{"id":"https://openalex.org/W3097201621","doi":"https://doi.org/10.3389/fbioe.2020.544311","title":"In vitro Label Free Raman Microspectroscopic Analysis to Monitor the Uptake, Fate and Impacts of Nanoparticle Based Materials","display_name":"In vitro Label Free Raman Microspectroscopic Analysis to Monitor the Uptake, Fate and Impacts of Nanoparticle Based Materials","publication_year":2020,"publication_date":"2020-10-29","ids":{"openalex":"https://openalex.org/W3097201621","doi":"https://doi.org/10.3389/fbioe.2020.544311","mag":"3097201621","pmid":"https://pubmed.ncbi.nlm.nih.gov/33195114","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7658377"},"language":"en","primary_location":{"id":"doi:10.3389/fbioe.2020.544311","doi":"https://doi.org/10.3389/fbioe.2020.544311","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbioe.2020.544311","pdf_url":"https://www.frontiersin.org/articles/10.3389/fbioe.2020.544311/pdf","source":{"id":"https://openalex.org/S2595131146","display_name":"Frontiers in Bioengineering and Biotechnology","issn_l":"2296-4185","issn":["2296-4185"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioengineering and Biotechnology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fbioe.2020.544311/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079930094","display_name":"Hugh James Byrne","orcid":"https://orcid.org/0000-0002-1735-8610","observed_orcids":["https://orcid.org/0000-0002-1735-8610"]},"institutions":[{"id":"https://openalex.org/I4210144925","display_name":"Technological University Dublin","ror":"https://ror.org/04t0qbt32","country_code":"IE","type":"education","lineage":["https://openalex.org/I4210144925"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"Hugh J. Byrne","raw_affiliation_strings":["FOCAS Research Institute, Technological University Dublin, Dublin, Ireland","Focas Research Institute [Dublin] (Camden Row, Dublin 8 - Ireland)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FOCAS Research Institute, Technological University Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I4210144925"]},{"raw_affiliation_string":"Focas Research Institute [Dublin] (Camden Row, Dublin 8 - Ireland)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073229240","display_name":"Franck Bonnier","orcid":"https://orcid.org/0000-0003-3658-4792","observed_orcids":["https://orcid.org/0000-0003-3658-4792"]},"institutions":[{"id":"https://openalex.org/I110017253","display_name":"Universit\u00e9 de Tours","ror":"https://ror.org/02wwzvj46","country_code":"FR","type":"education","lineage":["https://openalex.org/I110017253"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Franck Bonnier","raw_affiliation_strings":["UFR Sciences Pharmaceutiques, EA 6295 Nanom\u00e9dicaments et Nanosondes, Universit\u00e9 de Tours, Tours, France","NMNS - Nanom\u00e9dicaments et Nanosondes (Facult\u00e9 de pharmacie\r\n31 avenue Monge\r\n37200 Tours - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UFR Sciences Pharmaceutiques, EA 6295 Nanom\u00e9dicaments et Nanosondes, Universit\u00e9 de Tours, Tours, France","institution_ids":["https://openalex.org/I110017253"]},{"raw_affiliation_string":"NMNS - Nanom\u00e9dicaments et Nanosondes (Facult\u00e9 de pharmacie\r\n31 avenue Monge\r\n37200 Tours - France)","institution_ids":["https://openalex.org/I110017253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066652191","display_name":"Esen Efeo\u011flu","orcid":"https://orcid.org/0000-0002-3380-0499","observed_orcids":["https://orcid.org/0000-0002-3380-0499"]},"institutions":[{"id":"https://openalex.org/I4210144925","display_name":"Technological University Dublin","ror":"https://ror.org/04t0qbt32","country_code":"IE","type":"education","lineage":["https://openalex.org/I4210144925"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Esen Efeoglu","raw_affiliation_strings":["FOCAS Research Institute, Technological University Dublin, Dublin, Ireland","Focas Research Institute [Dublin] (Camden Row, Dublin 8 - Ireland)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FOCAS Research Institute, Technological University Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I4210144925"]},{"raw_affiliation_string":"Focas Research Institute [Dublin] (Camden Row, Dublin 8 - Ireland)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102869430","display_name":"Caroline Moore","orcid":"https://orcid.org/0000-0003-3152-5910","observed_orcids":["https://orcid.org/0000-0003-3152-5910"]},"institutions":[{"id":"https://openalex.org/I4210144925","display_name":"Technological University Dublin","ror":"https://ror.org/04t0qbt32","country_code":"IE","type":"education","lineage":["https://openalex.org/I4210144925"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Caroline Moore","raw_affiliation_strings":["FOCAS Research Institute, Technological University Dublin, Dublin, Ireland","Focas Research Institute [Dublin] (Camden Row, Dublin 8 - Ireland)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FOCAS Research Institute, Technological University Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I4210144925"]},{"raw_affiliation_string":"Focas Research Institute [Dublin] (Camden Row, Dublin 8 - Ireland)","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053316308","display_name":"Jennifer McIntyre","orcid":"https://orcid.org/0000-0001-6418-8960","observed_orcids":["https://orcid.org/0000-0001-6418-8960"]},"institutions":[{"id":"https://openalex.org/I4210144925","display_name":"Technological University Dublin","ror":"https://ror.org/04t0qbt32","country_code":"IE","type":"education","lineage":["https://openalex.org/I4210144925"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Jennifer McIntyre","raw_affiliation_strings":["FOCAS Research Institute, Technological University Dublin, Dublin, Ireland","Focas Research Institute [Dublin] (Camden Row, Dublin 8 - Ireland)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FOCAS Research Institute, Technological University Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I4210144925"]},{"raw_affiliation_string":"Focas Research Institute [Dublin] (Camden Row, Dublin 8 - Ireland)","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5079930094"],"corresponding_institution_ids":["https://openalex.org/I4210144925"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.2771,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.27376426,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"8","issue":"544311","first_page":"544311","last_page":"544311"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10131","display_name":"Gold and Silver Nanoparticles Synthesis and Applications","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2504","display_name":"Electronic, Optical and Magnetic Materials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12627","display_name":"Graphene and Nanomaterials Applications","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/micro-raman-spectroscopy","display_name":"micro-Raman spectroscopy","score":0.9350000023841858},{"id":"https://openalex.org/keywords/nanoparticle-uptake","display_name":"nanoparticle uptake","score":0.9190000295639038},{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"subcellular localization","score":0.968999981880188},{"id":"https://openalex.org/keywords/polystyrene-nanoparticles","display_name":"polystyrene nanoparticles","score":0.9829999804496765},{"id":"https://openalex.org/keywords/graphene","display_name":"graphene","score":0.8799999952316284},{"id":"https://openalex.org/keywords/mos2","display_name":"MoS2","score":0.9269999861717224},{"id":"https://openalex.org/keywords/endosomes","display_name":"endosomes","score":0.6359999775886536},{"id":"https://openalex.org/keywords/lysosomes","display_name":"lysosomes","score":0.9980000257492065},{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"endoplasmic reticulum","score":0.9470000267028809},{"id":"https://openalex.org/keywords/nanoparticle-degradation","display_name":"nanoparticle degradation","score":0.8920000195503235},{"id":"https://openalex.org/keywords/pamam-dendrimers","display_name":"PAMAM dendrimers","score":0.9580000042915344},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7260000109672546},{"id":"https://openalex.org/keywords/necrosis","display_name":"necrosis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/high-content-screening","display_name":"high-content screening","score":0.5789999961853027},{"id":"https://openalex.org/keywords/nanoparticle-toxicity","display_name":"nanoparticle