{"id":"https://openalex.org/W3097706829","doi":"https://doi.org/10.1182/blood-2020-133891","title":"Flotetuzumab and Other Cellular Immunotherapies Upregulate MHC Class II Expression on Acute Myeloid Leukemia Cells in Vitro and In Vivo","display_name":"Flotetuzumab and Other Cellular Immunotherapies Upregulate MHC Class II Expression on Acute Myeloid Leukemia Cells in Vitro and In Vivo","publication_year":2020,"publication_date":"2020-11-05","ids":{"openalex":"https://openalex.org/W3097706829","doi":"https://doi.org/10.1182/blood-2020-133891","mag":"3097706829"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2020-133891","doi":"https://doi.org/10.1182/blood-2020-133891","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2020-133891","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090607867","display_name":"Joseph C. Rimando","orcid":"https://orcid.org/0000-0002-4127-2091","observed_orcids":["https://orcid.org/0000-0002-4127-2091"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Rimando","raw_affiliation_strings":["Department of Medicine, Washington University School of Medicine, St. Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060952145","display_name":"Michael P. Rettig","orcid":"https://orcid.org/0000-0002-1091-0564","observed_orcids":["https://orcid.org/0000-0002-1091-0564"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael P. Rettig","raw_affiliation_strings":["Department of Internal Medicine, Division of Oncology, Washington Univ. School of Med., Saint Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Oncology, Washington Univ. School of Med., Saint Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112879104","display_name":"Matthew J Christopher","orcid":"https://orcid.org/0000-0003-4870-654X","observed_orcids":["https://orcid.org/0000-0003-4870-654X"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matt Christopher","raw_affiliation_strings":["Washington University School of Medicine, Saint Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, Saint Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048491248","display_name":"Julie Ritchey","orcid":"https://orcid.org/0009-0000-3964-504X","observed_orcids":["https://orcid.org/0009-0000-3964-504X"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie K Ritchey","raw_affiliation_strings":["Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055882180","display_name":"Miriam Y. Kim","orcid":"https://orcid.org/0000-0001-9609-0685","observed_orcids":["https://orcid.org/0000-0001-9609-0685"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miriam Y Kim","raw_affiliation_strings":["Washington University in St Louis, Saint Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University in St Louis, Saint Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071994294","display_name":"JOHN B. MUTH","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106297","display_name":"MacroGenics (United States)","ror":"https://ror.org/01hcd4187","country_code":"US","type":"company","lineage":["https://openalex.org/I4210106297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Muth","raw_affiliation_strings":["MacroGenics, Inc., Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MacroGenics, Inc., Rockville, MD","institution_ids":["https://openalex.org/I4210106297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012831496","display_name":"Jan Davidson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106297","display_name":"MacroGenics (United States)","ror":"https://ror.org/01hcd4187","country_code":"US","type":"company","lineage":["https://openalex.org/I4210106297"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jan Davidson","raw_affiliation_strings":["MacroGenics, Inc., Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MacroGenics, Inc., Rockville, MD","institution_ids":["https://openalex.org/I4210106297"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065066309","display_name":"John F. DiPersio","orcid":"https://orcid.org/0000-0002-0429-3133","observed_orcids":["https://orcid.org/0000-0002-0429-3133"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John F. DiPersio","raw_affiliation_strings":["Washington University School of Medicine, Saint Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, Saint Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.1577,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.51903067,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"136","issue":"Supplement 1","first_page":"22","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.8535000085830688,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.8535000085830688,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.06589999794960022,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.019500000402331352,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9430000185966492},{"id":"https://openalex.org/keywords/mhc-class-ii-upregulation","display_name":"MHC