{"id":"https://openalex.org/W3096936743","doi":"https://doi.org/10.3389/fcell.2020.570484","title":"Fine Particulate Matter Exposure Alters Pulmonary Microbiota Composition and Aggravates Pneumococcus-Induced Lung Pathogenesis","display_name":"Fine Particulate Matter Exposure Alters Pulmonary Microbiota Composition and Aggravates Pneumococcus-Induced Lung Pathogenesis","publication_year":2020,"publication_date":"2020-10-26","ids":{"openalex":"https://openalex.org/W3096936743","doi":"https://doi.org/10.3389/fcell.2020.570484","mag":"3096936743","pmid":"https://pubmed.ncbi.nlm.nih.gov/33195201","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7649221"},"language":"en","primary_location":{"id":"doi:10.3389/fcell.2020.570484","doi":"https://doi.org/10.3389/fcell.2020.570484","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2020.570484","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcell.2020.570484/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fcell.2020.570484/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100428126","display_name":"Yu\u2010Wen Chen","orcid":"https://orcid.org/0000-0003-2862-0415","observed_orcids":["https://orcid.org/0000-0003-2862-0415"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Wen Chen","raw_affiliation_strings":["Department of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048768864","display_name":"Shiao-Wen Li","orcid":"https://orcid.org/0000-0002-9048-092X","observed_orcids":["https://orcid.org/0000-0002-9048-092X"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shiao-Wen Li","raw_affiliation_strings":["Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109992903","display_name":"Chia-Der Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I4210126829","display_name":"China Medical University Hospital","ror":"https://ror.org/0368s4g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210126829"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chia-Der Lin","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, School of Medicine, China Medical University and Hospital, Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, School of Medicine, China Medical University and Hospital, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016","https://openalex.org/I4210126829"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101093820","display_name":"Mei-Zi Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Mei-Zi Huang","raw_affiliation_strings":["Department of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059719451","display_name":"Hwai\u2010Jeng Lin","orcid":"https://orcid.org/0000-0002-8175-3893","observed_orcids":["https://orcid.org/0000-0002-8175-3893"]},"institutions":[{"id":"https://openalex.org/I4210158385","display_name":"Taipei Medical University-Shuang Ho Hospital","ror":"https://ror.org/04k9dce70","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158385"]},{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hwai-Jeng Lin","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan","Division of Gastroenterology and Hepatology, Department of Internal Medicine, Shuang-Ho Hospital, New Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan","institution_ids":["https://openalex.org/I47519274"]},{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Shuang-Ho Hospital, New Taipei, Taiwan","institution_ids":["https://openalex.org/I4210158385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079594536","display_name":"Chia-Yin Chin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chia-Yin Chin","raw_affiliation_strings":["Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002520798","display_name":"Yi-Ru Lai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yi-Ru Lai","raw_affiliation_strings":["Department of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070961080","display_name":"Cheng\u2010Hsun Chiu","orcid":"https://orcid.org/0000-0003-4324-7743","observed_orcids":["https://orcid.org/0000-0003-4324-7743"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210116208","display_name":"Linkou Chang Gung Memorial Hospital","ror":"https://ror.org/02dnn6q67","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970","https://openalex.org/I4210116208"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Cheng-Hsun Chiu","raw_affiliation_strings":["Department of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan","Molecular Infectious Disease Research Center, Department of Pediatrics, Chang Gung Memorial Hospital, Linkou, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]},{"raw_affiliation_string":"Molecular Infectious Disease Research Center, Department of Pediatrics, Chang Gung Memorial Hospital, Linkou, Taiwan","institution_ids":["https://openalex.org/I3020100970","https://openalex.org/I4210116208"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053604922","display_name":"Chia-Yu