{"id":"https://openalex.org/W3097220283","doi":"https://doi.org/10.1016/j.urology.2020.10.030","title":"Hot or Not: Tumor Mutational Burden (TMB) as a Biomarker of Immunotherapy Response in Genitourinary Cancers","display_name":"Hot or Not: Tumor Mutational Burden (TMB) as a Biomarker of Immunotherapy Response in Genitourinary Cancers","publication_year":2020,"publication_date":"2020-11-01","ids":{"openalex":"https://openalex.org/W3097220283","doi":"https://doi.org/10.1016/j.urology.2020.10.030","mag":"3097220283","pmid":"https://pubmed.ncbi.nlm.nih.gov/33137348"},"language":"en","primary_location":{"id":"doi:10.1016/j.urology.2020.10.030","doi":"https://doi.org/10.1016/j.urology.2020.10.030","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.urology.2020.10.030","pdf_url":null,"source":{"id":"https://openalex.org/S196979320","display_name":"Urology","issn_l":"0090-4295","issn":["0090-4295","1527-9995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Urology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.urology.2020.10.030","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024381064","display_name":"Brian T. Halbert","orcid":"https://orcid.org/0000-0002-3515-6019","observed_orcids":["https://orcid.org/0000-0002-3515-6019"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Halbert","raw_affiliation_strings":["Division of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031890333","display_name":"David Johnson Einstein","orcid":"https://orcid.org/0000-0001-9163-3281","observed_orcids":["https://orcid.org/0000-0001-9163-3281"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David J. Einstein","raw_affiliation_strings":["Division of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA. Electronic address: deinstei@bidmc.harvard.edu","Division of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA. Electronic address: deinstei@bidmc.harvard.edu","institution_ids":["https://openalex.org/I1316535847"]},{"raw_affiliation_string":"Division of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA","institution_ids":["https://openalex.org/I1316535847"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5031890333"],"corresponding_institution_ids":["https://openalex.org/I1316535847"],"apc_list":{"value":2780,"currency":"USD","value_usd":2780},"apc_paid":null,"fwci":0.4877,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.52456747,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"147","issue":null,"first_page":"119","last_page":"126"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-mutational-burden","display_name":"tumor mutational burden","score":1.0},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.8240000009536743},{"id":"https://openalex.org/keywords/immunotherapy-response","display_name":"immunotherapy response","score":0.8849999904632568},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.8679999709129333},{"id":"https://openalex.org/keywords/pembrolizumab","display_name":"pembrolizumab","score":0.9980000257492065},{"id":"https://openalex.org/keywords/urological-cancer","display_name":"genitourinary cancer","score":0.8880000114440918},{"id":"https://openalex.org/keywords/neoantigens","display_name":"neoantigens","score":0.9049999713897705},{"id":"https://openalex.org/keywords/nonsynonymous-mutations","display_name":"non-synonymous mutations","score":0.875},{"id":"https://openalex.org/keywords/fda-approval","display_name":"FDA approval","score":0.5460000038146973}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8254633545875549},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.7376095056533813},{"id":"https://openalex.org/C2780057760","wikidata":"https://www.wikidata.org/wiki/Q13896859","display_name":"Pembrolizumab","level":4,"score":0.6012769341468811},{"id":"https://openalex.org/C149904235","wikidata":"https://www.wikidata.org/wiki/Q7049620","display_name":"Nonsynonymous substitution","level":4,"score":0.559209406375885},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5348742008209229},{"id":"https://openalex.org/C133507102","wikidata":"https://www.wikidata.org/wiki/Q4712977","display_name":"Genitourinary