{"id":"https://openalex.org/W3096591052","doi":"https://doi.org/10.1182/blood-2020-141074","title":"Acalabrutinib Plus RICE Followed By Autologous Hematopoietic Cell Transplantation and/or Acalabrutinib Maintenance Therapy for Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma","display_name":"Acalabrutinib Plus RICE Followed By Autologous Hematopoietic Cell Transplantation and/or Acalabrutinib Maintenance Therapy for Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma","publication_year":2020,"publication_date":"2020-11-05","ids":{"openalex":"https://openalex.org/W3096591052","doi":"https://doi.org/10.1182/blood-2020-141074","mag":"3096591052"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2020-141074","doi":"https://doi.org/10.1182/blood-2020-141074","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2020-141074","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003482749","display_name":"Neil A. Bailey","orcid":"https://orcid.org/0000-0002-3809-3236","observed_orcids":["https://orcid.org/0000-0002-3809-3236"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neil Bailey","raw_affiliation_strings":["Center for Blood Disorders and Stem Cell Transplantation, Swedish Cancer Institute, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Blood Disorders and Stem Cell Transplantation, Swedish Cancer Institute, Seattle, WA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074340745","display_name":"Tenzin Tsomo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tenzin Tsomo","raw_affiliation_strings":["Center for Blood Disorders and Stem Cell Transplantation, Swedish Cancer Institute, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Blood Disorders and Stem Cell Transplantation, Swedish Cancer Institute, Seattle, WA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019922443","display_name":"Jennie Szeto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennie Szeto","raw_affiliation_strings":["Center for Blood Disorders and Stem Cell Transplantation, Swedish Cancer Institute, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Blood Disorders and Stem Cell Transplantation, Swedish Cancer Institute, Seattle, WA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113514827","display_name":"William Bensinger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William I Bensinger","raw_affiliation_strings":["Center for Blood Disorders and Stem Cell Transplantation, Swedish Cancer Institute, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Blood Disorders and Stem Cell Transplantation, Swedish Cancer Institute, Seattle, WA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033698142","display_name":"Daniel N. Egan","orcid":"https://orcid.org/0000-0002-0523-1188","observed_orcids":["https://orcid.org/0000-0002-0523-1188","https://orcid.org/0000-0002-0173-5194"]},"institutions":[{"id":"https://openalex.org/I4210093417","display_name":"Swedish Medical Center","ror":"https://ror.org/004jktf35","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210093417","https://openalex.org/I94396219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Egan","raw_affiliation_strings":["Swedish Medical Center, seattle,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Swedish Medical Center, seattle,","institution_ids":["https://openalex.org/I4210093417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010999911","display_name":"Livia T. Hegerova","orcid":"https://orcid.org/0000-0003-4100-8351","observed_orcids":["https://orcid.org/0000-0003-4100-8351"]},"institutions":[{"id":"https://openalex.org/I4210093417","display_name":"Swedish Medical Center","ror":"https://ror.org/004jktf35","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210093417","https://openalex.org/I94396219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Livia Hegerova","raw_affiliation_strings":["Swedish Medical Center, seattle,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Swedish Medical Center, seattle,","institution_ids":["https://openalex.org/I4210093417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090982367","display_name":"Raya Mawad","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raya Mawad","raw_affiliation_strings":["Swedish Cancer Institute, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Swedish Cancer Institute, Seattle, WA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016464302","display_name":"Ami Batchelder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093417","display_name":"Swedish Medical Center","ror":"https://ror.org/004jktf35","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210093417","https://openalex.org/I94396219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ami Batchelder","raw_affiliation_strings":["Swedish Medical Center, seattle,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Swedish Medical Center, seattle,","institution_ids":["https://openalex.org/I4210093417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061825589","display_name":"Joanna Fesler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joanna