Yang","orcid":"https://orcid.org/0000-0002-5123-0856","observed_orcids":["https://orcid.org/0000-0002-5123-0856"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210093734","display_name":"Taoyuan Chang Gung Memorial Hospital","ror":"https://ror.org/00fk9d670","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210093734"]},{"id":"https://openalex.org/I4210116208","display_name":"Linkou Chang Gung Memorial Hospital","ror":"https://ror.org/02dnn6q67","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970","https://openalex.org/I4210116208"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Chia-Yu Yang","raw_affiliation_strings":["Department of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan","Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan","Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]},{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I3020100970","https://openalex.org/I4210093734","https://openalex.org/I4210116208"]},{"raw_affiliation_string":"Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024344102","display_name":"Chih\u2010Ho Lai","orcid":"https://orcid.org/0000-0001-7145-784X","observed_orcids":["https://orcid.org/0000-0001-7145-784X"]},"institutions":[{"id":"https://openalex.org/I143578492","display_name":"Asia University","ror":"https://ror.org/038a1tp19","country_code":"TW","type":"education","lineage":["https://openalex.org/I143578492"]},{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210116208","display_name":"Linkou Chang Gung Memorial Hospital","ror":"https://ror.org/02dnn6q67","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970","https://openalex.org/I4210116208"]},{"id":"https://openalex.org/I4210126829","display_name":"China Medical University Hospital","ror":"https://ror.org/0368s4g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210126829"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Chih-Ho Lai","raw_affiliation_strings":["Department of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan","Department of Nursing, Asia University, Taichung, Taiwan","Department of Otolaryngology-Head and Neck Surgery, School of Medicine, China Medical University and Hospital, Taichung, Taiwan","Molecular Infectious Disease Research Center, Department of Pediatrics, Chang Gung Memorial Hospital, Linkou, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]},{"raw_affiliation_string":"Department of Nursing, Asia University, Taichung, Taiwan","institution_ids":["https://openalex.org/I143578492"]},{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, School of Medicine, China Medical University and Hospital, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016","https://openalex.org/I4210126829"]},{"raw_affiliation_string":"Molecular Infectious Disease Research Center, Department of Pediatrics, Chang Gung Memorial Hospital, Linkou, Taiwan","institution_ids":["https://openalex.org/I3020100970","https://openalex.org/I4210116208"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5024344102","https://openalex.org/A5053604922"],"corresponding_institution_ids":["https://openalex.org/I143578492","https://openalex.org/I173093425","https://openalex.org/I184693016","https://openalex.org/I3020100970","https://openalex.org/I4210093734","https://openalex.org/I4210116208","https://openalex.org/I4210126829"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":2.2461,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":{"value":0.87885191,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"8","issue":null,"first_page":"570484","last_page":"570484"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10190","display_name":"Air Quality and Health Impacts","score":0.7788000106811523,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10190","display_name":"Air Quality and Health Impacts","score":0.7788000106811523,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11002","display_name":"Indoor Air Quality and Microbial Exposure","score":0.07620000094175339,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.060100000351667404,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pm2-5","display_name":"PM2.5","score":0.9509999752044678},{"id":"https://openalex.org/keywords/pulmonary-microbiota","display_name":"pulmonary microbiota","score":0.8429999947547913},{"id":"https://openalex.org/keywords/streptococcus-pneumoniae","display_name":"Streptococcus pneumoniae","score":0.9179999828338623},{"id":"https://openalex.org/keywords/pneumococcal-disease","display_name":"pneumococcal infection","score":0.9649999737739563},{"id":"https://openalex.org/keywords/dysbiosis","display_name":"dysbiosis","score":0.878000020980835},{"id":"https://openalex.org/keywords/respiratory-microbiome","display_name":"airway microbiome","score":0.7519999742507935},{"id":"https://openalex.org/keywords/streptococcus","display_name":"Streptococcus","score":0.8460000157356262},{"id":"https://openalex.org/keywords/prevotella","display_name":"Prevotella","score":0.8389999866485596},{"id":"https://openalex.org/keywords/leptotrichia","display_name":"Leptotrichia","score":0.8820000290870667},{"id":"https://openalex.org/keywords/granulicatella","display_name":"Granulicatella","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pulmonary-inflammation","display_name":"lung