{"id":"https://openalex.org/W3097828594","doi":"https://doi.org/10.1021/acssuschemeng.0c04707","title":"Green Mechanochemical Strategy for the Discovery and Selective Preparation of Polymorphs of Active Pharmaceutical Ingredient \u03b3-Aminobutyric Acid (GABA)","display_name":"Green Mechanochemical Strategy for the Discovery and Selective Preparation of Polymorphs of Active Pharmaceutical Ingredient \u03b3-Aminobutyric Acid (GABA)","publication_year":2020,"publication_date":"2020-11-05","ids":{"openalex":"https://openalex.org/W3097828594","doi":"https://doi.org/10.1021/acssuschemeng.0c04707","mag":"3097828594"},"language":"en","primary_location":{"id":"doi:10.1021/acssuschemeng.0c04707","doi":"https://doi.org/10.1021/acssuschemeng.0c04707","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acssuschemeng.0c04707","pdf_url":null,"source":{"id":"https://openalex.org/S2502047864","display_name":"ACS Sustainable Chemistry & Engineering","issn_l":"2168-0485","issn":["2168-0485"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Sustainable Chemistry & Engineering","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100730389","display_name":"Lingyu Wang","orcid":"https://orcid.org/0000-0001-6529-6939","observed_orcids":["https://orcid.org/0000-0001-6529-6939"]},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I4210156066","display_name":"State Key Laboratory of Chemical Engineering","ror":"https://ror.org/05803vc71","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210156066"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingyu Wang","raw_affiliation_strings":["State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, No. 92 Weijin Road, Tianjin 300072, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, No. 92 Weijin Road, Tianjin 300072, China","institution_ids":["https://openalex.org/I162868743","https://openalex.org/I4210156066"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109719822","display_name":"Guangxu Sun","orcid":"https://orcid.org/0000-0003-0801-5699","observed_orcids":["https://orcid.org/0000-0003-0801-5699"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guangxu Sun","raw_affiliation_strings":["Lab of Computational Chemistry and Drug Design, State Key Laboratory of Chemical Oncogeomics, Peking University Shenzhen Graduate School, No. 2199 Lishui Road, Shenzhen 518055, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab of Computational Chemistry and Drug Design, State Key Laboratory of Chemical Oncogeomics, Peking University Shenzhen Graduate School, No. 2199 Lishui Road, Shenzhen 518055, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100781984","display_name":"Keke Zhang","orcid":"https://orcid.org/0000-0003-2576-6929","observed_orcids":["https://orcid.org/0000-0003-2576-6929"]},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I4210156066","display_name":"State Key Laboratory of Chemical Engineering","ror":"https://ror.org/05803vc71","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210156066"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Keke Zhang","raw_affiliation_strings":["State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, No. 92 Weijin Road, Tianjin 300072, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, No. 92 Weijin Road, Tianjin 300072, China","institution_ids":["https://openalex.org/I162868743","https://openalex.org/I4210156066"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017570192","display_name":"Menghui Yao","orcid":"https://orcid.org/0000-0002-4883-5256","observed_orcids":["https://orcid.org/0000-0002-4883-5256"]},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I4210156066","display_name":"State Key Laboratory of Chemical Engineering","ror":"https://ror.org/05803vc71","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210156066"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Menghui Yao","raw_affiliation_strings":["State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, No. 92 Weijin Road, Tianjin 300072, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, No. 92 Weijin Road, Tianjin 300072, China","institution_ids":["https://openalex.org/I162868743","https://openalex.org/I4210156066"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110444648","display_name":"Yingdi Jin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405271797","display_name":"XtalPi (China)","ror":"https://ror.org/032kk6v87","country_code":"CN","type":"company","lineage":["https://openalex.org/I4405271797"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingdi Jin","raw_affiliation_strings":["XtalPi Inc., Shenzhen Jingtai Technology Co., Ltd., Floor 4, No. 9, Hualian Industrial Zone, Dalang Street, Longhua District, Shenzhen 518100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"XtalPi Inc., Shenzhen Jingtai Technology Co., Ltd., Floor 4, No. 9, Hualian Industrial Zone, Dalang Street, Longhua District, Shenzhen 518100, China","institution_ids":["https://openalex.org/I4405271797"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100605323","display_name":"Peiyu Zhang","orcid":"https://orcid.org/0000-0002-1715-5012","observed_orcids":["https://orcid.org/0000-0002-1715-5012"]},"institutions":[{"id":"https://openalex.org/I4405271797","display_name":"XtalPi (China)","ror":"https://ror.org/032kk6v87","country_code":"CN","type":"company","lineage":["https://openalex.org/I4405271797"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peiyu