{"id":"https://openalex.org/W3097435658","doi":"https://doi.org/10.1111/jdi.13457","title":"Favorable effect of sodium\u2013glucose cotransporter 2 inhibitor, dapagliflozin, on non\u2010alcoholic fatty liver disease compared with pioglitazone","display_name":"Favorable effect of sodium\u2013glucose cotransporter 2 inhibitor, dapagliflozin, on non\u2010alcoholic fatty liver disease compared with pioglitazone","publication_year":2020,"publication_date":"2020-11-01","ids":{"openalex":"https://openalex.org/W3097435658","doi":"https://doi.org/10.1111/jdi.13457","mag":"3097435658","pmid":"https://pubmed.ncbi.nlm.nih.gov/33131199","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8264405"},"language":"en","primary_location":{"id":"doi:10.1111/jdi.13457","doi":"https://doi.org/10.1111/jdi.13457","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jdi.13457","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jdi.13457","source":{"id":"https://openalex.org/S107365432","display_name":"Journal of Diabetes Investigation","issn_l":"2040-1116","issn":["2040-1116","2040-1124"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310322041","host_organization_name":"Asian Association for the Study of Diabetes","host_organization_lineage":["https://openalex.org/P4310322041"],"host_organization_lineage_names":["Asian Association for the Study of Diabetes"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Diabetes Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jdi.13457","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078843127","display_name":"Kyu Yong Cho","orcid":"https://orcid.org/0000-0002-3131-0832","observed_orcids":["https://orcid.org/0000-0002-3131-0832","https://orcid.org/0000-0003-4695-8188"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I4210141669","display_name":"Hokkaido University Hospital","ror":"https://ror.org/0419drx70","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210141669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kyu Yong Cho","raw_affiliation_strings":["Clinical Research and Medical Innovation Center, Hokkaido University Hospital, Sapporo, Japan","Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan"],"raw_orcid":"https://orcid.org/0000-0002-3131-0832","affiliations":[{"raw_affiliation_string":"Clinical Research and Medical Innovation Center, Hokkaido University Hospital, Sapporo, Japan","institution_ids":["https://openalex.org/I4210141669"]},{"raw_affiliation_string":"Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055696290","display_name":"Akinobu Nakamura","orcid":"https://orcid.org/0000-0002-8192-0006","observed_orcids":["https://orcid.org/0000-0002-8192-0006"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akinobu Nakamura","raw_affiliation_strings":["Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan"],"raw_orcid":"https://orcid.org/0000-0002-8192-0006","affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076641362","display_name":"Kazuno Omori","orcid":"https://orcid.org/0000-0001-5766-6047","observed_orcids":["https://orcid.org/0000-0001-5766-6047"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuno Omori","raw_affiliation_strings":["Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan"],"raw_orcid":"https://orcid.org/0000-0001-5766-6047","affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081575573","display_name":"Takahiro Takase","orcid":"https://orcid.org/0000-0001-6089-2395","observed_orcids":["https://orcid.org/0000-0001-6089-2395"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiro Takase","raw_affiliation_strings":["Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan"],"raw_orcid":"https://orcid.org/0000-0001-6089-2395","affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006626284","display_name":"Aika Miya","orcid":"https://orcid.org/0000-0002-3313-6946","observed_orcids":["https://orcid.org/0000-0002-3313-6946"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Aika Miya","raw_affiliation_strings":["Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan"],"raw_orcid":"https://orcid.org/0000-0002-3313-6946","affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050023508","display_name":"Kohei Yamamoto","orcid":"https://orcid.org/0000-0002-6227-7617","observed_orcids":["https://orcid.org/0000-0002-6227-7617"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kohei Yamamoto","raw_affiliation_strings":["Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060578424","display_name":"Hiroshi Nomoto","orcid":"https://orcid.org/0000-0003-0713-221X","observed_orcids":["https://orcid.org/0000-0003-0713-221X"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Nomoto","raw_affiliation_strings":["Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan"],"raw_orcid":"https://orcid.org/0000-0003-0713-221X","affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073112205","display_name":"Hiraku