toxicity","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6615610122680664},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.647588849067688},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5896044373512268},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5754698514938354},{"id":"https://openalex.org/C55637122","wikidata":"https://www.wikidata.org/wiki/Q903923","display_name":"Dendrimer","level":2,"score":0.5237476825714111},{"id":"https://openalex.org/C40003534","wikidata":"https://www.wikidata.org/wiki/Q862228","display_name":"Raman spectroscopy","level":2,"score":0.5179907083511353},{"id":"https://openalex.org/C2993415590","wikidata":"https://www.wikidata.org/wiki/Q862228","display_name":"Raman microspectroscopy","level":3,"score":0.48244673013687134},{"id":"https://openalex.org/C136009344","wikidata":"https://www.wikidata.org/wiki/Q336201","display_name":"Confocal","level":2,"score":0.47999829053878784},{"id":"https://openalex.org/C45206210","wikidata":"https://www.wikidata.org/wiki/Q2415817","display_name":"Nanoscopic scale","level":2,"score":0.4657977521419525},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.4574848711490631},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.4423012435436249},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.424453467130661},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34401482343673706},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2762458622455597},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.23997199535369873},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2129555642604828},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12236306071281433},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3389/fbioe.2020.544311","doi":"https://doi.org/10.3389/fbioe.2020.544311","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbioe.2020.544311","pdf_url":"https://www.frontiersin.org/articles/10.3389/fbioe.2020.544311/pdf","source":{"id":"https://openalex.org/S2595131146","display_name":"Frontiers in Bioengineering and Biotechnology","issn_l":"2296-4185","issn":["2296-4185"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioengineering and Biotechnology","raw_type":"journal-article"},{"id":"pmid:33195114","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33195114","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioengineering and biotechnology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7658377","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7658377/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Bioeng Biotechnol","raw_type":"Text"},{"id":"pmh:oai:arrow.tudublin.ie:radart-1074","doi":null,"is_oa":true,"landing_page_url":"https://arrow.tudublin.ie/radart/76","pdf_url":"https://arrow.tudublin.ie/radart/76","source":{"id":"https://openalex.org/S4377196307","display_name":"Arrow - TU Dublin (Technological University Dublin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210144925","host_organization_name":"Technological University Dublin","host_organization_lineage":["https://openalex.org/I4210144925"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Articles","raw_type":"article"},{"id":"pmh:oai:HAL:hal-03043599v1","doi":null,"is_oa":false,"landing_page_url":"https://univ-tours.hal.science/hal-03043599","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.frontiersin.org/articles/10.3389/fbioe.2020.544311/full","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:df7fe837bdee4f1b84fddad7e323bdec","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/df7fe837bdee4f1b84fddad7e323bdec","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fbioe.2020.544311","doi":"https://doi.org/10.3389/fbioe.2020.544311","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbioe.2020.544311","pdf_url":"https://www.frontiersin.org/articles/10.3389/fbioe.2020.544311/pdf","source":{"id":"https://openalex.org/S2595131146","display_name":"Frontiers in Bioengineering and Biotechnology","issn_l":"2296-4185","issn":["2296-4185"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioengineering and Biotechnology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.428600013256073}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320847","display_name":"Science Foundation