{"id":"https://openalex.org/W3095554591","doi":"https://doi.org/10.1111/jcmm.16070","title":"MAIR\u2010II deficiency ameliorates cardiac remodelling post\u2010myocardial infarction by suppressing TLR9\u2010mediated macrophage activation","display_name":"MAIR\u2010II deficiency ameliorates cardiac remodelling post\u2010myocardial infarction by suppressing TLR9\u2010mediated macrophage activation","publication_year":2020,"publication_date":"2020-11-02","ids":{"openalex":"https://openalex.org/W3095554591","doi":"https://doi.org/10.1111/jcmm.16070","mag":"3095554591","pmid":"https://pubmed.ncbi.nlm.nih.gov/33140535","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7753988"},"language":"en","primary_location":{"id":"doi:10.1111/jcmm.16070","doi":"https://doi.org/10.1111/jcmm.16070","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jcmm.16070","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcmm.16070","source":{"id":"https://openalex.org/S76698325","display_name":"Journal of Cellular and Molecular Medicine","issn_l":"1582-1838","issn":["1582-1838","1582-4934"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular and Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcmm.16070","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027517234","display_name":"Saori Yonebayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Saori Yonebayashi","raw_affiliation_strings":["Department of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan","Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan","institution_ids":["https://openalex.org/I146399215"]},{"raw_affiliation_string":"Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026699562","display_name":"Kazuko Tajiri","orcid":"https://orcid.org/0000-0002-9759-1008","observed_orcids":["https://orcid.org/0000-0002-9759-1008"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kazuko Tajiri","raw_affiliation_strings":["Department of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan"],"raw_orcid":"https://orcid.org/0000-0002-9759-1008","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060144706","display_name":"Nobuyuki Murakoshi","orcid":"https://orcid.org/0000-0001-5240-9754","observed_orcids":["https://orcid.org/0000-0001-5240-9754"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuyuki Murakoshi","raw_affiliation_strings":["Department of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004693656","display_name":"Dongzhu Xu","orcid":"https://orcid.org/0000-0001-6507-1959","observed_orcids":["https://orcid.org/0000-0001-6507-1959"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Dongzhu Xu","raw_affiliation_strings":["Department of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100336555","display_name":"Siqi Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Siqi Li","raw_affiliation_strings":["Department of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan","Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan","institution_ids":["https://openalex.org/I146399215"]},{"raw_affiliation_string":"Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086384018","display_name":"Duo Feng","orcid":"https://orcid.org/0000-0002-1401-0408","observed_orcids":["https://orcid.org/0000-0002-1401-0408"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Duo Feng","raw_affiliation_strings":["Department of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan","Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan","institution_ids":["https://openalex.org/I146399215"]},{"raw_affiliation_string":"Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023537042","display_name":"Yuta Okabe","orcid":"https://orcid.org/0009-0001-4718-720X","observed_orcids":["https://orcid.org/0009-0001-4718-720X"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuta Okabe","raw_affiliation_strings":["Department of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan","Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan","institution_ids":["https://openalex.org/I146399215"]},{"raw_affiliation_string":"Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053559301","display_name":"Zixun Yuan","orcid":"https://orcid.org/0009-0004-4597-2652","observed_orcids":["https://orcid.org/0009-0004-4597-2652"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Zixun Yuan","raw_affiliation_strings":["Department of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan","Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan","institution_ids":["https://openalex.org/I146399215"]},{"raw_affiliation_string":"Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004214060","display_name":"Zonghu Song","orcid":"https://orcid.org/0009-0003-2901-3294","observed_orcids":["https://orcid.org/0009-0003-2901-3294"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Zonghu Song","raw_affiliation_strings":["Department of Cardiology Faculty of Medicine University of Tsukuba  Tsukuba Japan","Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology Faculty of Medicine University of Tsukuba  Tsukuba Japan","institution_ids":["https://openalex.org/I146399215"]},{"raw_affiliation_string":"Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104034495","display_name":"Kazuhiro Aonuma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhiro Aonuma","raw_affiliation_strings":["Department of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083746251","display_name":"Akira Shibuya","orcid":"https://orcid.org/0000-0002-4480-4858","observed_orcids":["https://orcid.org/0000-0002-4480-4858"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I4387153004","display_name":"Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA)","ror":"https://ror.org/04br41767","country_code":"JP","type":"facility","lineage":["https://openalex.org/I146399215","https://openalex.org/I4387153004"]},{"id":"https://openalex.org/I4405286864","display_name":"R&D Center for Innovative Drug Discovery, University of