{"id":"https://openalex.org/W3097278438","doi":"https://doi.org/10.1161/circresaha.120.317104","title":"Clonal Hematopoiesis\u2013Driver DNMT3A Mutations Alter Immune Cells in Heart Failure","display_name":"Clonal Hematopoiesis\u2013Driver DNMT3A Mutations Alter Immune Cells in Heart Failure","publication_year":2020,"publication_date":"2020-11-06","ids":{"openalex":"https://openalex.org/W3097278438","doi":"https://doi.org/10.1161/circresaha.120.317104","mag":"3097278438","pmid":"https://pubmed.ncbi.nlm.nih.gov/33155517"},"language":"en","primary_location":{"id":"doi:10.1161/circresaha.120.317104","doi":"https://doi.org/10.1161/circresaha.120.317104","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circresaha.120.317104","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W3097278438"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004867030","display_name":"Wesley Tyler Abplanalp","orcid":"https://orcid.org/0000-0001-5996-8997","observed_orcids":["https://orcid.org/0000-0001-5996-8997"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wesley Tyler Abplanalp","raw_affiliation_strings":["German Center for Cardiovascular Research DZHK, Berlin, Germany, partner site Frankfurt Rhine-Main (W.T.A., A.M.Z., S.D.)","Institute for Cardiovascular Regeneration and Cardiopulmonary Institute, Goethe University, Frankfurt (W.T.A., D.J., B.S., M.M., S.D.)"],"raw_orcid":"https://orcid.org/0000-0001-5996-8997","affiliations":[{"raw_affiliation_string":"German Center for Cardiovascular Research DZHK, Berlin, Germany, partner site Frankfurt Rhine-Main (W.T.A., A.M.Z., S.D.)","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"Institute for Cardiovascular Regeneration and Cardiopulmonary Institute, Goethe University, Frankfurt (W.T.A., D.J., B.S., M.M., S.D.)","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088197125","display_name":"Sebastian Cremer","orcid":"https://orcid.org/0000-0002-6409-9279","observed_orcids":["https://orcid.org/0000-0002-6409-9279"]},"institutions":[{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sebastian Cremer","raw_affiliation_strings":["Department of Medicine, Cardiology (S.C., J.H., M.V.-N., A.M.Z.), Goethe University Hospital, Frankfurt","Sebastian Cremer Department of Medicine, Cardiology (S.C., J.H., M.V.-N., A.M.Z.), Goethe University Hospital, Frankfurt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Cardiology (S.C., J.H., M.V.-N., A.M.Z.), Goethe University Hospital, Frankfurt","institution_ids":["https://openalex.org/I4210132578"]},{"raw_affiliation_string":"Sebastian Cremer Department of Medicine, Cardiology (S.C., J.H., M.V.-N., A.M.Z.), Goethe University Hospital, Frankfurt","institution_ids":["https://openalex.org/I4210132578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005270356","display_name":"David John","orcid":"https://orcid.org/0000-0003-3217-5449","observed_orcids":["https://orcid.org/0000-0003-3217-5449"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"David John","raw_affiliation_strings":["Institute for Cardiovascular Regeneration and Cardiopulmonary Institute, Goethe University, Frankfurt (W.T.A., D.J., B.S., M.M., S.D.)","David John https://orcid.org/0000-0003-3217-5449 Institute for Cardiovascular Regeneration and Cardiopulmonary Institute, Goethe University, Frankfurt (W.T.A., D.J., B.S., M.M., S.D.)"],"raw_orcid":"https://orcid.org/0000-0003-3217-5449","affiliations":[{"raw_affiliation_string":"Institute for Cardiovascular Regeneration and Cardiopulmonary Institute, Goethe University, Frankfurt (W.T.A., D.J., B.S., M.M., S.D.)","institution_ids":["https://openalex.org/I114090438"]},{"raw_affiliation_string":"David John https://orcid.org/0000-0003-3217-5449 Institute for Cardiovascular Regeneration and Cardiopulmonary Institute, Goethe University, Frankfurt (W.T.A., D.J., B.S., M.M., S.D.)","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038606956","display_name":"Jedrzej Hoffmann","orcid":"https://orcid.org/0000-0003-0487-4373","observed_orcids":["https://orcid.org/0000-0003-0487-4373"]},"institutions":[{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jedrzej Hoffmann","raw_affiliation_strings":["Department of Medicine, Cardiology (S.C., J.H., M.V.-N., A.M.Z.), Goethe University Hospital, Frankfurt","Jedrzej Hoffmann https://orcid.org/0000-0003-0487-4373 Department of Medicine, Cardiology (S.C., J.H., M.V.