inflammation","score":0.921999990940094},{"id":"https://openalex.org/keywords/infection-susceptibility","display_name":"infection susceptibility","score":0.6740000247955322},{"id":"https://openalex.org/keywords/respiratory-diseases","display_name":"respiratory diseases","score":0.3720000088214874}],"concepts":[{"id":"https://openalex.org/C24245907","wikidata":"https://www.wikidata.org/wiki/Q498957","display_name":"Particulates","level":2,"score":0.7735421657562256},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.6769261360168457},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5804927945137024},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.4469083845615387},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.394270658493042},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.39290404319763184},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3523380160331726},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34916943311691284},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.1374940276145935},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.11093467473983765},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08750492334365845}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fcell.2020.570484","doi":"https://doi.org/10.3389/fcell.2020.570484","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2020.570484","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcell.2020.570484/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},{"id":"pmid:33195201","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33195201","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cell and developmental biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7649221","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7649221/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cell Dev Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:ef712fa22fab41308b424985a0677c4a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ef712fa22fab41308b424985a0677c4a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cell and Developmental Biology, Vol 8 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcell.2020.570484","doi":"https://doi.org/10.3389/fcell.2020.570484","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2020.570484","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcell.2020.570484/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3130073244","display_name":null,"funder_award_id":"BMRPE90","funder_id":"https://openalex.org/F4320323441","funder_display_name":"Chang Gung Memorial Hospital, Linkou"},{"id":"https://openalex.org/G3354510429","display_name":"Molecular Mechanism for Particulate Matter Exacerbates Bacteria-Induced Pulmonary Inflammation","funder_award_id":"MOST109-2320-B182-029-MY3","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G3798894264","display_name":"Mechanism of Bacterial Genotoxin-Induced Necroptosis to Facilitate Inflammation","funder_award_id":"MOST109-2320-B182-025-MY3","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G5537500462","display_name":null,"funder_award_id":"CMRPD1J0021-3","funder_id":"https://openalex.org/F4320323441","funder_display_name":"Chang Gung Memorial Hospital, Linkou"},{"id":"https://openalex.org/G8126544094","display_name":null,"funder_award_id":"CMRPD1F0431-3","funder_id":"https://openalex.org/F4320323441","funder_display_name":"Chang Gung Memorial Hospital, Linkou"},{"id":"https://openalex.org/G8719038368","display_name":null,"funder_award_id":"CMRPD1K0361","funder_id":"https://openalex.org/F4320323441","funder_display_name":"Chang Gung Memorial Hospital, Linkou"},{"id":"https://openalex.org/G900058448","display_name":null,"funder_award_id":"CMRPD1I0061-3","funder_id":"https://openalex.org/F4320323441","funder_display_name":"Chang Gung Memorial Hospital, Linkou"}],"funders":[{"id":"https://openalex.org/F4320321524","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46"},{"id":"https://openalex.org/F4320322767","display_name":"Chang Gung Medical Foundation","ror":"https://ror.org/02verss31"},{"id":"https://openalex.org/F4320322795","display_name":"Ministry of Science and Technology, Taiwan","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320323441","display_name":"Chang Gung Memorial Hospital, Linkou","ror":"https://ror.org/02dnn6q67"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3096936743.pdf","grobid_xml":"https://content.openalex.org/works/W3096936743.