{"id":"https://openalex.org/W3096442371","doi":null,"title":"Identifying Molecular Mechanisms of Progesterone-responsive Mammary Stem Cell Expansion","display_name":"Identifying Molecular Mechanisms of Progesterone-responsive Mammary Stem Cell Expansion","publication_year":2014,"publication_date":"2014-06-01","ids":{"openalex":"https://openalex.org/W3096442371","mag":"3096442371"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/94499","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/94499","pdf_url":"https://utoronto.scholaris.ca/bitstreams/8fb892a4-9b0d-40a1-8be6-bc7492b0e6ba/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/8fb892a4-9b0d-40a1-8be6-bc7492b0e6ba/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044314744","display_name":"Yu-Jia Shiah","orcid":"https://orcid.org/0009-0000-8365-9334","observed_orcids":["https://orcid.org/0009-0000-8365-9334","https://orcid.org/0000-0003-4989-2794"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yu-Jia Shiah","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4989-2794","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5044314744"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.8759999871253967,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.8759999871253967,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.06889999657869339,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.03720000013709068,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mammary-stem-cells","display_name":"mammary stem cells","score":0.9929999709129333},{"id":"https://openalex.org/keywords/mammary-gland","display_name":"mammary gland","score":0.7590000033378601},{"id":"https://openalex.org/keywords/mammary-epithelial-cells","display_name":"mammary epithelial cells","score":0.7139999866485596},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.777999997138977},{"id":"https://openalex.org/keywords/transcriptomics","display_name":"transcriptomics","score":0.8230000138282776},{"id":"https://openalex.org/keywords/breast-cancer-risk","display_name":"breast cancer risk","score":0.7120000123977661},{"id":"https://openalex.org/keywords/ovarian-hormones","display_name":"ovarian hormones","score":0.9020000100135803},{"id":"https://openalex.org/keywords/clonogenic-assay","display_name":"clonogenic assay","score":0.6980000138282776},{"id":"https://openalex.org/keywords/stem-cell-expansion","display_name":"stem cell expansion","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6190593242645264},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4963589310646057},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4554881155490875},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37580448389053345}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/94499","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/94499","pdf_url":"https://utoronto.scholaris.ca/bitstreams/8fb892a4-9b0d-40a1-8be6-bc7492b0e6ba/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:3096442371","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/bitstream/1807/94499/3/Shiah_Yu-Jia_201406_MSc_thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/94499","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/94499","pdf_url":"https://utoronto.scholaris.ca/bitstreams/8fb892a4-9b0d-40a1-8be6-bc7492b0e6ba/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3096442371.pdf","grobid_xml":"https://content.openalex.org/works/W3096442371.grobid-xml"},"referenced_works_count":134,"referenced_works":["https://openalex.org/W62108804","https://openalex.org/W156171614","https://openalex.org/W180269373","https://openalex.org/W1217425532","https://openalex.org/W1483776324","https://openalex.org/W1486018587","https://openalex.org/W1502936039","https://openalex.org/W1508838109","https://openalex.org/W1523335221","https://openalex.org/W1546952499","https://openalex.org/W1560424863","https://openalex.org/W1577060935","https://openalex.org/W1591891281","https://openalex.org/W1593442063","https://openalex.org/W1601214065","https://openalex.org/W1668963162","https://openalex.org/W1676092466","https://openalex.org/W1775510084","https://openalex.org/W1809740262","https://openalex.org/W1855943303","https://openalex.org/W1922502842","https://openalex.org/W1945743004","https://openalex.org/W1963676981","https://openalex.org/W1964895626","https://openalex.org/W1972810033","https://openalex.org/W1974536261","https://openalex.org/W1975401288","https://openalex.org/W1979440527","https://openalex.org/W1980772641","https://openalex.org/W1983624471","https://openalex.org/W1984433201","https://openalex.org/W1984836149","https://openalex.org/W1985695385","https://openalex.org/W1989281114","https://openalex.org/W1990133575","https://openalex.org/W1992665279","https://openalex.org/W1992901407","https://openalex.org/W1995612509","https://openalex.org/W1997387647","https://openalex.org/W1999591980","https://openalex.org/W2003407908","https://openalex.org/W2007229947