{"id":"https://openalex.org/W3097656702","doi":"https://doi.org/10.3390/vaccines8040637","title":"The Chicken MHC: Insights into Genetic Resistance, Immunity, and Inflammation Following Infectious Bronchitis Virus Infections","display_name":"The Chicken MHC: Insights into Genetic Resistance, Immunity, and Inflammation Following Infectious Bronchitis Virus Infections","publication_year":2020,"publication_date":"2020-11-02","ids":{"openalex":"https://openalex.org/W3097656702","doi":"https://doi.org/10.3390/vaccines8040637","mag":"3097656702","pmid":"https://pubmed.ncbi.nlm.nih.gov/33147703"},"language":"en","primary_location":{"id":"doi:10.3390/vaccines8040637","doi":"https://doi.org/10.3390/vaccines8040637","is_oa":true,"landing_page_url":"https://doi.org/10.3390/vaccines8040637","pdf_url":"https://www.mdpi.com/2076-393X/8/4/637/pdf?version=1604298955","source":{"id":"https://openalex.org/S4210226234","display_name":"Vaccines","issn_l":"2076-393X","issn":["2076-393X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccines","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2076-393X/8/4/637/pdf?version=1604298955","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100735105","display_name":"Ana Paula da Silva","orcid":"https://orcid.org/0000-0002-2007-8484","observed_orcids":["https://orcid.org/0000-0002-2007-8484"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ana P. da Silva","raw_affiliation_strings":["Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, USA"],"raw_orcid":"https://orcid.org/0000-0002-2007-8484","affiliations":[{"raw_affiliation_string":"Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003522840","display_name":"Rodrigo A. Gallardo","orcid":"https://orcid.org/0000-0003-4727-8256","observed_orcids":["https://orcid.org/0000-0003-4727-8256"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rodrigo A. Gallardo","raw_affiliation_strings":["Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, USA"],"raw_orcid":"https://orcid.org/0000-0003-4727-8256","affiliations":[{"raw_affiliation_string":"Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, USA","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5003522840"],"corresponding_institution_ids":["https://openalex.org/I84218800"],"apc_list":{"value":1800,"currency":"CHF","value_usd":1901},"apc_paid":{"value":1800,"currency":"CHF","value_usd":1901},"fwci":3.4384,"has_fulltext":true,"cited_by_count":51,"citation_normalized_percentile":{"value":0.9258027,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"8","issue":"4","first_page":"637","last_page":"637"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.017999999225139618,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chicken-major-histocompatibility-complex","display_name":"chicken major histocompatibility complex","score":0.9610000252723694},{"id":"https://openalex.org/keywords/infectious-bronchitis-virus","display_name":"infectious bronchitis virus","score":0.9800000190734863},{"id":"https://openalex.org/keywords/disease-resistance","display_name":"disease resistance","score":0.8100000023841858},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.7559999823570251},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9340000152587891},{"id":"https://openalex.org/keywords/macrophage-function","display_name":"macrophage function","score":0.9269999861717224},{"id":"https://openalex.org/keywords/mhc-haplotypes","display_name":"MHC haplotypes","score":0.47699999809265137},{"id":"https://openalex.org/keywords/non-mhc-genes","display_name":"non-MHC genes","score":0.6790000200271606},{"id":"https://openalex.org/keywords/poultry-infectious-diseases","display_name":"poultry infectious diseases","score":0.8500000238418579},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.4729999899864197}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7141410112380981},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.7122841477394104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6810940504074097},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.5714796185493469},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.5305445790290833},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5263508558273315},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.5026900768280029},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4592355191707611},{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.41782069206237793},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.36927109956741333},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21089449524879456},