class II upregulation","score":0.9610000252723694},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cd123","display_name":"CD123","score":0.6819999814033508},{"id":"https://openalex.org/keywords/bispecific-t-cell-engagers","display_name":"bispecific T-cell engagers","score":0.7720000147819519},{"id":"https://openalex.org/keywords/chimeric-antigen-receptor-t-cells","display_name":"chimeric antigen receptor T cells","score":0.8579999804496765},{"id":"https://openalex.org/keywords/t-cell-immunotherapy","display_name":"T cell therapy","score":0.5759999752044678},{"id":"https://openalex.org/keywords/thp-1-cells","display_name":"THP-1 cells","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5113689303398132},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5044478178024292},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.49676018953323364},{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.49399787187576294},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4934362471103668},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47866591811180115},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4397231638431549},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4312908351421356},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.4235951900482178},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.39885202050209045},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35717156529426575}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2020-133891","doi":"https://doi.org/10.1182/blood-2020-133891","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2020-133891","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4312110775","https://openalex.org/W4389220948","https://openalex.org/W3213230616","https://openalex.org/W3216414628","https://openalex.org/W7169921921","https://openalex.org/W2335061911","https://openalex.org/W1966103694","https://openalex.org/W2925256229","https://openalex.org/W2901738361","https://openalex.org/W4417010727"],"abstract_inverted_index":{"Background:":[0],"Allogeneic":[1],"hematopoietic":[2,704],"cell":[3,114,123,220,418,577,693],"transplantation":[4],"(allo-HCT)":[5],"is":[6,486,586,674],"the":[7,104,268,274,289,313,316,360,412,427,448,522,543,573,652,685,709],"only":[8,368,375,419],"curative":[9],"therapy":[10],"for":[11,250,279,306,319,638,700],"patients":[12,27,41,640,655,668],"with":[13,153,167,173,341,346,395,411,426,437,459,488,493,515,556,561,672],"high-risk":[14],"and":[15,59,82,87,107,128,172,207,233,248,265,271,300,322,336,344,383,397,416,519,530,559,563,592,619,644],"refractory":[16],"acute":[17],"myeloid":[18],"leukemia":[19],"(AML).":[20],"Unfortunately,":[21],"up":[22],"to":[23,97,121,242,288,310,401,432,444,467,484,504,540,600,625,647,690,707,730],"50":[24],"percent":[25,36],"of":[26,37,47,92,99,103,130,281,312,390,424,513,524,528,532,537,542,569,579,590,610,654,687,712,718,726,759],"relapse":[28,657],"after":[29,43,80,161,642,658,670],"allo-HCT.Recent":[30],"research":[31],"has":[32,75],"shown":[33],"that":[34,66,112,457],"30-50":[35],"AML":[38,117,133,151,574,580,597,603,614,639],"samples":[39,152,558],"from":[40,157,245,470,583],"relapsing":[42,160,641,669],"allo-HCT":[44,81,162,643,671],"have":[45,144],"downregulation":[46],"MHC":[48],"class":[49],"II":[50],"(MHC-II)":[51],"expression,":[52,147],"which":[53,143],"may":[54,95,645],"promote":[55],"immune":[56,100,649],"effector":[57],"evasion":[58],"disease":[60,108],"relapse.":[61],"These":[62,491],"studies":[63,321],"also":[64],"report":[65],"interferon":[67,688],"gamma":[68,689],"(IFN\u03b3)":[69],"can":[70],"restore":[71],"MHC-II":[72,93,131,146,155,226,293,404,449,474,495,570,611],"expression.":[73],"IFN\u03b3":[74,126,216,234,282,489,533],"never":[76],"been":[77],"systemically":[78],"administered":[79],"would":[83],"likely":[84],"cause":[85],"significant":[86,567,608],"potentially":[88],"life-threatening":[89],"toxicities.":[90],"Reinduction":[91],"expression":[94,156,227,405,571,612],"lead":[96,120,646],"re-engagement":[98],"effectors,":[101],"restoration":[102],"graft-versus-malignancy":[105],"effect,":[106],"control.":[109],"We":[110],"hypothesized":[111],"T":[113,122,179,213,263,286,373,377,384,398,417,502,517,564,733],"immunotherapies":[115,184,595,632],"targeting":[116,461,596],"cells":[118,141,287,350,374,378,394,399,430,503,518,565,581,615,706,734],"will":[119],"activation,":[124],"localized":[125],"release,":[127],"upregulation":[129,294,450,475,568,609],"on":[132,476,572,613,661,755],"cells.":[134,180,214,385,575],"Methods:":[135],"For":[136,325],"in":[137,267,273,315,326,548,550,617,620,651,703,746],"vitro":[138,388,618],"experiments,":[139,328],"THP1":[140,215,391],"(THP1s),":[142],"intermediate":[145],"or":[148,168,174,392,761],"primary":[149,348],"human":[150,176,261,285,333,371,500],"low":[154],"a":[158,197,253,438,445,464,505,634