{"id":"https://openalex.org/W3095642005","doi":"https://doi.org/10.34115/basrv4n5-029","title":"ATM Polymorphisms and their Relationship to Radiation Toxicity in Breast Cancer Patients / Polimorfismos ATM e sua rela\u00e7\u00e3o com a toxicidade por radia\u00e7\u00e3o em pacientes com c\u00e2ncer de mama","display_name":"ATM Polymorphisms and their Relationship to Radiation Toxicity in Breast Cancer Patients / Polimorfismos ATM e sua rela\u00e7\u00e3o com a toxicidade por radia\u00e7\u00e3o em pacientes com c\u00e2ncer de mama","publication_year":2020,"publication_date":"2020-10-22","ids":{"openalex":"https://openalex.org/W3095642005","doi":"https://doi.org/10.34115/basrv4n5-029","mag":"3095642005"},"language":"en","primary_location":{"id":"doi:10.34115/basrv4n5-029","doi":"https://doi.org/10.34115/basrv4n5-029","is_oa":true,"landing_page_url":"https://doi.org/10.34115/basrv4n5-029","pdf_url":null,"source":{"id":"https://openalex.org/S4210221185","display_name":"Brazilian Applied Science Review","issn_l":"2595-3621","issn":["2595-3621"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["erih-plus"],"host_organization":"https://openalex.org/P4310312106","host_organization_name":"Brazilian Journal of Development","host_organization_lineage":["https://openalex.org/P4310312106"],"host_organization_lineage_names":["Brazilian Journal of Development"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brazilian Applied Science Review","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.34115/basrv4n5-029","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049180547","display_name":"Satyaki Afonso Navinchandra","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Satyaki Afonso Navinchandra","raw_affiliation_strings":["University Sector"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Sector","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054864564","display_name":"Pollyana Rodrigues Pimenta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pollyana Rodrigues Pimenta","raw_affiliation_strings":["University Sector"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Sector","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018917500","display_name":"Jo\u00e3o Lino Franco Borges","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jo\u00e3o Lino Franco Borges","raw_affiliation_strings":["University Sector"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Sector","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079475430","display_name":"Ant\u00f4nio M\u00e1rcio Teodoro Cordeiro Silva","orcid":"https://orcid.org/0000-0003-0645-3599","observed_orcids":["https://orcid.org/0000-0003-0645-3599"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antonio M\u00e1rcio Teodoro Cordeiro Silva","raw_affiliation_strings":["University Sector"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Sector","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046574888","display_name":"Juliana Castro Dourado Pinezi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juliana Castro Dourado Pinezi","raw_affiliation_strings":["University Sector"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Sector","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112759957","display_name":"Yuri de Abreu Mendon\u00e7a","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuri de Abreu Mendon\u00e7a","raw_affiliation_strings":["University Sector"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Sector","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101776911","display_name":"Jos\u00e9 Cl\u00e1udio Casali da Rocha","orcid":"https://orcid.org/0000-0002-1838-2153","observed_orcids":["https://orcid.org/0000-0002-1838-2153"]},"institutions":[{"id":"https://openalex.org/I4210107299","display_name":"Hospital Erasto Gaertner","ror":"https://ror.org/01nfh3016","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210107299"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jose Claudio Casali da Rocha","raw_affiliation_strings":["Hospital Erasto Graetner, Servi\u00e7o de Oncogen\u00e9tica"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Erasto Graetner, Servi\u00e7o de Oncogen\u00e9tica","institution_ids":["https://openalex.org/I4210107299"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090915199","display_name":"Renata de Bastos Ascen\u00e7o Soares","orcid":"https://orcid.org/0000-0003-1029-325X","observed_orcids":["https://orcid.org/0000-0003-1029-325X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Renata de Bastos