{"id":"https://openalex.org/W3095615497","doi":"https://doi.org/10.1002/ijc.33383","title":"Targeting stromal cell Syndecan\u20102 reduces breast tumour growth, metastasis and limits immune evasion","display_name":"Targeting stromal cell Syndecan\u20102 reduces breast tumour growth, metastasis and limits immune evasion","publication_year":2020,"publication_date":"2020-11-05","ids":{"openalex":"https://openalex.org/W3095615497","doi":"https://doi.org/10.1002/ijc.33383","mag":"3095615497","pmid":"https://pubmed.ncbi.nlm.nih.gov/33152121","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7839764"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.33383","doi":"https://doi.org/10.1002/ijc.33383","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.33383","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.33383","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.33383","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063769039","display_name":"Paul Loftus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]},{"id":"https://openalex.org/I4210161530","display_name":"Orbsen Therapeutics (Ireland)","ror":"https://ror.org/056h3fs04","country_code":"IE","type":"company","lineage":["https://openalex.org/I4210161530"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Paul G. Loftus","raw_affiliation_strings":["Lambe Institute for Translational Research, National University of Ireland, Galway, Ireland","Orbsen Therapeutics, National University of Ireland, Galway, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lambe Institute for Translational Research, National University of Ireland, Galway, Ireland","institution_ids":["https://openalex.org/I188760350"]},{"raw_affiliation_string":"Orbsen Therapeutics, National University of Ireland, Galway, Ireland","institution_ids":["https://openalex.org/I188760350","https://openalex.org/I4210161530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066777800","display_name":"Luke Watson","orcid":"https://orcid.org/0000-0003-1200-6023","observed_orcids":["https://orcid.org/0000-0003-1200-6023"]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Luke Watson","raw_affiliation_strings":["Lambe Institute for Translational Research, National University of Ireland, Galway, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lambe Institute for Translational Research, National University of Ireland, Galway, Ireland","institution_ids":["https://openalex.org/I188760350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075683423","display_name":"Laura Deedigan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]},{"id":"https://openalex.org/I4210161530","display_name":"Orbsen Therapeutics (Ireland)","ror":"https://ror.org/056h3fs04","country_code":"IE","type":"company","lineage":["https://openalex.org/I4210161530"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Laura M. Deedigan","raw_affiliation_strings":["Orbsen Therapeutics, National University of Ireland, Galway, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orbsen Therapeutics, National University of Ireland, Galway, Ireland","institution_ids":["https://openalex.org/I188760350","https://openalex.org/I4210161530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091194391","display_name":"Eva Camarillo\u2010Retamosa","orcid":"https://orcid.org/0000-0001-8004-8968","observed_orcids":["https://orcid.org/0000-0001-8004-8968"]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]},{"id":"https://openalex.org/I4210161530","display_name":"Orbsen Therapeutics (Ireland)","ror":"https://ror.org/056h3fs04","country_code":"IE","type":"company","lineage":["https://openalex.org/I4210161530"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Eva Camarillo\u2010Retamosa","raw_affiliation_strings":["Orbsen Therapeutics, National University of Ireland, Galway, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orbsen Therapeutics, National University of Ireland, Galway, Ireland","institution_ids":["https://openalex.org/I188760350","https://openalex.org/I4210161530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000083069","display_name":"R\u00f3is\u00edn M. Dwyer","orcid":"https://orcid.org/0000-0002-5854-0339","observed_orcids":["https://orcid.org/0000-0002-5854-0339"]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"R\u00f3is\u00edn M. Dwyer","raw_affiliation_strings":["Lambe Institute for Translational Research, National University of Ireland, Galway, Ireland"],"raw_orcid":"https://orcid.org/0000-0002-5854-0339","affiliations":[{"raw_affiliation_string":"Lambe Institute for Translational Research, National University of Ireland, Galway, Ireland","institution_ids":["https://openalex.org/I188760350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016286147","display_name":"Lisa O\u2019Flynn","orcid":"https://orcid.org/0000-0002-9054-0726","observed_orcids":["https://orcid.org/0000-0002-9054-0726"]},"institutions":[{"id":"https://openalex.org/I157286207","display_name":"National