{"id":"https://openalex.org/W3096860088","doi":"https://doi.org/10.1016/j.cgh.2020.10.051","title":"A Phase 2 Double Blinded, Randomized Controlled Trial of Saroglitazar in Patients With Nonalcoholic Steatohepatitis","display_name":"A Phase 2 Double Blinded, Randomized Controlled Trial of Saroglitazar in Patients With Nonalcoholic Steatohepatitis","publication_year":2020,"publication_date":"2020-11-02","ids":{"openalex":"https://openalex.org/W3096860088","doi":"https://doi.org/10.1016/j.cgh.2020.10.051","mag":"3096860088","pmid":"https://pubmed.ncbi.nlm.nih.gov/33152542"},"language":"en","primary_location":{"id":"doi:10.1016/j.cgh.2020.10.051","doi":"https://doi.org/10.1016/j.cgh.2020.10.051","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cgh.2020.10.051","pdf_url":null,"source":{"id":"https://openalex.org/S6642600","display_name":"Clinical Gastroenterology and Hepatology","issn_l":"1542-3565","issn":["1542-3565","1542-7714"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Gastroenterology and Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004639766","display_name":"Mohammad Shadab Siddiqui","orcid":"https://orcid.org/0000-0001-7392-7489","observed_orcids":["https://orcid.org/0000-0001-7392-7489"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mohammad Shadab Siddiqui","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Virginia Commonwealth University, Richmond, Virginia. Electronic address: Mohammad.siddiqui@vcuhealth.org","Division of Gastroenterology and Hepatology, Virginia Commonwealth University, Richmond, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Virginia Commonwealth University, Richmond, Virginia. Electronic address: Mohammad.siddiqui@vcuhealth.org","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Virginia Commonwealth University, Richmond, Virginia","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I72019824"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020110586","display_name":"Michael O. Idowu","orcid":"https://orcid.org/0000-0002-7416-5444","observed_orcids":["https://orcid.org/0000-0002-7416-5444"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael O. Idowu","raw_affiliation_strings":["Department of Pathology, Virginia Commonwealth University, Richmond, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Virginia Commonwealth University, Richmond, Virginia","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Deven Parmar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Deven Parmar","raw_affiliation_strings":["Zydus Discovery DMCC, Dubai, United Arab Emirates"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zydus Discovery DMCC, Dubai, United Arab Emirates","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102923291","display_name":"Brian B. Borg","orcid":"https://orcid.org/0000-0002-1028-3089","observed_orcids":["https://orcid.org/0000-0002-1028-3089"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian B. Borg","raw_affiliation_strings":["Southern Therapy and Advanced Research LLC, Jackson, Mississippi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Therapy and Advanced Research LLC, Jackson, Mississippi","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024000693","display_name":"Douglas Scott Denham","orcid":"https://orcid.org/0000-0002-3466-1208","observed_orcids":["https://orcid.org/0000-0002-3466-1208"]},"institutions":[{"id":"https://openalex.org/I4210100270","display_name":"Clinical Trials of Texas","ror":"https://ror.org/017vjfp21","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210100270"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas Denham","raw_affiliation_strings":["Clinical Trials of Texas, Inc, San Antonio, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trials of Texas, Inc, San Antonio, Texas","institution_ids":["https://openalex.org/I4210100270"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045664376","display_name":"Nicole Loo","orcid":"https://orcid.org/0000-0001-6360-0909","observed_orcids":["https://orcid.org/0000-0001-6360-0909"]},"institutions":[{"id":"https://openalex.org/I4210138836","display_name":"Texas Liver Institute","ror":"https://ror.org/03yk6x532","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210138836"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole M. Loo","raw_affiliation_strings":["American Research Corporation, The Texas Liver Institute, San Antonio, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"American Research Corporation, The Texas Liver Institute, San Antonio, Texas","institution_ids":["https://openalex.org/I4210138836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040631294","display_name":"Donald J. Lazas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Donald Lazas","raw_affiliation_strings":["Digestive Health Research/Objective GI, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Digestive Health Research/Objective GI, Nashville, Tennessee","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019006253","display_name":"Ziad H Younes","orcid":"https://orcid.org/0000-0001-7382-3698","observed_orcids":["https://orcid.org/0000-0001-7382-3698"]},"institutions":[{"id":"https://openalex.org/I4210127962","display_name":"Gastro One (United States)","ror":"https://ror.org/02d32n026","country_code":"US","type":"company","lineage":["https://openalex.org/I4210127962"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ziad