{"id":"https://openalex.org/W3097288581","doi":"https://doi.org/10.1016/j.isci.2020.101746","title":"Age and Sex Influence Mitochondria and Cardiac Health in Offspring Exposed to Maternal Glucolipotoxicity","display_name":"Age and Sex Influence Mitochondria and Cardiac Health in Offspring Exposed to Maternal Glucolipotoxicity","publication_year":2020,"publication_date":"2020-10-28","ids":{"openalex":"https://openalex.org/W3097288581","doi":"https://doi.org/10.1016/j.isci.2020.101746","mag":"3097288581","pmid":"https://pubmed.ncbi.nlm.nih.gov/33225249","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7666357"},"language":"en","primary_location":{"id":"doi:10.1016/j.isci.2020.101746","doi":"https://doi.org/10.1016/j.isci.2020.101746","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2020.101746","pdf_url":"http://www.cell.com/article/S2589004220309433/pdf","source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cell.com/article/S2589004220309433/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044217564","display_name":"Eli John Louwagie","orcid":"https://orcid.org/0000-0001-8741-2240","observed_orcids":["https://orcid.org/0000-0001-8741-2240"]},"institutions":[{"id":"https://openalex.org/I189957204","display_name":"University of South Dakota","ror":"https://ror.org/0043h8f16","country_code":"US","type":"education","lineage":["https://openalex.org/I189957204"]},{"id":"https://openalex.org/I4210095855","display_name":"Sanford Research","ror":"https://ror.org/00sfn8y78","country_code":"US","type":"facility","lineage":["https://openalex.org/I1305840828","https://openalex.org/I4210095855"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eli J. Louwagie","raw_affiliation_strings":["Environmental Influences on Health and Disease Group, Sanford Research, Sioux Falls, SD 57104, USA","University of South Dakota Sanford School of Medicine, Sioux Falls, SD 57105, USA"],"raw_orcid":"https://orcid.org/0000-0001-8741-2240","affiliations":[{"raw_affiliation_string":"Environmental Influences on Health and Disease Group, Sanford Research, Sioux Falls, SD 57104, USA","institution_ids":["https://openalex.org/I4210095855"]},{"raw_affiliation_string":"University of South Dakota Sanford School of Medicine, Sioux Falls, SD 57105, USA","institution_ids":["https://openalex.org/I189957204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012829052","display_name":"Tricia D. Larsen","orcid":"https://orcid.org/0000-0002-9015-3929","observed_orcids":["https://orcid.org/0000-0002-9015-3929"]},"institutions":[{"id":"https://openalex.org/I4210095855","display_name":"Sanford Research","ror":"https://ror.org/00sfn8y78","country_code":"US","type":"facility","lineage":["https://openalex.org/I1305840828","https://openalex.org/I4210095855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tricia D. Larsen","raw_affiliation_strings":["Environmental Influences on Health and Disease Group, Sanford Research, Sioux Falls, SD 57104, USA"],"raw_orcid":"https://orcid.org/0000-0002-9015-3929","affiliations":[{"raw_affiliation_string":"Environmental Influences on Health and Disease Group, Sanford Research, Sioux Falls, SD 57104, USA","institution_ids":["https://openalex.org/I4210095855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005953956","display_name":"Angela L. Wachal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095855","display_name":"Sanford Research","ror":"https://ror.org/00sfn8y78","country_code":"US","type":"facility","lineage":["https://openalex.org/I1305840828","https://openalex.org/I4210095855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela L. Wachal","raw_affiliation_strings":["Environmental Influences on Health and Disease Group, Sanford Research, Sioux Falls, SD 57104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental Influences on Health and Disease Group, Sanford Research, Sioux Falls, SD 57104, USA","institution_ids":["https://openalex.org/I4210095855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047753101","display_name":"Tyler C. T. Gandy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095855","display_name":"Sanford Research","ror":"https://ror.org/00sfn8y78","country_code":"US","type":"facility","lineage":["https://openalex.org/I1305840828","https://openalex.org/I4210095855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tyler C.T. Gandy","raw_affiliation_strings":["Environmental