{"id":"https://openalex.org/W3097657199","doi":"https://doi.org/10.21873/invivo.12176","title":"Genomic Profiling and Clinicopathological Characteristics of Neuroendocrine Tumors of the Lung in East Asian Patients","display_name":"Genomic Profiling and Clinicopathological Characteristics of Neuroendocrine Tumors of the Lung in East Asian Patients","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3097657199","doi":"https://doi.org/10.21873/invivo.12176","mag":"3097657199","pmid":"https://pubmed.ncbi.nlm.nih.gov/33144445","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7811643"},"language":"en","primary_location":{"id":"doi:10.21873/invivo.12176","doi":"https://doi.org/10.21873/invivo.12176","is_oa":true,"landing_page_url":"https://doi.org/10.21873/invivo.12176","pdf_url":"https://iv.iiarjournals.org/content/invivo/34/6/3375.full.pdf","source":{"id":"https://openalex.org/S115443242","display_name":"In Vivo","issn_l":"0258-851X","issn":["0258-851X","1791-7549"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4322764940","host_organization_name":"Stanford University Highwire Press","host_organization_lineage":["https://openalex.org/P4322764940"],"host_organization_lineage_names":["Stanford University Highwire Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In Vivo","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://iv.iiarjournals.org/content/invivo/34/6/3375.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070538830","display_name":"Moonsik Kim","orcid":"https://orcid.org/0000-0002-5804-8790","observed_orcids":["https://orcid.org/0000-0002-5804-8790"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I2799970807","display_name":"Severance Hospital","ror":"https://ror.org/044kjp413","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"MOONSIK KIM","raw_affiliation_strings":["Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I2799970807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033084194","display_name":"Yeon Seung Chung","orcid":"https://orcid.org/0000-0003-0197-2699","observed_orcids":["https://orcid.org/0000-0003-0197-2699"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I2799970807","display_name":"Severance Hospital","ror":"https://ror.org/044kjp413","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"YEON SEUNG CHUNG","raw_affiliation_strings":["Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I2799970807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024402351","display_name":"Kyoung\u2010A Kim","orcid":"https://orcid.org/0000-0002-3521-7758","observed_orcids":["https://orcid.org/0000-0002-3521-7758"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I2799970807","display_name":"Severance Hospital","ror":"https://ror.org/044kjp413","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"KYOUNG A KIM","raw_affiliation_strings":["Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I2799970807"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020903295","display_name":"Hyo Sup Shim","orcid":"https://orcid.org/0000-0002-5718-3624","observed_orcids":["https://orcid.org/0000-0002-5718-3624"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I2799970807","display_name":"Severance Hospital","ror":"https://ror.org/044kjp413","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"HYO SUP SHIM","raw_affiliation_strings":["Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea shimhs@yuhs.ac","Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea shimhs@yuhs.ac","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791"]},{"raw_affiliation_string":"Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I2799970807"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9274,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.77124197,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"34","issue":"6","first_page":"3375","last_page":"3385"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.47609999775886536,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.47609999775886536,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.25949999690055847,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.2329999953508377,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-neuroendocrine-tumors","display_name":"lung neuroendocrine tumors","score":0.8960000276565552},{"id":"https://openalex.org/keywords/carcinoid-tumor","display_name":"carcinoid tumor","score":0.6980000138282776},{"id":"https://openalex.org/keywords/large-cell-neuroendocrine-carcinoma","display_name":"large cell neuroendocrine carcinoma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/small-cell-lung-cancer","display_name":"small cell lung cancer","score":0.9850000143051147},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.8349999785423279},{"id":"https://openalex.org/keywords/rb1-mutation","display_name":"RB1 