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.05212971568107605}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/vaccines8040637","doi":"https://doi.org/10.3390/vaccines8040637","is_oa":true,"landing_page_url":"https://doi.org/10.3390/vaccines8040637","pdf_url":"https://www.mdpi.com/2076-393X/8/4/637/pdf?version=1604298955","source":{"id":"https://openalex.org/S4210226234","display_name":"Vaccines","issn_l":"2076-393X","issn":["2076-393X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccines","raw_type":"journal-article"},{"id":"pmid:33147703","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33147703","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccines","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7711580","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7711580","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Vaccines (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:d0e96af4e2a641938b68ce8341705e23","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d0e96af4e2a641938b68ce8341705e23","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Vaccines, Vol 8, Iss 4, p 637 (2020)","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt8pt214sp","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/8pt214sp","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Vaccines, vol 8, iss 4","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/vaccines8040637","doi":"https://doi.org/10.3390/vaccines8040637","is_oa":true,"landing_page_url":"https://doi.org/10.3390/vaccines8040637","pdf_url":"https://www.mdpi.com/2076-393X/8/4/637/pdf?version=1604298955","source":{"id":"https://openalex.org/S4210226234","display_name":"Vaccines","issn_l":"2076-393X","issn":["2076-393X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccines","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6800000071525574}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306114","display_name":"U.S. Department of Agriculture","ror":"https://ror.org/01na82s61"},{"id":"https://openalex.org/F4320332564","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3097656702.pdf","grobid_xml":"https://content.openalex.org/works/W3097656702.grobid-xml"},"referenced_works_count":109,"referenced_works":["https://openalex.org/W322254205","https://openalex.org/W1483335900","https://openalex.org/W1487026765","https://openalex.org/W1497954397","https://openalex.org/W1520434148","https://openalex.org/W1555047237","https://openalex.org/W1585420923","https://openalex.org/W1628612784","https://openalex.org/W1634772899","https://openalex.org/W1828134047","https://openalex.org/W1853685514","https://openalex.org/W1900195980","https://openalex.org/W1901838434","https://openalex.org/W1965132632","https://openalex.org/W1972325113","https://openalex.org/W1973083295","https://openalex.org/W1974224059","https://openalex.org/W1980100959","https://openalex.org/W1981587719","https://openalex.org/W1984672418","https://openalex.org/W1986839001","https://openalex.org/W1993729558","https://openalex.org/W1994326776","https://openalex.org/W1997478731","https://openalex.org/W2001937160","https://openalex.org/W2007986159","https://openalex.org/W2012345214","https://openalex.org/W2019540882","https://openalex.org/W2022817248","https://openalex.org/W2023836973","https://openalex.org/W2025772004","https://openalex.org/W2027719498","https://openalex.org/W2031172221","https://openalex.org/W2031918213","https://openalex.org/W2032541736","https://openalex.org/W2032923498","https://openalex.org/W2037955897","https://openalex.org/W2045337113","https://openalex.org/W2048649778","https://openalex.org/W2048696206","https://openalex.org/W2048932273","https://openalex.org/W2049513356","https://openalex.org/W2051911145","https://openalex.org/W2052540886","https://openalex.org/W2055553534","https://openalex.org/W2058208580","https://openalex.org/W2058733766","https://openalex.org/W2061349596","https://openalex.org/W2065791310","https://openalex.org/W2074987617","https://openalex.org/W2076636393","https://openalex.org/W2077809663","https://openalex.org/W2079789301","https://openalex.org/W2083744992","https://openalex.org/W2085416001","https://openalex.org/W2087200105","https://openalex.org/W2087445318","https://openalex.org/W2091809643","https://openalex.org/W2094540620","https://openalex.org/W2102951352","https://openalex.org/W2103778306","https://openalex.org/W2105044345","https://openalex.org/W2105348546","https://openalex.org/W2106238085","https://openalex.org/W2106285437","https://openalex.org/W2113284921","https://openalex.org/W2119566550","https://openalex.org/W2122556663","https://