{"id":"https://openalex.org/W3096439282","doi":"https://doi.org/10.1182/blood-2020-143051","title":"Damage-Induced Pyroptotic Cell Death Facilitates Regeneration of the Thymus","display_name":"Damage-Induced Pyroptotic Cell Death Facilitates Regeneration of the Thymus","publication_year":2020,"publication_date":"2020-11-05","ids":{"openalex":"https://openalex.org/W3096439282","doi":"https://doi.org/10.1182/blood-2020-143051","mag":"3096439282"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2020-143051","doi":"https://doi.org/10.1182/blood-2020-143051","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2020-143051","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029209345","display_name":"Sinead M. Kinsella","orcid":"https://orcid.org/0000-0002-8456-043X","observed_orcids":["https://orcid.org/0000-0002-8456-043X"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sin\u00e9ad Kinsella","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050287471","display_name":"Cindy Evandy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cindy Evandy","raw_affiliation_strings":["Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089721310","display_name":"Kayla S. Hopwo","orcid":"https://orcid.org/0000-0001-5590-4224","observed_orcids":["https://orcid.org/0000-0001-5590-4224"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kayla S Hopwo","raw_affiliation_strings":["Clinical Research Division, Fred Hutch Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Division, Fred Hutch Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050055062","display_name":"Kirsten Cooper","orcid":"https://orcid.org/0000-0002-0711-2713","observed_orcids":["https://orcid.org/0000-0002-0711-2713"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kirsten Cooper","raw_affiliation_strings":["Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058991829","display_name":"Lorenzo Iovino","orcid":"https://orcid.org/0000-0002-3165-1899","observed_orcids":["https://orcid.org/0000-0002-3165-1899"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lorenzo Iovino","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002037759","display_name":"Colton W Smith","orcid":"https://orcid.org/0000-0003-3669-8327","observed_orcids":["https://orcid.org/0000-0003-3669-8327"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colton W Smith","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078913952","display_name":"Reema Jain","orcid":"https://orcid.org/0000-0002-8100-9300","observed_orcids":["https://orcid.org/0000-0002-8100-9300"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reema Jain","raw_affiliation_strings":["Fred Hutch Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutch Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066463475","display_name":"Paul C. DeRoos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul DeRoos","raw_affiliation_strings":["Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016053915","display_name":"Jarrod A. Dudakov","orcid":"https://orcid.org/0000-0001-6220-5632","observed_orcids":["https://orcid.org/0000-0001-6220-5632"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jarrod A Dudakov","raw_affiliation_strings":["Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210089486"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"136","issue":"Supplement 1","first_page":"28","last_page":"28"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.020999999716877937,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thymus-regeneration","display_name":"thymus regeneration","score":0.8209999799728394},{"id":"https://openalex.org/keywords/pyroptosis","display_name":"pyroptosis","score":0.8849999904632568},{"id":"https://openalex.org/keywords/cd4-cd8-double-negative-thymocytes","display_name":"CD4+CD8+ double-negative thymocytes","score":0.7950000166893005},{"id":"https://openalex.org/keywords/t-cell-reconstitution","display_name":"T cell reconstitution","score":0.7400000095367432},{"id":"https://openalex.org/keywords/il-22","display_name":"IL-22","score":0.6340000033378601},{"id":"https://openalex.org/keywords/bmp4","display_name":"BMP4","score":0.9020000100135803},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.7250000238418579},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.8100000023841858},{"id":"https://openalex.org/keywords/il-23","display_name":"IL-23","score":0.7919999957084656},{"id":"https://openalex.org/keywords/caspase-1","display_name":"caspase-1","score":0.7260000109672546},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.921999990940094},{"id":"https://openalex.org/keywords/hmgb1","display_name":"HMGB1","score":0.7979999780654907},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7760000228881836},{"id":"https://openalex.org/keywords/lactate-dehydrogenase","display_name":"lactate