-N., A.M.Z.), Goethe University Hospital, Frankfurt"],"raw_orcid":"https://orcid.org/0000-0003-0487-4373","affiliations":[{"raw_affiliation_string":"Department of Medicine, Cardiology (S.C., J.H., M.V.-N., A.M.Z.), Goethe University Hospital, Frankfurt","institution_ids":["https://openalex.org/I4210132578"]},{"raw_affiliation_string":"Jedrzej Hoffmann https://orcid.org/0000-0003-0487-4373 Department of Medicine, Cardiology (S.C., J.H., M.V.-N., A.M.Z.), Goethe University Hospital, Frankfurt","institution_ids":["https://openalex.org/I4210132578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015403767","display_name":"Bianca Schuhmacher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bianca Schuhmacher","raw_affiliation_strings":["Institute for Cardiovascular Regeneration and Cardiopulmonary Institute, Goethe University, Frankfurt (W.T.A., D.J., B.S., M.M., S.D.)","Bianca Schuhmacher Institute for Cardiovascular Regeneration and Cardiopulmonary Institute, Goethe University, Frankfurt (W.T.A., D.J., B.S., M.M., S.D.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cardiovascular Regeneration and Cardiopulmonary Institute, Goethe University, Frankfurt (W.T.A., D.J., B.S., M.M., S.D.)","institution_ids":["https://openalex.org/I114090438"]},{"raw_affiliation_string":"Bianca Schuhmacher Institute for Cardiovascular Regeneration and Cardiopulmonary Institute, Goethe University, Frankfurt (W.T.A., D.J., B.S., M.M., S.D.)","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046495529","display_name":"M Merten","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maximillian Merten","raw_affiliation_strings":["Institute for Cardiovascular Regeneration and Cardiopulmonary Institute, Goethe University, Frankfurt (W.T.A., D.J., B.S., M.M., S.D.)","Maximillian Merten Institute for Cardiovascular Regeneration and Cardiopulmonary Institute, Goethe University, Frankfurt (W.T.A., D.J., B.S., M.M., S.D.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cardiovascular Regeneration and Cardiopulmonary Institute, Goethe University, Frankfurt (W.T.A., D.J., B.S., M.M., S.D.)","institution_ids":["https://openalex.org/I114090438"]},{"raw_affiliation_string":"Maximillian Merten Institute for Cardiovascular Regeneration and Cardiopulmonary Institute, Goethe University, Frankfurt (W.T.A., D.J., B.S., M.M., S.D.)","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032832082","display_name":"Michael A. Rieger","orcid":"https://orcid.org/0000-0002-4158-5872","observed_orcids":["https://orcid.org/0000-0002-4158-5872"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]},{"id":"https://openalex.org/I4210161239","display_name":"Frankfurt Cancer Institute","ror":"https://ror.org/05bx21r34","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4210161239"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael A. Rieger","raw_affiliation_strings":["Department of Medicine, Hematology/Oncology (M.A.R.), Goethe University Hospital, Frankfurt","Frankfurt Cancer Institute (M.A.R.)","German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg (M.A.R.)","Michael A. Rieger Department of Medicine, Hematology/Oncology (M.A.R.), Goethe University Hospital, Frankfurt. German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg (M.A.R.). Frankfurt Cancer Institute (M.A.R.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Hematology/Oncology (M.A.R.), Goethe University Hospital, Frankfurt","institution_ids":["https://openalex.org/I4210132578"]},{"raw_affiliation_string":"Frankfurt Cancer Institute (M.A.R.)","institution_ids":["https://openalex.org/I4210161239"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg (M.A.R.)","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I4391767962"]},{"raw_affiliation_string":"Michael A. Rieger Department of Medicine, Hematology/Oncology (M.A.R.), Goethe University Hospital, Frankfurt. German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg (M.A.R.). Frankfurt Cancer Institute (M.A.R.)","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I4210132578","https://openalex.org/I4210161239","https://openalex.org/I4391767962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087348787","display_name":"Mariuca Vasa\u2010Nicotera","orcid":"https://orcid.org/0000-0002-6794-4941","observed_orcids":["https://orcid.org/0000-0002-6794-4941"]},"institutions":[{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mariuca Vasa-Nicotera","raw_affiliation_strings":["Department of Medicine, Cardiology (S.C., J.H., M.V.