{"id":"https://openalex.org/W3097354570","doi":"https://doi.org/10.1080/07373937.2020.1832514","title":"Production of bromelain aerosols using spray-freeze-drying technique for pulmonary supplementation","display_name":"Production of bromelain aerosols using spray-freeze-drying technique for pulmonary supplementation","publication_year":2020,"publication_date":"2020-10-28","ids":{"openalex":"https://openalex.org/W3097354570","doi":"https://doi.org/10.1080/07373937.2020.1832514","mag":"3097354570"},"language":"en","primary_location":{"id":"doi:10.1080/07373937.2020.1832514","doi":"https://doi.org/10.1080/07373937.2020.1832514","is_oa":false,"landing_page_url":"https://doi.org/10.1080/07373937.2020.1832514","pdf_url":null,"source":{"id":"https://openalex.org/S196498761","display_name":"Drying Technology","issn_l":"0737-3937","issn":["0737-3937","1532-2300"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drying Technology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062983363","display_name":"M. N. Lavanya","orcid":"https://orcid.org/0000-0003-0741-4970","observed_orcids":["https://orcid.org/0000-0003-0741-4970"]},"institutions":[{"id":"https://openalex.org/I116132077","display_name":"National Institute of Food Technology, Entrepreneurship and Management - Thanjavur","ror":"https://ror.org/00ytqcj07","country_code":"IN","type":"government","lineage":["https://openalex.org/I116132077","https://openalex.org/I4210160388"]},{"id":"https://openalex.org/I4210160388","display_name":"Ministry of Food Processing Industries","ror":"https://ror.org/04tqpcm97","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210160388"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"M. N. Lavanya","raw_affiliation_strings":["Computational Modeling and Nano Scale Processing Unit, Indian Institute of Food Processing Technology (IIFPT), Ministry of Food Processing Industries, Govt. of India, Thanjavur, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Modeling and Nano Scale Processing Unit, Indian Institute of Food Processing Technology (IIFPT), Ministry of Food Processing Industries, Govt. of India, Thanjavur, Tamil Nadu, India","institution_ids":["https://openalex.org/I116132077","https://openalex.org/I4210160388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091743315","display_name":"R. Preethi","orcid":"https://orcid.org/0000-0002-7570-9909","observed_orcids":["https://orcid.org/0000-0002-7570-9909"]},"institutions":[{"id":"https://openalex.org/I116132077","display_name":"National Institute of Food Technology, Entrepreneurship and Management - Thanjavur","ror":"https://ror.org/00ytqcj07","country_code":"IN","type":"government","lineage":["https://openalex.org/I116132077","https://openalex.org/I4210160388"]},{"id":"https://openalex.org/I4210160388","display_name":"Ministry of Food Processing Industries","ror":"https://ror.org/04tqpcm97","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210160388"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"R. Preethi","raw_affiliation_strings":["Computational Modeling and Nano Scale Processing Unit, Indian Institute of Food Processing Technology (IIFPT), Ministry of Food Processing Industries, Govt. of India, Thanjavur, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Modeling and Nano Scale Processing Unit, Indian Institute of Food Processing Technology (IIFPT), Ministry of Food Processing Industries, Govt. of India, Thanjavur, Tamil Nadu, India","institution_ids":["https://openalex.org/I116132077","https://openalex.org/I4210160388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011025838","display_name":"Jeyan Arthur Moses","orcid":"https://orcid.org/0000-0002-5546-4481","observed_orcids":["https://orcid.org/0000-0002-5546-4481"]},"institutions":[{"id":"https://openalex.org/I116132077","display_name":"National Institute of Food Technology, Entrepreneurship and Management - Thanjavur","ror":"https://ror.org/00ytqcj07","country_code":"IN","type":"government","lineage":["https://openalex.org/I116132077","https://openalex.org/I4210160388"]},{"id":"https://openalex.org/I4210160388","display_name":"Ministry of Food Processing Industries","ror":"https://ror.org/04tqpcm97","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210160388"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"J. A. Moses","raw_affiliation_strings":["Computational Modeling and Nano Scale Processing Unit, Indian Institute of Food Processing Technology (IIFPT), Ministry of Food Processing Industries, Govt. of India, Thanjavur, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Modeling and Nano Scale Processing Unit, Indian Institute of Food Processing Technology (IIFPT), Ministry of Food Processing Industries, Govt. of India, Thanjavur, Tamil Nadu, India","institution_ids":["https://openalex.org/I116132077","https://openalex.org/I4210160388"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050906878","display_name":"C. Anandharamakrishnan","orcid":"https://orcid.org/0000-0002-9599-5594","observed_orcids":["https://orcid.org/0000-0002-9599-5594"]},"institutions":[{"id":"https://openalex.org/I116132077","display_name":"National Institute of Food Technology, Entrepreneurship and Management - Thanjavur","ror":"https://ror.org/00ytqcj07","country_code":"IN","type":"government","lineage":["https://openalex.org/I116132077","https://openalex.org/I4210160388"]},{"id":"https://openalex.org/I4210160388","display_name":"Ministry of Food Processing Industries","ror":"https://ror.org/04tqpcm97","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210160388"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"C. Anandharamakrishnan","raw_affiliation_strings":["Computational Modeling and Nano Scale Processing Unit, Indian Institute of Food Processing Technology (IIFPT), Ministry of Food Processing Industries, Govt. of India, Thanjavur, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Modeling and Nano Scale Processing Unit, Indian Institute of Food Processing Technology (IIFPT), Ministry of Food Processing Industries, Govt. of India, Thanjavur, Tamil Nadu, India","institution_ids":["https://openalex.org/I116132077","https://openalex.org/I4210160388"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5050906878"],"corresponding_institution_ids":["https://openalex.org/I116132077","https://openalex.org/I4210160388"],"apc_list":null,"apc_paid":null,"fwci":1.1592,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.80951344,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"39","issue":"3","first_page":"358","last_page":"370"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.9365000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.9365000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13725","display_name":"Pineapple and bromelain studies","score":0.03440000116825104,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12048","display_name":"Microencapsulation and Drying Processes","score":0.023600000888109207,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bromelain","display_name":"bromelain","score":0.9990000128746033},{"id":"https://openalex.org/keywords/spray-freeze-drying","display_name":"spray freeze drying","score":0.9789999723434448},{"id":"https://openalex.org/keywords/dry-powder-inhaler","display_name":"dry powder inhaler","score":0.765999972820282},{"id":"https://openalex.org/keywords/pulmonary-drug-delivery","display_name":"pulmonary drug delivery","score":0.8820000290870667},{"id":"https://openalex.org/keywords/maltodextrin","display_name":"maltodextrin","score":0.8690000176429749},{"id":"https://openalex.org/keywords/core-to-wall-ratio","display_name":"core-to-wall ratio","score":0.984000027179718},{"id":"https://openalex.org/keywords/fine-particle-fraction","display_name":"fine particle fraction","score":0.7929999828338623},{"id":"https://openalex.org/keywords/mass-median-aerodynamic-diameter","display_name":"mass median aerodynamic diameter","score":0.8130000233650208},{"id":"https://openalex.org/keywords/enzyme-activity-retention","display_name":"enzyme activity retention","score":0.5260000228881836},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.7229999899864197},{"id":"https://openalex.org/keywords/dietary-bioactive-compounds","display_name":"dietary bioactive compounds","score":0.5649999976158142},{"id":"https://openalex.org/keywords/particle-morphology","display_name":"particle morphology","score":0.4059999883174896}],"concepts":[{"id":"https://openalex.org/C2779587474","wikidata":"https://www.wikidata.org/wiki/Q1066303","display_name":"Spray drying","level":2,"score":0.8035305738449097},{"id":"https://openalex.org/C2777846834","wikidata":"https://www.wikidata.org/wiki/Q177570","display_name":"Maltodextrin","level":3,"score":0.725017249584198},{"id":"https://openalex.org/C2777334355","wikidata":"https://www.wikidata.org/wiki/Q415756","display_name":"Bromelain","level":4,"score":0.6139121651649475},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5999608635902405},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.5640004873275757},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5616694092750549},{"id":"https://openalex.org/C2779345167","wikidata":"https://www.wikidata.org/wiki/Q104541","display_name":"Aerosol","level":2,"score":0.5283811092376709},{"id":"https://openalex.org/C84199377","wikidata":"https://www.wikidata.org/wiki/Q723912","display_name":"Freeze-drying","level":2,"score":0.5069263577461243},{"id":"https://openalex.org/C82085835","wikidata":"https://www.wikidata.org/wiki/Q16142045","display_name":"Aerosolization","level":3,"score":0.4683026075363159},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.36134010553359985},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.3402841091156006},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11206459999084473},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.08240523934364319},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06890547275543213},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1080/07373937.2020.1832514","doi":"https://doi.org/10.1080/07373937.2020.1832514","is_oa":false,"landing_page_url":"https://doi.org/10.1080/07373937.2020.1832514","pdf_url":null,"source":{"id":"https://openalex.org/S196498761","display_name":"Drying Technology","issn_l":"0737-3937","issn":["0737-3937","1532-2300"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drying Technology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320721","display_name":"Council