{"id":"https://openalex.org/W3096045819","doi":null,"title":"Studies of the epidemiology of human herpesvirus 6","display_name":"Studies of the epidemiology of human herpesvirus 6","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W3096045819","mag":"3096045819"},"language":"en","primary_location":{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10110185","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10110185/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109410397","display_name":"Julie D. Fox","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Julie D. Fox","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5109410397"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.635699987411499,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.635699987411499,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.3544999957084656,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-herpesvirus-6","display_name":"human herpesvirus 6","score":0.996999979019165},{"id":"https://openalex.org/keywords/viral-reactivation","display_name":"viral reactivation","score":0.8220000267028809},{"id":"https://openalex.org/keywords/reinfection","display_name":"reinfection","score":0.7110000252723694},{"id":"https://openalex.org/keywords/viral-coinfection","display_name":"viral coinfection","score":0.6370000243186951},{"id":"https://openalex.org/keywords/tissue-tropism","display_name":"tissue tropism","score":0.8830000162124634},{"id":"https://openalex.org/keywords/lymphoproliferative-disorders","display_name":"lymphoproliferative disorders","score":0.9409999847412109}],"concepts":[{"id":"https://openalex.org/C504460877","wikidata":"https://www.wikidata.org/wiki/Q155925","display_name":"Saliva","level":2,"score":0.5891774892807007},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5672782063484192},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5636280179023743},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5438123941421509},{"id":"https://openalex.org/C45189115","wikidata":"https://www.wikidata.org/wiki/Q502159","display_name":"Serology","level":3,"score":0.5372599959373474},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5116379857063293},{"id":"https://openalex.org/C2777399126","wikidata":"https://www.wikidata.org/wiki/Q6974","display_name":"Human herpesvirus 6","level":5,"score":0.49096348881721497},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4774263799190521},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.46877163648605347},{"id":"https://openalex.org/C2779820661","wikidata":"https://www.wikidata.org/wiki/Q6929","display_name":"Human cytomegalovirus","level":3,"score":0.45579278469085693},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.44312289357185364},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4426164925098419},{"id":"https://openalex.org/C2777732132","wikidata":"https://www.wikidata.org/wiki/Q6946","display_name":"Cytomegalovirus","level":5,"score":0.4194566011428833},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3983760476112366},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.26881977915763855},{"id":"https://openalex.org/C2776409557","wikidata":"https://www.wikidata.org/wiki/Q149348","display_name":"Herpesviridae","level":4,"score":0.260606586933136},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14908596873283386},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10110185","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10110185/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},{"id":"mag:3096045819","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10110185/","pdf_url":null,"source":{"id":"https://openalex.org/S4306508231","display_name":"Doctoral thesis, UCL (University College London).","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W62428440","https://openalex.org/W2030310625","https://openalex.org/W2069353669","https://openalex.org/W2074467183","https://openalex.org/W2166421599","https://openalex.org/W2383307076","https://openalex.org/W2088023584","https://openalex.org/W1997043495","https://openalex.org/W1723150221","https://openalex.org/W161375833"],"abstract_inverted_index":{"A":[0,246],"new":[1],"human":[2,18,45,53],"herpes":[3,19],"virus":[4,20,341],"was":[5,16,163,174,227,256],"isolated":[6],"in":[7,35,109,132,170,183,202,235,308,314,322,335],"1986":[8],"from":[9,243,291],"patients":[10],"with":[11,44,52,60,147,176],"various":[12,295],"lymphoproliferative":[13],"disorders":[14],"and":[15,55,69,78,95,98,111,126,155,168,178,194,208,238,253,300,318,347],"designated":[17],"6":[21],"(HHV6).":[22],"This":[23],"thesis":[24],"describes":[25],"work":[26],"undertaken":[27],"to":[28,37,104,121,136,143,199,209,258,278,304,350],"define":[29],"the":[30,56,67,89,99,127,150,156,179,184,201,223,230,270,298,340,343],"epidemiology":[31,68],"of":[32,41,50,58,72,86,91,101,129,153,159,186,206,215,219,232,249,269,274,282,320,339],"HHV6":[33,42,51,59,73,92,123,130,148,161,165,207,216,220,233,260,283,309,312,321,332],"infection":[34,43,162],"order":[36],"determine":[38,200,305],"any":[39,211,306],"association":[40,214],"disease.":[46],"The":[47,84,272,324],"close":[48],"relationship":[49],"cytomegalovirus":[54],"interaction":[57],"other":[61,187],"viruses":[62],"are":[63,115,181,286],"discussed.":[64],"Work":[65],"on":[66,75],"pathogenic":[70],"significance":[71],"depends":[74],"having":[76],"sensitive":[77],"specific":[79,93],"assays":[80,87,103],"for":[81,88,229,267],"antibody":[82,97,106,124,166,310],"detection.":[83],"development":[85],"detection":[90,231],"IgM":[94],"IgG":[96],"use":[100],"these":[102],"establish":[105],"prevalence":[107,167],"levels":[108],"normal":[110],"patient":[112,172],"population":[113],"groups":[114,173],"described.":[116],"Most":[117],"adults":[118,133],"were":[119,134,141,197,289],"found":[120,142,257],"be":[122,259],"positive":[125],"majority":[128],"infections":[131],"due":[135],"reactivation":[137,281],"or":[138],"reinfection.":[139],"Children":[140],"have":[144,265],"been":[145],"infected":[146],"during":[149,284,297,342],"first":[151],"year":[152],"life":[154],"clinical":[157],"consequences":[158],"primary":[160],"investigated.":[164],"titre":[169],"adult":[171],"compared":[175],"controls":[177],"results":[180,273,334],"discussed":[182,327],"context":[185],"published":[188],"serological":[189],"reports.":[190],"In":[191],"situ":[192],"hybridization":[193],"immunohistochemical":[195],"staining":[196],"used":[198,228],"vivo":[203],"tissue":[204],"tropism":[205],"investigate":[210,279],"potential":[212],"disease":[213],"infection.":[217],"Amplification":[218],"DNA":[221,234,261,313],"by":[222],"polymerase":[224],"chain":[225],"reaction":[226],"saliva":[236,254],"samples":[237,255,317],"peripheral":[239,315],"blood":[240,316],"mononuclear":[241],"cells":[242],"healthy":[244],"individuals.":[245],"large":[247],"proportion":[248],"salivary":[250],"gland":[251],"tissues":[252],"positive,":[262],"which":[263,333],"may":[264],"implications":[266],"transmission":[268,349],"virus.":[271],"a":[275],"prospective":[276],"study":[277],"possible":[280],"pregnancy":[285],"presented.":[287],"Samples":[288],"taken":[290],"pregnant":[292,329],"women":[293,330],"at":[294],"times":[296],"antenatal":[299],"early":[301,344],"postnatal":[302,345],"period":[303,346],"change":[307],"profile,":[311],"shedding":[319,338],"saliva.":[323],"postulate":[325],"is":[326],"that":[328],"reactivate":[331],"increased":[336],"salival":[337],"thus":[348],"their":[351],"newborn":[352],"offspring.":[353]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2020-11-09T00:00:00"}