-N., A.M.Z.), Goethe University Hospital, Frankfurt","Mariuca Vasa-Nicotera https://orcid.org/0000-0002-6794-4941 Department of Medicine, Cardiology (S.C., J.H., M.V.-N., A.M.Z.), Goethe University Hospital, Frankfurt"],"raw_orcid":"https://orcid.org/0000-0002-6794-4941","affiliations":[{"raw_affiliation_string":"Department of Medicine, Cardiology (S.C., J.H., M.V.-N., A.M.Z.), Goethe University Hospital, Frankfurt","institution_ids":["https://openalex.org/I4210132578"]},{"raw_affiliation_string":"Mariuca Vasa-Nicotera https://orcid.org/0000-0002-6794-4941 Department of Medicine, Cardiology (S.C., J.H., M.V.-N., A.M.Z.), Goethe University Hospital, Frankfurt","institution_ids":["https://openalex.org/I4210132578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061907666","display_name":"Andreas Michael Zeiher","orcid":"https://orcid.org/0000-0003-1711-5819","observed_orcids":["https://orcid.org/0000-0003-1711-5819","https://orcid.org/0000-0002-6084-6484"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas M. Zeiher","raw_affiliation_strings":["German Center for Cardiovascular Research DZHK, Berlin, Germany, partner site Frankfurt Rhine-Main (W.T.A., A.M.Z., S.D.)","Institute for Cardiovascular Regeneration and Cardiopulmonary Institute, Goethe University, Frankfurt (W.T.A., D.J., B.S., M.M., S.D.)","Andreas M. Zeiher Institute for Cardiovascular Regeneration and Cardiopulmonary Institute, Goethe University, Frankfurt (W.T.A., D.J., B.S., M.M., S.D.). German Center for Cardiovascular Research DZHK, Berlin, Germany, partner site Frankfurt Rhine-Main (W.T.A., A.M.Z., S.D.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Cardiovascular Research DZHK, Berlin, Germany, partner site Frankfurt Rhine-Main (W.T.A., A.M.Z., S.D.)","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"Institute for Cardiovascular Regeneration and Cardiopulmonary Institute, Goethe University, Frankfurt (W.T.A., D.J., B.S., M.M., S.D.)","institution_ids":["https://openalex.org/I114090438"]},{"raw_affiliation_string":"Andreas M. Zeiher Institute for Cardiovascular Regeneration and Cardiopulmonary Institute, Goethe University, Frankfurt (W.T.A., D.J., B.S., M.M., S.D.). German Center for Cardiovascular Research DZHK, Berlin, Germany, partner site Frankfurt Rhine-Main (W.T.A., A.M.Z., S.D.)","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210127591"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025706940","display_name":"Stefanie Dimmeler","orcid":"https://orcid.org/0000-0002-1045-2436","observed_orcids":["https://orcid.org/0000-0002-1045-2436"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Stefanie Dimmeler","raw_affiliation_strings":["German Center for Cardiovascular Research DZHK, Berlin, Germany, partner site Frankfurt Rhine-Main (W.T.A., A.M.Z., S.D.)","Institute for Cardiovascular Regeneration and Cardiopulmonary Institute, Goethe University, Frankfurt (W.T.A., D.J., B.S., M.M., S.D.)","Stefanie Dimmeler Institute for Cardiovascular Regeneration and Cardiopulmonary Institute, Goethe University, Frankfurt (W.T.A., D.J., B.S., M.M., S.D.). German Center for Cardiovascular Research DZHK, Berlin, Germany, partner site Frankfurt Rhine-Main (W.T.A., A.M.Z., S.D.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Cardiovascular Research DZHK, Berlin, Germany, partner site Frankfurt Rhine-Main (W.T.A., A.M.Z., S.D.)","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"Institute for Cardiovascular Regeneration and Cardiopulmonary Institute, Goethe University, Frankfurt (W.T.A., D.J., B.S., M.M., S.D.)","institution_ids":["https://openalex.org/I114090438"]},{"raw_affiliation_string":"Stefanie Dimmeler Institute for Cardiovascular Regeneration and Cardiopulmonary Institute, Goethe University, Frankfurt (W.T.A., D.J., B.S., M.M., S.D.). German Center for Cardiovascular Research DZHK, Berlin, Germany, partner site Frankfurt Rhine-Main (W.T.A., A.M.Z., S.D.)","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210127591"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5025706940"],"corresponding_institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210127591"],"apc_list":null,"apc_paid":null,"fwci":18.8571,"has_fulltext":false,"cited_by_count":276,"citation_normalized_percentile":{"value":0.9958268,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"128","issue":"2","first_page":"216","last_page":"228"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.4684999883174896,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.4684999883174896,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.18549999594688416,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.17190000414848328,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clonal-hematopoiesis","display_name":"clonal