Influences on Health and Disease Group, Sanford Research, Sioux Falls, SD 57104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental Influences on Health and Disease Group, Sanford Research, Sioux Falls, SD 57104, USA","institution_ids":["https://openalex.org/I4210095855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074858941","display_name":"Julie A. Eclov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095855","display_name":"Sanford Research","ror":"https://ror.org/00sfn8y78","country_code":"US","type":"facility","lineage":["https://openalex.org/I1305840828","https://openalex.org/I4210095855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie A. Eclov","raw_affiliation_strings":["Environmental Influences on Health and Disease Group, Sanford Research, Sioux Falls, SD 57104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental Influences on Health and Disease Group, Sanford Research, Sioux Falls, SD 57104, USA","institution_ids":["https://openalex.org/I4210095855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040300280","display_name":"Todd Christopher Rideout","orcid":"https://orcid.org/0000-0002-1834-7083","observed_orcids":["https://orcid.org/0000-0002-1834-7083"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd C. Rideout","raw_affiliation_strings":["Department of Exercise and Nutrition Sciences, State University of New York, Buffalo, NY 14214, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Exercise and Nutrition Sciences, State University of New York, Buffalo, NY 14214, USA","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090302207","display_name":"Katherine A. Kern","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine A. Kern","raw_affiliation_strings":["Department of Exercise and Nutrition Sciences, State University of New York, Buffalo, NY 14214, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Exercise and Nutrition Sciences, State University of New York, Buffalo, NY 14214, USA","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028432025","display_name":"Jacob T. Cain","orcid":"https://orcid.org/0000-0003-0230-9979","observed_orcids":["https://orcid.org/0000-0003-0230-9979"]},"institutions":[{"id":"https://openalex.org/I4210095855","display_name":"Sanford Research","ror":"https://ror.org/00sfn8y78","country_code":"US","type":"facility","lineage":["https://openalex.org/I1305840828","https://openalex.org/I4210095855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob T. Cain","raw_affiliation_strings":["Environmental Influences on Health and Disease Group, Sanford Research, Sioux Falls, SD 57104, USA"],"raw_orcid":"https://orcid.org/0000-0003-0230-9979","affiliations":[{"raw_affiliation_string":"Environmental Influences on Health and Disease Group, Sanford Research, Sioux Falls, SD 57104, USA","institution_ids":["https://openalex.org/I4210095855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041064178","display_name":"Ruthellen H. Anderson","orcid":"https://orcid.org/0000-0001-8346-4617","observed_orcids":["https://orcid.org/0000-0001-8346-4617"]},"institutions":[{"id":"https://openalex.org/I189957204","display_name":"University of South Dakota","ror":"https://ror.org/0043h8f16","country_code":"US","type":"education","lineage":["https://openalex.org/I189957204"]},{"id":"https://openalex.org/I4210095855","display_name":"Sanford Research","ror":"https://ror.org/00sfn8y78","country_code":"US","type":"facility","lineage":["https://openalex.org/I1305840828","https://openalex.org/I4210095855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruthellen H. Anderson","raw_affiliation_strings":["Environmental Influences on Health and Disease Group, Sanford Research, Sioux Falls, SD 57104, USA","University of South Dakota Sanford School of Medicine, Sioux Falls, SD 57105, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental Influences on Health and Disease Group, Sanford Research, Sioux Falls, SD 57104, USA","institution_ids":["https://openalex.org/I4210095855"]},{"raw_affiliation_string":"University of South Dakota Sanford School of Medicine, Sioux Falls, SD 57105, USA","institution_ids":["https://openalex.org/I189957204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029082047","display_name":"Kennedy S Mdaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095855","display_name":"Sanford