system","level":2,"score":0.4908602833747864},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.38478413224220276},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3810935914516449},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3301440179347992},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2951585054397583},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2200416624546051},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2187575399875641},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.21214863657951355},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15089640021324158},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13231712579727173}],"mesh":[{"descriptor_ui":"D000077982","descriptor_name":"Progression-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014565","descriptor_name":"Urogenital Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014565","descriptor_name":"Urogenital Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014565","descriptor_name":"Urogenital Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014565","descriptor_name":"Urogenital Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.urology.2020.10.030","doi":"https://doi.org/10.1016/j.urology.2020.10.030","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.urology.2020.10.030","pdf_url":null,"source":{"id":"https://openalex.org/S196979320","display_name":"Urology","issn_l":"0090-4295","issn":["0090-4295","1527-9995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Urology","raw_type":"journal-article"},{"id":"pmid:33137348","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33137348","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Urology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.urology.2020.10.030","doi":"https://doi.org/10.1016/j.urology.2020.10.030","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.urology.2020.10.030","pdf_url":null,"source":{"id":"https://openalex.org/S196979320","display_name":"Urology","issn_l":"0090-4295","issn":["0090-4295","1527-9995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Urology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320306163","display_name":"Prostate Cancer Foundation","ror":"https://ror.org/01npwtv09"},{"id":"https://openalex.org/F4320316943","display_name":"Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology","ror":"https://ror.org/01xd6q208"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W1578291413","https://openalex.org/W1604315162","https://openalex.org/W1889335134","https://openalex.org/W1923058706","https://openalex.org/W1940241680","https://openalex.org/W1979811833","https://openalex.org/W2000905326","https://openalex.org/W2010121426","https://openalex.org/W2049553585","https://openalex.org/W2103959341","https://openalex.org/W2104885590","https://openalex.org/W2114031931","https://openalex.org/W2149793889","https://openalex.org/W2152061559","https://openalex.org/W2160834915","https://openalex.org/W2196466144","https://openalex.org/W2289712604","https://openalex.org/W2401074278","https://openalex.org/W2559804019","https://openalex.org/W2566478217","https://openalex.org/W2588916311","https://openalex.org/W2606495925","https://openalex.org/W2725858612","https://openalex.org/W2741036937","https://openalex.org/W2747774814","https://openalex.org/W2760107878","https://openalex.org/W2771888931","https://openalex.org/W2777192533","https://openalex.org/W2779221466","https://openalex.org/W2782224317","https://openalex.org/W2785803176","https://openalex.org/W2788431960","https://openalex.org/W2788746158","https://openalex.org/W2789900707","https://openalex.org/W2797675588","https://openalex.org/W2801309958","https://openalex.org/W2805302875","https://openalex.org/W2808021061","https://openalex.org/W2883118933","https://openalex.org/W2888408613","https://openalex.org/W2888758049","https://openalex.org/W2892340405","https://openalex.org/W2897002925","https://openalex.org/W2897581535","https://openalex.org/W2908503672","https://openalex.org/W2909248871","https://openalex.org/W2909312563","https://openalex.org/W2909486828","https://openalex.org/W2909679049","https://openalex.org/W2913484031","https://openalex.org/W2916451481","https://openalex.org/W2918511688","https://openalex.org/W2921052875","https://openalex.org/W2923722049","https://openalex.org/W2942052760","https://openalex.org/W2944320012","https://openalex.org/W2974280214","https://openalex.org/W2981647581","https://openalex.org/W2981696991","https://openalex.org/W2983442161","https://openalex.org/W2987436342","https://openalex.org/W2994938720","https://openalex.org/W3010839046","https://openalex.org/W3083986479","https://openalex.org/W3087464965","https://openalex.org/W3088957028","https://openalex.org/W3092302767","https://openalex.org/W6742026208","https://openalex.org/W6769647292"],"related_works":["https://openalex.org/W3101416564","https://openalex.org/W4393203256","https://openalex.org/W4401908548","https://openalex.org/W4283644334","https://openalex.org/W3112886041","https://openalex.org/W4390279712","https://openalex.org/W2987966587","https://openalex.org/W4385636785","https://openalex.org/W4390509618","https://openalex.org/W4410301654"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-11-09T00:00:00"}