Kameda","orcid":"https://orcid.org/0000-0003-1870-6688","observed_orcids":["https://orcid.org/0000-0003-1870-6688"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiraku Kameda","raw_affiliation_strings":["Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan"],"raw_orcid":"https://orcid.org/0000-0003-1870-6688","affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018695765","display_name":"Shinji Taneda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shinji Taneda","raw_affiliation_strings":["Diabetes Center, Manda Memorial Hospital, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes Center, Manda Memorial Hospital, Sapporo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110352459","display_name":"Yoshio Kurihara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshio Kurihara","raw_affiliation_strings":["Kurihara Clinic, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kurihara Clinic, Sapporo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102416199","display_name":"Shin Aoki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shin Aoki","raw_affiliation_strings":["Aoki Clinic, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aoki Clinic, Sapporo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079071350","display_name":"Tatsuya Atsumi","orcid":"https://orcid.org/0000-0001-5657-962X","observed_orcids":["https://orcid.org/0000-0001-5657-962X"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuya Atsumi","raw_affiliation_strings":["Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032820934","display_name":"Hideaki Miyoshi","orcid":"https://orcid.org/0000-0002-5909-3243","observed_orcids":["https://orcid.org/0000-0002-5909-3243"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hideaki Miyoshi","raw_affiliation_strings":["Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan","Division of Diabetes and Obesity, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan"],"raw_orcid":"https://orcid.org/0000-0002-5909-3243","affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"Division of Diabetes and Obesity, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5032820934"],"corresponding_institution_ids":["https://openalex.org/I205349734"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":3.551,"has_fulltext":true,"cited_by_count":58,"citation_normalized_percentile":{"value":0.9453777,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"12","issue":"7","first_page":"1272","last_page":"1277"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.05460000038146973,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dapagliflozin","display_name":"dapagliflozin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pioglitazone","display_name":"pioglitazone","score":0.9850000143051147},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.8849999904632568},{"id":"https://openalex.org/keywords/sglt2-inhibitors","display_name":"SGLT2 inhibitors","score":0.9089999794960022},{"id":"https://openalex.org/keywords/thiazolidinediones","display_name":"thiazolidinediones","score":0.8949999809265137},{"id":"https://openalex.org/keywords/fatty-liver-index","display_name":"fatty liver index","score":0.9850000143051147},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.9629999995231628},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.8539999723434448},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.859000027179718},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.828000009059906},{"id":"https://openalex.org/keywords/drug-switching","display_name":"drug switching","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C2778384471","wikidata":"https://www.wikidata.org/wiki/Q417765","display_name":"Pioglitazone","level":4,"score":0.97449791431427},{"id":"https://openalex.org/C2777422806","wikidata":"https://www.wikidata.org/wiki/Q409898","display_name":"Dapagliflozin","level":4,"score":0.9736955165863037},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.862299919128418},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7317334413528442},{"id":"https://openalex.org/C2776954865","wikidata":"https://www.wikidata.org/wiki/Q1546498","display_name":"Nonalcoholic fatty liver disease","level":4,"score":0.6463130712509155},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5854685306549072},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5551549792289734},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.5126113295555115},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5084964036941528},{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.5039882063865662},{"id":"https://openalex.org/C2777538456","wikidata":"https://www.wikidata.org/wiki/Q311213","display_name":"Glycated