Research","ror":"https://ror.org/00sfn8y78","country_code":"US","type":"facility","lineage":["https://openalex.org/I1305840828","https://openalex.org/I4210095855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kennedy S. Mdaki","raw_affiliation_strings":["Environmental Influences on Health and Disease Group, Sanford Research, Sioux Falls, SD 57104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental Influences on Health and Disease Group, Sanford Research, Sioux Falls, SD 57104, USA","institution_ids":["https://openalex.org/I4210095855"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082457108","display_name":"Michelle Leigh Baack","orcid":"https://orcid.org/0000-0001-5966-669X","observed_orcids":["https://orcid.org/0000-0001-5966-669X"]},"institutions":[{"id":"https://openalex.org/I1305840828","display_name":"Sanford Health","ror":"https://ror.org/003smky23","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1305840828"]},{"id":"https://openalex.org/I189957204","display_name":"University of South Dakota","ror":"https://ror.org/0043h8f16","country_code":"US","type":"education","lineage":["https://openalex.org/I189957204"]},{"id":"https://openalex.org/I4210095855","display_name":"Sanford Research","ror":"https://ror.org/00sfn8y78","country_code":"US","type":"facility","lineage":["https://openalex.org/I1305840828","https://openalex.org/I4210095855"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michelle L. Baack","raw_affiliation_strings":["Boekelheide Neonatal Intensive Care Unit, Sanford Children's Hospital, Sioux Falls, SD 57117, USA","Environmental Influences on Health and Disease Group, Sanford Research, Sioux Falls, SD 57104, USA","University of South Dakota Sanford School of Medicine, Sioux Falls, SD 57105, USA"],"raw_orcid":"https://orcid.org/0000-0001-5966-669X","affiliations":[{"raw_affiliation_string":"Boekelheide Neonatal Intensive Care Unit, Sanford Children's Hospital, Sioux Falls, SD 57117, USA","institution_ids":["https://openalex.org/I1305840828"]},{"raw_affiliation_string":"Environmental Influences on Health and Disease Group, Sanford Research, Sioux Falls, SD 57104, USA","institution_ids":["https://openalex.org/I4210095855"]},{"raw_affiliation_string":"University of South Dakota Sanford School of Medicine, Sioux Falls, SD 57105, USA","institution_ids":["https://openalex.org/I189957204"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5044217564","https://openalex.org/A5082457108"],"corresponding_institution_ids":["https://openalex.org/I1305840828","https://openalex.org/I189957204","https://openalex.org/I4210095855"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":2.163,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.87698034,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":97},"biblio":{"volume":"23","issue":"11","first_page":"101746","last_page":"101746"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.8500999808311462,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.8500999808311462,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.060499999672174454,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.01759999990463257,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetes-in-pregnancy","display_name":"diabetes in pregnancy","score":0.7300000190734863},{"id":"https://openalex.org/keywords/cardiomyopathy","display_name":"cardiomyopathy","score":0.7609999775886536},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.7409999966621399},{"id":"https://openalex.org/keywords/mitophagy","display_name":"mitophagy","score":0.6830000281333923},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.7080000042915344},{"id":"https://openalex.org/keywords/mitochondrial-turnover","display_name":"mitochondrial turnover","score":0.5249999761581421},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.6460000276565552},{"id":"https://openalex.org/keywords/metabolic-stress","display_name":"metabolic stress","score":0.5720000267028809},{"id":"https://openalex.org/keywords/mitochondrial-cell-death","display_name":"mitochondrial cell