Younes","raw_affiliation_strings":["Gastro One, Clinical Research Department, Germantown, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastro One, Clinical Research Department, Germantown, Tennessee","institution_ids":["https://openalex.org/I4210127962"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070639714","display_name":"Arun Jayant Sanyal","orcid":"https://orcid.org/0000-0001-8682-5748","observed_orcids":["https://orcid.org/0000-0001-8682-5748"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arun J. Sanyal","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Virginia Commonwealth University, Richmond, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Virginia Commonwealth University, Richmond, Virginia","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I72019824"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5004639766"],"corresponding_institution_ids":["https://openalex.org/I184840846","https://openalex.org/I72019824"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":7.7041,"has_fulltext":false,"cited_by_count":93,"citation_normalized_percentile":{"value":0.98344589,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"19","issue":"12","first_page":"2670","last_page":"2672"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/saroglitazar","display_name":"saroglitazar","score":0.9990000128746033},{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":1.0},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9549999833106995},{"id":"https://openalex.org/keywords/ppar-alpha-gamma-agonist","display_name":"PPAR alpha/gamma agonist","score":0.7839999794960022},{"id":"https://openalex.org/keywords/histologic-improvement","display_name":"histologic improvement","score":0.8920000195503235},{"id":"https://openalex.org/keywords/liver-histopathology","display_name":"liver histopathology","score":0.5989999771118164},{"id":"https://openalex.org/keywords/western-populations","display_name":"Western populations","score":0.4970000088214874}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8586045503616333},{"id":"https://openalex.org/C2776954865","wikidata":"https://www.wikidata.org/wiki/Q1546498","display_name":"Nonalcoholic fatty liver disease","level":4,"score":0.689328670501709},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.6560748815536499},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5285821557044983},{"id":"https://openalex.org/C3018708256","wikidata":"https://www.wikidata.org/wiki/Q1546498","display_name":"Nonalcoholic steatohepatitis","level":5,"score":0.509182870388031},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.47402387857437134},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4185486137866974},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.38706591725349426},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.32840681076049805},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.15388450026512146},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010666","descriptor_name":"Phenylpropionates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047493","descriptor_name":"PPAR alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cgh.2020.10.051","doi":"https://doi.org/10.1016/j.cgh.2020.10.051","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cgh.2020.10.051","pdf_url":null,"source":{"id":"https://openalex.org/S6642600","display_name":"Clinical Gastroenterology and Hepatology","issn_l":"1542-3565","issn":["1542-3565","1542-7714"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Gastroenterology and Hepatology","raw_type":"journal-article"},{"id":"pmid:33152542","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33152542","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association","raw_type":"Clinical Trial, Phase II"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320307776","display_name":"Merck","ror":"https://ror.org/02891sr49"},{"id":"https://openalex.org/F4320307778","display_name":"Novartis","ror":"https://ror.org/02f9zrr09"},{"id":"https://openalex.org/F4320308573","display_name":"Gilead Sciences","ror":"https://ror.org/056546b03"},{"id":"https://openalex.org/F4320309117","display_name":"AbbVie","ror":"https://ror.org/02g5p4n58"},{"id":"https://openalex.org/F4320310388","display_name":"Novartis Pharmaceuticals Corporation","ror":"https://ror.org/028fhxy95"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320322546","display_name":"Shire","ror":"https://ror.org/02hb3t423"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W2067740038","https://openalex.org/W2082761367","https://openalex.org/W2136305760","https://openalex.org/W2794639926","https://openalex.org/W2950722971"],"related_works":["https://openalex.org/W3214437148","https://openalex.org/W2883008246","https://openalex.org/W7216104251","https://openalex.org/W4403332333","https://openalex.org/W4226126575","https://openalex.org/W3112075036","https://openalex.org/W4387734719","https://openalex.org/W3033969740","https://openalex.org/W3176795422","https://openalex.org/W2768977224"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":20},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":21},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-11-09T00:00:00"}