Tsukuba","ror":"https://ror.org/03bm18y75","country_code":"JP","type":"facility","lineage":["https://openalex.org/I146399215","https://openalex.org/I4405286864"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Shibuya","raw_affiliation_strings":["Department of Immunology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan","Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tsukuba, Japan","R&D Center for Innovative Drug Discovery University of Tsukuba Tsukuba Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan","institution_ids":["https://openalex.org/I146399215"]},{"raw_affiliation_string":"Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tsukuba, Japan","institution_ids":["https://openalex.org/I146399215","https://openalex.org/I4387153004"]},{"raw_affiliation_string":"R&D Center for Innovative Drug Discovery University of Tsukuba Tsukuba Japan","institution_ids":["https://openalex.org/I146399215","https://openalex.org/I4405286864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078388970","display_name":"Kazutaka Aonuma","orcid":"https://orcid.org/0000-0002-2332-111X","observed_orcids":["https://orcid.org/0000-0002-2332-111X"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazutaka Aonuma","raw_affiliation_strings":["Department of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011276506","display_name":"Masaki Ieda","orcid":"https://orcid.org/0000-0003-4724-3299","observed_orcids":["https://orcid.org/0000-0003-4724-3299"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaki Ieda","raw_affiliation_strings":["Department of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan","institution_ids":["https://openalex.org/I146399215"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5026699562"],"corresponding_institution_ids":["https://openalex.org/I146399215"],"apc_list":{"value":3080,"currency":"USD","value_usd":3080},"apc_paid":{"value":3080,"currency":"USD","value_usd":3080},"fwci":0.8095,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.72506895,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"24","issue":"24","first_page":"14481","last_page":"14490"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13254","display_name":"Macrophage Migration Inhibitory Factor","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9570000171661377},{"id":"https://openalex.org/keywords/cardiac-remodeling","display_name":"cardiac remodeling","score":0.9950000047683716},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.9200000166893005},{"id":"https://openalex.org/keywords/tlr9","display_name":"TLR9","score":0.8270000219345093},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5090000033378601},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.5799999833106995},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.718999981880188},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8820000290870667},{"id":"https://openalex.org/keywords/infarct-size","display_name":"infarct size","score":0.7390000224113464},{"id":"https://openalex.org/keywords/bone-marrow-derived-macrophages","display_name":"bone marrow-derived macrophages","score":0.7730000019073486}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7798455357551575},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.6298750638961792},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5975471138954163},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.587586522102356},{"id":"https://openalex.org/C2779138994","wikidata":"https://www.wikidata.org/wiki/Q15332550","display_name":"TLR9","level":5,"score":0.5811668038368225},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5216772556304932},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4854181706905365},{"id":"https://openalex.org/C2779537366","wikidata":"https://www.wikidata.org/wiki/Q7920323","display_name":"Ventricular remodeling","level":3,"score":0.4736151397228241},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.4137308895587921},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.4129767417907715},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4093596041202545},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.40515613555908203},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.382463276386261},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3328489661216736},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.21333542466163635},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.18371975421905518},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.09877419471740723},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06236734986305237},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004452","descriptor_name":"Echocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008262","descriptor_name":"Macrophage Activation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019056","descriptor_name":"Receptors, Polymeric Immunoglobulin","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D020257","descriptor_name":"Ventricular Remodeling","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051217","descriptor_name":"Toll-Like Receptor 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1111/jcmm.16070","doi":"https://doi.org/10.1111/jcmm.16070","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jcmm.16070","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcmm.16070","source":{"id":"https://openalex.org/S76698325","display_name":"Journal of Cellular and Molecular Medicine","issn_l":"1582-1838","issn":["1582-1838","1582-4934"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular and Molecular Medicine","raw_type":"journal-article"},{"id":"pmid:33140535","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33140535","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular and molecular medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7753988","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7753988/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Mol