{"id":"https://openalex.org/W3096570346","doi":"https://doi.org/10.1158/1538-7445.tumhet2020-ia22","title":"Abstract IA22: Single cell proteomics to capture human dysplasia and dysfunction","display_name":"Abstract IA22: Single cell proteomics to capture human dysplasia and dysfunction","publication_year":2020,"publication_date":"2020-11-01","ids":{"openalex":"https://openalex.org/W3096570346","doi":"https://doi.org/10.1158/1538-7445.tumhet2020-ia22","mag":"3096570346"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.tumhet2020-ia22","doi":"https://doi.org/10.1158/1538-7445.tumhet2020-ia22","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.tumhet2020-ia22","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045383208","display_name":"Sean C. Bendall","orcid":"https://orcid.org/0000-0003-1341-2453","observed_orcids":["https://orcid.org/0000-0003-1341-2453"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sean Bendall","raw_affiliation_strings":["Stanford University School of Medicine, Palo Alto, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University School of Medicine, Palo Alto, CA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5045383208"],"corresponding_institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"80","issue":"21_Supplement","first_page":"IA22","last_page":"IA22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.5878999829292297,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.5878999829292297,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.3246999979019165,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.020999999716877937,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mass-cytometry","display_name":"mass cytometry","score":0.8450000286102295},{"id":"https://openalex.org/keywords/multiplexed-ion-beam-imaging","display_name":"MIBI","score":0.8820000290870667},{"id":"https://openalex.org/keywords/single-cell-proteomics","display_name":"single-cell proteomics","score":0.890999972820282},{"id":"https://openalex.org/keywords/automated-cell-classification","display_name":"automated cell classification","score":0.6299999952316284},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.8289999961853027},{"id":"https://openalex.org/keywords/proteome-dynamics","display_name":"proteome dynamics","score":0.753000020980835},{"id":"https://openalex.org/keywords/cellular-dysfunction","display_name":"cellular dysfunction","score":0.4129999876022339}],"concepts":[{"id":"https://openalex.org/C2778015335","wikidata":"https://www.wikidata.org/wiki/Q17051163","display_name":"Mass cytometry","level":4,"score":0.8060196042060852},{"id":"https://openalex.org/C117717151","wikidata":"https://www.wikidata.org/wiki/Q3589155","display_name":"Epigenome","level":5,"score":0.6332379579544067},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.6181665658950806},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5881600379943848},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.5100070238113403},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.46611812710762024},{"id":"https://openalex.org/C94795543","wikidata":"https://www.wikidata.org/wiki/Q3813754","display_name":"Human proteome project","level":4,"score":0.44940727949142456},{"id":"https://openalex.org/C2780339063","wikidata":"https://www.wikidata.org/wiki/Q5201367","display_name":"Cytometry","level":3,"score":0.43844518065452576},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.43703263998031616},{"id":"https://openalex.org/C2993684226","wikidata":"https://www.wikidata.org/wiki/Q2662727","display_name":"Human cell","level":3,"score":0.4359106719493866},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35670003294944763},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.351410835981369},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.34488242864608765},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.25748583674430847},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.145938903093338},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1423005759716034},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.0},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.tumhet2020-ia22","doi":"https://doi.org/10.1158/1538-7445.tumhet2020-ia22","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.tumhet2020-ia22","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2744301679","https://openalex.org/W4213032000","https://openalex.org/W3154046765","https://openalex.org/W4255938438","https://openalex.org/W2606306441","https://openalex.org/W4399654826","https://openalex.org/W2899253101","https://openalex.org/W2893401080","https://openalex.org/W7166566916","https://openalex.org/W3166627873"],"abstract_inverted_index":{"Abstract":[0],"Single":[1,203,225],"cell":[2,19,40,156,204],"analysis,":[3],"starting":[4],"with":[5,38,111],"the":[6,17,98,130,216],"earliest":[7],"low":[8],"parameter":[9],"fluorescent":[10,67],"cytometry":[11,43],"and":[12,48,103,126,151,178,189,195,210],"microscopy":[13],"experiments,":[14],"helped":[15],"define":[16],"major":[18],"subsets":[20],"of":[21,34,63,88,100,120,144,174,215],"human":[22,92,175,208],"cellular":[23,176],"systems":[24],"as":[25,78],"we":[26,83,95,135],"understand":[27,185],"them":[28],"today.":[29],"Now,":[30],"a":[31],"novel":[32],"combination":[33],"elemental":[35],"mass":[36],"spectrometry":[37],"single":[39,155],"analysis":[41],"(mass":[42],"\u2013":[44,53],"CyTOF,":[45],"Science":[46],"2011)":[47],"imaging":[49,52],"(multiplexed":[50],"ionbeam":[51],"MIBI,":[54],"Nature":[55,163],"Med.":[56,164],"2014,":[57],"Cell":[58],"2018)":[59],"offers":[60],"routine":[61],"examination":[62],">50":[64],"parameters":[65],"without":[66],"agents":[68],"or":[69],"interference":[70],"from":[71,153],"spectral":[72],"overlap":[73],"using":[74],"heavy":[75],"metal":[76],"isotopes":[77],"reporters.":[79],"With":[80],"these":[81,101,112,167],"platforms,":[82],"have":[84],"reached":[85],"new":[86,168,172],"levels":[87,119],"organizational":[89],"understanding":[90],"in":[91,114,187],"pathobiology.":[93],"Here,":[94],"will":[96,136],"review":[97],"evolution":[99],"technologies":[102],"present":[104],"our":[105],"latest":[106],"efforts":[107,139],"to":[108,116,133,140,147,184,206,227],"create":[109],"assays":[110],"platforms":[113],"order":[115],"quantify":[117],"multiple":[118],"regulation":[121],"including":[122],"metabolism,":[123],"proteome":[124],"dynamics,":[125],"chromatin":[127],"content":[128],"regulating":[129],"epigenome.":[131],"Further":[132],"this,":[134],"highlight":[137],"recent":[138],"leverage":[141],"structural":[142],"characteristics":[143],"leukemia":[145],"dysplasias":[146],"facilitate":[148],"automated":[149,194],"identification":[150],"classification":[152],"multiplexed":[154],"datasets":[157],"(Tsai":[158],"&":[159],"Glass":[160],"et":[161],"al.":[162],"2020).":[165],"Overall,":[166],"approaches":[169],"can":[170,181],"reveal":[171],"layers":[173],"organization":[177],"structure":[179],"that":[180],"be":[182],"exploited":[183],"dysfunction":[186,211],"general":[188],"provide":[190],"avenues":[191],"for":[192],"more":[193],"robust":[196],"clinical":[197],"classification.":[198],"Citation":[199],"Format:":[200],"Sean":[201],"Bendall.":[202],"proteomics":[205],"capture":[207],"dysplasia":[209],"[abstract].":[212],"In:":[213],"Proceedings":[214],"AACR":[217],"Virtual":[218],"Special":[219],"Conference":[220],"on":[221],"Tumor":[222],"Heterogeneity:":[223],"From":[224],"Cells":[226],"Clinical":[228],"Impact;":[229],"2020":[230],"Sep":[231],"17-18.":[232],"Philadelphia":[233],"(PA):":[234],"AACR;":[235],"Cancer":[236],"Res":[237],"2020;80(21":[238],"Suppl):Abstract":[239],"nr":[240],"IA22.":[241]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2020-11-09T00:00:00"}