University of Ireland, Maynooth","ror":"https://ror.org/048nfjm95","country_code":"IE","type":"education","lineage":["https://openalex.org/I157286207"]},{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]},{"id":"https://openalex.org/I4210161530","display_name":"Orbsen Therapeutics (Ireland)","ror":"https://ror.org/056h3fs04","country_code":"IE","type":"company","lineage":["https://openalex.org/I4210161530"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Lisa O'Flynn","raw_affiliation_strings":["Lisa O'Flynn, Avectas Ltd, Maynooth University, Co Kildare, Ireland","Orbsen Therapeutics, National University of Ireland, Galway, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lisa O'Flynn, Avectas Ltd, Maynooth University, Co Kildare, Ireland","institution_ids":["https://openalex.org/I157286207"]},{"raw_affiliation_string":"Orbsen Therapeutics, National University of Ireland, Galway, Ireland","institution_ids":["https://openalex.org/I188760350","https://openalex.org/I4210161530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062232837","display_name":"Senthilkumar Alagesan","orcid":"https://orcid.org/0000-0002-8302-1282","observed_orcids":["https://orcid.org/0000-0002-8302-1282"]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]},{"id":"https://openalex.org/I4210161530","display_name":"Orbsen Therapeutics (Ireland)","ror":"https://ror.org/056h3fs04","country_code":"IE","type":"company","lineage":["https://openalex.org/I4210161530"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Senthilkumar Alagesan","raw_affiliation_strings":["Orbsen Therapeutics, National University of Ireland, Galway, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orbsen Therapeutics, National University of Ireland, Galway, Ireland","institution_ids":["https://openalex.org/I188760350","https://openalex.org/I4210161530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030580193","display_name":"Matthew Dallas Griffin","orcid":"https://orcid.org/0000-0002-8701-8056","observed_orcids":["https://orcid.org/0000-0002-8701-8056"]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Matthew Griffin","raw_affiliation_strings":["Lambe Institute for Translational Research, National University of Ireland, Galway, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lambe Institute for Translational Research, National University of Ireland, Galway, Ireland","institution_ids":["https://openalex.org/I188760350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079875502","display_name":"Timothy O\u2019Brien","orcid":"https://orcid.org/0000-0001-9028-5481","observed_orcids":["https://orcid.org/0000-0001-9028-5481"]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Timothy O'Brien","raw_affiliation_strings":["Lambe Institute for Translational Research, National University of Ireland, Galway, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lambe Institute for Translational Research, National University of Ireland, Galway, Ireland","institution_ids":["https://openalex.org/I188760350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026851409","display_name":"Michael Joseph Kerin","orcid":"https://orcid.org/0000-0003-4164-5561","observed_orcids":["https://orcid.org/0000-0003-4164-5561"]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Michael J. Kerin","raw_affiliation_strings":["Lambe Institute for Translational Research, National University of Ireland, Galway, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lambe Institute for Translational Research, National University of Ireland, Galway, Ireland","institution_ids":["https://openalex.org/I188760350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091419246","display_name":"Stephen J. Elliman","orcid":"https://orcid.org/0000-0003-2121-8407","observed_orcids":["https://orcid.org/0000-0003-2121-8407"]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]},{"id":"https://openalex.org/I4210161530","display_name":"Orbsen Therapeutics (Ireland)","ror":"https://ror.org/056h3fs04","country_code":"IE","type":"company","lineage":["https://openalex.org/I4210161530"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Stephen J. Elliman","raw_affiliation_strings":["Orbsen Therapeutics, National University of Ireland, Galway, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orbsen Therapeutics, National University of Ireland, Galway, Ireland","institution_ids":["https://openalex.org/I188760350","https://openalex.org/I4210161530"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002401264","display_name":"Laura R. Barkley","orcid":"https://orcid.org/0000-0001-8026-5284","observed_orcids":["https://orcid.org/0000-0001-8026-5284"]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"Laura R. Barkley","raw_affiliation_strings":["Lambe Institute for Translational Research, National University of