{"id":"https://openalex.org/W3095667367","doi":"https://doi.org/10.3389/fimmu.2020.580335","title":"The Change of Soluble Programmed Cell Death-Ligand 1 in Glioma Patients Receiving Radiotherapy and Its Impact on Clinical Outcomes","display_name":"The Change of Soluble Programmed Cell Death-Ligand 1 in Glioma Patients Receiving Radiotherapy and Its Impact on Clinical Outcomes","publication_year":2020,"publication_date":"2020-10-30","ids":{"openalex":"https://openalex.org/W3095667367","doi":"https://doi.org/10.3389/fimmu.2020.580335","mag":"3095667367","pmid":"https://pubmed.ncbi.nlm.nih.gov/33224142","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7668030"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2020.580335","doi":"https://doi.org/10.3389/fimmu.2020.580335","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2020.580335","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2020.580335/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2020.580335/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111033592","display_name":"Xingchen Ding","orcid":"https://orcid.org/0000-0002-4229-5340","observed_orcids":["https://orcid.org/0000-0002-4229-5340"]},"institutions":[{"id":"https://openalex.org/I4210100830","display_name":"Shandong Tumor Hospital","ror":"https://ror.org/01413r497","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210100830"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xing-Chen Ding","raw_affiliation_strings":["Department of Oncology, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China","Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China","institution_ids":["https://openalex.org/I4210163399"]},{"raw_affiliation_string":"Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China","institution_ids":["https://openalex.org/I4210100830","https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100462044","display_name":"Liangliang Wang","orcid":"https://orcid.org/0000-0001-8340-5190","observed_orcids":["https://orcid.org/0000-0001-8340-5190"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liang-Liang Wang","raw_affiliation_strings":["Department of Radiation and Cellular Oncology, Ludwig Center for Metastasis Research, The University of Chicago, Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation and Cellular Oncology, Ludwig Center for Metastasis Research, The University of Chicago, Chicago, IL, United States","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053045291","display_name":"Yufang Zhu","orcid":"https://orcid.org/0000-0003-0300-5192","observed_orcids":["https://orcid.org/0000-0003-0300-5192"]},"institutions":[{"id":"https://openalex.org/I4210100830","display_name":"Shandong Tumor Hospital","ror":"https://ror.org/01413r497","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210100830"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu-Fang Zhu","raw_affiliation_strings":["Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China","institution_ids":["https://openalex.org/I4210100830","https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100622348","display_name":"Yandong Li","orcid":"https://orcid.org/0000-0001-8153-081X","observed_orcids":["https://orcid.org/0000-0001-8153-081X"]},"institutions":[{"id":"https://openalex.org/I4210162087","display_name":"Affiliated Hospital of Jining Medical University","ror":"https://ror.org/05e8kbn88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162087"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan-Dong Li","raw_affiliation_strings":["Department of Anesthesiology, Affiliated Hospital of Jining Medical University, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Affiliated Hospital of Jining Medical University, Jinan, China","institution_ids":["https://openalex.org/I4210162087"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shu-Lun Nie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100830","display_name":"Shandong Tumor Hospital","ror":"https://ror.org/01413r497","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210100830"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shu-Lun Nie","raw_affiliation_strings":["Department of Oncology, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China","Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China","institution_ids":["https://openalex.org/I4210163399"]},{"raw_affiliation_string":"Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China","institution_ids":["https://openalex.org/I4210100830","https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101754229","display_name":"Jia