{"id":"https://openalex.org/W3097132181","doi":"https://doi.org/10.1182/blood-2020-142720","title":"Differential Use of Rap1 Effectors for Integrin Activation in Platelets and Lymphocytes","display_name":"Differential Use of Rap1 Effectors for Integrin Activation in Platelets and Lymphocytes","publication_year":2020,"publication_date":"2020-11-04","ids":{"openalex":"https://openalex.org/W3097132181","doi":"https://doi.org/10.1182/blood-2020-142720","mag":"3097132181"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2020-142720","doi":"https://doi.org/10.1182/blood-2020-142720","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2020-142720","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090002430","display_name":"Fr\u00e9d\u00e9ric Lagarrigue","orcid":"https://orcid.org/0000-0002-4660-8666","observed_orcids":["https://orcid.org/0000-0002-4660-8666"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210099749","display_name":"Institut de Pharmacologie et de Biologie Structurale","ror":"https://ror.org/016zvc994","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210099749","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Frederic Lagarrigue","raw_affiliation_strings":["Department of Medicine, University of California San Diego, La Jolla, CA","Institut de Pharmacologie et Biologie Structurale, IPBS, Universit\u00e9 de Toulouse, CNRS, UPS, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Institut de Pharmacologie et Biologie Structurale, IPBS, Universit\u00e9 de Toulouse, CNRS, UPS, Toulouse, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I134560555","https://openalex.org/I4210099749","https://openalex.org/I4405258862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024465098","display_name":"Hao Sun","orcid":"https://orcid.org/0000-0002-4790-8847","observed_orcids":["https://orcid.org/0000-0002-4790-8847"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hao Sun","raw_affiliation_strings":["Department of Medicine, University of California San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047095751","display_name":"Alexandre R. Gingras","orcid":"https://orcid.org/0000-0002-5373-0176","observed_orcids":["https://orcid.org/0000-0002-5373-0176"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandre R Gingras","raw_affiliation_strings":["Department of Medicine, University of California San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032907445","display_name":"Mark H. Ginsberg","orcid":"https://orcid.org/0000-0002-5685-5417","observed_orcids":["https://orcid.org/0000-0002-5685-5417"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark H Ginsberg","raw_affiliation_strings":["Department of Medicine, University of California San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.22111591,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"136","issue":"Supplement 1","first_page":"27","last_page":"28"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rap1","display_name":"Rap1","score":0.9909999966621399},{"id":"https://openalex.org/keywords/talin-1","display_name":"talin-1","score":0.7699999809265137},{"id":"https://openalex.org/keywords/integrin-activation","display_name":"integrin activation","score":0.8640000224113464},{"id":"https://openalex.org/keywords/riam","display_name":"RIAM","score":0.6970000267028809},{"id":"https://openalex.org/keywords/rap1a","display_name":"Rap1A","score":0.7509999871253967},{"id":"https://openalex.org/keywords/rap1b","display_name":"Rap1b","score":0.996999979019165},{"id":"https://openalex.org/keywords/integrin-alpha4beta1","display_name":"alpha4beta1 integrin","score":0.7139999866485596},{"id":"https://openalex.org/keywords/integrin-alpha4beta7","display_name":"alpha4beta7 integrin","score":0.8569999933242798},{"id":"https://openalex.org/keywords/glycoprotein-iib-iiia","display_name":"integrin \u03b1IIb\u03b23","score":0.9390000104904175},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.8069999814033508},{"id":"https://openalex.org/keywords/t-cell-homing","display_name":"T cell homing","score":0.9110000133514404},{"id":"https://openalex.org/keywords/cell-type-specific-signaling","display_name":"cell type-specific signaling","score":0.5400000214576721},{"id":"https://openalex.org/keywords/hemostasis","display_name":"hemostasis","score":0.7210000157356262},{"id":"https://openalex.org/keywords/immune-function","display_name":"immune function","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.6719927191734314},{"id":"https://openalex.org/C2776179587","wikidata":"https://www.wikidata.org/wiki/Q54461864","display_name":"Rap1","level":3,"score":0.5905610918998718},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.5467357635498047},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5130659341812134},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46869850158691406},{"id":"https://openalex.org/C156585808","wikidata":"https://www.wikidata.org/wiki/Q18028043","display_name":"Integrin, beta 