Ireland, Galway, Ireland"],"raw_orcid":"https://orcid.org/0000-0001-8026-5284","affiliations":[{"raw_affiliation_string":"Lambe Institute for Translational Research, National University of Ireland, Galway, Ireland","institution_ids":["https://openalex.org/I188760350"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5002401264"],"corresponding_institution_ids":["https://openalex.org/I188760350"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":1.1636,"has_fulltext":true,"cited_by_count":48,"citation_normalized_percentile":{"value":0.76579182,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"148","issue":"5","first_page":"1245","last_page":"1259"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.8246999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.8246999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.1460999995470047,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/syndecan-2","display_name":"syndecan-2","score":0.9800000190734863},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7889999747276306},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.878000020980835},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.8529999852180481},{"id":"https://openalex.org/keywords/smad7","display_name":"Smad7","score":0.9959999918937683},{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cxcr4","display_name":"CXCR4","score":0.9890000224113464},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.9890000224113464},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7990000247955322},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7440000176429749},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.9359999895095825},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.3970000147819519}],"concepts":[{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.8112120032310486},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6856763362884521},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6731077432632446},{"id":"https://openalex.org/C129470790","wikidata":"https://www.wikidata.org/wiki/Q415718","display_name":"CXCR4","level":4,"score":0.5629875659942627},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5239917635917664},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5000166893005371},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.4957774579524994},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.49374160170555115},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.45978716015815735},{"id":"https://openalex.org/C65001120","wikidata":"https://www.wikidata.org/wiki/Q14912913","display_name":"Syndecan 1","level":3,"score":0.4324647784233093},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3798246681690216},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3513847589492798},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.34194400906562805},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3065106272697449},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.23092162609100342},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20654967427253723},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053669","descriptor_name":"Syndecan-2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D053669","descriptor_name":"Syndecan-2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D057131","descriptor_name":"Immune Evasion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/ijc.33383","doi":"https://doi.org/10.1002/ijc.33383","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.33383","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.33383","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7839764","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7839764","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Cancer","raw_type":"Text"},{"id":"pmid:33152121","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33152121","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/ijc.33383","doi":"https://doi.org/10.1002/ijc.33383","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.33383","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.33383","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2739590004","display_name":null,"funder_award_id":"2015NovSP676","funder_id":"https://openalex.org/F4320311542","funder_display_name":"Breast Cancer Now"},{"id":"https://openalex.org/G4702655905","display_name":null,"funder_award_id":"EBPPG/2015/215","funder_id":"https://openalex.org/F4320321056","funder_display_name":"Irish Research Council"},{"id":"https://openalex.org/G5841804009","display_name":null,"funder_award_id":"EBPPG/2014/109","funder_id":"https://openalex.org/F4320321056","funder_display_name":"Irish Research Council"},{"id":"https://openalex.org/G6319581991","display_name":null,"funder_award_id":"072101","funder_id":"https://openalex.org/F4320308625","funder_display_name":"Flight Attendant Medical Research Institute"},{"id":"https://openalex.org/G735326009","display_name":"Development