Yang","orcid":"https://orcid.org/0000-0001-5218-8218","observed_orcids":["https://orcid.org/0000-0001-5218-8218"]},"institutions":[{"id":"https://openalex.org/I4210100830","display_name":"Shandong Tumor Hospital","ror":"https://ror.org/01413r497","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210100830"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia Yang","raw_affiliation_strings":["Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China","institution_ids":["https://openalex.org/I4210100830","https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102854287","display_name":"Hua Laura Liang","orcid":"https://orcid.org/0000-0001-5512-8595","observed_orcids":["https://orcid.org/0000-0001-5512-8595"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hua Liang","raw_affiliation_strings":["Department of Radiation and Cellular Oncology, Ludwig Center for Metastasis Research, The University of Chicago, Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation and Cellular Oncology, Ludwig Center for Metastasis Research, The University of Chicago, Chicago, IL, United States","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054855052","display_name":"Ralph R. Weichselbaum","orcid":"https://orcid.org/0000-0002-5643-8939","observed_orcids":["https://orcid.org/0000-0002-5643-8939"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph R. Weichselbaum","raw_affiliation_strings":["Department of Radiation and Cellular Oncology, Ludwig Center for Metastasis Research, The University of Chicago, Chicago, IL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation and Cellular Oncology, Ludwig Center for Metastasis Research, The University of Chicago, Chicago, IL, United States","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100648209","display_name":"Jinming Yu","orcid":"https://orcid.org/0000-0001-5933-9912","observed_orcids":["https://orcid.org/0000-0001-5933-9912"]},"institutions":[{"id":"https://openalex.org/I4210100830","display_name":"Shandong Tumor Hospital","ror":"https://ror.org/01413r497","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210100830"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jin-Ming Yu","raw_affiliation_strings":["Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China","institution_ids":["https://openalex.org/I4210100830","https://openalex.org/I4210163399"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038178490","display_name":"Man Hu","orcid":"https://orcid.org/0000-0003-4409-286X","observed_orcids":["https://orcid.org/0000-0003-4409-286X"]},"institutions":[{"id":"https://openalex.org/I4210100830","display_name":"Shandong Tumor Hospital","ror":"https://ror.org/01413r497","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210100830"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Man Hu","raw_affiliation_strings":["Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China","institution_ids":["https://openalex.org/I4210100830","https://openalex.org/I4210163399"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5038178490","https://openalex.org/A5100648209"],"corresponding_institution_ids":["https://openalex.org/I4210100830","https://openalex.org/I4210163399"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.692,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.680428,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"11","issue":null,"first_page":"580335","last_page":"580335"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.8773999810218811,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.8773999810218811,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.11869999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/soluble-pd-l1","display_name":"soluble PD-L1","score":0.9459999799728394},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.9340000152587891},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.9900000095367432},{"id":"https://openalex.org/keywords/circulating-tumor-markers","display_name":"circulating tumor markers","score":0.7689999938011169},{"id":"https://openalex.org/keywords/idh1-mutation","display_name":"IDH1 mutation","score":0.9739999771118164},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.8640000224113464},{"id":"https://openalex.org/keywords/pd-l1-inhibitors","display_name":"PD-L1 inhibitors","score":0.8949999809265137},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.8230000138282776},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.6819999814033508},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9620000123977661}],"concepts":[{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.833773136138916},{"id":"https://openalex.org/C2777150147","wikidata":"https://www.wikidata.org/wiki/Q261968","display_name":"Isocitrate