mutation","score":0.8149999976158142},{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.6880000233650208},{"id":"https://openalex.org/keywords/pik3ca","display_name":"PIK3CA","score":0.8989999890327454},{"id":"https://openalex.org/keywords/anaplastic-lymphoma-kinase","display_name":"anaplastic lymphoma kinase","score":0.902999997138977},{"id":"https://openalex.org/keywords/mek1","display_name":"MEK1","score":0.9639999866485596},{"id":"https://openalex.org/keywords/idh1","display_name":"IDH1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/erbb2-amplification","display_name":"ERBB2 amplification","score":0.9039999842643738},{"id":"https://openalex.org/keywords/fgfr1","display_name":"FGFR1","score":0.9020000100135803},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/mycn","display_name":"MYCN","score":0.9340000152587891},{"id":"https://openalex.org/keywords/pd-l1-expression","display_name":"PD-L1 expression","score":0.921999990940094},{"id":"https://openalex.org/keywords/east-asian-patients","display_name":"East Asian patients","score":0.6850000023841858},{"id":"https://openalex.org/keywords/clinicopathological-features","display_name":"clinicopathological features","score":0.75},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.7310000061988831},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.996999979019165}],"concepts":[{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.8295975923538208},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6682488322257996},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5693508982658386},{"id":"https://openalex.org/C2779066768","wikidata":"https://www.wikidata.org/wiki/Q1981276","display_name":"Neuroendocrine tumors","level":2,"score":0.5304346084594727},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.5278494358062744},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.48652738332748413},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.46554407477378845},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4351944029331207},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.42025938630104065},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41277796030044556},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3811781704425812},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34706151485443115},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3187491297721863},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2824099063873291},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.14428701996803284},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.11077827215194702},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09944561123847961}],"mesh":[{"descriptor_ui":"D000090063","descriptor_name":"Proto-Oncogene Mas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018358","descriptor_name":"Neuroendocrine Tumors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055752","descriptor_name":"Small Cell Lung Carcinoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.21873/invivo.12176","doi":"https://doi.org/10.21873/invivo.12176","is_oa":true,"landing_page_url":"https://doi.org/10.21873/invivo.12176","pdf_url":"https://iv.iiarjournals.org/content/invivo/34/6/3375.full.pdf","source":{"id":"https://openalex.org/S115443242","display_name":"In Vivo","issn_l":"0258-851X","issn":["0258-851X","1791-7549"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4322764940","host_organization_name":"Stanford University Highwire Press","host_organization_lineage":["https://openalex.org/P4322764940"],"host_organization_lineage_names":["Stanford University Highwire Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In Vivo","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:6727737","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7811643","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:33144445","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33144445","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In vivo (Athens, Greece)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7811643","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7811643/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In Vivo","raw_type":"Text"},{"id":"pmh:oai:ir.ymlib.yonsei.ac.kr:22282913/180769","doi":null,"is_oa":true,"landing_page_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/180769","pdf_url":null,"source":{"id":"https://openalex.org/S4306400691","display_name":"YUHSpace (Yonsei University Medical Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193775966","host_organization_name":"Yonsei University","host_organization_lineage":["https://openalex.org/I193775966"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.21873/invivo.12176","doi":"https://doi.org/10.21873/invivo.12176","is_oa":true,"landing_page_url":"https://doi.org/10.21873/invivo.12176","pdf_url":"https://iv.iiarjournals.org/content/invivo/34/6/3375.full.pdf","source":{"id":"https://openalex.org/S115443242","display_name":"In Vivo","issn_l":"0258-851X","issn":["0258-851X","1791-7549"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4322764940","host_organization_name":"Stanford University Highwire Press","host_organization_lineage":["https://openalex.org/P4322764940"],"host_organization_lineage_names":["Stanford University Highwire Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In Vivo","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3097657199.pdf","grobid_xml":"https://content.openalex.org/works/W3097657199.