{"id":"https://openalex.org/W3096924331","doi":"https://doi.org/10.1371/journal.pone.0240885","title":"Whole egg consumption increases gene expression within the glutathione pathway in the liver of Zucker Diabetic Fatty rats","display_name":"Whole egg consumption increases gene expression within the glutathione pathway in the liver of Zucker Diabetic Fatty rats","publication_year":2020,"publication_date":"2020-11-03","ids":{"openalex":"https://openalex.org/W3096924331","doi":"https://doi.org/10.1371/journal.pone.0240885","mag":"3096924331","pmid":"https://pubmed.ncbi.nlm.nih.gov/33141822","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7608885"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0240885","doi":"https://doi.org/10.1371/journal.pone.0240885","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0240885","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0240885&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0240885&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110792775","display_name":"Joe L. Webb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joe L. Webb","raw_affiliation_strings":["Department of Food Science and Human Nutrition, Iowa State University, Ames, IA, United States of America","Interdepartmental Graduate Program in Nutritional Sciences, Iowa State University, Ames, IA, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Human Nutrition, Iowa State University, Ames, IA, United States of America","institution_ids":["https://openalex.org/I173911158"]},{"raw_affiliation_string":"Interdepartmental Graduate Program in Nutritional Sciences, Iowa State University, Ames, IA, United States of America","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026471497","display_name":"Amanda E. Bries","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda E. Bries","raw_affiliation_strings":["Department of Food Science and Human Nutrition, Iowa State University, Ames, IA, United States of America","Interdepartmental Graduate Program in Nutritional Sciences, Iowa State University, Ames, IA, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Human Nutrition, Iowa State University, Ames, IA, United States of America","institution_ids":["https://openalex.org/I173911158"]},{"raw_affiliation_string":"Interdepartmental Graduate Program in Nutritional Sciences, Iowa State University, Ames, IA, United States of America","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062226711","display_name":"Brooke Vogel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brooke Vogel","raw_affiliation_strings":["Department of Food Science and Human Nutrition, Iowa State University, Ames, IA, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Human Nutrition, Iowa State University, Ames, IA, United States of America","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113770146","display_name":"Claudia A Carrillo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claudia Carrillo","raw_affiliation_strings":["Department of Food Science and Human Nutrition, Iowa State University, Ames, IA, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Human Nutrition, Iowa State University, Ames, IA, United States of America","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046737758","display_name":"Lily Harvison","orcid":"https://orcid.org/0000-0003-1926-8640","observed_orcids":["https://orcid.org/0000-0003-1926-8640"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lily Harvison","raw_affiliation_strings":["Department of Food Science and Human Nutrition, Iowa State University, Ames, IA, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-1926-8640","affiliations":[{"raw_affiliation_string":"Department of Food Science and Human Nutrition, Iowa State University, Ames, IA, United States of America","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048814005","display_name":"Tim A. Day","orcid":"https://orcid.org/0000-0002-9037-6540","observed_orcids":["https://orcid.org/0000-0002-9037-6540"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy A. Day","raw_affiliation_strings":["Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA, United States of America","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011820270","display_name":"Michael J. Kimber","orcid":"https://orcid.org/0000-0002-4715-9313","observed_orcids":["https://orcid.org/0000-0002-4715-9313"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Kimber","raw_affiliation_strings":["Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-4715-9313","affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA, United States of America","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073855968","display_name":"Rudy J. Valentine","orcid":"https://orcid.org/0000-0003-4915-6615","observed_orcids":["https://orcid.org/0000-0003-4915-6615"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rudy J. Valentine","raw_affiliation_strings":["Department of Kinesiology, Iowa State University, Ames, IA, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Kinesiology, Iowa State University, Ames, IA, United States of America","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071653094","display_name":"Matthew James