Zhang","raw_affiliation_strings":["XtalPi Inc., Shenzhen Jingtai Technology Co., Ltd., Floor 4, No. 9, Hualian Industrial Zone, Dalang Street, Longhua District, Shenzhen 518100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"XtalPi Inc., Shenzhen Jingtai Technology Co., Ltd., Floor 4, No. 9, Hualian Industrial Zone, Dalang Street, Longhua District, Shenzhen 518100, China","institution_ids":["https://openalex.org/I4405271797"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081877199","display_name":"Songgu Wu","orcid":"https://orcid.org/0000-0003-4329-4654","observed_orcids":["https://orcid.org/0000-0003-4329-4654","https://orcid.org/0000-0003-3956-5351"]},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I4210156066","display_name":"State Key Laboratory of Chemical Engineering","ror":"https://ror.org/05803vc71","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210156066"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Songgu Wu","raw_affiliation_strings":["State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, No. 92 Weijin Road, Tianjin 300072, China"],"raw_orcid":"https://orcid.org/0000-0003-4329-4654","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, No. 92 Weijin Road, Tianjin 300072, China","institution_ids":["https://openalex.org/I162868743","https://openalex.org/I4210156066"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054467654","display_name":"Junbo Gong","orcid":"https://orcid.org/0000-0002-3376-3296","observed_orcids":["https://orcid.org/0000-0002-3376-3296"]},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I4210156066","display_name":"State Key Laboratory of Chemical Engineering","ror":"https://ror.org/05803vc71","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210156066"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Junbo Gong","raw_affiliation_strings":["State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, No. 92 Weijin Road, Tianjin 300072, China"],"raw_orcid":"https://orcid.org/0000-0002-3376-3296","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, No. 92 Weijin Road, Tianjin 300072, China","institution_ids":["https://openalex.org/I162868743","https://openalex.org/I4210156066"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5054467654","https://openalex.org/A5081877199"],"corresponding_institution_ids":["https://openalex.org/I162868743","https://openalex.org/I4210156066"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":1.3054,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.76929943,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"8","issue":"45","first_page":"16781","last_page":"16790"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10798","display_name":"Crystallography and molecular interactions","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gaba","display_name":"GABA","score":0.9860000014305115},{"id":"https://openalex.org/keywords/mechanochemical-milling","display_name":"mechanochemical milling","score":0.8560000061988831},{"id":"https://openalex.org/keywords/green-synthesis","display_name":"green synthesis","score":0.5580000281333923},{"id":"https://openalex.org/keywords/crystal-structure-prediction","display_name":"crystal structure prediction","score":0.6489999890327454},{"id":"https://openalex.org/keywords/polymorph-stability","display_name":"polymorph stability","score":0.6949999928474426},{"id":"https://openalex.org/keywords/surface-stability","display_name":"surface stability","score":0.75},{"id":"https://openalex.org/keywords/crystal-size-effects","display_name":"crystal size effects","score":0.4569999873638153},{"id":"https://openalex.org/keywords/active-pharmaceutical-ingredients","display_name":"active pharmaceutical ingredients","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C2779414652","wikidata":"https://www.wikidata.org/wiki/Q3604505","display_name":"Aminobutyric acid","level":3,"score":0.5605108737945557},{"id":"https://openalex.org/C2781285689","wikidata":"https://www.wikidata.org/wiki/Q21921428","display_name":"Crystal (programming language)","level":2,"score":0.5351238250732422},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.529812216758728},{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.5141046643257141},{"id":"https://openalex.org/C45904493","wikidata":"https://www.wikidata.org/wiki/Q912807","display_name":"Active ingredient","level":2,"score":0.5124967098236084},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.5087171196937561},{"id":"https://openalex.org/C2780471494","wikidata":"https://www.wikidata.org/wiki/Q146505","display_name":"Solvent","level":2,"score":0.4917297661304474},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.46763017773628235},{"id":"https://openalex.org/C115624301","wikidata":"https://www.wikidata.org/wiki/Q895901","display_name":"Crystal structure","level":2,"score":0.42481857538223267},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.3904290795326233},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37868839502334595},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3711871802806854},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.29941636323928833},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2871306538581848},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.11502748727798462},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acssuschemeng.0c04707","doi":"https://doi.org/10.1021/acssuschemeng.0c04707","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acssuschemeng.0c04707","pdf_url":null,"source":{"id":"https://openalex.org/S2502047864","display_name":"ACS