,664],"patient":[159],"(AML-low":[163],"cells)":[164],"were":[165,185,222,303,339,357],"co-cultured":[166],"without":[169,175],"T-cell":[170,183,594,631],"immunotherapy":[171,714],"MHC-mismatched":[177],"CD3+":[178,262],"The":[181,298,622],"following":[182,361],"tested:":[186],"flotetuzumab":[187],"(FLZ),":[188],"an":[189,549,756],"investigational":[190],"CD123":[191,428,460],"x":[192,199,440],"CD3":[193,200,441],"bispecific":[194,201,442],"DART\u00ae":[195],"molecule;":[196],"CD33":[198,439],"molecule":[202],"(Creative":[203],"Biolabs,":[204],"Shirley,":[205],"NY);":[206],"CD123-directed":[208],"chimeric":[209],"antigen":[210],"receptor":[211],"(CAR)":[212],"receptor-1":[217],"(IFN\u03b3R1)":[218],"knockout":[219,536],"lines":[221],"generated":[223],"using":[224],"CRISPR-Cas9.":[225],"was":[228,257,451],"measured":[229],"by":[230,629,716,736],"flow":[231],"cytometry":[232],"concentrations":[235,527],"via":[236],"Luminex":[237],"immunoflourescence":[238],"assay.":[239],"In":[240,387],"order":[241],"rescue":[243,468],"THP1s":[244,272,314,425,469,477,492,510,514],"FLZ-induced":[246,473],"death":[247],"allow":[249],"longitudinal":[251,320],"evaluation,":[252],"transwell":[254,465],"plate":[255],"system":[256,466],"used,":[258],"placing":[259],"THP1s,":[260],"cells,":[264],"FLZ":[266,367,382,396,414,520,562,591,673],"top":[269],"well":[270,318,606],"bottom":[275,290],"well.":[276],"This":[277],"allowed":[278],"diffusion":[280],"but":[283],"not":[284,452],"wells,":[291],"permitting":[292],"while":[295],"limiting":[296],"death.":[297],"upper":[299],"lower":[301,317],"wells":[302],"coincubated":[304],"together":[305],"24":[307],"hours":[308,408,481],"prior":[309],"harvesting":[311],"mixed-lymphocyte":[323],"reactions.":[324],"vivo":[327,551],"NOD-scid":[329],"IL2Rgammanull":[330],"mice":[331,356,554,585],"expressing":[332],"IL-3,":[334],"GM-CSF,":[335],"SCF":[337],"(NSG-S)":[338],"irradiated":[340],"250":[342],"rads":[343],"injected":[345,555],"10e6":[347],"AML-low":[349,393,557],"per":[351,379],"mouse.":[352],"After":[353],"5.5":[354],"weeks,":[355],"divided":[358],"into":[359],"groups:":[362],"1)":[363],"untreated":[364,509],"control;":[365],"2)":[366],"(2mg/kg);":[369],"3)":[370],"mismatched":[372,499],"(10e7":[376],"mouse);":[380],"4)":[381],"Results:":[386],"co-culture":[389],"led":[400,431,443,539,599],"significantly":[402],"increased":[403],"at":[406,479],"48":[407],"when":[409],"compared":[410],"control,":[413],"only,":[415],"groups":[420],"(Figure":[421,545],"1A-B).":[422],"Co-culture":[423],"CAR-T":[429],"similar":[433,446],"results.":[434],"Although":[435],"co-incubation":[436],"result,":[447],"nearly":[453],"as":[454,456,605,607],"dramatic":[455],"seen":[458,487],"agents.":[462],"Using":[463],"FLZ-mediated":[471],"toxicity,":[472],"peaked":[478],"48-72":[480],"(similar":[482],"kinetics":[483],"what":[485],"alone).":[490],"upregulated":[494],"activated":[496],"third-party":[497],"donor":[498],"CD4+":[501,516],"greater":[506],"extent":[507],"than":[508],"controls.":[511],"Co-cultures":[512],"induced":[521],"secretion":[523],"very":[525],"high":[526],"IFN\u03b3,":[529],"blockade":[531],"signaling":[534],"through":[535],"IFN\u03b3R1":[538],"abrogation":[541],"effect":[544,623],"1C-D).":[546],"Finally,":[547],"model,":[552],"NSG-S":[553],"treated":[560],"showed":[566],"Single":[576],"RNA-sequencing":[578],"purified":[582],"these":[584,662],"ongoing.":[587],"Conclusions:":[588],"Use":[589],"other":[593],"antigens":[598],"both":[601,616],"direct":[602],"killing":[604],"vivo.":[621],"appears":[624],"be":[626],"mediated":[627],"primarily":[628],"IFN\u03b3.":[630],"represent":[633],"promising":[635],"treatment":[636],"approach":[637],"enhanced":[648],"recognition":[650],"30-50%":[653],"who":[656],"allo-HCT.":[659],"Based":[660],"results,":[663],"clinical":[665],"trial":[666],"treating":[667],"planned.":[675],"Disclosures":[676],"Christopher:":[677],"Boulder":[678],"Bioscience:":[679],"Patents":[680,696,722],"&":[681,697,723],"Royalties:":[682,698,724],"IP":[683],"around":[684],"use":[686,725],"treat":[691],"stem":[692,705],"transplant.":[694],"Kim:Tmunity:":[695],"methods":[699],"gene":[701],"editing":[702],"enhance":[708,731],"therapeutic":[710],"efficacy":[711],"antigen-specific":[713],"(Licensed":[715],"University":[717],"Pennsylvania);":[719],"Neoimmune":[720],"Tech:":[721],"long-acting":[727],"IL-7":[728],"analogs":[729],"CAR":[732],"(licensed":[735],"Washington":[737],"University).":[738],"Muth:MacroGenics,":[739],"Inc.:":[740],"Current":[741,743,750],"Employment,":[742],"equity":[744],"holder":[745],"publicly-traded":[747],"company.":[748],"Davidson:MacroGenics:":[749],"Employment.":[751],"DiPersio:Magenta":[752],"Therapeutics:":[753],"Membership":[754],"entity's":[757],"Board":[758],"Directors":[760],"advisory":[762],"committees.":[763]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2020-11-09T00:00:00"}
