{"id":"https://openalex.org/W3095322907","doi":"https://doi.org/10.3390/ijms21218240","title":"Antigen Design for Successful Isolation of Highly Challenging Therapeutic Anti-GPCR Antibodies","display_name":"Antigen Design for Successful Isolation of Highly Challenging Therapeutic Anti-GPCR Antibodies","publication_year":2020,"publication_date":"2020-11-03","ids":{"openalex":"https://openalex.org/W3095322907","doi":"https://doi.org/10.3390/ijms21218240","mag":"3095322907","pmid":"https://pubmed.ncbi.nlm.nih.gov/33153215","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7663707"},"language":"en","primary_location":{"id":"doi:10.3390/ijms21218240","doi":"https://doi.org/10.3390/ijms21218240","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms21218240","pdf_url":"https://www.mdpi.com/1422-0067/21/21/8240/pdf?version=1604484702","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/21/21/8240/pdf?version=1604484702","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007019509","display_name":"Man\u2010Seok Ju","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Man-Seok Ju","raw_affiliation_strings":["Department of Biomedical Sciences, Korea University College of Medicine, Seoul 02841, Korea","Institute of Human Genetics, Korea University College of Medicine, Seoul 02841, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Korea University College of Medicine, Seoul 02841, Korea","institution_ids":["https://openalex.org/I197347611"]},{"raw_affiliation_string":"Institute of Human Genetics, Korea University College of Medicine, Seoul 02841, Korea","institution_ids":["https://openalex.org/I197347611"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044505570","display_name":"Sang Taek Jung","orcid":"https://orcid.org/0000-0001-7217-979X","observed_orcids":["https://orcid.org/0000-0001-7217-979X"]},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]},{"id":"https://openalex.org/I4405260934","display_name":"Korea University Anam Hospital","ror":"https://ror.org/04gjj3027","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I197347611","https://openalex.org/I2799980853","https://openalex.org/I4405260934"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sang Taek Jung","raw_affiliation_strings":["BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul 02841, Korea","Biomedical Research Center, Korea University Anam Hospital, Seoul 02841, Korea","Department of Biomedical Sciences, Graduate School, Korea University, Seoul 02841, Korea","Department of Biomedical Sciences, Korea University College of Medicine, Seoul 02841, Korea","Institute of Human Genetics, Korea University College of Medicine, Seoul 02841, Korea"],"raw_orcid":"https://orcid.org/0000-0001-7217-979X","affiliations":[{"raw_affiliation_string":"BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul 02841, Korea","institution_ids":["https://openalex.org/I197347611"]},{"raw_affiliation_string":"Biomedical Research Center, Korea University Anam Hospital, Seoul 02841, Korea","institution_ids":["https://openalex.org/I4405260934"]},{"raw_affiliation_string":"Department of Biomedical Sciences, Graduate School, Korea University, Seoul 02841, Korea","institution_ids":["https://openalex.org/I197347611"]},{"raw_affiliation_string":"Department of Biomedical Sciences, Korea University College of Medicine, Seoul 02841, Korea","institution_ids":["https://openalex.org/I197347611"]},{"raw_affiliation_string":"Institute of Human Genetics, Korea University College of Medicine, Seoul 02841, Korea","institution_ids":["https://openalex.org/I197347611"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044505570"],"corresponding_institution_ids":["https://openalex.org/I197347611","https://openalex.org/I4405260934"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2112},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2112},"fwci":0.214,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.18798729,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"21","issue":"21","first_page":"8240","last_page":"8240"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9243000149726868,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9243000149726868,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.06960000097751617,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.9950000047683716},{"id":"https://openalex.org/keywords/therapeutic-antibodies","display_name":"therapeutic antibodies","score":0.7689999938011169},{"id":"https://openalex.org/keywords/antibody-isolation","display_name":"antibody isolation","score":0.609000027179718},{"id":"https://openalex.org/keywords/antigen-design","display_name":"antigen design","score":0.8209999799728394},{"id":"https://openalex.org/keywords/antibody-drug-conjugates","display_name":"antibody-drug conjugates","score":0.7749999761581421}],"concepts":[{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.8256312012672424},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5717458128929138},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5385743975639343},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5277327299118042},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.49384862184524536},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4470163583755493},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4346693754196167},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.41280892491340637},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32390260696411133},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3193025290966034},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.25243282318115234},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13353171944618225}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018604","descriptor_name":"Epitope Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms21218240","doi":"https://doi.org/10.3390/ijms21218240","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms21218240","pdf_url":"https://www.mdpi.com/1422-0067/21/21/8240/pdf?version=1604484702","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:33153215","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33153215","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7663707","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7663707/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:a6cde488704145be800c3e5b823fb95f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a6cde488704145be800c3e5b823fb95f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 