Sustainable Chemistry & Engineering","issn_l":"2168-0485","issn":["2168-0485"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Sustainable Chemistry & Engineering","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2943868742","display_name":"\u6eb6\u5242\u4ecb\u5bfc\u5feb\u901f\u76f8\u8f6c\u5316\u7684\u5206\u5b50\u673a\u5236\u548c\u53ef\u63a7\u5236\u5907\u7814\u7a76","funder_award_id":"21808158","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3383340858","display_name":null,"funder_award_id":"2017 ZX09101001","funder_id":"https://openalex.org/F4320321540","funder_display_name":"Ministry of Science and Technology of the People's Republic of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321540","display_name":"Ministry of Science and Technology of the People's Republic of China","ror":"https://ror.org/027s68j25"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1966099081","https://openalex.org/W1981368803","https://openalex.org/W2000536749","https://openalex.org/W2001961403","https://openalex.org/W2007395042","https://openalex.org/W2007572329","https://openalex.org/W2026912788","https://openalex.org/W2044354092","https://openalex.org/W2055245203","https://openalex.org/W2058749860","https://openalex.org/W2071082437","https://openalex.org/W2073349723","https://openalex.org/W2075730622","https://openalex.org/W2079105963","https://openalex.org/W2079475128","https://openalex.org/W2082342794","https://openalex.org/W2083084862","https://openalex.org/W2087698390","https://openalex.org/W2128868542","https://openalex.org/W2138489711","https://openalex.org/W2257290984","https://openalex.org/W2282425106","https://openalex.org/W2346538334","https://openalex.org/W2470117954","https://openalex.org/W2491083677","https://openalex.org/W2508411237","https://openalex.org/W2508844932","https://openalex.org/W2586339436","https://openalex.org/W2611255263","https://openalex.org/W2786078771","https://openalex.org/W2808302226","https://openalex.org/W2883643517","https://openalex.org/W2883957483","https://openalex.org/W2884506076","https://openalex.org/W2895745265","https://openalex.org/W2896908291","https://openalex.org/W2909336725","https://openalex.org/W2921936306","https://openalex.org/W2947648367","https://openalex.org/W2952283778","https://openalex.org/W2959524987","https://openalex.org/W2973169358","https://openalex.org/W2995711032","https://openalex.org/W4243832616","https://openalex.org/W4244837715"],"related_works":["https://openalex.org/W4324090982","https://openalex.org/W4402929657","https://openalex.org/W4200335932","https://openalex.org/W2334884000","https://openalex.org/W1975601818","https://openalex.org/W4400986590","https://openalex.org/W2031730514","https://openalex.org/W4205670049","https://openalex.org/W3203610479","https://openalex.org/W6887990954"],"abstract_inverted_index":{"This":[0],"study":[1],"exploited":[2],"a":[3,11,37,63,98],"mechanochemical":[4,34,69],"strategy":[5],"to":[6,209],"discover":[7],"new":[8,64],"polymorphs":[9,21,118,150],"of":[10,19,55,101,115,134,144,180,197],"drug":[12],"and":[13,40,79,162,185],"meanwhile":[14],"realize":[15],"the":[16,33,45,52,56,93,120,128,142,145,155,158,163,170,175,189,194,202],"selective":[17,113],"preparation":[18],"various":[20,198],"without":[22],"using":[23],"bulk":[24],"solvents.":[25],"It":[26],"is":[27,36,72,83,124,207],"worth":[28],"noting":[29],"that":[30,169],"in":[31],"practice,":[32],"approach":[35],"unique":[38],"green":[39],"highly":[41],"efficient":[42],"method.":[43,131],"On":[44,92],"one":[46],"hand,":[47,95],"about":[48],"20":[49],"years":[50],"after":[51],"last":[53],"discovery":[54],"\u03b3-aminobutyric":[57],"acid":[58],"(GABA)":[59],"polymorph,":[60],"we":[61,110],"identified":[62],"GABA":[65,117,199],"polymorph":[66,203],"(Form-III)":[67],"by":[68,75,86,127],"milling.":[70],"Form-III":[71],"available":[73],"exclusively":[74],"milling":[76,121,152,156,212],"at":[77],"present,":[78],"its":[80],"crystal":[81,87,159,190],"structure":[82,88],"also":[84],"determined":[85],"prediction":[89],"(CSP)":[90],"methods.":[91],"other":[94],"through":[96],"introducing":[97],"trace":[99,135],"amount":[100],"solvents":[102,181],"with":[103,182,204],"different":[104,149,183],"hydrogen":[105],"bond":[106],"donor/acceptor":[107],"(\u03b1/\u03b2)":[108],"abilities,":[109],"can":[111],"achieve":[112],"control":[114],"three":[116],"during":[119],"process,":[122],"which":[123],"not":[125],"accessible":[126],"traditional":[129],"solution-based":[130],"The":[132,178],"mechanism":[133],"solvent-directed":[136],"polymorphic":[137],"outcomes":[138],"was":[139],"investigated":[140],"from":[141],"change":[143],"stability":[146,172,196,206],"relationship":[147],"between":[148],"under":[151,211],"conditions.":[153,213],"As":[154],"proceeds,":[157],"size":[160],"decreases":[161],"surface":[164,171,191,195],"effect":[165],"becomes":[166],"significant":[167],"so":[168],"will":[173,192],"dominate":[174],"overall":[176],"stability.":[177],"adsorption":[179],"\u03b1":[184],"\u03b2":[186],"values":[187],"on":[188],"affect":[193],"polymorphs.":[200],"Consequently,":[201],"higher":[205],"able":[208],"survive":[210]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-11-09T00:00:00"}