Ascen\u00e7o Soares","raw_affiliation_strings":["University Sector"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Sector","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"4","issue":"5","first_page":"3123","last_page":"3148"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.7797999978065491,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.7797999978065491,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.08410000056028366,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.07769999653100967,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atm-gene","display_name":"ATM gene","score":0.9580000042915344},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9789999723434448},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9649999737739563},{"id":"https://openalex.org/keywords/radiotherapy-toxicity","display_name":"radiotherapy toxicity","score":0.902999997138977},{"id":"https://openalex.org/keywords/late-skin-toxicity","display_name":"late skin toxicity","score":0.7960000038146973},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7260000109672546},{"id":"https://openalex.org/keywords/personalized-radiotherapy","display_name":"personalized radiotherapy","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5433909893035889},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.529988706111908},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5026366710662842},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49895262718200684},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4934767484664917},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41611039638519287},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3322848081588745}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.34115/basrv4n5-029","doi":"https://doi.org/10.34115/basrv4n5-029","is_oa":true,"landing_page_url":"https://doi.org/10.34115/basrv4n5-029","pdf_url":null,"source":{"id":"https://openalex.org/S4210221185","display_name":"Brazilian Applied Science Review","issn_l":"2595-3621","issn":["2595-3621"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["erih-plus"],"host_organization":"https://openalex.org/P4310312106","host_organization_name":"Brazilian Journal of Development","host_organization_lineage":["https://openalex.org/P4310312106"],"host_organization_lineage_names":["Brazilian Journal of Development"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brazilian Applied Science Review","raw_type":"journal-article"},{"id":"pmh:oai:ojs2.ojs.brazilianjournals.com.br:article/18605","doi":null,"is_oa":false,"landing_page_url":"https://ojs.brazilianjournals.com.br/ojs/index.php/BASR/article/view/18605","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:FIEP","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.34115/basrv4n5-029","doi":"https://doi.org/10.34115/basrv4n5-029","is_oa":true,"landing_page_url":"https://doi.org/10.34115/basrv4n5-029","pdf_url":null,"source":{"id":"https://openalex.org/S4210221185","display_name":"Brazilian Applied Science Review","issn_l":"2595-3621","issn":["2595-3621"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["erih-plus"],"host_organization":"https://openalex.org/P4310312106","host_organization_name":"Brazilian Journal of Development","host_organization_lineage":["https://openalex.org/P4310312106"],"host_organization_lineage_names":["Brazilian Journal of Development"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brazilian Applied Science Review","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320321837","display_name":"Ministerio de Econom\u00eda y Competitividad","ror":"https://ror.org/034900433"},{"id":"https://openalex.org/F4320321992","display_name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia e Inova\u00e7\u00e3o","ror":"https://ror.org/050zdnc69"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322904","display_name":"Financiadora de Estudos e