],"symptom":[55,89,125,156,162,222],"progression.":[56,223],"Furthermore,":[57],"duration":[61,105,132,176,213,232],"hsCRP":[68,118,151,181],"explored.":[70],"METHODS:":[71],"267":[72],"individuals":[73,123,138,154],"(males=":[74],"139,":[75],"females=":[76],"128)":[77],"with":[78,124,155,202,220],"were":[80,119,146],"included.":[81],"Duration":[82],"as":[86,88,92,240],"well":[87],"progression,":[90],"defined":[91],"increase":[94],"severity":[96],"symptoms,":[98],"number":[99],"episodes":[101,107],"a":[102,109,170,203,211,234,241],"year":[103],"within":[108],"period":[110],"1.5":[112],"years":[113],"past":[116],"evaluated.":[120],"RESULTS:":[121],"Male":[122],"progression":[126,141,157,163],"over":[127],"time":[128],"had":[129],"significantly":[130,147],"lower":[131,221],"compared":[136,158],"without":[139,161],"symptoms":[140],"(U=":[142,164],"47.4,":[143],"p=.037).":[144],"There":[145],"higher":[148],"male":[153],"males":[160],"47.5,":[165],"p=.027).":[166],"Further,":[167,210],"there":[168],"significant":[171,245],"negative":[172],"correlation":[173],"whole":[185],"sample":[186],"(r=":[187],"-.276,":[188],"p<.05).":[189],"CONCLUSION:":[190],"Our":[191],"results":[192],"show":[193],"that":[194],"an":[195],"altered":[196],"state":[198],"may":[199,217],"be":[200,218],"associated":[201,219],"more":[204],"severe":[205],"illness":[206],"longer":[212],"shown":[225],"hsCRP-levels":[228],"suggests":[233],"potential":[235],"anti-inflammatory":[236],"effect":[237,248],"mediator":[242],"its":[244],"positive":[246],"outcome":[247]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-11-23T00:00:00"}