of Syndecan-2 based therapeutics for the treatment of breast cancer.","funder_award_id":"15/IFA/3039","funder_id":"https://openalex.org/F4320320847","funder_display_name":"Science Foundation Ireland"}],"funders":[{"id":"https://openalex.org/F4320308625","display_name":"Flight Attendant Medical Research Institute","ror":"https://ror.org/00ybhm522"},{"id":"https://openalex.org/F4320311542","display_name":"Breast Cancer Now","ror":"https://ror.org/02qa92s63"},{"id":"https://openalex.org/F4320320847","display_name":"Science Foundation Ireland","ror":"https://ror.org/0271asj38"},{"id":"https://openalex.org/F4320321056","display_name":"Irish Research Council","ror":"https://ror.org/051xex213"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3095615497.pdf","grobid_xml":"https://content.openalex.org/works/W3095615497.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1539256479","https://openalex.org/W1562355542","https://openalex.org/W1979704965","https://openalex.org/W1985689259","https://openalex.org/W1988176449","https://openalex.org/W1996702301","https://openalex.org/W2001213911","https://openalex.org/W2020040573","https://openalex.org/W2023906705","https://openalex.org/W2025371271","https://openalex.org/W2036944746","https://openalex.org/W2047564123","https://openalex.org/W2048253455","https://openalex.org/W2051400608","https://openalex.org/W2055475863","https://openalex.org/W2065735171","https://openalex.org/W2069272506","https://openalex.org/W2074270121","https://openalex.org/W2085963386","https://openalex.org/W2086834665","https://openalex.org/W2087837666","https://openalex.org/W2097903924","https://openalex.org/W2104250407","https://openalex.org/W2105055793","https://openalex.org/W2113266466","https://openalex.org/W2118323175","https://openalex.org/W2119547813","https://openalex.org/W2126619407","https://openalex.org/W2127686099","https://openalex.org/W2141247392","https://openalex.org/W2141248581","https://openalex.org/W2145063352","https://openalex.org/W2145742835","https://openalex.org/W2146457049","https://openalex.org/W2156569937","https://openalex.org/W2166171496","https://openalex.org/W2171433554","https://openalex.org/W2428263333","https://openalex.org/W2526446404","https://openalex.org/W2569856193","https://openalex.org/W2738330632","https://openalex.org/W2747321868","https://openalex.org/W2781525129","https://openalex.org/W2786031287","https://openalex.org/W2790543400","https://openalex.org/W2911526204","https://openalex.org/W2916383095","https://openalex.org/W4243761225"],"related_works":["https://openalex.org/W2972377704","https://openalex.org/W3169343149","https://openalex.org/W2870834822","https://openalex.org/W3174433200","https://openalex.org/W150636694","https://openalex.org/W2019693522","https://openalex.org/W2015476253","https://openalex.org/W2166443360","https://openalex.org/W2078029458","https://openalex.org/W2525107653"],"abstract_inverted_index":{"Tumour":[0],"stromal":[1,17,38,141],"cells":[2,39],"support":[3],"tumourigenesis.":[4],"We":[5],"report":[6],"that":[7,91,139],"Syndecan-2":[8],"(SDC2)":[9],"is":[10],"expressed":[11],"on":[12],"a":[13,87],"nonepithelial,":[14],"nonhaematopoietic,":[15],"nonendothelial":[16],"cell":[18],"population":[19],"within":[20,132,143],"breast":[21,45,119],"cancer":[22,46,120],"tissue.":[23],"In":[24,41],"vitro,":[25],"syndecan-2":[26,50,142],"modulated":[27],"TGF\u03b2":[28,55,71,154],"signalling":[29,56,72,155],"(SMAD7,":[30,57,73],"PAI-1),":[31,58],"migration":[32],"and":[33,61,78,95,112,130,149,156],"immunosuppression":[34,131],"of":[35,49,66,98,105,123],"patient-derived":[36],"tumour-associated":[37],"(TASCs).":[40],"an":[42,116],"orthotopic":[43,117],"immunocompromised":[44],"model,":[47,121],"overexpression":[48,122],"in":[51,68,100,125],"TASCs":[52,69,99,126],"significantly":[53],"enhanced":[54],"tumour":[59,76,128,147],"growth":[60,77,129,148],"metastasis,":[62],"whereas":[63],"reducing":[64],"levels":[65],"SDC2":[67],"attenuated":[70],"PAI-1,":[74],"CXCR4),":[75],"metastasis.":[79],"To":[80],"explore":[81],"the":[82,93,133,144],"potential":[83],"for":[84],"therapeutic":[85],"application,":[86],"syndecan-2-peptide":[88,124],"was":[89],"generated":[90],"inhibited":[92],"migratory":[94],"immunosuppressive":[96,107],"properties":[97],"association":[101],"with":[102],"reduced":[103,127],"expression":[104],"TGF\u03b2-regulated":[106],"genes,":[108],"such":[109],"as":[110],"CXCR4":[111],"PD-L1.":[113],"Moreover,":[114],"using":[115],"syngeneic":[118],"TME.":[134],"These":[135],"data":[136],"provide":[137],"evidence":[138],"targeting":[140],"TME":[145],"inhibits":[146],"metastasis":[150],"due":[151],"to":[152],"decreased":[153],"increased":[157],"immune":[158],"control.":[159]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":24},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":3}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2020-11-09T00:00:00"}