6","level":4,"score":0.4428955614566803},{"id":"https://openalex.org/C171779818","wikidata":"https://www.wikidata.org/wiki/Q3799301","display_name":"Integrin alpha M","level":3,"score":0.42418161034584045},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3561721742153168},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.3498613238334656},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2647211253643036},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.22172865271568298},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18182459473609924},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17740759253501892}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1182/blood-2020-142720","doi":"https://doi.org/10.1182/blood-2020-142720","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2020-142720","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmh:oai:HAL:hal-03450212v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-03450212","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"62nd ASH Annual Meeting & Exposition, Dec 2020, Virtual Meeting, United States","raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3199828317","https://openalex.org/W3033905875","https://openalex.org/W7024038599","https://openalex.org/W7061541749","https://openalex.org/W2901644785","https://openalex.org/W3088809948","https://openalex.org/W4213426383","https://openalex.org/W1966302652","https://openalex.org/W1980407390","https://openalex.org/W2015592150"],"abstract_inverted_index":{"Rap1":[0,38,129,146,230,248],"is":[1,44],"a":[2,162,175,207,284],"major":[3],"convergence":[4],"point":[5,142],"of":[6,34,52,56,73,79,87,92,103,105,117,168,195,214,292],"the":[7,19,35,97,115,219,259,270],"platelet":[8,172],"and":[9,23,29,39,64,82,135,138,152,171,234,249,268,276],"lymphocyte":[10],"signaling":[11],"pathways":[12],"that":[13,179,229,245,269],"result":[14],"in":[15,41,49,58,94,120,132,181,223,239,256,264,273,283],"talin1":[16,40,88,133,150,163,187,204,224,235,250],"binding":[17,130,147,231],"to":[18,96,108,148,174,178,232,294],"integrin":[20,25,42,66,118,169,196,220,254,274],"\u03b2-cytoplasmic":[21],"domain":[22],"consequent":[24],"activation,":[26,197],"effective":[27],"hemostasis":[28],"immune":[30],"functions.":[31],"The":[32,101],"nature":[33],"connection":[36],"between":[37,261],"activation":[43,67,72,91,119,167,221,275],"an":[45],"important":[46],"remaining":[47],"gap":[48],"our":[50],"understanding":[51],"this":[53],"process.":[54],"Deletion":[55],"RIAM":[57,199,215,233],"T":[59,106,123,189,201,226,240],"cells":[60,107,190,202,227,267],"partially":[61,237],"suppressed":[62,90],"\u03b1L\u03b22":[63],"\u03b14\u03b27":[65],"but":[68],"did":[69],"not":[70],"block":[71,145],"\u03b14\u03b21.":[74],"In":[75,156,185],"sharp":[76],"contrast,":[77,186],"deletion":[78,86],"both":[80,149,247],"Rap1a":[81],"Rap1b":[83],"isoforms":[84],"or":[85],"profoundly":[89],"\u03b14\u03b21":[93],"addition":[95],"other":[98],"two":[99,128],"integrins.":[100],"loss":[102,116,194],"homing":[104],"peripheral":[109],"lymphoid":[110],"organs":[111],"was":[112],"correlated":[113],"with":[114],"these":[121],"mutant":[122],"cells.":[124,241],"We":[125],"recently":[126],"identified":[127],"sites":[131],"F0":[134,151],"F1":[136,153],"domains":[137,154],"generated":[139],"mice":[140],"bearing":[141],"mutations,":[143],"which":[144,158],"(R35E,R118E).":[155],"platelets,":[157],"lack":[159],"endogenous":[160],"RIAM,":[161],"(R35E,R118E)":[164,205],"mutation":[165],"suppresses":[166],"\u03b1IIb\u03b23":[170],"aggregation":[173],"similar":[176],"extent":[177],"observed":[180],"Rap1a,b":[182],"null":[183,200],"platelets.":[184],"(R35E,R118E)-expressing":[188,225],"manifest":[191],"only":[192],"partial":[193],"whereas":[198],"expressing":[203],"exhibit":[206],"much":[208],"more":[209],"profound":[210],"defect.":[211],"Importantly,":[212],"overexpression":[213],"can":[216,280],"completely":[217],"rescue":[218],"defect":[222],"indicating":[228],"are":[236,251],"redundant":[238],"These":[242],"findings":[243],"reveal":[244],"although":[246],"essential":[252],"for":[253],"action":[255],"blood":[257,266,277],"cells,":[258],"connections":[260],"them":[262],"vary":[263],"different":[265],"final":[271],"steps":[272],"cell":[278],"function":[279],"be":[281],"manipulated":[282],"cell-type":[285],"specific":[286],"manner.":[287],"Disclosures":[288],"No":[289],"relevant":[290],"conflicts":[291],"interest":[293],"declare.":[295]},"counts_by_year":[],"updated_date":"2026-10-25T09:29:13.331239","created_date":"2020-11-09T00:00:00"}