Ireland","ror":"https://ror.org/0271asj38"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3097201621.pdf","grobid_xml":"https://content.openalex.org/works/W3097201621.grobid-xml"},"referenced_works_count":129,"referenced_works":["https://openalex.org/W186797727","https://openalex.org/W195624623","https://openalex.org/W1483333322","https://openalex.org/W1546843241","https://openalex.org/W1842251000","https://openalex.org/W1955390271","https://openalex.org/W1965115054","https://openalex.org/W1973700929","https://openalex.org/W1973724012","https://openalex.org/W1978145906","https://openalex.org/W1979905588","https://openalex.org/W1980505853","https://openalex.org/W1981880358","https://openalex.org/W1982188792","https://openalex.org/W1984801309","https://openalex.org/W1987583385","https://openalex.org/W1990590536","https://openalex.org/W2001705187","https://openalex.org/W2007310701","https://openalex.org/W2009992051","https://openalex.org/W2015115648","https://openalex.org/W2017701041","https://openalex.org/W2021980355","https://openalex.org/W2023203784","https://openalex.org/W2026734776","https://openalex.org/W2030399243","https://openalex.org/W2031846091","https://openalex.org/W2036846975","https://openalex.org/W2036950867","https://openalex.org/W2039123138","https://openalex.org/W2039357273","https://openalex.org/W2044508938","https://openalex.org/W2045824562","https://openalex.org/W2052034198","https://openalex.org/W2058122340","https://openalex.org/W2059084199","https://openalex.org/W2059654203","https://openalex.org/W2062925715","https://openalex.org/W2064620482","https://openalex.org/W2064750581","https://openalex.org/W2067438336","https://openalex.org/W2068575510","https://openalex.org/W2071024234","https://openalex.org/W2072443063","https://openalex.org/W2073928735","https://openalex.org/W2074564329","https://openalex.org/W2077458217","https://openalex.org/W2081221904","https://openalex.org/W2081245603","https://openalex.org/W2084694220","https://openalex.org/W2087478412","https://openalex.org/W2089506690","https://openalex.org/W2091273808","https://openalex.org/W2091323116","https://openalex.org/W2095482077","https://openalex.org/W2096258412","https://openalex.org/W2100235363","https://openalex.org/W2117172764","https://openalex.org/W2117416272","https://openalex.org/W2117665793","https://openalex.org/W2119952633","https://openalex.org/W2122982309","https://openalex.org/W2126747233","https://openalex.org/W2127893823","https://openalex.org/W2131281238","https://openalex.org/W2137152281","https://openalex.org/W2141883105","https://openalex.org/W2147377968","https://openalex.org/W2147564235","https://openalex.org/W2148293029","https://openalex.org/W2154773020","https://openalex.org/W2157073047","https://openalex.org/W2158686972","https://openalex.org/W2159031378","https://openalex.org/W2159264991","https://openalex.org/W2159367422","https://openalex.org/W2160797083","https://openalex.org/W2171510198","https://openalex.org/W2193607295","https://openalex.org/W2287149428","https://openalex.org/W2295097024","https://openalex.org/W2300671107","https://openalex.org/W2324022855","https://openalex.org/W2340866171","https://openalex.org/W2343296710","https://openalex.org/W2416192628","https://openalex.org/W2418032759","https://openalex.org/W2464103576","https://openalex.org/W2470913420","https://openalex.org/W2471541622","https://openalex.org/W2494690972","https://openalex.org/W2499370681","https://openalex.org/W2539651361","https://openalex.org/W2554168993","https://openalex.org/W2563115000","https://openalex.org/W2596887231","https://openalex.org/W2606487236","https://openalex.org/W2609282721","https://openalex.org/W2720601066","https://openalex.org/W2735235995","https://openalex.org/W2742316108","https://openalex.org/W2745554026","https://openalex.org/W2766603150","https://openalex.org/W2769855558","https://openalex.org/W2778660884","https://openalex.org/W2780527497","https://openalex.org/W2782232876","https://openalex.org/W2790631129","https://openalex.org/W2792447227","https://openalex.org/W2796363429","https://openalex.org/W2800989749","https://openalex.org/W2808700992","https://openalex.org/W2808848745","https://openalex.org/W2884050184","https://openalex.org/W2892519484","https://openalex.org/W2895907102","https://openalex.org/W2898260012