hematopoiesis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/dnmt3a-mutation","display_name":"DNMT3A mutation","score":0.9890000224113464},{"id":"https://openalex.org/keywords/chronic-heart-failure","display_name":"chronic heart failure","score":0.9919999837875366},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.8259999752044678},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7250000238418579},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.8399999737739563},{"id":"https://openalex.org/keywords/monocyte-endothelial-adhesion","display_name":"monocyte-endothelial adhesion","score":0.8700000047683716},{"id":"https://openalex.org/keywords/resistin","display_name":"resistin","score":0.8640000224113464},{"id":"https://openalex.org/keywords/monocyte-t-cell-interaction","display_name":"monocyte-T cell interaction","score":0.7789999842643738},{"id":"https://openalex.org/keywords/t-cell-subsets","display_name":"T cell subsets","score":0.5799999833106995},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.746999979019165},{"id":"https://openalex.org/keywords/aortic-stenosis","display_name":"aortic stenosis","score":0.781000018119812},{"id":"https://openalex.org/keywords/single-cell-transcriptomics","display_name":"single-cell transcriptomics","score":0.6079999804496765}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6750407218933105},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.6738461256027222},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.6153768301010132},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5300155878067017},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5090941786766052},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49184322357177734},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4030708968639374},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3596068024635315},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35474735498428345},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3482448160648346},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30517274141311646},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25953906774520874},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.2226182520389557}],"mesh":[{"descriptor_ui":"D000074084","descriptor_name":"THP-1 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000082182","descriptor_name":"Clonal Hematopoiesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000090205","descriptor_name":"DNA Methyltransferase 3A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004248","descriptor_name":"DNA (Cytosine-5-)-Methyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004248","descriptor_name":"DNA (Cytosine-5-)-Methyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019899","descriptor_name":"Paracrine Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055261","descriptor_name":"Immunogenetic Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1161/circresaha.120.317104","doi":"https://doi.org/10.1161/circresaha.120.317104","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circresaha.120.317104","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},{"id":"pmid:33155517","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33155517","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320312069","display_name":"Deutsches Zentrum f\u00fcr Herz-Kreislaufforschung","ror":"https://ror.org/031t5w623"},{"id":"https://openalex.org/F4320326500","display_name":"Deutsche Gesellschaft f\u00fcr Kardiologie-Herz und Kreislaufforschung.","ror":"https://ror.org/02p22ad51"},{"id":"https://openalex.org/F4320334678","display_name":"European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1975758736","https://openalex.org/W2149858388","https://openalex.org/W2161767894","https://openalex.org/W2166679134","https://openalex.org/W2284527432","https://openalex.org/W2525290462","https://openalex.org/W2578808037","https://openalex.org/W2628145035","https://openalex.org/W2702751937","https://openalex.org/W2746821888","https://openalex.org/W2748400555","https://openalex.org/W2766943569","https://openalex.org/W2767453057","https://openalex.org/W2791059232","https://openalex.org/W2791529560","https://openalex