{"id":"https://openalex.org/W3097017178","doi":"https://doi.org/10.3390/ijms21218016","title":"Enhancer of Zeste Homolog 2 (EZH2) Mediates Glucolipotoxicity-Induced Apoptosis in \u03b2-Cells","display_name":"Enhancer of Zeste Homolog 2 (EZH2) Mediates Glucolipotoxicity-Induced Apoptosis in \u03b2-Cells","publication_year":2020,"publication_date":"2020-10-29","ids":{"openalex":"https://openalex.org/W3097017178","doi":"https://doi.org/10.3390/ijms21218016","mag":"3097017178","pmid":"https://pubmed.ncbi.nlm.nih.gov/33137873","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7672588"},"language":"en","primary_location":{"id":"doi:10.3390/ijms21218016","doi":"https://doi.org/10.3390/ijms21218016","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms21218016","pdf_url":"https://www.mdpi.com/1422-0067/21/21/8016/pdf","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/21/21/8016/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045005201","display_name":"Tina Dahlby","orcid":"https://orcid.org/0000-0003-1656-0814","observed_orcids":["https://orcid.org/0000-0003-1656-0814"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Tina Dahlby","raw_affiliation_strings":["Department of Biomedical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068182112","display_name":"Christian Simon","orcid":"https://orcid.org/0000-0002-5866-5967","observed_orcids":["https://orcid.org/0000-0002-5866-5967"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2801134892","display_name":"Novo Nordisk Foundation","ror":"https://ror.org/04txyc737","country_code":"DK","type":"facility","lineage":["https://openalex.org/I2801134892"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Christian Simon","raw_affiliation_strings":["Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, DK-2200 Copenhagen, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-5866-5967","affiliations":[{"raw_affiliation_string":"Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, DK-2200 Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2801134892"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069392374","display_name":"Marie Balslev Backe","orcid":"https://orcid.org/0000-0001-5442-0818","observed_orcids":["https://orcid.org/0000-0001-5442-0818"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Marie Balslev Backe","raw_affiliation_strings":["Department of Biomedical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038834398","display_name":"Mattias Salling Dahll\u00f6f","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Mattias Salling Dahll\u00f6f","raw_affiliation_strings":["Department of Biomedical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080133005","display_name":"Edward B. Holson","orcid":"https://orcid.org/0000-0002-9084-237X","observed_orcids":["https://orcid.org/0000-0002-9084-237X"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward Holson","raw_affiliation_strings":["Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075249814","display_name":"Bridget K. Wagner","orcid":"https://orcid.org/0000-0002-2629-361X","observed_orcids":["https://orcid.org/0000-0002-2629-361X"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bridget K. Wagner","raw_affiliation_strings":["Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085197434","display_name":"Marianne B\u00f6ni\u2010Schnetzler","orcid":"https://orcid.org/0000-0001-5569-5506","observed_orcids":["https://orcid.org/0000-0001-5569-5506"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Marianne B\u00f6ni-Schnetzler","raw_affiliation_strings":["Department of Biomedicine, University Hospital and University of Basel, 4031 Basel, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-5569-5506","affiliations":[{"raw_affiliation_string":"Department of Biomedicine, University Hospital and University of Basel, 4031 Basel, Switzerland","institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078846951","display_name":"Micha\u0142 Marzec","orcid":"https://orcid.org/0000-0001-9698-6019","observed_orcids":["https://orcid.org/0000-0001-9698-6019"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Michal Tomasz Marzec","raw_affiliation_strings":["Department of Biomedical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark"],"raw_orcid":"https://orcid.org/0000-0001-9698-6019","affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065473828","display_name":"Morten Lundh","orcid":"https://orcid.org/0000-0003-0918-577X","observed_orcids":["https://orcid.org/0000-0003-0918-577X"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Morten Lundh","raw_affiliation_strings":["Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA","Department of Biomedical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark"],"raw_orcid":"https://orcid.org/0000-0003-0918-577X","affiliations":[{"raw_affiliation_string":"Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Department of Biomedical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010404114","display_name":"Thomas R Mandrup-Poulsen","orcid":"https://orcid.org/0000-0002-3215-9273","observed_orcids":["https://orcid.org/0000-0002-3215-9273"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Thomas