","https://openalex.org/W2010867675","https://openalex.org/W2011842532","https://openalex.org/W2013444425","https://openalex.org/W2013864031","https://openalex.org/W2014157399","https://openalex.org/W2014254693","https://openalex.org/W2015341941","https://openalex.org/W2018518608","https://openalex.org/W2024339691","https://openalex.org/W2027604384","https://openalex.org/W2028326666","https://openalex.org/W2034841837","https://openalex.org/W2035371626","https://openalex.org/W2036638605","https://openalex.org/W2044261540","https://openalex.org/W2051320963","https://openalex.org/W2054211750","https://openalex.org/W2057826198","https://openalex.org/W2058004364","https://openalex.org/W2069062374","https://openalex.org/W2069474362","https://openalex.org/W2071524757","https://openalex.org/W2073327370","https://openalex.org/W2073823142","https://openalex.org/W2077290869","https://openalex.org/W2077690851","https://openalex.org/W2077986050","https://openalex.org/W2081098333","https://openalex.org/W2082161467","https://openalex.org/W2082485803","https://openalex.org/W2087372058","https://openalex.org/W2089031748","https://openalex.org/W2089361444","https://openalex.org/W2090590686","https://openalex.org/W2090722238","https://openalex.org/W2091005988","https://openalex.org/W2091841926","https://openalex.org/W2095671568","https://openalex.org/W2096758922","https://openalex.org/W2097795580","https://openalex.org/W2098658264","https://openalex.org/W2099737493","https://openalex.org/W2100875367","https://openalex.org/W2102209707","https://openalex.org/W2104625179","https://openalex.org/W2105099929","https://openalex.org/W2107433421","https://openalex.org/W2109178214","https://openalex.org/W2110153755","https://openalex.org/W2112780046","https://openalex.org/W2113472355","https://openalex.org/W2114990515","https://openalex.org/W2115210458","https://openalex.org/W2117282567","https://openalex.org/W2117468155","https://openalex.org/W2117963341","https://openalex.org/W2120865735","https://openalex.org/W2122855814","https://openalex.org/W2123106337","https://openalex.org/W2124218468","https://openalex.org/W2128517115","https://openalex.org/W2130410032","https://openalex.org/W2130642820","https://openalex.org/W2131494886","https://openalex.org/W2133111499","https://openalex.org/W2133465414","https://openalex.org/W2133660543","https://openalex.org/W2134318982","https://openalex.org/W2135230352","https://openalex.org/W2138019532","https://openalex.org/W2139298168","https://openalex.org/W2139703939","https://openalex.org/W2142061858","https://openalex.org/W2144080981","https://openalex.org/W2146974679","https://openalex.org/W2147028876","https://openalex.org/W2147109452","https://openalex.org/W2148482472","https://openalex.org/W2152274187","https://openalex.org/W2154229564","https://openalex.org/W2156624320","https://openalex.org/W2156873226","https://openalex.org/W2159610509","https://openalex.org/W2159675211","https://openalex.org/W2159941442","https://openalex.org/W2160697532","https://openalex.org/W2160779973","https://openalex.org/W2162045495","https://openalex.org/W2167940954","https://openalex.org/W2191177322","https://openalex.org/W2980657582","https://openalex.org/W7074130486"],"related_works":["https://openalex.org/W2423242218","https://openalex.org/W2051783431","https://openalex.org/W2005242533","https://openalex.org/W7133020054","https://openalex.org/W3190790001","https://openalex.org/W1984433201","https://openalex.org/W7097892987","https://openalex.org/W2754221009","https://openalex.org/W2809422028","https://openalex.org/W1999342334"],"abstract_inverted_index":{"Progesterone":[0],"is":[1],"a":[2],"key":[3],"mediator":[4],"of":[5,44],"cellular":[6],"changes":[7,13],"in":[8,74],"the":[9,17,23,42,75],"mammary":[10,48,76],"gland.":[11,77],"These":[12],"occur":[14],"naturally":[15],"during":[16],"reproductive":[18],"cycle":[19],"and":[20,29,99],"likely":[21],"underlie":[22],"correlation":[24],"between":[25],"ovarian":[26],"hormone":[27,53],"exposure":[28],"breast":[30],"cancer":[31],"risk.":[32],"This":[33],"study":[34,41],"utilizes":[35],"microarray":[36],"gene":[37],"expression":[38],"profiling":[39],"to":[40,66,88],"effects":[43],"progesterone":[45],"on":[46],"distinct":[47],"epithelial":[49],"subsets,":[50],"under":[51],"defined":[52],"conditions.":[54],"Through":[55],"these":[56],"transcriptomic":[57],"analyses,":[58,90],"we":[59,81],"yield":[60],"critical":[61],"information":[62],"that":[63],"enables":[64],"us":[65],"better":[67],"understand":[68],"molecular":[69],"mechanisms":[70],"underpinning":[71],"progesterone-driven":[72],"actions":[73],"In":[78],"this":[79],"study,":[80],"combined":[82],"bioinformatics":[83],"approaches":[84],"ranging":[85],"from":[86],"pre-processing":[87],"functional":[89],"with":[91],"wet":[92],"lab":[93],"techniques":[94],"such":[95],"as":[96],"clonogenic":[97],"assays":[98]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-11-09T00:00:00"}