.org/W2800927741","https://openalex.org/W2803478601","https://openalex.org/W2804231581","https://openalex.org/W2805322110","https://openalex.org/W2806102216","https://openalex.org/W2889026905","https://openalex.org/W2904739194","https://openalex.org/W2942472270","https://openalex.org/W2969918675","https://openalex.org/W2971653336","https://openalex.org/W2982291252","https://openalex.org/W2993117431","https://openalex.org/W2998000661","https://openalex.org/W3013784317","https://openalex.org/W3037859040"],"related_works":["https://openalex.org/W3109049004","https://openalex.org/W3101608412","https://openalex.org/W4387621017","https://openalex.org/W4388596144","https://openalex.org/W4386458396","https://openalex.org/W4281720690","https://openalex.org/W4395036953","https://openalex.org/W2981981301","https://openalex.org/W4386442283","https://openalex.org/W3007313206"],"abstract_inverted_index":{"Rationale:":[0],"Clonal":[1],"hematopoiesis":[2],"driven":[3],"by":[4,99,234],"mutations":[5,40,89,98,110,284],"of":[6,16,22,46,57,73,104,116,168,188,195,220,237,277,298],"DNMT3A":[7,37,86,97,109,128,169,189,228,286],"(DNA":[8],"methyltransferase":[9],"3a)":[10],"is":[11],"associated":[12],"with":[13,24,83,93,106,120,125,279],"increased":[14,114,178,193,235],"incidence":[15],"cardiovascular":[17],"disease":[18],"and":[19,29,69,90,95,151,157,177,213,244,263,274],"poor":[20],"prognosis":[21],"patients":[23,82,92,105,124,278],"chronic":[25,299],"heart":[26],"failure":[27],"(HF)":[28],"aortic":[30],"stenosis.":[31],"Although":[32],"experimental":[33],"studies":[34],"suggest":[35],"that":[36,271],"clonal":[38,87,282],"hematopoiesis\u2013driver":[39,88,283],"may":[41,222,293],"enhance":[42],"inflammation,":[43],"specific":[44,132],"signatures":[45],"inflammatory":[47,117,138,154],"cells":[48,59,77,276],"in":[49,62,80,170,225,246,285],"humans":[50,63],"are":[51],"missing.":[52],"Objective:":[53],"To":[54],"define":[55],"subsets":[56],"immune":[58],"mediating":[60],"inflammation":[61],"using":[64],"single-cell":[65,100],"RNA":[66,101],"sequencing.":[67,102],"Methods":[68],"Results:":[70],"Transcriptomic":[71],"profiles":[72],"peripheral":[74],"blood":[75],"mononuclear":[76],"were":[78,135,231],"analyzed":[79],"n=6":[81],"HF":[84,94,107,126,280],"harboring":[85,281],"n=4":[91],"no":[96],"Monocytes":[103],"carrying":[108],"demonstrated":[111],"a":[112,173,288],"significantly":[113],"expression":[115,194,236],"genes":[118,134],"compared":[119],"monocytes":[121,171,273],"derived":[122],"from":[123],"without":[127],"mutations.":[129],"Among":[130],"the":[131,136,147,152,184,210,238,296],"upregulated":[133],"prototypic":[137],"IL":[139],"(interleukin)":[140],"IL1B":[141],"(interleukin":[142],"1B),":[143],"IL6,":[144],"IL8":[145],",":[146,150,202,204,206,218],"inflammasome":[148],"NLRP3":[149],"macrophage":[153],"proteins":[155],"CCL3":[156],"CCL4":[158],"as":[159,161,207,209],"well":[160,208],"resistin,":[162],"which":[163,221,292],"augments":[164],"monocyte-endothelial":[165],"adhesion.":[166],"Silencing":[167],"induced":[172],"paracrine":[174],"proinflammatory":[175],"activation":[176],"adhesion":[179,215],"to":[180,295],"endothelial":[181],"cells.":[182],"Furthermore,":[183],"classical":[185],"monocyte":[186],"subset":[187],"mutation":[190,229],"carriers":[191,230],"showed":[192],"T-cell":[196,239],"stimulating":[197],"immunoglobulin":[198],"superfamily":[199],"members":[200],"CD300LB":[201],"CD83":[203],"SIGLEC12":[205],"CD2":[211],"ligand":[212],"cell":[214,249,253,257],"molecule":[216],"CD58":[217],"all":[219],"be":[223],"involved":[224],"monocyte\u2013T-cell":[226],"interactions.":[227],"further":[232],"characterized":[233],"alpha":[240],"receptor":[241],"constant":[242],"chain":[243],"changes":[245],"T":[247,251,255,275],"helper":[248,252,256],"1,":[250],"2,":[254],"17,":[258],"CD8+":[259],"effector,":[260],"CD4+":[261],"memory,":[262],"regulatory":[264],"T-cell\u2013specific":[265],"signatures.":[266],"Conclusions:":[267],"This":[268],"study":[269],"demonstrates":[270],"circulating":[272],"exhibit":[287],"highly":[289],"inflamed":[290],"transcriptome,":[291],"contribute":[294],"aggravation":[297],"HF.":[300]},"counts_by_year":[{"year":2026,"cited_by_count":45},{"year":2025,"cited_by_count":48},{"year":2024,"cited_by_count":66},{"year":2023,"cited_by_count":54},{"year":2022,"cited_by_count":33},{"year":2021,"cited_by_count":29},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2020-11-09T00:00:00"}
