{"id":"https://openalex.org/W3096534846","doi":"https://doi.org/10.18097/pbmc20206605357","title":"Molecular mechanisms of the cardiotoxic action of anthracycline antibiotics and statin-induced cytoprotective reactions of cardiomyocytes","display_name":"Molecular mechanisms of the cardiotoxic action of anthracycline antibiotics and statin-induced cytoprotective reactions of cardiomyocytes","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3096534846","doi":"https://doi.org/10.18097/pbmc20206605357","mag":"3096534846","pmid":"https://pubmed.ncbi.nlm.nih.gov/33140729"},"language":"ru","primary_location":{"id":"doi:10.18097/pbmc20206605357","doi":"https://doi.org/10.18097/pbmc20206605357","is_oa":true,"landing_page_url":"https://doi.org/10.18097/pbmc20206605357","pdf_url":"http://pbmc.ibmc.msk.ru/pdf/PBMC-2020-66-5-357","source":{"id":"https://openalex.org/S4306504416","display_name":"Biomeditsinskaya Khimiya","issn_l":"2310-6905","issn":["2310-6905","2310-6972"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["medline","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/I4210152028","host_organization_name":"Institute of Biomedical Chemistry","host_organization_lineage":["https://openalex.org/I4210152028"],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomeditsinskaya Khimiya","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://pbmc.ibmc.msk.ru/pdf/PBMC-2020-66-5-357","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111355924","display_name":"\u0422\u0443\u0440\u0441\u0443\u043d\u043e\u0432\u0430 \u041d\u0430\u0442\u0430\u043b\u044c\u044f \u0412\u043b\u0430\u0434\u0438\u043c\u0438\u0440\u043e\u0432\u043d\u0430","orcid":"https://orcid.org/0009-0003-7796-6292","observed_orcids":["https://orcid.org/0009-0003-7796-6292"]},"institutions":[{"id":"https://openalex.org/I4210128002","display_name":"Institute of Molecular Pathology and Pathomorphology","ror":"https://ror.org/02trrjx85","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210128002"]},{"id":"https://openalex.org/I4210134550","display_name":"Federal Research Center of Fundamental and Translational Medicine","ror":"https://ror.org/04545k330","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210134550"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"N.V. Tursunova","raw_affiliation_strings":["Institute of Molecular Pathology and Pathomorphology, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Pathology and Pathomorphology, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia","institution_ids":["https://openalex.org/I4210128002","https://openalex.org/I4210134550"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005986779","display_name":"\u041a\u043b\u0438\u043d\u043d\u0438\u043a\u043e\u0432\u0430 \u041c\u0430\u0440\u0438\u043d\u0430 \u0413\u0435\u043d\u043d\u0430\u0434\u044c\u0435\u0432\u043d\u0430","orcid":"https://orcid.org/0009-0008-5508-0411","observed_orcids":["https://orcid.org/0009-0008-5508-0411","https://orcid.org/0000-0001-9909-5027"]},"institutions":[{"id":"https://openalex.org/I4210128002","display_name":"Institute of Molecular Pathology and Pathomorphology","ror":"https://ror.org/02trrjx85","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210128002"]},{"id":"https://openalex.org/I4210134550","display_name":"Federal Research Center of Fundamental and Translational Medicine","ror":"https://ror.org/04545k330","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210134550"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"M.G. Klinnikova","raw_affiliation_strings":["Institute of Molecular Pathology and Pathomorphology, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Pathology and Pathomorphology, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia","institution_ids":["https://openalex.org/I4210128002","https://openalex.org/I4210134550"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029643162","display_name":"O. A. Babenko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128002","display_name":"Institute of Molecular Pathology and Pathomorphology","ror":"https://ror.org/02trrjx85","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210128002"]},{"id":"https://openalex.org/I4210134550","display_name":"Federal Research Center of Fundamental and Translational Medicine","ror":"https://ror.org/04545k330","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210134550"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"O.A. Babenko","raw_affiliation_strings":["Institute of Molecular Pathology and