Rowling","orcid":"https://orcid.org/0000-0003-0457-9876","observed_orcids":["https://orcid.org/0000-0003-0457-9876"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew J. Rowling","raw_affiliation_strings":["Department of Food Science and Human Nutrition, Iowa State University, Ames, IA, United States of America","Interdepartmental Graduate Program in Nutritional Sciences, Iowa State University, Ames, IA, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Human Nutrition, Iowa State University, Ames, IA, United States of America","institution_ids":["https://openalex.org/I173911158"]},{"raw_affiliation_string":"Interdepartmental Graduate Program in Nutritional Sciences, Iowa State University, Ames, IA, United States of America","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075114223","display_name":"Stephanie Clark","orcid":"https://orcid.org/0000-0002-3253-3042","observed_orcids":["https://orcid.org/0000-0002-3253-3042"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Clark","raw_affiliation_strings":["Department of Food Science and Human Nutrition, Iowa State University, Ames, IA, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Human Nutrition, Iowa State University, Ames, IA, United States of America","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037306424","display_name":"Elizabeth M. McNeill","orcid":"https://orcid.org/0000-0001-6590-1545","observed_orcids":["https://orcid.org/0000-0001-6590-1545"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth M. McNeill","raw_affiliation_strings":["Department of Food Science and Human Nutrition, Iowa State University, Ames, IA, United States of America","Genetics and Genomics Graduate Program, Iowa State University, Ames, IA, United States of America","Interdepartmental Graduate Program in Nutritional Sciences, Iowa State University, Ames, IA, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Human Nutrition, Iowa State University, Ames, IA, United States of America","institution_ids":["https://openalex.org/I173911158"]},{"raw_affiliation_string":"Genetics and Genomics Graduate Program, Iowa State University, Ames, IA, United States of America","institution_ids":["https://openalex.org/I173911158"]},{"raw_affiliation_string":"Interdepartmental Graduate Program in Nutritional Sciences, Iowa State University, Ames, IA, United States of America","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080476506","display_name":"Kevin Lee Schalinske","orcid":"https://orcid.org/0000-0001-5910-8719","observed_orcids":["https://orcid.org/0000-0001-5910-8719"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kevin L. Schalinske","raw_affiliation_strings":["Department of Food Science and Human Nutrition, Iowa State University, Ames, IA, United States of America","Interdepartmental Graduate Program in Nutritional Sciences, Iowa State University, Ames, IA, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-5910-8719","affiliations":[{"raw_affiliation_string":"Department of Food Science and Human Nutrition, Iowa State University, Ames, IA, United States of America","institution_ids":["https://openalex.org/I173911158"]},{"raw_affiliation_string":"Interdepartmental Graduate Program in Nutritional Sciences, Iowa State University, Ames, IA, United States of America","institution_ids":["https://openalex.org/I173911158"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5080476506"],"corresponding_institution_ids":["https://openalex.org/I173911158"],"apc_list":{"value":1695,"currency":"USD","value_usd":1695},"apc_paid":{"value":1695,"currency":"USD","value_usd":1695},"fwci":0.2932,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.55578457,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"15","issue":"11","first_page":"e0240885","last_page":"e0240885"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10866","display_name":"Nutritional Studies and Diet","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9769999980926514},{"id":"https://openalex.org/keywords/zucker-diabetic-fatty-rats","display_name":"Zucker diabetic fatty rats","score":0.7990000247955322},{"id":"https://openalex.org/keywords/glutathione-metabolism","display_name":"glutathione metabolism","score":0.8399999737739563},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.7139999866485596},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.671999990940094},{"id":"https://openalex.org/keywords/nutrigenomics","display_name":"nutrigenomics","score":0.9620000123977661},{"id":"https://openalex.org/keywords/dietary-protein","display_name":"dietary protein","score":0.5350000262260437},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.5490000247955322},{"id":"https://openalex.org/keywords/kidney","display_name":"kidney","score":0.9700000286102295},{"id":"https://openalex.org/keywords/ros-scavenging","display_name":"reactive oxygen species