death","score":0.6259999871253967},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cross-fostering","display_name":"cross-fostering","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.8348491191864014},{"id":"https://openalex.org/C2779324830","wikidata":"https://www.wikidata.org/wiki/Q1806192","display_name":"Mitophagy","level":4,"score":0.7863847017288208},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.760746955871582},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.6759471893310547},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5859315395355225},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5796797275543213},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.524605393409729},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4879457354545593},{"id":"https://openalex.org/C2780655333","wikidata":"https://www.wikidata.org/wiki/Q333203","display_name":"Weaning","level":2,"score":0.4772182106971741},{"id":"https://openalex.org/C100206155","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Bioenergetics","level":3,"score":0.44948726892471313},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.42460933327674866},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.4127146005630493},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35964435338974},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.35600030422210693},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.2610464096069336},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.19906872510910034},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.13140857219696045},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12672436237335205},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.isci.2020.101746","doi":"https://doi.org/10.1016/j.isci.2020.101746","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2020.101746","pdf_url":"http://www.cell.com/article/S2589004220309433/pdf","source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},{"id":"pmid:33225249","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33225249","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7666357","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7666357/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.isci.2020.101746","doi":"https://doi.org/10.1016/j.isci.2020.101746","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2020.101746","pdf_url":"http://www.cell.com/article/S2589004220309433/pdf","source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1452361649","display_name":"Center for Pediatric Research","funder_award_id":"P20GM103620","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G893237163","display_name":"Lipotoxic Effects of Maternal Diabetes and High Fat Diet on the Developing Heart","funder_award_id":"K08HD078504","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G8943891522","display_name":"Center for Cancer Biology","funder_award_id":"P20GM103548","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8967127746","display_name":"Cardiovascular protection by phytosterols in dyslipidemic mothers and progeny","funder_award_id":"K01AT007826","funder_id":"https://openalex.org/F4320337593","funder_display_name":"National Center for Complementary and Integrative Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337364","display_name":"National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"},{"id":"https://openalex.org/F4320337593","display_name":"National Center for Complementary and Integrative Health","ror":"https://ror.org/00190t495"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3097288581.pdf"},"referenced_works_count":86,"referenced_works":["https://openalex.org/W24389446","https://openalex.org/W1511926315","https://openalex.org/W1706536722","https://openalex.org/W1764986690","https://openalex.org/W1965109791","https://openalex.org/W1966861594","https://openalex.org/W1968733054","https://openalex.org/W1969703390","https://openalex.org/W1995429651","https://openalex.org/W2006499762","https://openalex.org/W2010084879","https://openalex.org/W2029453996","https://openalex.org/W2030989951","https://openalex.org/W2040765436","https://openalex.org/W2041570625","https://openalex.org/W2045372180","https://openalex.org/W2054828537","https://openalex.org/W2069636519","https://openalex.org/W2071058949","https://openalex.org/W2073049802","https://openalex.org/W2075213782","https://openalex.org/W2080632495","https://openalex.org/W2090038499","https://openalex.org/W2091240270","https://openalex.org/W2112794454","https://openalex.org/W2114819974","https://openalex.org/W2115758983","https://openalex.org/W2116562304","https://openalex.org/W2116825246","https://openalex.org/W2129261218","https://openalex.org/W2129601242","