Mandrup-Poulsen","raw_affiliation_strings":["Department of Biomedical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-3215-9273","affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5010404114"],"corresponding_institution_ids":["https://openalex.org/I124055696"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2112},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2112},"fwci":0.6846,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.70684884,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"21","issue":"21","first_page":"8016","last_page":"8016"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.01979999989271164,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ezh2","display_name":"EZH2","score":0.996999979019165},{"id":"https://openalex.org/keywords/glucolipotoxicity","display_name":"glucolipotoxicity","score":0.9570000171661377},{"id":"https://openalex.org/keywords/beta-cell-apoptosis","display_name":"beta-cell apoptosis","score":0.7670000195503235},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9909999966621399},{"id":"https://openalex.org/keywords/hdac3-inhibition","display_name":"HDAC3 inhibition","score":0.7919999957084656},{"id":"https://openalex.org/keywords/histone-methyltransferase","display_name":"histone methyltransferase","score":0.949999988079071},{"id":"https://openalex.org/keywords/insulin-producing-cells","display_name":"insulin-producing cells","score":0.6970000267028809},{"id":"https://openalex.org/keywords/islets","display_name":"islets","score":0.5600000023841858},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.5429999828338623},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7260000109672546},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.7900000214576721}],"concepts":[{"id":"https://openalex.org/C50171091","wikidata":"https://www.wikidata.org/wiki/Q17917770","display_name":"EZH2","level":4,"score":0.7478814721107483},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6134118437767029},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.5935280323028564},{"id":"https://openalex.org/C13721689","wikidata":"https://www.wikidata.org/wiki/Q18033475","display_name":"HDAC3","level":5,"score":0.5838513374328613},{"id":"https://openalex.org/C150425827","wikidata":"https://www.wikidata.org/wiki/Q2560317","display_name":"Histone methyltransferase","level":4,"score":0.5712240934371948},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5580118298530579},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5156773328781128},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.46526575088500977},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4627751111984253},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.4571206271648407},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.4560844600200653},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44067421555519104},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.394294798374176},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.3656960129737854},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.33314040303230286},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1453709900379181},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.111246258020401}],"mesh":[{"descriptor_ui":"D000071221","descriptor_name":"Enhancer of Zeste Homolog 2 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000071221","descriptor_name":"Enhancer of Zeste Homolog 2 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D013549","descriptor_name":"Sweetening Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms21218016","doi":"https://doi.org/10.3390/ijms21218016","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms21218016","pdf_url":"https://www.mdpi.com/1422-0067/21/21/8016/pdf","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7672588","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7672588","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:33137873","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33137873","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire/53439f07-a940-42a5-8ec7-3cc9eaddea08","doi":null,"is_oa":true,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/53439f07-a940-42a5-8ec7-3cc9eaddea08","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dahlby, T, Simon, C, Backe, M B, Dahllof, M S, Holson, E, Wagner, B K, Boni-Schnetzler, M, Marzec, M T, Lundh, M & Mandrup-Poulsen, T 2020, 'Enhancer of Zeste Homolog 2 (EZH2) Mediates Glucolipotoxicity-Induced Apoptosis in beta-Cells', International Journal of Molecular Sciences, vol. 21, no. 21, 8016. https://doi.org/10.3390/ijms21218016","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3390/ijms21218016","doi":"https://doi.org/10.3390/ijms21218016","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms21218016","pdf_url":"https://www.mdpi.com/1422-0067/21/21/8016/pdf","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3187737109","display_name":null,"funder_award_id":"16-0314","funder_id":"https://openalex.org/F4320323030","funder_display_name":"Augustinus Fonden"}],"funders":[{"id":"https://openalex.org/F4320315655","display_name":"Danish Diabetes Academy","ror":"https://ror.org/05xbkrn90"},{"id":"https://openalex.org/F4320323030","display_name":"Augustinus Fonden","ror":"https://ror.org/030y53541"},{"id":"https://openalex.org/F4320335119","display_name":"Fonden til L\u00e6gevidenskabens Fremme","ror":"https://ror.org/02kdrgt12"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3097017178.pdf","grobid_xml":"https://content.openalex.org/works/W3097017178.