Pathomorphology, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Pathology and Pathomorphology, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia","institution_ids":["https://openalex.org/I4210128002","https://openalex.org/I4210134550"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087166684","display_name":"Elena L. Lushnikova","orcid":"https://orcid.org/0000-0002-3269-2465","observed_orcids":["https://orcid.org/0000-0002-3269-2465"]},"institutions":[{"id":"https://openalex.org/I4210128002","display_name":"Institute of Molecular Pathology and Pathomorphology","ror":"https://ror.org/02trrjx85","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210128002"]},{"id":"https://openalex.org/I4210134550","display_name":"Federal Research Center of Fundamental and Translational Medicine","ror":"https://ror.org/04545k330","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210134550"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E.L. Lushnikova","raw_affiliation_strings":["Institute of Molecular Pathology and Pathomorphology, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Pathology and Pathomorphology, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia","institution_ids":["https://openalex.org/I4210128002","https://openalex.org/I4210134550"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0878,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.11549447,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"66","issue":"5","first_page":"357","last_page":"371"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anthracycline-induced-cardiotoxicity","display_name":"anthracycline cardiotoxicity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.921999990940094},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.8980000019073486},{"id":"https://openalex.org/keywords/free-radical-oxidation","display_name":"free radical oxidation","score":0.8029999732971191},{"id":"https://openalex.org/keywords/rho-gtpases","display_name":"Rho GTPases","score":0.847000002861023},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.8889999985694885},{"id":"https://openalex.org/keywords/topoisomerase-ii-inhibition","display_name":"topoisomerase II inhibition","score":0.871999979019165},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.781000018119812},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.671999990940094},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.5299999713897705},{"id":"https://openalex.org/keywords/chemotherapy-side-effects","display_name":"chemotherapy side effects","score":0.5830000042915344},{"id":"https://openalex.org/keywords/synergistic-and-antagonistic-effects","display_name":"synergistic and antagonistic effects","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C2778233292","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiotoxicity","level":3,"score":0.6992504000663757},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6967715620994568},{"id":"https://openalex.org/C2776802502","wikidata":"https://www.wikidata.org/wiki/Q417589","display_name":"Anthracycline","level":4,"score":0.5888766646385193},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.5422812700271606},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.5177942514419556},{"id":"https://openalex.org/C2777482532","wikidata":"https://www.wikidata.org/wiki/Q668093","display_name":"Atorvastatin","level":2,"score":0.5017573833465576},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4741237461566925},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.4705534279346466},{"id":"https://openalex.org/C3454156","wikidata":"https://www.wikidata.org/wiki/Q1144241","display_name":"Side effect (computer science)","level":2,"score":0.421404629945755},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3718819320201874},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.30993571877479553},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.153815358877182},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09183713793754578},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.07924571633338928},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018943","descriptor_name":"Anthracyclines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066126","descriptor_name":"Cardiotoxicity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.18097/pbmc20206605357","doi":"https://doi.org/10.18097/pbmc20206605357","is_oa":true,"landing_page_url":"https://doi.org/10.18097/pbmc20206605357","pdf_url":"http://pbmc.ibmc.msk.ru/pdf/PBMC-2020-66-5-357","source":{"id":"https://openalex.org/S4306504416","display_name":"Biomeditsinskaya