dehydrogenase","level":3,"score":0.7779392004013062},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7670280933380127},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.638113260269165},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6332448124885559},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5443427562713623},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5305343866348267},{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.43155378103256226},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.408652126789093},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3324200510978699},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2076452672481537},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09912598133087158},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.08981451392173767},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007521","descriptor_name":"Isocitrate Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2020.580335","doi":"https://doi.org/10.3389/fimmu.2020.580335","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2020.580335","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2020.580335/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmid:33224142","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33224142","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7668030","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7668030/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:18249c2a09c04ffaa64760f4783df0be","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/18249c2a09c04ffaa64760f4783df0be","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 11 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2020.580335","doi":"https://doi.org/10.3389/fimmu.2020.580335","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2020.580335","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2020.580335/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1991414251","display_name":null,"funder_award_id":"2019-04","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G4056579318","display_name":null,"funder_award_id":"2019-04","funder_id":"https://openalex.org/F4320328999","funder_display_name":"Shandong First Medical University"},{"id":"https://openalex.org/G4371663478","display_name":null,"funder_award_id":"2019ZL002","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G5767903527","display_name":null,"funder_award_id":"2019GGX101057","funder_id":"https://openalex.org/F4320333596","funder_display_name":"Key Technology Research and Development Program of Shandong"},{"id":"https://openalex.org/G5903270158","display_name":null,"funder_award_id":"2019-04","funder_id":"https://openalex.org/F4320329000","funder_display_name":"Shandong Academy of Medical Sciences"},{"id":"https://openalex.org/G6813374813","display_name":null,"funder_award_id":"2019ZL002","funder_id":"https://openalex.org/F4320329000","funder_display_name":"Shandong Academy of Medical Sciences"},{"id":"https://openalex.org/G6986831259","display_name":null,"funder_award_id":"2019ZL002","funder_id":"https://openalex.org/F4320328999","funder_display_name":"Shandong First Medical University"},{"id":"https://openalex.org/G7261853453","display_name":null,"funder_award_id":"2018YFE0114100","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G7622468739","display_name":null,"funder_award_id":"2018YFE0114100","funder_id":"https://openalex.org/F4320336026","funder_display_name":"National Key Research and Development Program of China Stem Cell and Translational Research"}],"funders":[{"id":"https://openalex.org/F4320328999","display_name":"Shandong First Medical University","ror":null},{"id":"https://openalex.org/F4320329000","display_name":"Shandong Academy of Medical Sciences","ror":"https://ror.org/05jb9pq57"},{"id":"https://openalex.org/F4320333596","display_name":"Key Technology Research and Development Program of Shandong","ror":null},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320336026","display_name":"National Key Research and Development Program of China Stem Cell and Translational Research","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3095667367.pdf","grobid_xml":"https://content.openalex.org/works/W3095667367.