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W1544643600","https://openalex.org/W1753698591","https://openalex.org/W1985599412","https://openalex.org/W1991618746","https://openalex.org/W2010784732","https://openalex.org/W2023601680","https://openalex.org/W2032548496","https://openalex.org/W2056279562","https://openalex.org/W2059480255","https://openalex.org/W2083089709","https://openalex.org/W2100364589","https://openalex.org/W2117457769","https://openalex.org/W2125579347","https://openalex.org/W2130082585","https://openalex.org/W2132629114","https://openalex.org/W2133856765","https://openalex.org/W2138480014","https://openalex.org/W2142802314","https://openalex.org/W2152657820","https://openalex.org/W2152885278","https://openalex.org/W2165067288","https://openalex.org/W2170024099","https://openalex.org/W2253274866","https://openalex.org/W2275537745","https://openalex.org/W2288620069","https://openalex.org/W2322206707","https://openalex.org/W2401404581","https://openalex.org/W2421280540","https://openalex.org/W2509551256","https://openalex.org/W2554506152","https://openalex.org/W2587341409","https://openalex.org/W2607434574","https://openalex.org/W2615901364","https://openalex.org/W2697814775","https://openalex.org/W2777703562","https://openalex.org/W2778644383","https://openalex.org/W2783937591","https://openalex.org/W2793404076","https://openalex.org/W2801050647","https://openalex.org/W2804415416","https://openalex.org/W2804679688","https://openalex.org/W2884138484","https://openalex.org/W2897976336","https://openalex.org/W2908356671","https://openalex.org/W2911899248","https://openalex.org/W2916308866","https://openalex.org/W2918234787","https://openalex.org/W2949675525","https://openalex.org/W2951489107","https://openalex.org/W2952463830","https://openalex.org/W2953461188","https://openalex.org/W2963102813","https://openalex.org/W2993153957","https://openalex.org/W2999046098","https://openalex.org/W3003031591","https://openalex.org/W3007517500","https://openalex.org/W3022099302","https://openalex.org/W3030441098","https://openalex.org/W3047274831","https://openalex.org/W4240779311"],"related_works":["https://openalex.org/W4292393927","https://openalex.org/W4386607645","https://openalex.org/W7155365701","https://openalex.org/W2914516507","https://openalex.org/W3107525487","https://openalex.org/W4381470634","https://openalex.org/W4367834678","https://openalex.org/W4402242007","https://openalex.org/W3007517500","https://openalex.org/W2778705929"],"abstract_inverted_index":{"Exposure":[0],"to":[1,151,159,190,210],"fine":[2],"particulate":[3],"matter":[4],"(PM)":[5],"with":[6,16,74,127,134,154,161,180],"aerodynamic":[7],"diameter":[8],"\u2264":[9],"2.5":[10],"\u03bcm":[11],"(PM2.5)":[12],"is":[13],"closely":[14],"correlated":[15],"respiratory":[17],"diseases.":[18],"Microbiota":[19],"plays":[20],"a":[21,101,169],"key":[22],"role":[23],"in":[24,123,148,175,186],"maintaining":[25],"body":[26],"homeostasis":[27],"including":[28],"regulation":[29],"of":[30,70,83,103,177],"host":[31],"immune":[32],"status":[33],"and":[34,44,56,105,112,143,182,206,213],"metabolism.":[35],"As":[36],"reported":[37],"recently,":[38],"PM2.5":[39,51,71,129,152,181,192,201],"exposure":[40,72],"causes":[41],"microbiota":[42,54,82,118,204],"dysbiosis":[43],"thus":[45],"promoting":[46],"disease":[47],"progression.":[48],"However,":[49],"whether":[50],"alters":[52,202],"pulmonary":[53],"distribution":[55],"aggravates":[57],"bacteria-induced":[58],"pathogenesis":[59],"remains":[60],"unknown.":[61],"In":[62],"this":[63],"study,":[64],"we":[65],"used":[66],"mouse":[67],"experimental":[68],"models":[69],"combined":[73,153],"Streptococcus":[75],"pneumonia":[76],"infection.":[77],"We":[78],"characterized":[79],"the":[80,95,124,135,203],"airway":[81],"bronchoalveolar":[84],"lavage":[85],"fluid":[86],"(BALF)":[87],"by":[88,100],"sequencing":[89],"16S":[90],"rRNA":[91],"V3\u2013V4":[92],"amplicon":[93],"on":[94],"Illumina":[96],"MiSeq":[97],"platform,":[98],"followed":[99],"combination":[102],"bioinformatics":[104],"statistical":[106],"analyses.":[107],"Shannon-diversity":[108],"index,":[109],"observed":[110],"ASVs,":[111],"Fisher\u2019s":[113],"diversity":[114],"index":[115],"indicated":[116],"that":[117,168,185,200],"richness":[119],"was":[120,173],"significantly":[121],"decreased":[122],"mice":[125,149,160,178,187],"treated":[126,179],"either":[128,191],"or":[130,193],"pneumococcus":[131,183],"when":[132],"compared":[133,158],"control":[136],"group.":[137],"The":[138],"genera":[139],"Streptococcus,":[140],"Prevotella,":[141],"Leptotrichia,":[142],"Granulicatella":[144],"were":[145],"remarkably":[146],"increased":[147],"exposed":[150,189],"pneumococcal":[155,162,194,211],"infection":[156,163,195,212],"as":[157],"alone.":[164,196],"Histopathological":[165],"examination":[166],"exhibited":[167],"more":[170],"pronounced":[171],"inflammation":[172],"present":[174],"lungs":[176],"than":[184],"groups":[188],"Our":[197],"results":[198],"demonstrate":[199],"composition,":[205],"thereby":[207],"enhancing":[208],"susceptibility":[209],"exacerbating":[214],"lung":[215],"pathogenesis.":[216]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-11-09T00:00:00"}