dehydrogenase","score":0.8450000286102295},{"id":"https://openalex.org/keywords/metabolic-remodeling","display_name":"metabolic remodeling","score":0.46299999952316284},{"id":"https://openalex.org/keywords/radiation-injury","display_name":"radiation injury","score":0.3190000057220459}],"concepts":[{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.6710797548294067},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.629274845123291},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5961472988128662},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5289680361747742},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5167076587677002},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4958072602748871},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4471632242202759},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.43361419439315796},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4329730272293091},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.42422422766685486}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2020-143051","doi":"https://doi.org/10.1182/blood-2020-143051","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2020-143051","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2992538372","https://openalex.org/W3203498823","https://openalex.org/W4313383136","https://openalex.org/W3082545754","https://openalex.org/W3048933529","https://openalex.org/W2960796899","https://openalex.org/W7118124766","https://openalex.org/W4406104571","https://openalex.org/W4411744952","https://openalex.org/W4310099679"],"abstract_inverted_index":{"T":[0,24,73,180,594],"cell":[1,74,260,305,451,458,595],"reconstitution":[2,75,596],"after":[3,105,155,210,255,295,309,335,422,597],"transplant":[4,16],"is":[5,76,95,453,465],"critically":[6],"dependent":[7],"on":[8,45,119,468],"the":[9,49,59,88,120,146,164,176,183,205,213,225,246,268,367,455,501,509],"thymus;":[10],"an":[11,79,316,379],"inverse":[12],"relationship":[13],"between":[14],"a":[15,42,52,96,191,286,300,569,584],"recipient's":[17],"age":[18],"and":[19,36,87,128,197,203,285,325,358,405,470,487,554,593],"their":[20],"capacity":[21],"to":[22,55,237,245,615],"generate":[23],"lymphocytes":[25],"(in":[26],"particular":[27],"CD4+T":[28],"cells)":[29],"has":[30,51],"been":[31],"found":[32],"in":[33,187,199,253,288,293,307,318,377,383,401,409,443,475,485,519,545,557],"several":[34],"studies,":[35],"thymic":[37,116,420,591],"function":[38,104,434],"pre-transplant":[39],"can":[40,263,449,537],"have":[41,110,504],"significant":[43],"impact":[44],"clinical":[46,97],"outcomes.":[47],"Although":[48],"thymus":[50,230,552],"remarkable":[53],"ability":[54],"repair":[56],"following":[57,234],"damage,":[58],"mechanisms":[60,149],"underlying":[61],"this":[62,69,272,491,535],"endogenous":[63],"regeneration":[64,266,421,592],"remain":[65,157],"poorly":[66],"understood.":[67],"Despite":[68],"regenerative":[70,217,426],"capacity,":[71],"delayed":[72],"associated":[77],"with":[78,221,271,478,547],"increased":[80,278,373,402,406],"risk":[81],"of":[82,85,90,122,166,178,185,207,215,228,248,267,280,303,366,375,397,457,512,526,559,613],"infections,":[83],"relapse":[84],"malignancy":[86],"development":[89],"secondary":[91],"malignancies.":[92],"Therefore,":[93,219],"there":[94],"demand":[98],"for":[99,195,360,589],"therapeutics":[100],"that":[101,150,163,204,224,243,345,416,474,507,534,601],"restore":[102],"immune":[103],"damage.":[106],"Our":[107,159],"recent":[108],"studies":[109],"identified":[111,162,364],"two":[112],"key":[113,192,229],"pathways":[114],"driving":[115],"regeneration;":[117,576],"centered":[118],"secretion":[121],"BMP4":[123,198],"by":[124,130,338,372,424,454,541,579,603],"endothelial":[125],"cells":[126,133,189,347],"(ECs)":[127],"IL-22":[129],"innate":[131],"lymphoid":[132],"(Dudakov":[134],"2012":[135],"Science":[136],"336:91;":[137],"Dudakov":[138],"2017":[139],"Blood130:933;":[140],"Wertheimer":[141],"2018":[142,355],"Sci":[143,356],"Immunol3:19).":[144],