{"id":"https://openalex.org/W3097389409","doi":"https://doi.org/10.1016/s0959-8049(20)31080-7","title":"Milademetan, an oral MDM2 inhibitor, in well-differentiated/ dedifferentiated liposarcoma: results from a phase 1 study in patients with solid tumors or lymphomas","display_name":"Milademetan, an oral MDM2 inhibitor, in well-differentiated/ dedifferentiated liposarcoma: results from a phase 1 study in patients with solid tumors or lymphomas","publication_year":2020,"publication_date":"2020-10-01","ids":{"openalex":"https://openalex.org/W3097389409","doi":"https://doi.org/10.1016/s0959-8049(20)31080-7","mag":"3097389409"},"language":"en","primary_location":{"id":"doi:10.1016/s0959-8049(20)31080-7","doi":"https://doi.org/10.1016/s0959-8049(20)31080-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0959-8049(20)31080-7","pdf_url":null,"source":{"id":"https://openalex.org/S16731738","display_name":"European Journal of Cancer","issn_l":"0959-8049","issn":["0959-8049","1879-0852"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034595315","display_name":"Mrinal M. Gounder","orcid":"https://orcid.org/0000-0001-8468-0119","observed_orcids":["https://orcid.org/0000-0001-8468-0119"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.M. Gounder","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center and Weill Cornell Medical Center, Medicine, New York- NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center and Weill Cornell Medical Center, Medicine, New York- NY, USA","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037195922","display_name":"Todd Michael Bauer","orcid":"https://orcid.org/0000-0002-3078-5043","observed_orcids":["https://orcid.org/0000-0002-3078-5043"]},"institutions":[{"id":"https://openalex.org/I4210100810","display_name":"Sarah Cannon","ror":"https://ror.org/014t21j89","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210100810"]},{"id":"https://openalex.org/I4210135086","display_name":"Tennessee Oncology","ror":"https://ror.org/03754ky26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210135086"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T.M. Bauer","raw_affiliation_strings":["Sarah Cannon Research Institute and Tennessee Oncology- PLLC, Drug Development, Nashville- TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sarah Cannon Research Institute and Tennessee Oncology- PLLC, Drug Development, Nashville- TN, USA","institution_ids":["https://openalex.org/I4210100810","https://openalex.org/I4210135086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006913373","display_name":"Gary K. Schwartz","orcid":"https://orcid.org/0000-0003-1813-5061","observed_orcids":["https://orcid.org/0000-0003-1813-5061"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G.K. Schwartz","raw_affiliation_strings":["Columbia University Medical Center, Department of Medicine/Division of Hematology Oncology, New York- NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University Medical Center, Department of Medicine/Division of Hematology Oncology, New York- NY, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064953304","display_name":"Patricia Mucci LoRusso","orcid":"https://orcid.org/0000-0001-7144-036X","observed_orcids":["https://orcid.org/0000-0001-7144-036X"]},"institutions":[{"id":"https://openalex.org/I2802730090","display_name":"Yale Cancer Center","ror":"https://ror.org/03j7sze86","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802730090","https://openalex.org/I4210117499","https://openalex.org/I4210165192"]},{"id":"https://openalex.org/I4210165192","display_name":"Smilow Cancer Hospital","ror":"https://ror.org/05q3szf80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210117499","https://openalex.org/I4210165192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. LoRusso","raw_affiliation_strings":["Smillow Cancer Hospital at Yale-New Haven, Yale Cancer Center, New Haven- CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Smillow Cancer Hospital at Yale-New Haven, Yale Cancer Center, New Haven- CT, USA","institution_ids":["https://openalex.org/I2802730090","https://openalex.org/I4210165192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063242045","display_name":"Parveen Kumar","orcid":"https://orcid.org/0000-0002-5750-9663","observed_orcids":["https://orcid.org/0000-0002-5750-9663"]},"institutions":[{"id":"https://openalex.org/I4210162815","display_name":"Daiichi Sankyo (United States)","ror":"https://ror.org/055werx92","country_code":"US","type":"company","lineage":["https://openalex.org/I4210104626","https://openalex.org/I4210162815"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Kumar","raw_affiliation_strings":["Daiichi Sankyo- Inc., Oncology Clinical Development, Basking Ridge- NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Daiichi Sankyo- Inc., Oncology Clinical Development, Basking Ridge- NJ, USA","institution_ids":["https://openalex.org/I4210162815"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002683542","display_name":"Kazuki Kato","orcid":"https://orcid.org/0000-0003-0643-1023","observed_orcids":["https://orcid.org/0000-0003-0643-1023"]},"institutions":[{"id":"https://openalex.org/I4210162815","display_name":"Daiichi Sankyo (United States)","ror":"https://ror.org/055werx92","country_code":"US","type":"company","lineage":["https://openalex.org/I4210104626","https://openalex.org/I4210162815"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Kato","raw_affiliation_strings":["Daiichi Sankyo- Inc., Oncology Research & Development, Basking Ridge- NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Daiichi Sankyo- Inc., Oncology Research & Development, Basking Ridge- NJ, USA","institution_ids":["https://openalex.org/I4210162815"]}]},{"author_position":"middle","author":{"id":null,"display_name":"B. Tao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162815","display_name":"Daiichi