Khimiya","issn_l":"2310-6905","issn":["2310-6905","2310-6972"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["medline","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/I4210152028","host_organization_name":"Institute of Biomedical Chemistry","host_organization_lineage":["https://openalex.org/I4210152028"],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomeditsinskaya Khimiya","raw_type":"journal-article"},{"id":"pmid:33140729","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33140729","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomeditsinskaia khimiia","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.18097/pbmc20206605357","doi":"https://doi.org/10.18097/pbmc20206605357","is_oa":true,"landing_page_url":"https://doi.org/10.18097/pbmc20206605357","pdf_url":"http://pbmc.ibmc.msk.ru/pdf/PBMC-2020-66-5-357","source":{"id":"https://openalex.org/S4306504416","display_name":"Biomeditsinskaya Khimiya","issn_l":"2310-6905","issn":["2310-6905","2310-6972"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["medline","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/I4210152028","host_organization_name":"Institute of Biomedical Chemistry","host_organization_lineage":["https://openalex.org/I4210152028"],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomeditsinskaya Khimiya","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3096534846.pdf","grobid_xml":"https://content.openalex.org/works/W3096534846.grobid-xml"},"referenced_works_count":94,"referenced_works":["https://openalex.org/W1072651658","https://openalex.org/W1120544291","https://openalex.org/W1915620309","https://openalex.org/W1930501916","https://openalex.org/W1951308530","https://openalex.org/W1963621262","https://openalex.org/W1964088193","https://openalex.org/W1966861594","https://openalex.org/W1969144125","https://openalex.org/W1973814322","https://openalex.org/W1978983696","https://openalex.org/W1982778125","https://openalex.org/W1983822030","https://openalex.org/W1991516806","https://openalex.org/W1991583073","https://openalex.org/W1998140849","https://openalex.org/W1999854541","https://openalex.org/W2008886404","https://openalex.org/W2011710975","https://openalex.org/W2013429872","https://openalex.org/W2015615030","https://openalex.org/W2016636623","https://openalex.org/W2028044362","https://openalex.org/W2031311519","https://openalex.org/W2039920784","https://openalex.org/W2044590638","https://openalex.org/W2049727461","https://openalex.org/W2051357882","https://openalex.org/W2052637997","https://openalex.org/W2064488040","https://openalex.org/W2066902317","https://openalex.org/W2070832781","https://openalex.org/W2080009224","https://openalex.org/W2084304742","https://openalex.org/W2086469250","https://openalex.org/W2088491250","https://openalex.org/W2096211999","https://openalex.org/W2098886952","https://openalex.org/W2112300595","https://openalex.org/W2120087347","https://openalex.org/W2125304966","https://openalex.org/W2125683592","https://openalex.org/W2132001873","https://openalex.org/W2132973959","https://openalex.org/W2133584350","https://openalex.org/W2134242032","https://openalex.org/W2134599751","https://openalex.org/W2136507649","https://openalex.org/W2136727847","https://openalex.org/W2136765652","https://openalex.org/W2137405846","https://openalex.org/W2142678310","https://openalex.org/W2148580947","https://openalex.org/W2150171020","https://openalex.org/W2151600204","https://openalex.org/W2153709731","https://openalex.org/W2159700909","https://openalex.org/W2162514244","https://openalex.org/W2165079456","https://openalex.org/W2165752493","https://openalex.org/W2170452186","https://openalex.org/W2212776653","https://openalex.org/W2253116428","https://openalex.org/W2267561229","https://openalex.org/W2285368761","https://openalex.org/W2294881102","https://openalex.org/W2317946219","https://openalex.org/W2394924032","https://openalex.org/W2396139649","https://openalex.org/W2422664499","https://openalex.org/W2517162981","https://openalex.org/W2524574476","https://openalex.org/W2556923697","https://openalex.org/W2559406810","https://openalex.org/W2570787279","https://openalex.org/W2577541469","https://openalex.org/W2587416719","https://openalex.org/W2597749648","https://openalex.org/W2604571360","https://openalex.org/W2748821417","https://openalex.org/W2749508920","https://openalex.org/W2765612046","https://openalex.org/W2793794684","https://openalex.org/W2794139372","https://openalex.org/W2802804112","https://openalex.org/W2803569339","https://openalex.org/W2885488580","https://openalex.org/W2935851573","https://openalex.org/W2953817630","https://openalex.org/W2966756181","https://openalex.org/W2992641315","https://openalex.org/W3005801915","https://openalex.org/W3007790435","https://openalex.org/W4249338315"],"related_works":["https://openalex.org/W4395004229","https://openalex.org/W2577541469","https://openalex.org/W4400608662","https://openalex.org/W1978983696","https://openalex.org/W2026652277","https://openalex.org/W982330761","https://openalex.org/W2736135258","https://openalex.org/W166021776","https://openalex.org/W2999269162","https://openalex.org/W4291238068"],"abstract_inverted_index":{"The":[0,22,137,175,196,268],"manifestation":[1],"of":[2,7,16,28,31,37,47,68,75,92,111,124,140,142,146,153,159,177,185,198,201,204,231,242,277,322],"the":[3,14,25,29,34,45,66,72,88,93,122,143,151,157,163,173,180,189,205,221,229,274,283,295,323],"side":[4,238],"cardiotoxic":[5,109,214],"effect":[6,36,168,276],"anthracycline":[8,62,298,332],"antibiotics":[9,299],"limits":[10],"their":[11,134,167,279],"use":[12,67,105,230,330],"in":[13,19,44,64,71,169,212,256,310,331],"treatment":[15,74,286],"malignant":[17],"processes":[18,46],"some":[20,311,316],"patients.":[21],"review":[23,269],"analyzes":[24,271],"main":[26,138],"causes":[27,251],"susceptibility":[30],"cardiomyocytes":[32],"to":[33,57,60,86,104,107,121,155,253,281,285],"damaging":[35],"anthracyclines,":[38],"primarily":[39],"associated":[40],"with":[41,258,287],"an":[42],"increase":[43],"free":[48],"radical":[49],"oxidation.":[50],"Currently,":[51],"research":[52],"is":[53,102,150,172,218,302],"widely":[54],"carried":[55],"out":[56],"find":[58],"ways":[59],"reduce":[61,108],"cardiotoxicity,":[63],"particular,":[65],"cardioprotective":[69,135],"agents":[70],"complex":[73],"tumors.":[76],"Hydroxymethylglutaryl":[77],"coenzyme":[78],"A":[79],"reductase":[80],"inhibitors":[81],"(statins)":[82],"have":[83],"been":[84,292],"shown":[85,293],"improve":[87],"function":[89],"and":[90,117,128,148,166,182,246,300,327],"metabolism":[91],"cardiovascular":[94],"system":[95],"under":[96],"various":[97],"pathological":[98],"impacts,":[99],"therefore,":[100],"it":[101,224],"proposed":[103],"them":[106,252],"complications":[110],"chemotherapy.":[112],"Statins":[113],"exhibit":[114],"direct":[115],"(hypolipidemic)":[116],"pleiotropic":[118],"effects":[119],"due":[120],"blockade":[123,203],"mevalonic":[125],"acid":[126],"synthesis":[127],"downward":[129],"biochemical":[130],"cascades":[131],"that":[132,228,294],"determine":[133],"properties.":[136],"point":[139],"intersection":[141],"pharmacological":[144],"activity":[145],"anthracyclines":[147],"statins":[149,178,232,301,319],"ability":[152,280],"both":[154],"regulate":[156],"functioning":[158],"small":[160],"GTPase":[161],"from":[162],"Rho":[164,186],"family,":[165],"this":[170],"regard":[171],"opposite.":[174],"influence":[176],"on":[179,273],"modification":[181],"membrane":[183],"dislocation":[184],"proteins":[187],"mediates":[188],"indirect":[190],"antioxidant,":[191],"anti-inflammatory,":[192],"endothelioprotective,":[193],"antiapoptotic":[194],"effect.":[195],"mechanism":[197],"statin":[199],"inhibition":[200],"doxorubicin":[202],"DNA-topoisomerase":[206],"complex,":[207],"which":[208,249],"may":[209],"be":[210,226,234,254],"important":[211],"preventing":[213],"damage":[215],"during":[216],"chemotherapy,":[217],"discussed.":[219],"At":[220],"same":[222],"time,":[223],"should":[225],"noted":[227],"can":[233],"accompanied":[235],"by":[236,306,313],"adverse":[237,317],"effects:":[239],"a":[240],"provocation":[241],"increased":[243],"insulin":[244],"resistance":[245],"glucose":[247],"tolerance,":[248],"often":[250],"canceled":[255],"patients":[257],"impaired":[259],"carbohydrate":[260],"metabolism,":[261],"so":[262],"further":[263],"studies":[264],"are":[265,320],"needed":[266],"here.":[267],"also":[270,309],"data":[272],"antitumor":[275],"statins,":[278],"sensitize":[282],"tumor":[284],"cytostatic":[288],"drug.":[289],"It":[290],"has":[291],"relationship":[296],"between":[297],"characterized":[303],"not":[304],"only":[305],"antagonism,":[307],"but":[308],"cases":[312],"synergism.":[314],"Despite":[315],"effects,":[318],"one":[321],"most":[324],"promising":[325],"cardio-":[326],"vasoprotectors":[328],"for":[329],"cardiomyopathy.":[333]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-11-09T00:00:00"}