","https://openalex.org/W2939963827","https://openalex.org/W2941843410","https://openalex.org/W2944054909","https://openalex.org/W2952294644","https://openalex.org/W2976785046","https://openalex.org/W2989933322","https://openalex.org/W2999561293","https://openalex.org/W3006002856","https://openalex.org/W3016693918","https://openalex.org/W3087446464","https://openalex.org/W4238768614","https://openalex.org/W6654328966"],"related_works":["https://openalex.org/W2802945122","https://openalex.org/W2742316108","https://openalex.org/W2464103576","https://openalex.org/W2808700992","https://openalex.org/W2780527497","https://openalex.org/W4414075450","https://openalex.org/W7072227880","https://openalex.org/W3087446464","https://openalex.org/W2260057744","https://openalex.org/W2062925715"],"abstract_inverted_index":{"The":[0,132],"continued":[1],"emergence":[2],"of":[3,23,48,96,106,145,166,198,206,225,233,240,259,272,274,283,289,301],"nanoscale":[4,236],"materials":[5,58],"for":[6,185,277,298],"nanoparticle-based":[7],"therapy,":[8],"sensing":[9],"and":[10,37,42,51,98,142,150,181,214,242,287,295],"imaging,":[11],"as":[12,14,103,110,195],"well":[13],"their":[15,35,158,174],"more":[16],"general":[17],"adoption":[18],"in":[19,46,66,115,178,222,254,269,278,293],"a":[20,40,73,104,116,129,196,223,302],"broad":[21],"range":[22],"industrial":[24],"applications,":[25],"has":[26,134,219],"placed":[27],"increasing":[28],"demands":[29],"on":[30,157,246],"the":[31,78,93,121,139,164,204,212,229,247,257,260,265,270,284,296,299],"ability":[32,79],"to":[33,62,80,101,137,172,191,209,231,267],"assess":[34],"interactions":[36],"impacts":[38,288],"at":[39,128],"cellular":[41,68,140,248],"subcellular":[43,130,143,176,193],"level,":[44],"both":[45],"terms":[47],"potentially":[49],"beneficial":[50],"detrimental":[52],"effects.":[53],"Notably,":[54],"however,":[55],"many":[56],"such":[57,109],"have":[59],"been":[60,135,220],"shown":[61],"interfere":[63],"with":[64],"conventional":[65],"vitro":[67],"assays":[69],"that":[70],"record":[71],"only":[72],"single":[74],"colorimetric":[75],"end-point,":[76],"challenging":[77],"rapidly":[81],"screen":[82],"cytological":[83],"responses.":[84],"As":[85],"an":[86],"alternative,":[87],"Raman":[88,207,275],"microspectroscopy":[89,208,276],"can":[90,125],"spatially":[91],"profile":[92],"biochemical":[94],"content":[95,307],"cells,":[97],"any":[99],"changes":[100],"it":[102,168,188],"result":[105],"exogenous":[107],"agents,":[108,114],"toxicants":[111],"or":[112],"therapeutic":[113],"label":[117,280,304],"free":[118,281,305],"manner.":[119],"In":[120,163],"confocal":[122],"mode,":[123],"analysis":[124,282,309],"be":[126],"performed":[127],"level.":[131],"technique":[133],"employed":[136,171,190],"confirm":[138],"uptake":[141],"localisation":[144],"polystyrene":[146],"nanoparticles":[147],"(PSNPs),":[148],"graphene":[149],"molybdenum":[151],"disulphide":[152],"micro/nano":[153],"plates":[154],"(MoS2),":[155],"based":[156,245,291],"respective":[159],"characteristic":[160],"spectroscopic":[161,249,308],"signatures.":[162],"case":[165],"PSNPs":[167],"was":[169,189,251],"further":[170],"identify":[173],"local":[175],"environment":[177],"endosomes,":[179],"lysosomes":[180],"endoplasmic":[182],"reticulum,":[183],"while":[184],"MoS2":[186],"particles,":[187],"monitor":[192],"degradation":[194],"function":[197],"time.":[199],"For":[200],"amine":[201],"functionalised":[202],"PSNPs,":[203],"potential":[205],"quantitatively":[210],"characterise":[211],"dose":[213],"time":[215],"dependent":[216],"toxic":[217],"responses":[218,230,250],"explored,":[221],"number":[224],"cell":[226],"lines.":[227],"Comparing":[228],"those":[232],"poly":[234],"(amidoamine)":[235],"polymeric":[237],"dendrimers,":[238],"differentiation":[239],"apoptotic":[241],"necrotic":[243],"pathways":[244],"demonstrated.":[252],"Drawing":[253],"particular":[255],"from":[256],"experience":[258],"authors,":[261],"this":[262],"paper":[263],"details":[264],"progress":[266],"date":[268],"development":[271,300],"applications":[273],"vitro,":[279,294],"uptake,":[285],"fate":[286],"nanoparticle":[290],"materials,":[292],"prospects":[297],"routine,":[303],"high":[306],"technique.":[310]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-11-09T00:00:00"}