scavenging","score":0.7649999856948853},{"id":"https://openalex.org/keywords/glucuronidation","display_name":"glucuronidation","score":0.6520000100135803},{"id":"https://openalex.org/keywords/methylation","display_name":"methylation","score":0.7120000123977661},{"id":"https://openalex.org/keywords/conjugation","display_name":"conjugation","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7417300939559937},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6888383030891418},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.6409934163093567},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5701999664306641},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4665655195713043},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.456114262342453},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.44432199001312256},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.42085641622543335},{"id":"https://openalex.org/C97633540","wikidata":"https://www.wikidata.org/wiki/Q4328195","display_name":"Nutrigenomics","level":3,"score":0.41353198885917664},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3934938311576843},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.349420428276062},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2545793652534485},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09916016459465027}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004531","descriptor_name":"Eggs","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004531","descriptor_name":"Eggs","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004531","descriptor_name":"Eggs","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004531","descriptor_name":"Eggs","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011924","descriptor_name":"Rats, Zucker","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011924","descriptor_name":"Rats, Zucker","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011924","descriptor_name":"Rats, Zucker","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011924","descriptor_name":"Rats, Zucker","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054647","descriptor_name":"Nutrigenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054647","descriptor_name":"Nutrigenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054647","descriptor_name":"Nutrigenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054647","descriptor_name":"Nutrigenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0240885","doi":"https://doi.org/10.1371/journal.pone.0240885","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0240885","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0240885&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7608885","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7608885","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:33141822","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33141822","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:dr.lib.iastate.edu:20.500.12876/96304","doi":null,"is_oa":false,"landing_page_url":"https://dr.lib.iastate.edu/handle/20.500.12876/96304","pdf_url":null,"source":{"id":"https://openalex.org/S4377196104","display_name":"Iowa State University Digital Repository (Iowa State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173911158","host_organization_name":"Iowa State University","host_organization_lineage":["https://openalex.org/I173911158"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"archive/lib.dr.iastate.edu/fshn_hs_pubs/38/2020_GS_Alert_Pub_ClarkS_Whole_egg_consumption.pdf|||Fri Jan 14 23:52:47 UTC 2022","raw_type":"article"},{"id":"pmh:oai:lib.dr.iastate.edu:fshn_hs_pubs-1038","doi":null,"is_oa":true,"landing_page_url":"https://lib.dr.iastate.edu/cgi/viewcontent.cgi?article=1038&context=fshn_hs_pubs","pdf_url":null,"source":{"id":"https://openalex.org/S4377196104","display_name":"Iowa State University Digital Repository (Iowa State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173911158","host_organization_name":"Iowa State University","host_organization_lineage":["https://openalex.org/I173911158"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Food Science and Human Nutrition Publications","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:6afb54eea5b74f8d8ee5202d2c782d41","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6afb54eea5b74f8d8ee5202d2c782d41","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 15, Iss 11, p e0240885 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0240885","doi":"https://doi.org/10.1371/journal.pone.0240885","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0240885","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0240885&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482},{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.6735000014305115}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311090","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3096924331.pdf","grobid_xml":"https://content.openalex.org/works/W3096924331.