of Scientific and Industrial Research, India","ror":"https://ror.org/021wm7p51"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W118084076","https://openalex.org/W118517707","https://openalex.org/W624566856","https://openalex.org/W1145070682","https://openalex.org/W1508056905","https://openalex.org/W1508540579","https://openalex.org/W1869177231","https://openalex.org/W1915983093","https://openalex.org/W1955245455","https://openalex.org/W1963941895","https://openalex.org/W1965269308","https://openalex.org/W1972156427","https://openalex.org/W1972508650","https://openalex.org/W1972651324","https://openalex.org/W1980803266","https://openalex.org/W1981810319","https://openalex.org/W1982230721","https://openalex.org/W1982235761","https://openalex.org/W1983470373","https://openalex.org/W1984230056","https://openalex.org/W1985136065","https://openalex.org/W1993041699","https://openalex.org/W1993548548","https://openalex.org/W1997472351","https://openalex.org/W1999122040","https://openalex.org/W2000477211","https://openalex.org/W2003132032","https://openalex.org/W2006479738","https://openalex.org/W2012661664","https://openalex.org/W2015903951","https://openalex.org/W2026325996","https://openalex.org/W2033386809","https://openalex.org/W2040365897","https://openalex.org/W2049281680","https://openalex.org/W2053298762","https://openalex.org/W2077091492","https://openalex.org/W2081985867","https://openalex.org/W2092208606","https://openalex.org/W2092278613","https://openalex.org/W2101883647","https://openalex.org/W2132916726","https://openalex.org/W2149933623","https://openalex.org/W2155296829","https://openalex.org/W2158994879","https://openalex.org/W2169304291","https://openalex.org/W2232055132","https://openalex.org/W2328984514","https://openalex.org/W2402275665","https://openalex.org/W2584285022","https://openalex.org/W2765624753","https://openalex.org/W2769698496","https://openalex.org/W2790450739","https://openalex.org/W2800662521","https://openalex.org/W2801301059","https://openalex.org/W2896129094","https://openalex.org/W2896318634","https://openalex.org/W2909181608","https://openalex.org/W2920461546","https://openalex.org/W2921505462","https://openalex.org/W2969978017","https://openalex.org/W3000599706","https://openalex.org/W3044327249"],"related_works":["https://openalex.org/W3092157677","https://openalex.org/W3158358793","https://openalex.org/W4409359448","https://openalex.org/W4200546663","https://openalex.org/W4410199726","https://openalex.org/W2312998347","https://openalex.org/W1965787425","https://openalex.org/W1508056905","https://openalex.org/W3036066386","https://openalex.org/W2006449737"],"abstract_inverted_index":{"Spray-freeze-drying":[0],"(SFD)":[1],"is":[2],"a":[3,53],"promising":[4],"technique":[5],"to":[6,14,43,69,76,88,111,121,129,133,172],"produce":[7,205],"inhalable":[8],"dry":[9],"powder":[10],"formulations":[11,92],"that":[12,158,202],"able":[13],"retain":[15],"the":[16,45,57,61,64,101,125,147,159,195,211],"integrity":[17],"of":[18,150,161,174,181,191,219],"bioactive":[19],"compounds.":[20],"Therefore,":[21],"in":[22,95],"this":[23,199],"study":[24,200],"bromelain":[25,46,116,162],"aerosols":[26,206],"were":[27,74,93],"developed":[28,58],"using":[29],"SFD":[30,203],"by":[31],"varying":[32],"core-to-wall":[33],"ratios":[34],"(1:10,":[35],"1:25":[36,196],"and":[37,49,79,100,124,165,170,189,210,225],"1:50).":[38],"The":[39,72,114,143,153],"maltodextrin":[40],"was":[41,127,163,176],"used":[42,215],"protect":[44],"during":[47],"freezing":[48],"drying":[50],"stages":[51],"had":[52,97],"significant":[54],"effect":[55],"on":[56],"aerosols;":[59],"as":[60],"concentration":[62,117],"increased,":[63],"emitted":[65],"dosage":[66],"level":[67],"increased":[68],"around":[70],"97.2%.":[71],"particles":[73,182],"found":[75,128],"be":[77,130,214],"spherical":[78],"highly":[80],"porous,":[81],"with":[82,207,222],"geometric":[83],"diameter":[84,106],"ranging":[85],"between":[86,109,119,131],"4.71":[87],"7.46":[89],"\u00b5m.":[90,113],"All":[91],"low":[94],"density,":[96],"excellent":[98],"flowability":[99],"theoretical":[102],"mass":[103],"median":[104],"aerodynamic":[105],"(MMADt)":[107],"ranged":[108,118],"2.97":[110],"3.33":[112],"total":[115],"413.73":[120],"462":[122],"mg/g":[123],"activity":[126],"333.22":[132],"404.64":[134],"casein":[135],"digestion":[136],"units\u22121":[137],"(CDU)\u22121":[138],"for":[139,167,194,216],"all":[140],"three":[141],"formulations.":[142,152],"XRD":[144],"patterns":[145],"explained":[146],"crystalline":[148],"nature":[149],"these":[151],"in-vitro":[154],"release":[155,160,175],"profile":[156],"showed":[157,183],"slow":[164],"sustained":[166],"12":[168],"h":[169],"46":[171],"55%":[173],"estimated.":[177],"In-vitro":[178],"aerosol":[179],"performance":[180],"84.28%":[184],"fine":[185],"particle":[186],"fraction":[187],"(FPF)":[188],"MMAD":[190],"3.2":[192],"\u00b5m":[193],"formulation.":[197],"Thus,":[198],"confirmed":[201],"can":[204,213],"desired":[208],"properties":[209],"approach":[212],"pulmonary":[217],"supplementation":[218],"food":[220],"bioactives":[221],"good":[223],"retention":[224],"activity.":[226]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-11-09T00:00:00"}