Fesler","raw_affiliation_strings":["Center for Blood Disorders and Stem Cell Transplantation, Swedish Cancer Institute, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Blood Disorders and Stem Cell Transplantation, Swedish Cancer Institute, Seattle, WA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005527100","display_name":"Heather Holdread","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093417","display_name":"Swedish Medical Center","ror":"https://ror.org/004jktf35","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210093417","https://openalex.org/I94396219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather Holdread","raw_affiliation_strings":["Swedish Medical Center, seattle,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Swedish Medical Center, seattle,","institution_ids":["https://openalex.org/I4210093417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007556940","display_name":"Sonia Glennie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sonia Glennie","raw_affiliation_strings":["Center for Blood Disorders and Stem Cell Transplantation, Swedish Cancer Institute, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Blood Disorders and Stem Cell Transplantation, Swedish Cancer Institute, Seattle, WA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004927489","display_name":"Judson Hall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093417","display_name":"Swedish Medical Center","ror":"https://ror.org/004jktf35","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210093417","https://openalex.org/I94396219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judson Hall","raw_affiliation_strings":["Swedish Medical Center, seattle,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Swedish Medical Center, seattle,","institution_ids":["https://openalex.org/I4210093417"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Joey Ferry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093417","display_name":"Swedish Medical Center","ror":"https://ror.org/004jktf35","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210093417","https://openalex.org/I94396219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joey Ferry","raw_affiliation_strings":["Swedish Medical Center, seattle,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Swedish Medical Center, seattle,","institution_ids":["https://openalex.org/I4210093417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074253669","display_name":"Megumi Bailey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093417","display_name":"Swedish Medical Center","ror":"https://ror.org/004jktf35","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210093417","https://openalex.org/I94396219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megumi Bailey","raw_affiliation_strings":["Swedish Medical Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Swedish Medical Center, Seattle, WA","institution_ids":["https://openalex.org/I4210093417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013504867","display_name":"David Kane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093417","display_name":"Swedish Medical Center","ror":"https://ror.org/004jktf35","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210093417","https://openalex.org/I94396219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Kane","raw_affiliation_strings":["Swedish Medical Center, seattle,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Swedish Medical Center, seattle,","institution_ids":["https://openalex.org/I4210093417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040412322","display_name":"John M. Pagel","orcid":"https://orcid.org/0000-0001-5745-8125","observed_orcids":["https://orcid.org/0000-0001-5745-8125","https://orcid.org/0000-0003-2875-4878"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John M. Pagel","raw_affiliation_strings":["Center for Blood Disorders and Stem Cell Transplantation, Swedish Cancer Institute, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Blood Disorders and Stem Cell Transplantation, Swedish Cancer Institute, Seattle, WA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036220283","display_name":"Krish Patel","orcid":"https://orcid.org/0000-0002-2446-098X","observed_orcids":["https://orcid.org/0000-0002-2446-098X","https://orcid.org/0009-0009-0218-0651"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Krish Patel","raw_affiliation_strings":["Center for Blood Disorders and Stem Cell Transplantation, Swedish Cancer Institute, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Blood Disorders and Stem Cell Transplantation, Swedish Cancer Institute, Seattle, WA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"136","issue":"Supplement 1","first_page":"34","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12212","display_name":"CNS Lymphoma Diagnosis and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acalabrutinib","display_name":"acalabrutinib","score":0.9850000143051147},{"id":"https://openalex.org/keywords/relapsed-refractory-diffuse-large-b-cell-lymphoma","display_name":"relapsed/refractory