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1822273632","https://openalex.org/W1964184380","https://openalex.org/W1968273304","https://openalex.org/W1976813240","https://openalex.org/W1978046301","https://openalex.org/W1989277387","https://openalex.org/W1990253204","https://openalex.org/W2008912763","https://openalex.org/W2018289835","https://openalex.org/W2020541351","https://openalex.org/W2030272109","https://openalex.org/W2030868499","https://openalex.org/W2032643735","https://openalex.org/W2034674017","https://openalex.org/W2041198714","https://openalex.org/W2059467226","https://openalex.org/W2060870711","https://openalex.org/W2061963900","https://openalex.org/W2067031563","https://openalex.org/W2093957010","https://openalex.org/W2107018762","https://openalex.org/W2107277218","https://openalex.org/W2110065044","https://openalex.org/W2129064235","https://openalex.org/W2133930860","https://openalex.org/W2137616809","https://openalex.org/W2152387070","https://openalex.org/W2156981113","https://openalex.org/W2164665661","https://openalex.org/W2165912352","https://openalex.org/W2170551349","https://openalex.org/W2189374332","https://openalex.org/W2226653601","https://openalex.org/W2236591107","https://openalex.org/W2249970729","https://openalex.org/W2289140356","https://openalex.org/W2301348447","https://openalex.org/W2389750676","https://openalex.org/W2612843518","https://openalex.org/W2759604000","https://openalex.org/W2765281411","https://openalex.org/W2774743973","https://openalex.org/W2782327081","https://openalex.org/W2783866598","https://openalex.org/W2885949601","https://openalex.org/W2899168038","https://openalex.org/W2913242032","https://openalex.org/W2921233346","https://openalex.org/W2953799040","https://openalex.org/W2961380655","https://openalex.org/W2963857299","https://openalex.org/W2978684981","https://openalex.org/W2995329001","https://openalex.org/W3001214052","https://openalex.org/W3010628370","https://openalex.org/W3017860351","https://openalex.org/W4231254854","https://openalex.org/W4237335579","https://openalex.org/W6813094581"],"related_works":["https://openalex.org/W7135280565","https://openalex.org/W3160879594","https://openalex.org/W3108322894","https://openalex.org/W2953122349","https://openalex.org/W3194027221","https://openalex.org/W2975999861","https://openalex.org/W2766606962","https://openalex.org/W2794409143","https://openalex.org/W2621405237","https://openalex.org/W4399462455"],"abstract_inverted_index":{"Nutrigenomic":[0],"evidence":[1],"supports":[2],"the":[3,14,17,44,51,73,208,215,258,267],"idea":[4],"that":[5,35,180,204],"Type":[6],"2":[7],"Diabetes":[8],"Mellitus":[9],"(T2DM)":[10],"arises":[11],"due":[12],"to":[13,42,108,114,186],"interactions":[15],"between":[16],"transcriptome,":[18],"individual":[19],"genetic":[20],"profiles,":[21],"lifestyle,":[22],"and":[23,69,77,88,110,139,145,162,177,198,217,237],"diet.":[24],"Since":[25],"eggs":[26],"are":[27,245],"a":[28,115,122],"nutrient":[29],"dense":[30],"food":[31],"containing":[32],"bioactive":[33],"ingredients":[34],"modify":[36],"gene":[37,154],"expression,":[38],"our":[39],"goal":[40],"was":[41,156],"examine":[43],"role":[45],"of":[46,101,189,196,219,239,261,269],"whole":[47,58,123,191,223,263],"egg":[48,59,226,264],"consumption":[49,60,227,265],"on":[50,149],"transcriptome":[52],"during":[53,249,266],"T2DM.":[54,270],"We":[55,173],"analyzed":[56],"whether":[57],"in":[61,160,184,207,214],"Zucker":[62],"Diabetic":[63],"Fatty":[64],"(ZDF)":[65],"rats":[66,84,221],"alters":[67],"microRNA":[68],"mRNA":[70],"expression":[71,155],"across":[72],"adipose,":[74],"liver,":[75],"kidney,":[76],"prefrontal":[78],"cortex":[79],"tissue.":[80],"Male":[81],"ZDF":[82,220],"(fa/fa)":[83],"(n":[85,93],"=":[86,94],"12)":[87,95],"their":[89],"lean":[90],"controls":[91],"(fa/+)":[92],"were":[96,111,133,146,181,212],"obtained":[97],"at":[98,171],"6":[99],"wk":[100,188],"age.":[102],"Rats":[103],"had":[104],"ad":[105],"libitum":[106],"access":[107],"water":[109],"randomly":[112],"assigned":[113],"modified":[116],"semi-purified":[117],"AIN93G":[118],"casein-based":[119],"diet":[120],"or":[121],"egg-based":[124,192],"diet,":[125],"both":[126],"providing":[127],"20%":[128],"protein":[129],"(w/w).":[130],"TotalRNA":[131],"libraries":[132],"prepared":[134],"using":[135,158],"QuantSeq":[136],"3'":[137],"mRNA-Seq":[138],"Lexogen":[140],"smallRNA":[141],"library":[142],"prep":[143],"kits":[144],"further":[147],"sequenced":[148],"an":[150],"Illumina":[151],"HighSeq3000.":[152],"Differential":[153],"conducted":[157],"DESeq2":[159],"R":[161],"Benjamini-Hochberg":[163],"adjusted":[164],"P-values":[165],"controlling":[166],"for":[167],"false":[168],"discovery":[169],"rate":[170],"5%.":[172],"identified":[174],"9":[175],"microRNAs":[176],"583":[178],"genes":[179,206],"differentially":[182],"expressed":[183],"response":[185,260],"8":[187],"consuming":[190],"diets.":[193],"Kyto":[194],"Encyclopedia":[195],"Genes":[197],"Genomes/Gene":[199],"ontology":[200],"pathway":[201,211],"analyses":[202],"demonstrated":[203],"12":[205],"glutathione":[209,230],"metabolism":[210],"upregulated":[213],"liver":[216],"kidney":[218],"fed":[222],"egg.":[224],"Whole":[225],"primarily":[228],"altered":[229],"pathways":[231,244],"such":[232],"as":[233],"conjugation,":[234],"methylation,":[235],"glucuronidation,":[236],"detoxification":[238],"reactive":[240],"oxygen":[241],"species.":[242],"These":[243],"often":[246],"negatively":[247],"affected":[248],"T2DM,":[250],"therefore":[251],"this":[252],"data":[253],"provides":[254],"unique":[255],"insight":[256],"into":[257],"nutrigenomic":[259],"dietary":[262],"progression":[268]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2020-11-09T00:00:00"}