hemoglobin","level":4,"score":0.5033723711967468},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.4777638018131256},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.46105706691741943},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.340011864900589},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1449388861656189}],"mesh":[{"descriptor_ui":"D000077203","descriptor_name":"Sodium-Glucose Transporter 2 Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000077205","descriptor_name":"Pioglitazone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001559","descriptor_name":"Benzhydryl Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005723","descriptor_name":"gamma-Glutamyltransferase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005960","descriptor_name":"Glucosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006442","descriptor_name":"Glycated Hemoglobin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015431","descriptor_name":"Weight Loss","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055105","descriptor_name":"Waist Circumference","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1111/jdi.13457","doi":"https://doi.org/10.1111/jdi.13457","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jdi.13457","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jdi.13457","source":{"id":"https://openalex.org/S107365432","display_name":"Journal of Diabetes Investigation","issn_l":"2040-1116","issn":["2040-1116","2040-1124"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310322041","host_organization_name":"Asian Association for the Study of Diabetes","host_organization_lineage":["https://openalex.org/P4310322041"],"host_organization_lineage_names":["Asian Association for the Study of Diabetes"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Diabetes Investigation","raw_type":"journal-article"},{"id":"pmid:33131199","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33131199","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of diabetes investigation","raw_type":"Equivalence Trial"},{"id":"pmh:oai:pubmedcentral.nih.gov:8264405","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8264405/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Diabetes Investig","raw_type":"Text"},{"id":"pmh:oai:irdb.nii.ac.jp:01364:0007195294","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2115/82892","pdf_url":"https://eprints.lib.hokudai.ac.jp/repo/huscap/all/82892/JDI%2012%201272-1277.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Diabetes Investigation","raw_type":"journal article"},{"id":"pmh:oai:doaj.org/article:ffadb1ffdf4c4d3d9a134f5dc545c62d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ffadb1ffdf4c4d3d9a134f5dc545c62d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Diabetes Investigation, Vol 12, Iss 7, Pp 1272-1277 (2021)","raw_type":"article"},{"id":"pmh:oai:eprints.lib.hokudai.ac.jp:2115/82892","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2115/82892","pdf_url":null,"source":{"id":"https://openalex.org/S4306400549","display_name":"Hokkaido University Collection of Scholarly and Academic Papers (Hokkaido University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205349734","host_organization_name":"Hokkaido University","host_organization_lineage":["https://openalex.org/I205349734"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1111/jdi.13457","doi":"https://doi.org/10.1111/jdi.13457","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jdi.13457","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jdi.13457","source":{"id":"https://openalex.org/S107365432","display_name":"Journal of Diabetes Investigation","issn_l":"2040-1116","issn":["2040-1116","2040-1124"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310322041","host_organization_name":"Asian Association for the Study of Diabetes","host_organization_lineage":["https://openalex.org/P4310322041"],"host_organization_lineage_names":["Asian Association for the Study of Diabetes"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Diabetes Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320309052","display_name":"Alexion Pharmaceuticals","ror":"https://ror.org/031ywxc85"},{"id":"https://openalex.org/F4320309117","display_name":"AbbVie","ror":"https://ror.org/02g5p4n58"},{"id":"https://openalex.org/F4320310465","display_name":"Takeda Pharmaceutical Company","ror":"https://ror.org/04hjbmv12"},{"id":"https://openalex.org/F4320316238","display_name":"Kowa Company","ror":"https://ror.org/009z2z347"},{"id":"https://openalex.org/F4320316495","display_name":"Kissei","ror":"https://ror.org/028gkfr23"},{"id":"https://openalex.org/F4320322148","display_name":"Eisai","ror":"https://ror.org/04vvh7p27"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320323024","display_name":"Astellas Pharma","ror":"https://ror.org/01cjash87"},{"id":"https://openalex.org/F4320324177","display_name":"Otsuka Pharmaceutical","ror":"https://ror.org/013k5y296"},{"id":"https://openalex.org/F4320324271","display_name":"Astellas Foundation for