"However,":[145],"specific":[147],"regulatory":[148],"trigger":[151],"these":[152,216],"regeneration-associated":[153],"factors":[154,427,437],"damage":[156,211,256,310,336,392,423,598],"unclear.":[158],"previous":[160,343],"work":[161],"presence":[165],"homeostatic":[167],"apoptotic":[168,173,208],"CD4+CD8+":[169],"(DP)":[170],"thymocytes,":[171],"as":[172,428,430,447,600],"thymocytes":[174,209,353,399],"form":[175],"bulk":[177],"developing":[179],"cells,":[181],"suppress":[182],"production":[184,214],"IL-23":[186],"dendritic":[188],"(DCs),":[190],"downstream":[193],"mediator":[194],"IL-22,":[196],"ECs":[200],"(Fig.":[201,311,340,393,411,528,562],"1A),":[202],"depletion":[206],"precedes":[212],"factors.":[218],"together":[220],"our":[222,274,342,414],"findings":[223,344,565],"metabolic":[226,239,251,386],"needs":[227],"populations":[231],"alter":[232],"drastically":[233],"injury":[235,561],"due":[236],"damage-induced":[238],"remodeling,":[240],"we":[241,314,363,472,503,531],"hypothesized":[242],"further":[244,505],"loss":[247],"DP-specific":[249],"suppression,":[250],"dysfunction":[252],"DPs":[254,294,308],"triggers":[257],"mitochondrial-induced":[258,361],"pyroptotic":[259,304,398,439],"death,":[261],"which":[262,444,464,521],"directly":[264,431,582],"promote":[265],"thymus.":[269],"Consistent":[270],"hypothesis,":[273],"preliminary":[275],"data":[276],"shows":[277],"levels":[279,374],"cl-caspase":[281,289],"1":[282],"(pyroptotic":[283],"caspase)":[284,292],"decrease":[287],"3":[290],"(apoptotic":[291],"SL-TBI":[296,339],"(550":[297],"cGy),":[298],"demonstrating":[299],"preferential":[301],"induction":[302],"death":[306],"1B).":[312],"Furthermore,":[313,395],"demonstrated":[315,506],"increase":[317],"extracellular":[319],"lactate":[320],"dehydrogenase":[321],"(LDH)":[322],"levels,":[323],"HMGB-1":[324],"TNF\u237a[canonical":[326],"damage-associated":[327],"molecular":[328,572],"patterns":[329],"(DAMPs)":[330],"released":[331],"during":[332],"ICD]":[333],"acutely":[334],"caused":[337,602],"1C).Given":[341],"stromal":[346],"are":[348],"more":[349],"radio-resistant":[350],"than":[351],"DP":[352],"(Wertheimer":[354],"Immunol3:19),":[357],"evidence":[359],"pyroptosis,":[362],"hyperpolarization":[365],"mitochondrial":[368],"membrane":[369],"potential":[370],"accompanied":[371],"ROS":[376],"DPs,":[378],"effect":[380,492],"not":[381,566],"observed":[382],"TECs,":[384,469],"suggesting":[385],"stability":[387],"confers":[388],"protection":[389],"against":[390],"acute":[391,560],"1D).":[394],"co-culture":[396],"results":[400],"IL12p40+":[403],"DCs":[404],"Foxn1":[407,484,517],"expression":[408,518],"TECs":[410],"1E),":[412],"strengthening":[413],"hypothesis":[415],"cell-cell":[417],"communication":[418],"drives":[419],"inducing":[425],"well":[429],"promoting":[432],"TEC":[433],"via":[435],"secreted":[436],"from":[438,500],"DPs.":[440],"One":[441],"way":[442],"DAMPs,":[445],"such":[446,599],"ATP,":[448],"initiate":[450],"signaling":[452,544],"activation":[456,497],"surface":[459],"purinergic":[460],"receptors,":[461],"including":[462],"P2Y2":[463,481,488,496,543],"widely":[466],"expressed":[467],"here":[471,533],"demonstrate":[473,532],"vitro":[476],"treatment":[477],"ATP":[479,550],"or":[480,549,606],"agonist":[482],"increases":[483],"cTECs,":[486,520],"antagonism":[489],"reverses":[490],"(Fig":[493],"1F).":[494],"As":[495],"promotes":[498],"Ca2+efflux":[499],"ER,":[502],"stimulating":[508],"intracellular":[510],"release":[511],"Ca2+,":[513],"using":[514],"tunicamycin,":[515],"induced":[516],"was":[522],"reversed":[523],"upon":[524],"inhibition":[525],"Ca2+release":[527],"1G).":[529],"Importantly,":[530],"pathway":[536],"be":[538],"therapeutically":[539],"targeted":[540],"activating":[542],"vivo":[546],"MRS2568":[548],"enhances":[551],"cellularity":[553],"expands":[555],"cTECs":[556],"models":[558],"1H&I).":[563],"These":[564],"only":[567],"reveal":[568],"novel":[570],"metabolic-mediated":[571],"mechanism":[573],"governing":[574],"tissue":[575],"but":[577],"also":[578],"targeting":[580],"FOXN1":[581],"offers":[583],"potentially":[585],"superior":[586],"therapeutic":[587],"strategy":[588],"boosting":[590],"HCT,":[604],"infection":[605],"cytoreductive":[607],"therapy.":[608],"Disclosures":[609],"No":[610],"relevant":[611],"conflicts":[612],"interest":[614],"declare.":[616]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2020-11-09T00:00:00"}