diffuse large B-cell lymphoma","score":0.9509999752044678},{"id":"https://openalex.org/keywords/bruton-tyrosine-kinase-inhibitors","display_name":"BTK inhibitors","score":0.8539999723434448},{"id":"https://openalex.org/keywords/autologous-stem-cell-transplantation","display_name":"autologous stem cell transplantation","score":0.968999981880188},{"id":"https://openalex.org/keywords/maintenance-therapy","display_name":"maintenance therapy","score":0.8059999942779541},{"id":"https://openalex.org/keywords/complete-response","display_name":"complete response","score":0.8080000281333923},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9449999928474426},{"id":"https://openalex.org/keywords/b-cell-receptor-signaling","display_name":"B cell receptor signaling","score":0.7900000214576721},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.8399999737739563},{"id":"https://openalex.org/keywords/second-line-treatment","display_name":"second-line therapy","score":0.6959999799728394},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.3140000104904175},{"id":"https://openalex.org/keywords/transplant-ineligible-patients","display_name":"transplant-ineligible patients","score":0.5429999828338623},{"id":"https://openalex.org/keywords/transplant-eligible-patients","display_name":"transplant-eligible patients","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C2778559949","wikidata":"https://www.wikidata.org/wiki/Q2626074","display_name":"Diffuse large B-cell lymphoma","level":3,"score":0.6955323219299316},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5686748027801514},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5614435076713562},{"id":"https://openalex.org/C90059517","wikidata":"https://www.wikidata.org/wiki/Q423572","display_name":"Bruton's tyrosine kinase","level":4,"score":0.5302289128303528},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5167940855026245},{"id":"https://openalex.org/C2780790343","wikidata":"https://www.wikidata.org/wiki/Q5090610","display_name":"Chemoimmunotherapy","level":4,"score":0.5151097178459167},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49584445357322693},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49304649233818054},{"id":"https://openalex.org/C2778283404","wikidata":"https://www.wikidata.org/wiki/Q6736822","display_name":"Maintenance therapy","level":3,"score":0.4386964440345764},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.35890233516693115},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.3420826494693756},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.24232766032218933},{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.21542426943778992},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2020-141074","doi":"https://doi.org/10.1182/blood-2020-141074","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2020-141074","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3217713280","https://openalex.org/W4405039298","https://openalex.org/W2885447112","https://openalex.org/W3212748355","https://openalex.org/W3047660169","https://openalex.org/W3095720014","https://openalex.org/W2103563361","https://openalex.org/W7171939697","https://openalex.org/W2951755491","https://openalex.org/W3175785263"],"abstract_inverted_index":{"Background:":[0],"Patients":[1,365,406,474,508,529],"with":[2,23,28,41,166,180,202,228,335,339,379,416,435,447,487,515],"relapsed/refractory":[3],"(R/R)":[4],"diffuse":[5],"large":[6],"B-cell":[7,70],"lymphoma":[8],"(DLBCL)":[9],"often":[10],"have":[11],"a":[12,101,154,188,386,409,468,494,567],"poor":[13],"prognosis":[14],"despite":[15],"therapies":[16],"using":[17,562],"second-line":[18,24,59,151,295,315],"chemoimmunotherapy.":[19],"Achievement":[20],"of":[21,35,47,69,86,91,107,134,144,163,191,196,212,225,308,325,328,333,345,356,363,372,385,393,412,427,453,470,481,493,505,675],"CR":[22,284,436],"therapy":[25,60,152,199,233,466],"is":[26,137,217,245,259,279,303,420,574,685],"associated":[27],"improved":[29,63],"long-term":[30,194],"outcomes.":[31],"Unfortunately,":[32],"only":[33],"25-35%":[34],"patients":[36,179,201,250,264,293,313,329,395,434,459],"achieve":[37],"complete":[38],"response":[39,353,439],"(CR)":[40],"RICE":[42,167,229,336,374,413,482,563],"chemotherapy":[43,168],"alone.":[44],"The":[45,132,209,273,297],"addition":[46],"novel":[48],"targeted":[49],"agents":[50],"such":[51],"as":[52,100,153,230,305,464,566],"Bruton":[53],"Tyrosine":[54],"Kinase":[55],"inhibitors":[56,129],"(BTKi)":[57],"to":[58,80,138,149,156,218,247,261,280,290,430,444,519,542],"may":[61,183],"offer":[62],"treatment":[64,537],"responses":[65],"given":[66],"the":[67,87,105,140,146,161,185,197,220,282,306,326,550],"importance":[68],"receptor":[71],"(BCR)":[72],"signaling":[73,96,117],"in":[74,104,118,169,234,292,312,366,377,396,414,475,485,549,692],"DLBCL.":[75,108,204],"BTK":[76],"has":[77,97],"been":[78,98],"shown":[79],"be":[81,124,543,547,581],"essential":[82],"for":[83,187,