Research on Metabolic Disorders","ror":"https://ror.org/01cjash87"},{"id":"https://openalex.org/F4320327566","display_name":"Mitsubishi Tanabe Pharma Corporation","ror":"https://ror.org/038ehsm73"},{"id":"https://openalex.org/F4320327845","display_name":"Ono Pharmaceutical","ror":"https://ror.org/022jefx64"},{"id":"https://openalex.org/F4320332736","display_name":"Novartis Pharma","ror":"https://ror.org/0013shd50"},{"id":"https://openalex.org/F4320333003","display_name":"Chugai Pharmaceutical","ror":"https://ror.org/01vepzj85"},{"id":"https://openalex.org/F4320333624","display_name":"Eli Lilly Japan","ror":"https://ror.org/01sv7f575"},{"id":"https://openalex.org/F4320333876","display_name":"Novo Nordisk Pharma","ror":"https://ror.org/05gzvb546"},{"id":"https://openalex.org/F4320338262","display_name":"Daiichi Sankyo Europe","ror":"https://ror.org/01qhj1g70"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3097435658.pdf","grobid_xml":"https://content.openalex.org/works/W3097435658.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1856151485","https://openalex.org/W1967972402","https://openalex.org/W1969734540","https://openalex.org/W1993016112","https://openalex.org/W2062812115","https://openalex.org/W2064387090","https://openalex.org/W2064890337","https://openalex.org/W2095238078","https://openalex.org/W2098555833","https://openalex.org/W2103156933","https://openalex.org/W2111946630","https://openalex.org/W2131534367","https://openalex.org/W2152524374","https://openalex.org/W2321568725","https://openalex.org/W2506843278","https://openalex.org/W2561077285","https://openalex.org/W2732773839","https://openalex.org/W2742155329","https://openalex.org/W2790286202","https://openalex.org/W2890673765","https://openalex.org/W2896131986","https://openalex.org/W2902717147","https://openalex.org/W2961666778"],"related_works":["https://openalex.org/W3115388830","https://openalex.org/W4404978033","https://openalex.org/W3167353726","https://openalex.org/W4310069577","https://openalex.org/W3115762316","https://openalex.org/W4410750468","https://openalex.org/W3129584656","https://openalex.org/W4364353556","https://openalex.org/W2761135733","https://openalex.org/W2976960323"],"abstract_inverted_index":{"AIMS/INTRODUCTION:":[0],"Sodium-glucose":[1],"cotransporter":[2,55],"2":[3,41],"inhibitors,":[4],"as":[5,7],"well":[6],"thiazolidines,":[8],"suppress":[9],"nonalcoholic":[10],"fatty":[11,91],"liver":[12,92],"disease":[13],"(NAFLD);":[14],"however,":[15],"few":[16],"comparative":[17],"studies":[18],"have":[19],"been":[20],"reported.":[21],"Dapagliflozin":[22,193],"has":[23],"shown":[24],"non-inferiority":[25],"compared":[26,144],"with":[27,39,119,145,174,202],"pioglitazone":[28,73,84,147,199],"for":[29,49,57,74,85,108],"glycemic":[30,212],"control,":[31],"and":[32,103,182],"superiority":[33],"regarding":[34],"weight":[35],"reduction":[36],"in":[37,127,133,167,176,188,200,205],"patients":[38,71,201],"type":[40],"diabetes.":[42],"We":[43],"carried":[44],"out":[45],"a":[46,86,170],"secondary":[47],"analysis":[48,162],"the":[50,109,134,146,165,189],"favorable":[51],"effects":[52],"of":[53,96,111,116],"sodium-glucose":[54],"inhibitors":[56],"NAFLD.":[58,112,203],"MATERIALS":[59],"AND":[60],"METHODS:":[61],"In":[62],"this":[63,128],"multicenter,":[64],"open-label,":[65],"prospective,":[66],"randomized,":[67],"parallel-group":[68],"comparison":[69],"trial,":[70],"taking":[72],"\u226512":[75],"weeks":[76],"were":[77,125],"randomly":[78],"switched":[79],"to":[80,140,152,211],"dapagliflozin":[81,135,190],"or":[82],"continued":[83],"further":[87],"24":[88],"weeks.":[89],"The":[90],"index":[93],"(FLI),":[94],"consisting":[95],"body":[97],"mass":[98],"index,":[99],"triglycerides,":[100],"waist":[101],"circumference":[102],"\u03b3-glutamyl":[104],"transpeptidase,":[105],"was":[106],"used":[107],"evaluation":[110],"RESULTS:":[113],"A":[114],"total":[115],"53":[117],"participants":[118],"NAFLD":[120],"(27":[121],"dapagliflozin;":[122],"26":[123],"pioglitazone)":[124],"included":[126],"analysis.":[129],"FLI":[130,168,206],"decreased":[131],"significantly":[132,171],"group":[136,148],"(48.7":[137],"\u00b1":[138,142,150,154],"23.4":[139],"42.1":[141],"23.9)":[143],"(49.0":[149],"26.1":[151],"51.1":[153],"25.8;":[155],"P":[156],"<":[157,186],"0.01).":[158],"Multiple":[159],"linear":[160],"regression":[161],"showed":[163],"that":[164],"changes":[166,175],"had":[169],"positive":[172],"correlation":[173],"glycated":[177],"hemoglobin":[178],"(P":[179,185],"=":[180],"0.03)":[181],"insulin":[183],"level":[184],"0.01)":[187],"group.":[191],"CONCLUSION:":[192],"might":[194],"be":[195,208],"more":[196],"beneficial":[197],"than":[198],"Improvements":[204],"would":[207],"closely":[209],"related":[210],"control.":[213]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":19},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-11-09T00:00:00"}