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1903523058","https://openalex.org/W2113548725","https://openalex.org/W2143827882","https://openalex.org/W2251438188","https://openalex.org/W2294290225","https://openalex.org/W2484492934","https://openalex.org/W2556183148","https://openalex.org/W2566723262","https://openalex.org/W2586030734","https://openalex.org/W2586885021","https://openalex.org/W2603972544","https://openalex.org/W2611497676","https://openalex.org/W2755581088","https://openalex.org/W2786504081","https://openalex.org/W2786536352","https://openalex.org/W2786927525","https://openalex.org/W2791321105","https://openalex.org/W2792828274","https://openalex.org/W2807156901","https://openalex.org/W2810630532","https://openalex.org/W2887257735","https://openalex.org/W2888018398","https://openalex.org/W2892249755","https://openalex.org/W2902787388","https://openalex.org/W2915449550","https://openalex.org/W2928432651","https://openalex.org/W2938898812","https://openalex.org/W2944477537","https://openalex.org/W2969244921","https://openalex.org/W2983605061","https://openalex.org/W2987617989","https://openalex.org/W2990077099","https://openalex.org/W2995123342","https://openalex.org/W3025975370"],"related_works":["https://openalex.org/W4206244793","https://openalex.org/W2600618283","https://openalex.org/W2895814165","https://openalex.org/W2611497676","https://openalex.org/W4386955430","https://openalex.org/W1906881916","https://openalex.org/W3170784255","https://openalex.org/W2193961691","https://openalex.org/W4410381001","https://openalex.org/W4414687929"],"abstract_inverted_index":{"BACKGROUND/AIM:":[0],"In":[1],"recent":[2],"years,":[3],"the":[4,12,24,192],"genomic":[5],"landscape":[6],"of":[7,11,27,39,81,99,117,147,202,229],"neuroendocrine":[8,57],"tumors":[9,179],"(NETs)":[10],"lung":[13,47,63],"has":[14],"been":[15],"investigated.":[16],"However,":[17],"more":[18,170],"data":[19],"are":[20],"necessary":[21],"to":[22,75],"elucidate":[23],"heterogeneous":[25],"nature":[26],"NETs,":[28],"especially":[29],"in":[30,94,112,173,177,212,226],"East":[31,213],"Asian":[32,214],"patients.":[33,215],"PATIENTS":[34],"AND":[35],"METHODS:":[36],"A":[37],"total":[38],"64":[40],"patients":[41,72,230],"who":[42],"underwent":[43],"surgical":[44],"resection":[45],"for":[46],"NETs":[48,175,196],"[26":[49],"typical":[50],"or":[51,107,218],"atypical":[52],"carcinoid":[53,100,178],"tumors,":[54,101],"21":[55],"large-cell":[56],"carcinomas":[58,64],"(LCNECs),":[59],"and":[60,68,86,97,103,138,163,204],"19":[61],"small-cell":[62],"(SCLCs)]":[65],"were":[66,73,92,169],"enrolled,":[67],"samples":[69],"from":[70],"46":[71],"subjected":[74],"targeted":[76],"next-generation":[77],"sequencing.":[78],"RESULTS:":[79],"Co-mutations":[80],"tumor":[82],"protein":[83,133],"p53":[84],"(TP53)":[85],"RB":[87],"transcriptional":[88],"corepressor":[89],"1":[90,136,141,158,186],"(RB1)":[91],"detected":[93],"15%,":[95],"42%,":[96],"93%":[98],"LCNECs,":[102],"SCLCs,":[104],"respectively.":[105],"Oncogenic":[106],"targetable":[108],"genetic":[109],"alterations":[110,168],"identified":[111],"this":[113],"study":[114],"included":[115],"mutations":[116],"KRAS":[118],"proto-oncogene":[119,165],"(KRAS),":[120],"phosphatidylinositol-4,5-bisphosphate":[121],"3-kinase":[122],"catalytic":[123],"subunit":[124],"alpha":[125],"(PIK3CA),":[126],"ALK":[127],"receptor":[128,149,157],"tyrosine":[129,150],"kinase":[130,134,135,151],"(ALK),":[131],"mitogen-activated":[132],"(MAP2K1),":[137],"isocitrate":[139],"dehydrogenase":[140],"(IDH1),":[142],"as":[143,145,222],"well":[144],"amplifications":[146],"erb-b2":[148],"2":[152],"(ERBB2),":[153],"fibroblast":[154],"growth":[155],"factor":[156],"(FGFR1),":[159],"CD274":[160],"molecule":[161],"(CD274),":[162],"MYCN":[164],"(MYCN).":[166],"These":[167],"frequently":[171],"found":[172],"high-grade":[174,232],"than":[176],"(33.3%":[180],"vs.":[181],"7.7%).":[182],"Programmed":[183],"cell":[184],"death-ligand":[185],"expression":[187],"was":[188,206],"strongly":[189],"associated":[190,208],"with":[191,209,231],"LCNEC":[193],"subtype":[194],"among":[195],"(p=0.002).":[197],"CONCLUSION:":[198],"The":[199],"mutational":[200],"status":[201],"TP53":[203],"RB1":[205],"significantly":[207],"NET":[210],"subtypes":[211],"Targeted":[216],"therapy":[217],"immunotherapy":[219],"may":[220],"serve":[221],"a":[223,227],"treatment":[224],"option":[225],"subset":[228],"NETs.":[233]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-11-09T00:00:00"}