Med","raw_type":"Text"},{"id":"pmh:oai:irdb.nii.ac.jp:00843:0005348793","doi":null,"is_oa":true,"landing_page_url":"https://tsukuba.repo.nii.ac.jp/records/2003773","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Cellular and Molecular Medicine","raw_type":"journal article"},{"id":"pmh:oai:tsukuba.repo.nii.ac.jp:02003773","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2241/0002003773","pdf_url":null,"source":{"id":"https://openalex.org/S4306402076","display_name":"Terrestrial Environment Research Center (University of Tsukuba)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I146399215","host_organization_name":"University of Tsukuba","host_organization_lineage":["https://openalex.org/I146399215"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1111/jcmm.16070","doi":"https://doi.org/10.1111/jcmm.16070","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jcmm.16070","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcmm.16070","source":{"id":"https://openalex.org/S76698325","display_name":"Journal of Cellular and Molecular Medicine","issn_l":"1582-1838","issn":["1582-1838","1582-4934"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular and Molecular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3131094943","display_name":"Immune Integrated Omics Analysis for Elucidating the Mechanisms of Immune Checkpoint Inhibitor-Induced Myocarditi","funder_award_id":"20K08396","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7908439918","display_name":"A new treatment strategy for myocardial infarction targeting neutrophil extracellular traps","funder_award_id":"17K09567","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3095554591.pdf","grobid_xml":"https://content.openalex.org/works/W3095554591.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1924442012","https://openalex.org/W1980290838","https://openalex.org/W1985982112","https://openalex.org/W1991872527","https://openalex.org/W1994029289","https://openalex.org/W2036305046","https://openalex.org/W2037994205","https://openalex.org/W2041663579","https://openalex.org/W2055682254","https://openalex.org/W2073879109","https://openalex.org/W2086309499","https://openalex.org/W2089477170","https://openalex.org/W2092943609","https://openalex.org/W2106412056","https://openalex.org/W2113648760","https://openalex.org/W2123503904","https://openalex.org/W2133380563","https://openalex.org/W2134219545","https://openalex.org/W2151928790","https://openalex.org/W2155011488","https://openalex.org/W2165667580","https://openalex.org/W2259003342","https://openalex.org/W2273461839","https://openalex.org/W2317801401","https://openalex.org/W2363034775","https://openalex.org/W2537170726","https://openalex.org/W2567252132","https://openalex.org/W2601496498","https://openalex.org/W2607063177","https://openalex.org/W2763341318","https://openalex.org/W2765859773","https://openalex.org/W2791537582","https://openalex.org/W2889654052","https://openalex.org/W2894555689","https://openalex.org/W2924610177","https://openalex.org/W2952484942","https://openalex.org/W2989679854"],"related_works":["https://openalex.org/W7030161758","https://openalex.org/W2764192481","https://openalex.org/W144353986","https://openalex.org/W7155537748","https://openalex.org/W2784080437","https://openalex.org/W2086514569","https://openalex.org/W2128743029","https://openalex.org/W4409633427","https://openalex.org/W2055682254","https://openalex.org/W1967414132"],"abstract_inverted_index":{"Abstract":[0],"Macrophages":[1],"are":[2],"fundamental":[3],"components":[4],"of":[5,66,88,147],"inflammation":[6,185],"in":[7,24,43,46,51,68,85,128,190],"post\u2010myocardial":[8],"infarction":[9],"(MI)":[10],"and":[11,17,64,114,124,197],"contribute":[12],"to":[13,59,83,100,178,193],"adverse":[14,194],"cardiac":[15,109,112,195],"remodelling":[16,196],"heart":[18],"failure.":[19],"However,":[20,48],"the":[21],"regulatory":[22],"mechanisms":[23],"macrophage":[25,151,188],"activation":[26,152,189],"have":[27],"not":[28],"been":[29],"fully":[30],"elucidated.":[31],"Previous":[32],"studies":[33],"showed":[34],"that":[35,73,163],"myeloid\u2010associated":[36],"immunoglobulin\u2013like":[37],"receptor":[38,155],"II":[39],"(MAIR\u2010II)":[40],"is":[41,53],"involved":[42],"inflammatory":[44],"responses":[45],"macrophages.":[47],"its":[49],"role":[50,63],"MI":[52],"unknown.":[54],"Thus,":[55],"this":[56],"study":[57],"aimed":[58],"determine":[60],"a":[61,143,170],"novel":[62,144],"mechanism":[65,146],"MAIR\u2010II":[67,182],"MI.":[69,140],"We":[70],"first":[71],"identified":[72],"MAIR\u2010II\u2013positive":[74],"myeloid":[75],"cells":[76],"were":[77],"abundant":[78],"from":[79],"post\u2010MI":[80],"days":[81],"3":[82],"5":[84],"infarcted":[86],"hearts":[87],"C57BL/6J":[89],"(WT)":[90],"mice":[91,104,132],"induced":[92],"by":[93,153,169],"permanent":[94],"left":[95],"coronary":[96],"artery":[97],"ligation.":[98],"Compared":[99],"WT,":[101],"MAIR\u2010II\u2013deficient":[102],"(Cd300c2\u2212/\u2212)":[103],"had":[105,134],"longer":[106],"survival,":[107],"ameliorated":[108],"remodelling,":[110],"improved":[111],"function":[113],"smaller":[115],"infarct":[116],"sizes.":[117],"Moreover,":[118],"we":[119,149,161],"detected":[120],"lower":[121],"pro\u2010inflammatory":[122,137,175],"cytokine":[123],"fibrotic":[125],"gene":[126],"expressions":[127],"Cd300c2\u2212/\u2212\u2010infarcted":[129],"hearts.":[130],"These":[131],"also":[133],"less":[135,174],"infiltrating":[136],"macrophages":[138,167],"following":[139],"To":[141],"elucidate":[142],"molecular":[145],"MAIR\u2010II,":[148],"considered":[150],"Toll\u2010like":[154],"(TLR)":[156],"9\u2013mediated":[157],"inflammation.":[158],"In":[159,180],"vitro,":[160],"observed":[162],"Cd300c2\u2212/\u2212":[164],"bone":[165],"marrow\u2013derived":[166],"stimulated":[168],"TLR9":[171],"agonist":[172],"expressed":[173],"cytokines":[176],"compared":[177],"WT.":[179],"conclusion,":[181],"may":[183],"enhance":[184],"via":[186],"TLR9\u2010mediated":[187],"MI,":[191],"leading":[192],"poor":[198],"prognosis.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-11-09T00:00:00"}