{"id":"https://openalex.org/W3096601482","doi":null,"title":"Papel dos inflamassomas no controle da infec\u00e7\u00e3o por Trypanosoma cruzi","display_name":"Papel dos inflamassomas no controle da infec\u00e7\u00e3o por Trypanosoma cruzi","publication_year":2013,"publication_date":"2013-07-30","ids":{"openalex":"https://openalex.org/W3096601482","mag":"3096601482"},"language":"pt","primary_location":{"id":"pmh:oai:repositorio.unifesp.br:11600/47908","doi":null,"is_oa":true,"landing_page_url":"https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=151546","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UNIFESP","raw_type":"info:eu-repo/semantics/masterThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=151546","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076861459","display_name":"Virginia Mendes Gon\u00e7alves","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Virginia Mendes Gon\u00e7alves","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5076861459"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9063000082969666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9063000082969666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.07460000365972519,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trypanosoma-cruzi","display_name":"Trypanosoma cruzi","score":0.9610000252723694},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.9259999990463257},{"id":"https://openalex.org/keywords/caspase-1","display_name":"caspase-1","score":0.996999979019165},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.972000002861023},{"id":"https://openalex.org/keywords/chagas-disease","display_name":"Chagas disease","score":0.8379999995231628},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8220000267028809},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8889999985694885},{"id":"https://openalex.org/keywords/myd88","display_name":"MyD88","score":0.7710000276565552},{"id":"https://openalex.org/keywords/splenocytes","display_name":"splenocytes","score":0.7770000100135803},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.640999972820282},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9679999947547913}],"concepts":[{"id":"https://openalex.org/C2777625466","wikidata":"https://www.wikidata.org/wiki/Q150162","display_name":"Trypanosoma cruzi","level":3,"score":0.5812749862670898},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5281434059143066},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.13123440742492676},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.07680559158325195},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repositorio.unifesp.br:11600/47908","doi":null,"is_oa":true,"landing_page_url":"https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=151546","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UNIFESP","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"mag:3096601482","doi":null,"is_oa":false,"landing_page_url":"https://repositorio.unifesp.br/handle/11600/47908","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:repositorio.unifesp.br:11600/47908","doi":null,"is_oa":true,"landing_page_url":"https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=151546","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UNIFESP","raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2140577495","https://openalex.org/W1994070088","https://openalex.org/W3123873987","https://openalex.org/W1622459581","https://openalex.org/W7120747473","https://openalex.org/W1895137784","https://openalex.org/W7096383341","https://openalex.org/W2800398697","https://openalex.org/W1511295326","https://openalex.org/W4389393003"],"abstract_inverted_index":{"Demonstramos":[0],"pela":[1],"primeira":[2],"vez":[3,159],"que":[4,38,89,160,192],"a":[5,11,102,109,117,142,149,161,166,205],"infec\u00e7\u00e3o":[6,53,187],"pelo":[7,54,188],"T.":[8,55,75,99,156,189],"cruzi":[9],"induz":[10,204],"produ\u00e7\u00e3o":[12,84,118,206],"de":[13,15,29,33,67,69,85,93,113,119,151,168,198,202,207],"IL-1\u03b2":[14,169],"uma":[16,81,158,195],"forma":[17],"dependente":[18,197],"NLRP3":[19,46,152,183],"e":[20,24,61,71,124,127,138,170,200],"caspase-1.":[21],"Camundongos":[22],"NLRP3-/-":[23,70],"caspase1-/-apresentaram":[25],"um":[26,210],"elevado":[27],"n\u00famero":[28],"parasitas,":[30],"apresentando":[31],"picos":[32],"parasitemia":[34],"mais":[35,130],"altos":[36],"do":[37,44,98,111,135,181],"animais":[39],"MyD88-/-,":[40],"indicando":[41],"o":[42,179],"envolvimento":[43],"inflamassoma":[45,182],"no":[47,184],"controle":[48,185],"da":[49,52,104,186],"fase":[50],"aguda":[51],"cruzi.":[56,76,100],"As":[57],"citocinas":[58],"inflamat\u00f3rias":[59],"IL-6":[60],"IFN-\u03b3":[62],"foram":[63],"encontradas":[64],"nas":[65],"culturas":[66],"esplen\u00f3citos":[68],"caspase1-/-":[72],"infectados":[73],"com":[74],"Por\u00e9m":[77],"essas":[78],"c\u00e9lulas":[79,134],"apresentaram":[80],"defici\u00eancia":[82],"na":[83,91],"\u00f3xido":[86],"n\u00edtrico":[87],"(NO),":[88],"reflete":[90],"permissividade":[92],"seus":[94],"macr\u00f3fagos":[95,122],"\u00e0":[96],"replica\u00e7\u00e3o":[97],"Curiosamente,":[101],"inibi\u00e7\u00e3o":[103,163],"caspase-1,":[105],"z-YVAD-fmk,":[106],"mas":[107],"n\u00e3o":[108],"presen\u00e7a":[110],"antagonista":[112],"IL-1R":[114],"(IL-1Ra)":[115],"aboliram":[116],"NO":[120],"em":[121,153,173],"WT":[123],"MyD88-/":[125],"-":[126,137],"os":[128,175],"tornaram":[129],"suscept\u00edveis":[131],"como":[132],"as":[133],"NLRP3-/":[136],"caspase-1-/-.":[139],"Al\u00e9m":[140],"disso,":[141],"catepsina":[143],"B":[144],"parece":[145],"ser":[146],"necess\u00e1ria":[147],"para":[148,214],"ativa\u00e7\u00e3o":[150],"resposta":[154],"ao":[155],"cruzi,":[157,190],"sua":[162],"farmacol\u00f3gica":[164],"aboliu":[165],"secre\u00e7\u00e3o":[167],"NO.":[171],"Tomados":[172],"conjunto":[174],"nossos":[176],"resultados":[177],"demonstram":[178],"papel":[180],"demonstrando":[191],"NLRP3,":[193],"por":[194],"via":[196],"caspase-1":[199],"independente":[201],"IL-1R,":[203],"NO,":[208],"atribuindo":[209],"novo":[211],"mecanismo":[212],"efetor":[213],"estes":[215],"receptores.":[216]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2020-11-09T00:00:00"}