Projetos","ror":"https://ror.org/030w99567"},{"id":"https://openalex.org/F4320323204","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Goi\u00e1s","ror":"https://ror.org/00w8cq239"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1979081265","https://openalex.org/W2001815897","https://openalex.org/W2012177834","https://openalex.org/W2014927158","https://openalex.org/W2017262213","https://openalex.org/W2026388494","https://openalex.org/W2029313959","https://openalex.org/W2033138450","https://openalex.org/W2040931790","https://openalex.org/W2046247026","https://openalex.org/W2050762542","https://openalex.org/W2075542946","https://openalex.org/W2088754604","https://openalex.org/W2089667219","https://openalex.org/W2114061012","https://openalex.org/W2116163701","https://openalex.org/W2136078375","https://openalex.org/W2153684756","https://openalex.org/W2735495803","https://openalex.org/W2750741153","https://openalex.org/W2760874931","https://openalex.org/W2790131403","https://openalex.org/W2792571019"],"related_works":["https://openalex.org/W7120557254","https://openalex.org/W2806468168","https://openalex.org/W2899207983","https://openalex.org/W2990310159","https://openalex.org/W4393978909","https://openalex.org/W1954722189","https://openalex.org/W2113246498","https://openalex.org/W2042216248","https://openalex.org/W2021675765","https://openalex.org/W2591971087"],"abstract_inverted_index":{"Aims:":[0],"The":[1,86,156],"breast":[2,68],"cancer":[3,69,136],"is":[4,260],"one":[5],"of":[6,27,35,45,62,79,84,132,146,159,168,173,191,217,222,270,289,298,319,323,325],"the":[7,33,55,97,147,165,182,202,223,283,296,302,317],"most":[8],"common":[9],"types":[10],"and":[11,20,82,96,129,164,237,315,321],"it":[12],"treatment":[13,304,320],"brings":[14],"complications":[15,314],"such":[16],"as":[17,77],"skin,":[18],"dermis":[19],"subcutaneous":[21,256],"toxicity.":[22],"Studies":[23],"about":[24],"genetic":[25],"variations":[26],"patients":[28,66,98,133,160,185,200,312],"are":[29],"those":[30],"that":[31],"enable":[32],"identification":[34],"prognostic":[36],"factors":[37],"for":[38,140,205,248,311],"treatment,":[39],"generally":[40],"based":[41,123],"on":[42,124],"greater":[43],"risk":[44,216,247],"injury":[46],"to":[47,179,196,280,295],"healthy":[48],"tissue.":[49,300],"Study":[50],"design:":[51],"This":[52],"study":[53,87],"examined":[54],"association":[56],"between":[57],"single":[58,284],"nucleotide":[59],"polymorphisms":[60,212,228],"(SNPs)":[61],"ATM":[63,148,259],"gene":[64,149,263,291],"in":[65,74,127,276],"with":[67,70,134,264,305],"adverse":[71],"reactions":[72],"presented":[73],"normal":[75,299],"tissues":[76],"result":[78],"radiotherapy.":[80],"Place":[81],"Duration":[83],"Study:":[85],"was":[88,161,170],"conduct":[89],"at":[90,101,141,255],"Pontif\u00edcia":[91],"Universidade":[92],"Cat\u00f3lica":[93],"de":[94,106],"Goi\u00e1s,":[95,111],"were":[99,150],"recruited":[100],"Hospital":[102],"Ara\u00fajo":[103],"Jorge,":[104],"Associa\u00e7\u00e3o":[105],"Combate":[107],"ao":[108],"C\u00e2ncer":[109],"em":[110],"Radiotherapy":[112],"Service.":[113],"Methodology:":[114],"We":[115],"evaluated":[116],"76":[117],"patients,":[118],"through":[119],"a":[120,188,261],"retrospective":[121],"study,":[122],"data":[125],"contained":[126],"records":[128,131],"teletherapy":[130],"this":[135,290],"who":[137,209],"underwent":[138],"radiotherapy":[139],"least":[142],"5":[143],"years.":[144],"Polymorphisms":[145],"analyzed":[151,186],"by":[152],"microarray":[153],"technique.":[154],"Results:":[155],"mean":[157],"age":[158],"50":[162],"years":[163],"total":[166],"dose":[167],"radiation":[169,203,307],"an":[171,245],"average":[172],"50,21":[174],"Gy":[175],"ranging":[176],"from":[177],"45Gy":[178],"50.4Gy.":[180],"Regarding":[181],"late":[183,250],"toxicities,":[184],"showed":[187],"higher":[189],"frequency":[190],"low-grade":[192],"morbidities":[193],"when":[194],"compared":[195],"high":[197],"grade.":[198],"Nineteen":[199],"interrupted":[201],"therapy":[204],"any":[206],"reason.":[207],"Patients":[208,226],"have":[210,213],"studied":[211],"no":[214],"increased":[215,246],"developing":[218,249],"acute":[219],"toxicity":[220,297],"changes":[221],"skin.":[224],"(P>.05).":[225],"presenting":[227],"AX-8315255":[229],"(TTT":[230],"insertion)":[231],"(RR=11.0,":[232,239],"1.08":[233,240],"-":[234,241],"111.97,":[235,242],"p=0.045)":[236,243],"rs56128736":[238],"had":[244],"skin":[251],"toxicity,":[252],"but":[253],"not":[254],"tract.":[257],"Conclusion:":[258],"large":[262],"many":[265],"variants":[266,286],"documented.":[267],"Association":[268],"studies":[269],"these":[271],"SNPs":[272],"will":[273],"be":[274,309],"needed":[275],"larger":[277],"sample":[278],"groups":[279],"establish":[281],"whether":[282],"base":[285],"or":[287],"haplotypes":[288],"may":[292],"indeed":[293],"contribute":[294],"Thus,":[301],"personalized":[303],"ionizing":[306],"can":[308],"prescribed":[310],"decreasing":[313],"improving":[316],"effectiveness":[318],"quality":[322],"life":[324],"patients.":[326]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2020-11-09T00:00:00"}