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1811917379","https://openalex.org/W1953828328","https://openalex.org/W2064994363","https://openalex.org/W2073125824","https://openalex.org/W2088763423","https://openalex.org/W2098746033","https://openalex.org/W2106050839","https://openalex.org/W2125616358","https://openalex.org/W2145758395","https://openalex.org/W2148977460","https://openalex.org/W2324094374","https://openalex.org/W2604996547","https://openalex.org/W2605377619","https://openalex.org/W2615165013","https://openalex.org/W2615603032","https://openalex.org/W2618677300","https://openalex.org/W2742534733","https://openalex.org/W2762777471","https://openalex.org/W2764040657","https://openalex.org/W2765809081","https://openalex.org/W2772391116","https://openalex.org/W2784868445","https://openalex.org/W2792937256","https://openalex.org/W2793255936","https://openalex.org/W2794763378","https://openalex.org/W2796584001","https://openalex.org/W2891760302","https://openalex.org/W2900529161","https://openalex.org/W2916635720","https://openalex.org/W2954542121","https://openalex.org/W2975969522","https://openalex.org/W3000082715","https://openalex.org/W3002118723","https://openalex.org/W3084251573","https://openalex.org/W4234865248","https://openalex.org/W4239429986"],"related_works":["https://openalex.org/W4239429986","https://openalex.org/W3208376916","https://openalex.org/W3093549692","https://openalex.org/W3002118723","https://openalex.org/W3004916741","https://openalex.org/W3089400946","https://openalex.org/W2977275234","https://openalex.org/W4200311763","https://openalex.org/W3157536493","https://openalex.org/W2909158562"],"abstract_inverted_index":{"Background:":[0],"The":[1,70,139,172,187,264],"programmed":[2,44],"cell":[3],"death":[4],"ligand":[5],"1":[6,46],"(PD-L1)":[7],"plays":[8],"a":[9,30,239,252,276],"key":[10],"role":[11,25],"in":[12,52,62,82,212,220,259],"glioma":[13,63,86,107,227,260,288],"development.":[14],"However,":[15,57],"due":[16],"to":[17,76,93,159,255],"the":[18,24,40,58,78,83,131,198,208,257,273],"specificity":[19],"of":[20,26,42,60,72,80,85,148,210,226,267,275,278],"glioma's":[21],"anatomical":[22],"position,":[23],"its":[27,95],"expression":[28,59,147],"as":[29],"tumor":[31],"biomarker":[32,254],"is":[33],"limited.":[34],"It":[35],"has":[36],"been":[37],"proven":[38],"that":[39,207,219,231,248,272],"levels":[41,133],"soluble":[43],"death-ligand":[45],"(sPD-L1)":[47],"are":[48,165],"associated":[49],"with":[50,97,110,181,235,293],"prognosis":[51],"many":[53],"malignancies":[54],"including":[55],"glioma.":[56],"sPD-L1":[61,81,132,163,175,211,249,268],"patients":[64,87,108,215,261],"receiving":[65,262],"radiotherapy":[66],"(RT)":[67],"remains":[68],"unclear.":[69],"purpose":[71],"this":[73],"study":[74,246],"was":[75,216],"evaluate":[77],"concentration":[79],"plasma":[84],"before":[88,125],"and":[89,92,104,120,126,145,176,191,282],"after":[90,127,269],"RT":[91,111,236,270,283],"explore":[94],"relationship":[96],"clinical":[98,177],"outcomes.":[99],"Methods:":[100],"Between":[101],"October":[102],"2017":[103],"September":[105],"2018,":[106],"treated":[109],"(30":[112],"\u00b1":[113],"10":[114],"Gy,":[115],"2":[116],"Gy/f)":[117],"were":[118,123,150,157,179,195],"enrolled,":[119],"blood":[121],"samples":[122],"collected":[124],"RT.":[128,263],"We":[129],"quantified":[130],"by":[134,152,168,197],"enzyme-linked":[135],"immunosorbent":[136],"assay":[137],"(ELISA).":[138],"isocitrate":[140],"dehydrogenase-1":[141],"(IDH-1)":[142],"mutational":[143],"status":[144],"Ki-67":[146],"tumors":[149],"evaluated":[151],"immunohistochemistry.":[153],"Glioma":[154],"murine":[155,228],"model":[156,229],"used":[158],"address":[160],"whether":[161],"circulating":[162],"molecules":[164],"directly":[166],"targeted":[167],"an":[169,224],"anti-PD-L1":[170,232],"antibody.":[171],"associations":[173],"between":[174],"features":[178],"assessed":[180],"Pearson's":[182],"or":[183],"Spearman's":[184],"correlation":[185],"analysis.":[186],"progression-free":[188],"survival":[189,193],"(PFS)":[190],"overall":[192],"(OS)":[194],"determined":[196],"Kaplan-Meier":[199],"method.":[200],"Results:":[201],"<":[202],"0.001).":[203],"Further":[204],"analysis":[205,225],"showed":[206],"level":[209,266],"IDH-1":[213,294],"mutation":[214],"higher":[217],"than":[218],"wild-type":[221],"patients.":[222],"Furthermore,":[223],"indicated":[230],"antibody":[233],"combine":[234],"can":[237],"be":[238,251,285],"potentially":[240],"powerful":[241],"cancer":[242],"therapy.":[243],"Conclusion:":[244],"This":[245],"reported":[247],"might":[250,284],"potential":[253],"predict":[256],"outcome":[258],"elevated":[265],"suggested":[271],"strategy":[274],"combination":[277],"immune":[279],"checkpoint":[280],"inhibitors":[281],"promising":[286],"for":[287,291],"patients,":[289],"especially":[290],"those":[292],"mutations.":[295]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-11-09T00:00:00"}