https://openalex.org/W2130483595","https://openalex.org/W2136196341","https://openalex.org/W2139528450","https://openalex.org/W2144687501","https://openalex.org/W2146207777","https://openalex.org/W2153291580","https://openalex.org/W2154612721","https://openalex.org/W2159214535","https://openalex.org/W2259843633","https://openalex.org/W2267961811","https://openalex.org/W2285110546","https://openalex.org/W2299303320","https://openalex.org/W2313372982","https://openalex.org/W2338588589","https://openalex.org/W2344187877","https://openalex.org/W2399066332","https://openalex.org/W2422156972","https://openalex.org/W2468377411","https://openalex.org/W2498282032","https://openalex.org/W2515929107","https://openalex.org/W2586331924","https://openalex.org/W2588111394","https://openalex.org/W2592588133","https://openalex.org/W2606559217","https://openalex.org/W2607367045","https://openalex.org/W2615426230","https://openalex.org/W2622627400","https://openalex.org/W2752185298","https://openalex.org/W2756660214","https://openalex.org/W2761962880","https://openalex.org/W2765740324","https://openalex.org/W2768967052","https://openalex.org/W2784314232","https://openalex.org/W2788640168","https://openalex.org/W2788644497","https://openalex.org/W2794069673","https://openalex.org/W2886098050","https://openalex.org/W2890933287","https://openalex.org/W2894244352","https://openalex.org/W2895925119","https://openalex.org/W2897131651","https://openalex.org/W2898666867","https://openalex.org/W2900295033","https://openalex.org/W2903607803","https://openalex.org/W2905188478","https://openalex.org/W2933414168","https://openalex.org/W2939684559","https://openalex.org/W2941044139","https://openalex.org/W2949571715","https://openalex.org/W2982212858","https://openalex.org/W2992178815","https://openalex.org/W2999460439","https://openalex.org/W3020094969","https://openalex.org/W4248825847","https://openalex.org/W6769589751"],"related_works":["https://openalex.org/W3135444093","https://openalex.org/W2890897466","https://openalex.org/W2299303320","https://openalex.org/W3122499612","https://openalex.org/W4403246207","https://openalex.org/W2949571715","https://openalex.org/W7160904901","https://openalex.org/W3097111046","https://openalex.org/W4415671787","https://openalex.org/W7222422399"],"abstract_inverted_index":{"Infants":[0],"of":[1,7,33,143],"diabetic":[2],"mothers":[3],"are":[4],"at":[5,9],"risk":[6,32],"cardiomyopathy":[8,34],"birth":[10],"and":[11,35,52,59,102,125,133,140],"myocardial":[12],"infarction":[13],"in":[14,37,65,79,85,99,145],"adulthood,":[15],"but":[16,82],"prevention":[17],"is":[18,90],"hindered":[19],"because":[20],"mechanisms":[21],"remain":[22],"unknown.":[23],"We":[24],"previously":[25],"showed":[26],"that":[27],"maternal":[28],"glucolipotoxicity":[29],"increases":[30],"the":[31],"mortality":[36],"newborn":[38],"rats":[39],"through":[40],"fuel-mediated":[41],"mitochondrial":[42,100,129],"dysfunction.":[43],"Here":[44],"we":[45],"demonstrate":[46],"ongoing":[47],"cardiometabolic":[48],"consequences":[49],"by":[50,73,92],"cross-fostering":[51],"following":[53,62],"echocardiography,":[54],"cardiomyocyte":[55],"bioenergetics,":[56],"mitochondria-mediated":[57,134],"turnover,":[58],"cell":[60,135],"death":[61],"metabolic":[63,120],"stress":[64],"aged":[66,86],"adults.":[67],"Like":[68],"humans,":[69],"cardiac":[70],"function":[71],"improves":[72],"weaning":[74],"with":[75],"no":[76],"apparent":[77],"differences":[78],"early":[80],"adulthood":[81],"declines":[83],"again":[84],"diabetes-exposed":[87],"offspring.":[88],"This":[89],"preceded":[91],"impaired":[93],"oxidative":[94],"phosphorylation,":[95],"exaggerated":[96],"age-related":[97],"increase":[98,124],"number,":[101],"higher":[103],"oxygen":[104],"consumption.":[105],"Prenatally":[106],"exposed":[107,118],"male":[108],"cardiomyocytes":[109,126],"have":[110,127],"more":[111],"mitolysosomes":[112],"indicating":[113],"high":[114],"baseline":[115],"turnover;":[116],"when":[117],"to":[119],"stress,":[121],"mitophagy":[122],"cannot":[123],"faster":[128],"membrane":[130],"potential":[131],"loss":[132],"death.":[136],"Details":[137],"highlight":[138],"age-":[139],"sex-specific":[141],"roles":[142],"mitochondria":[144],"developmentally":[146],"programmed":[147],"adult":[148],"heart":[149],"disease.":[150]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2020-11-09T00:00:00"}