200,254,270,276,300,348,467,569,690],"BCR-mediated":[84],"activation":[85],"NF-":[88],"\u03baB/Rel":[89],"family":[90],"transcription":[92],"factors":[93],"and":[94,142,176,193,207,223,317,337,361,404,545,577],"BCR":[95,116],"recognized":[99],"key":[102],"pathway":[103],"pathogenesis":[106],"Moreover,":[109],"NF-\u03baB":[110],"activity":[111],"relies":[112],"upon":[113],"chronic":[114],"active":[115],"activated":[119],"B-cell-like":[120],"DLBCL,":[121],"which":[122],"can":[123,580],"potentially":[125],"blocked":[126],"by":[127,498],"kinase":[128],"targeting":[130],"BTK.":[131],"goal":[133],"this":[135,213,693],"study":[136,190,241,536],"examine":[139],"feasibility":[141,162],"efficacy":[143,192,224],"adding":[145],"BTKi,":[147],"acalabrutinib,":[148,380],"standard":[150,373],"means":[155],"improve":[157],"disease":[158,511,524,532],"response.":[159,432],"Establishing":[160],"combining":[164,226],"acalabrutinib":[165,227,319,334,347,461,488,516],"autologous":[170,255,271,400,445],"hematopoietic":[171,457],"cell":[172,402],"transplantation":[173],"(HCT)":[174],"eligible":[175,253],"HCT":[177,291,340,349,446],"ineligible":[178,269,350],"R/R":[181,203,235,248,262],"DLBCL":[182,236,249,263,691],"provide":[184],"foundation":[186],"larger":[189],"outcomes":[195,540,555],"combination":[198,378,415,486],"Study":[205],"Design":[206],"Methods:":[208],"primary":[210,274,298],"objective":[211],"phase":[214],"2":[215,342,370,391],"trial":[216,573],"evaluate":[219],"tolerability,":[221],"feasibility,":[222],"second":[231],"line":[232],"patients.":[237],"There":[238],"are":[239,252,266,533],"two":[240],"cohorts.":[242],"Cohort":[243,257],"A":[244,278,368,398],"open":[246,260],"who":[251,265],"HCT.":[256,272],"B":[258,302,477],"considered":[267],"medically":[268],"endpoint":[275,299],"cohort":[277,301,367,397,476],"estimate":[281,307],"confirmed":[283],"rate":[285],"(RECIL":[286],"2017":[287],"criteria)":[288],"prior":[289],"undergoing":[294,314],"therapy.":[296,320],"defined":[304],"one-year":[309],"progression-free":[310],"survival":[311],"induction":[316],"maintenance":[318,346,465,517],"Secondary":[321],"endpoints":[322],"include":[323],"assessment":[324],"proportion":[327],"completing":[330],"3":[331,429,479],"cycles":[332,344,371,392,480,522],"proceeding":[338],"or":[341,437,526,677],"additional":[343,472,521,578],"patients,":[351],"overall":[352],"rate,":[354],"incidence":[355,362],"Grade":[357],"3/4":[358],"adverse":[359],"events,":[360],"SAEs.":[364],"receive":[369,408,478],"salvage":[375,483],"chemoimmunotherapy":[376,484,564],"100mg":[381,462,489],"BID":[382,463,490],"day":[383,388,425,491],"1-21":[384,492],"21":[387],"cycle.":[389],"After":[390,455],"therapy,":[394],"undergo":[399],"stem":[401],"mobilization":[403],"collection.":[405],"then":[407],"3rd":[410],"cycle":[411,428,496],"acalabrutinib.":[417],"PET-CT":[418,499],"(PET3)":[419,500],"performed":[421],"14-21":[422,501],"days":[423,452,502],"after":[424,441,503],"1":[426],"assess":[431],"Those":[433],"partial":[438],"(PR)":[440],"PET3":[442,513],"proceed":[443],"BEAM":[448],"conditioning":[449],"within":[450],"28-42":[451],"PET3.":[454],"adequate":[456],"recovery,":[458],"restart":[460],"period":[469],"12":[471,520],"months.":[473],"21-day":[495],"followed":[497],"start":[504],"Cycle":[506],"3.":[507],"without":[509],"progressive":[510,531],"at":[512],"continue":[514,541],"up":[518],"until":[523],"progression":[525],"unacceptable":[527],"toxicity.":[528],"demonstrating":[530],"withdrawn":[534],"from":[535,556],"but":[538],"their":[539],"recorded":[544],"will":[546],"included":[548],"final":[551],"data":[552],"analysis.":[553],"Historical":[554],"completed,":[557],"published":[558],"prospective":[559],"clinical":[560],"trials":[561],"serve":[565],"reference":[568],"statistical":[570],"calculations.":[571],"This":[572],"currently":[575],"ongoing":[576],"information":[579],"found":[582],"on":[583,671],"clinicaltrials.gov":[584],"NCT":[585],"listing":[586],"NCT03736616":[587],"Disclosures":[588],"Bensinger:":[589],"BMS:":[590],"Consultancy,":[591,598,605,612,619,626,646,650,656,665,669],"Honoraria,":[592,599,606,613,620,627],"Research":[593,600,607,614,621,628,657],"Funding,":[594,601,608,615,622,629,658],"Speakers":[595,602,609,616,623,630,633,637,640,643,647,651,659,666],"Bureau;":[596,603,610,617,624,634,641,648,652,660,667],"Sanofi:":[597],"Janssen:":[604,642,649],"Amgen:":[611],"GSK:":[618],"Regeneron:":[625],"Bureau.":[631,638,644],"Mawad:Abbvie:":[632],"Adaptive":[635,661],"Biotechnologies:":[636,662],"Glennie:Pharmacyclics:":[639],"Patel:Pharmacyclics:":[645],"Kite:":[653],"Consultancy;":[654,663],"AstraZeneca:":[655],"Genentech:":[664],"Celgene/BMS:":[668],"Membership":[670],"an":[672,687],"entity's":[673],"Board":[674],"Directors":[676],"advisory":[678],"committees;":[679],"BeiGene:":[680],"Consultancy.":[681],"OffLabel":[682],"Disclosure:":[683],"Acalabrutinib":[684],"used":[686],"investigational":[688],"agent":[689],"study.":[694]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-11-09T00:00:00"}