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W189857981","https://openalex.org/W1550552214","https://openalex.org/W1605507149","https://openalex.org/W1970420856","https://openalex.org/W1971981721","https://openalex.org/W1977199336","https://openalex.org/W1979182598","https://openalex.org/W1983580359","https://openalex.org/W1985003152","https://openalex.org/W1987086068","https://openalex.org/W1998986309","https://openalex.org/W2003766657","https://openalex.org/W2004380688","https://openalex.org/W2010832962","https://openalex.org/W2014359105","https://openalex.org/W2020230403","https://openalex.org/W2021809018","https://openalex.org/W2026550637","https://openalex.org/W2032294094","https://openalex.org/W2042089533","https://openalex.org/W2048164783","https://openalex.org/W2048565142","https://openalex.org/W2052311839","https://openalex.org/W2053116646","https://openalex.org/W2055315295","https://openalex.org/W2077737366","https://openalex.org/W2078943080","https://openalex.org/W2088202626","https://openalex.org/W2089560759","https://openalex.org/W2098466396","https://openalex.org/W2100624249","https://openalex.org/W2101065953","https://openalex.org/W2102933118","https://openalex.org/W2103077763","https://openalex.org/W2103226094","https://openalex.org/W2108390464","https://openalex.org/W2108709856","https://openalex.org/W2112915315","https://openalex.org/W2113634596","https://openalex.org/W2116634113","https://openalex.org/W2137450588","https://openalex.org/W2149049209","https://openalex.org/W2149477971","https://openalex.org/W2151258444","https://openalex.org/W2158300687","https://openalex.org/W2160689782","https://openalex.org/W2160697532","https://openalex.org/W2162980664","https://openalex.org/W2164575981","https://openalex.org/W2165064047","https://openalex.org/W2167250543","https://openalex.org/W2170524079","https://openalex.org/W2181817569","https://openalex.org/W2285137452","https://openalex.org/W2342737942","https://openalex.org/W2587128226","https://openalex.org/W2767146486","https://openalex.org/W2913854962","https://openalex.org/W2965828947"],"related_works":["https://openalex.org/W2801983486","https://openalex.org/W7220853036","https://openalex.org/W4405485599","https://openalex.org/W1983580359","https://openalex.org/W1988090989","https://openalex.org/W1972299138","https://openalex.org/W2117939030","https://openalex.org/W7100070581","https://openalex.org/W2161542744","https://openalex.org/W2999168132"],"abstract_inverted_index":{"Selective":[0],"inhibition":[1],"of":[2,15,26,34,40,51,59,84,104,110,133],"histone":[3,86],"deacetylase":[4],"3":[5],"(HDAC3)":[6],"prevents":[7],"glucolipotoxicity-induced":[8,73,93,102,127],"\u03b2-cell":[9,36],"dysfunction":[10],"and":[11,76,131],"apoptosis":[12,77,130],"by":[13,78],"alleviation":[14,27],"proapoptotic":[16],"endoplasmic":[17],"reticulum":[18],"(ER)":[19],"stress-signaling,":[20],"but":[21,138],"the":[22,35,47,65,105,134],"precise":[23],"molecular":[24],"mechanisms":[25],"are":[28],"unexplored.":[29],"By":[30],"unbiased":[31],"microarray":[32],"analysis":[33],"gene":[37,114],"expression":[38],"profile":[39],"insulin-producing":[41],"cells":[42,98],"exposed":[43],"to":[44],"glucolipotoxicity":[45],"in":[46,116],"presence":[48],"or":[49],"absence":[50],"a":[52,154,158],"selective":[53],"HDAC3":[54],"inhibitor,":[55],"we":[56],"identified":[57],"Enhancer":[58],"zeste":[60],"homolog":[61],"2":[62],"(EZH2)":[63],"as":[64,153,157],"sole":[66],"target":[67],"candidate.":[68],"\u03b2-Cells":[69],"were":[70,99],"protected":[71,100],"against":[72,101],"ER":[74,128],"stress":[75],"EZH2":[79,85,96,123,151],"attenuation.":[80],"Small":[81],"molecule":[82],"inhibitors":[83],"methyltransferase":[87,155],"activity":[88],"rescued":[89],"human":[90],"islets":[91],"from":[92,126,140],"apoptosis.":[94],"Moreover,":[95],"knockdown":[97],"downregulation":[103,132],"protective":[106],"non-canonical":[107,135],"Nuclear":[108],"factor":[109],"kappa":[111],"light":[112],"polypeptide":[113],"enhancer":[115],"B-cells":[117],"(NF\u03baB)":[118],"pathway.":[119],"We":[120],"conclude":[121],"that":[122],"deficiency":[124],"protects":[125],"stress,":[129],"NF\u03baB":[136],"pathway,":[137],"not":[139],"insulin":[141],"secretory":[142],"dysfunction.":[143],"The":[144],"mechanism":[145],"likely":[146],"involves":[147],"transcriptional":[148],"regulation":[149],"via":[150],"functioning":[152],"and/or":[156],"methylation-dependent":[159],"transcription":[160],"factor.":[161]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-11-09T00:00:00"}