openalex.org/W2123659965","https://openalex.org/W2127553986","https://openalex.org/W2130397181","https://openalex.org/W2134054751","https://openalex.org/W2135511295","https://openalex.org/W2139569154","https://openalex.org/W2144959890","https://openalex.org/W2145407859","https://openalex.org/W2145603212","https://openalex.org/W2148630729","https://openalex.org/W2150620795","https://openalex.org/W2152258983","https://openalex.org/W2153726243","https://openalex.org/W2153771344","https://openalex.org/W2164438542","https://openalex.org/W2179575449","https://openalex.org/W2222690289","https://openalex.org/W2232261973","https://openalex.org/W2274313736","https://openalex.org/W2307546246","https://openalex.org/W2312765002","https://openalex.org/W2314592284","https://openalex.org/W2320310474","https://openalex.org/W2330571474","https://openalex.org/W2334358150","https://openalex.org/W2398686340","https://openalex.org/W2485341684","https://openalex.org/W2485995414","https://openalex.org/W2537837741","https://openalex.org/W2597129987","https://openalex.org/W2621083295","https://openalex.org/W2745172266","https://openalex.org/W2781503113","https://openalex.org/W2888886020","https://openalex.org/W2909764550","https://openalex.org/W2913941797","https://openalex.org/W2980509519","https://openalex.org/W2990697809","https://openalex.org/W3014720321","https://openalex.org/W4235405487","https://openalex.org/W6754522343"],"related_works":["https://openalex.org/W1551592253","https://openalex.org/W2050558417","https://openalex.org/W2135436588","https://openalex.org/W3030144597","https://openalex.org/W2498374562","https://openalex.org/W2951371476","https://openalex.org/W4231524083","https://openalex.org/W2044757050","https://openalex.org/W2073938056","https://openalex.org/W2978663344"],"abstract_inverted_index":{"The":[0],"chicken":[1,48,191,237],"immune":[2,119],"system":[3],"has":[4,79,114],"provided":[5],"an":[6,143],"immense":[7],"contribution":[8],"to":[9,64,74,93,169,198,232],"basic":[10],"immunology":[11],"knowledge":[12],"by":[13,208],"establishing":[14],"major":[15,40],"landmarks":[16],"and":[17,38,70,96,125,152,204,211,225],"discoveries":[18],"that":[19,117],"defined":[20],"concepts":[21],"widely":[22,81],"used":[23],"today.":[24],"One":[25],"of":[26,35,55,130,189],"many":[27],"special":[28],"features":[29],"on":[30,213,222],"chickens":[31],"is":[32,175],"the":[33,47,51,56,68,94,108,131,139,187,190,205,223],"presence":[34],"a":[36,61,105,146,171],"compact":[37],"simple":[39],"histocompatibility":[41],"complex":[42],"(MHC).":[43],"Despite":[44],"its":[45,97],"simplicity,":[46],"MHC":[49,69,95,192,224],"maintains":[50],"essential":[52],"counterpart":[53],"genes":[54,227],"mammalian":[57],"MHC,":[58],"allowing":[59],"for":[60,83,163],"strong":[62],"association":[63,78],"be":[65,128,156],"detected":[66],"between":[67],"resistance":[71,134,154,234],"or":[72,135,145],"susceptibility":[73],"infectious":[75,86,89,167,199],"diseases.":[76],"This":[77],"been":[80,115],"studied":[82],"several":[84],"poultry":[85,194],"diseases,":[87],"including":[88],"bronchitis.":[90],"In":[91,182],"addition":[92],"linked":[98],"genes,":[99],"other":[100],"non-MHC":[101,226],"loci":[102],"may":[103],"play":[104],"role":[106,206],"in":[107,142,158,193,235],"mechanisms":[109],"underlying":[110],"such":[111,121,165],"resistance.":[112],"It":[113],"reported":[116],"innate":[118,150,209],"responses,":[120],"as":[122,166],"macrophage":[123],"function":[124],"inflammation,":[126],"might":[127],"some":[129,236],"factors":[132],"driving":[133],"susceptibility,":[136],"consequently":[137],"influencing":[138],"disease":[140,180,195,214],"outcome":[141],"individual":[144],"population.":[147],"Information":[148],"about":[149],"immunity":[151,210],"genetic":[153],"can":[155,228],"helpful":[157],"developing":[159],"effective":[160],"preventative":[161],"measures":[162],"diseases":[164],"bronchitis,":[168],"which":[170],"systemic":[172],"antibody":[173],"response":[174],"often":[176],"not":[177],"associated":[178],"with":[179],"protection.":[181],"this":[183],"review,":[184],"we":[185],"summarize":[186],"importance":[188],"resistance,":[196],"particularly":[197],"bronchitis":[200],"virus":[201],"(IBV)":[202],"infections":[203],"played":[207],"inflammation":[212],"outcome.":[215],"We":[216],"highlight":[217],"how":[218],"future":[219],"studies":[220],"focusing":[221],"potentially":[229],"bring":[230],"clarity":[231],"observed":[233],"B":[238],"haplotype":[239],"lines.":[240]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":4}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}