Sankyo (United States)","ror":"https://ror.org/055werx92","country_code":"US","type":"company","lineage":["https://openalex.org/I4210104626","https://openalex.org/I4210162815"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Tao","raw_affiliation_strings":["Daiichi Sankyo- Inc., Biostatistics, Basking Ridge- NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Daiichi Sankyo- Inc., Biostatistics, Basking Ridge- NJ, USA","institution_ids":["https://openalex.org/I4210162815"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Y. Hong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162815","display_name":"Daiichi Sankyo (United States)","ror":"https://ror.org/055werx92","country_code":"US","type":"company","lineage":["https://openalex.org/I4210104626","https://openalex.org/I4210162815"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. Hong","raw_affiliation_strings":["Daiichi Sankyo- Inc., Quantitative Clinical Pharmacology, Basking Ridge- NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Daiichi Sankyo- Inc., Quantitative Clinical Pharmacology, Basking Ridge- NJ, USA","institution_ids":["https://openalex.org/I4210162815"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041841940","display_name":"Pratik Shashikant Patel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162815","display_name":"Daiichi Sankyo (United States)","ror":"https://ror.org/055werx92","country_code":"US","type":"company","lineage":["https://openalex.org/I4210104626","https://openalex.org/I4210162815"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Patel","raw_affiliation_strings":["Daiichi Sankyo- Inc., Clinical Biomarkers- Translational Science, Basking Ridge-NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Daiichi Sankyo- Inc., Clinical Biomarkers- Translational Science, Basking Ridge-NJ, USA","institution_ids":["https://openalex.org/I4210162815"]}]},{"author_position":"last","author":{"id":null,"display_name":"D. Hong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Hong","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Medicine, Houston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Medicine, Houston, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":1.6596,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.86721529,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"138","issue":null,"first_page":"S3","last_page":"S4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.8134999871253967,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.8134999871253967,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.1817999929189682,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/milademetan","display_name":"milademetan","score":0.9169999957084656},{"id":"https://openalex.org/keywords/mdm2-inhibitors","display_name":"MDM2 inhibitors","score":0.8640000224113464},{"id":"https://openalex.org/keywords/well-differentiated-liposarcoma","display_name":"well-differentiated liposarcoma","score":0.9800000190734863},{"id":"https://openalex.org/keywords/dedifferentiated-liposarcoma","display_name":"dedifferentiated liposarcoma","score":1.0},{"id":"https://openalex.org/keywords/p53-degradation","display_name":"p53 degradation","score":0.7749999761581421},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.9210000038146973},{"id":"https://openalex.org/keywords/oral-anticancer-drugs","display_name":"oral anticancer drugs","score":0.7360000014305115},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.8579999804496765},{"id":"https://openalex.org/keywords/lymphoma","display_name":"lymphoma","score":0.7649999856948853}],"concepts":[{"id":"https://openalex.org/C2776192174","wikidata":"https://www.wikidata.org/wiki/Q18028978","display_name":"Mdm2","level":3,"score":0.8665117025375366},{"id":"https://openalex.org/C2779568860","wikidata":"https://www.wikidata.org/wiki/Q1827425","display_name":"Liposarcoma","level":3,"score":0.6932125687599182},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6726393699645996},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.6414021849632263},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.5698893666267395},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4761207699775696},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.42699742317199707},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.3612206280231476},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.3064994812011719},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29932355880737305},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.27605634927749634},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.27409911155700684},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27059730887413025},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.15089848637580872},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.10569623112678528},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.060695499181747437}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0959-8049(20)31080-7","doi":"https://doi.org/10.1016/s0959-8049(20)31080-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0959-8049(20)31080-7","pdf_url":null,"source":{"id":"https://openalex.org/S16731738","display_name":"European Journal of Cancer","issn_l":"0959-8049","issn":["0959-8049","1879-0852"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cancer","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4389279791","https://openalex.org/W4387809592","https://openalex.org/W4281705492","https://openalex.org/W4282963912","https://openalex.org/W4200593165","https://openalex.org/W4392880625","https://openalex.org/W190480427","https://openalex.org/W4353101182","https://openalex.org/W2793554119","https://openalex.org/W2560009730"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-11-09T00:00:00"}