21, Iss 8240, p 8240 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms21218240","doi":"https://doi.org/10.3390/ijms21218240","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms21218240","pdf_url":"https://www.mdpi.com/1422-0067/21/21/8240/pdf?version=1604484702","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1780227575","display_name":null,"funder_award_id":"2019R1A4A1029000","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"},{"id":"https://openalex.org/G2579467062","display_name":null,"funder_award_id":"2020M3E5E2037775","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G2625638438","display_name":null,"funder_award_id":"and 2019R1A6A3A01097279","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"},{"id":"https://openalex.org/G2830403459","display_name":null,"funder_award_id":"2020M3E5E2037775","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"},{"id":"https://openalex.org/G3456696519","display_name":null,"funder_award_id":"2020-ER5311","funder_id":"https://openalex.org/F4320334876","funder_display_name":"Korea National Institute of Health"},{"id":"https://openalex.org/G3737561125","display_name":null,"funder_award_id":"2019R1A4A1029000","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G4949452136","display_name":null,"funder_award_id":"2019R1F1A1059834","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G5351522475","display_name":null,"funder_award_id":"2020-ER5311-00","funder_id":"https://openalex.org/F4320334876","funder_display_name":"Korea National Institute of Health"},{"id":"https://openalex.org/G8169335062","display_name":null,"funder_award_id":"2019R1F1A1059834","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"},{"id":"https://openalex.org/G8413349689","display_name":null,"funder_award_id":"2019R1A6A3A01097279","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"},{"id":"https://openalex.org/F4320334876","display_name":"Korea National Institute of Health","ror":"https://ror.org/00qdsfq65"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3095322907.pdf","grobid_xml":"https://content.openalex.org/works/W3095322907.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W1524399027","https://openalex.org/W1967006002","https://openalex.org/W1971793561","https://openalex.org/W1982201527","https://openalex.org/W1990572429","https://openalex.org/W1992735132","https://openalex.org/W2006419043","https://openalex.org/W2028820426","https://openalex.org/W2030085576","https://openalex.org/W2030975239","https://openalex.org/W2031818051","https://openalex.org/W2047487535","https://openalex.org/W2051785641","https://openalex.org/W2054738595","https://openalex.org/W2064046777","https://openalex.org/W2069750786","https://openalex.org/W2081867678","https://openalex.org/W2102089654","https://openalex.org/W2102917831","https://openalex.org/W2105128791","https://openalex.org/W2107656195","https://openalex.org/W2109844644","https://openalex.org/W2120321866","https://openalex.org/W2129741568","https://openalex.org/W2129983555","https://openalex.org/W2133811076","https://openalex.org/W2136160086","https://openalex.org/W2139840825","https://openalex.org/W2140499532","https://openalex.org/W2147241078","https://openalex.org/W2154599526","https://openalex.org/W2157499432","https://openalex.org/W2157631823","https://openalex.org/W2160536323","https://openalex.org/W2160798258","https://openalex.org/W2166075265","https://openalex.org/W2166810828","https://openalex.org/W2167282403","https://openalex.org/W2283260670","https://openalex.org/W2324052799","https://openalex.org/W2325729551","https://openalex.org/W2396208409","https://openalex.org/W2410433645","https://openalex.org/W2558217333","https://openalex.org/W2587450560","https://openalex.org/W2593766198","https://openalex.org/W2601321887","https://openalex.org/W2622258449","https://openalex.org/W2765153686","https://openalex.org/W2766334144","https://openalex.org/W2770965214","https://openalex.org/W2774455409","https://openalex.org/W2779666226","https://openalex.org/W2790293499","https://openalex.org/W2809922249","https://openalex.org/W2810133728","https://openalex.org/W2811448052","https://openalex.org/W2890180880","https://openalex.org/W2891221883","https://openalex.org/W2965861649","https://openalex.org/W2971376713","https://openalex.org/W2977572299","https://openalex.org/W2990970256","https://openalex.org/W3006224482","https://openalex.org/W4245153854"],"related_works":["https://openalex.org/W2260910199","https://openalex.org/W4309862447","https://openalex.org/W2734750805","https://openalex.org/W2740185469","https://openalex.org/W1970663569","https://openalex.org/W1996175175","https://openalex.org/W4389951972","https://openalex.org/W3014589367","https://openalex.org/W3021913813","https://openalex.org/W7125122679"],"abstract_inverted_index":{"G-protein-coupled":[0],"receptors":[1],"(GPCR)":[2],"transmit":[3],"extracellular":[4],"signals":[5],"into":[6],"cells":[7],"to":[8,19,39,71,103,110,122],"regulate":[9],"a":[10],"variety":[11],"of":[12,22,29,32,60,78,119],"cellular":[13,85],"functions":[14],"and":[15,26,45,67,87,106],"are":[16,47,101],"closely":[17],"related":[18],"the":[20,23,27,58,72,117],"homeostasis":[21],"human":[24],"body":[25],"progression":[28],"various":[30,108],"types":[31],"diseases.":[33],"Great":[34],"attention":[35],"has":[36,64],"been":[37,65,98],"paid":[38],"GPCRs":[40],"as":[41],"excellent":[42],"drug":[43],"targets,":[44],"there":[46],"many":[48],"commercially":[49],"available":[50],"small-molecule":[51],"chemical":[52],"drugs":[53],"against":[54],"GPCRs.":[55],"Despite":[56],"this,":[57],"development":[59],"therapeutic":[61,120],"anti-GPCR":[62,94],"antibodies":[63,95,121],"delayed":[66],"is":[68],"challenging":[69],"due":[70],"difficulty":[73],"in":[74],"preparing":[75],"active":[76,112],"forms":[77],"GPCR":[79,113],"antigens,":[80],"resulting":[81],"from":[82],"their":[83],"low":[84],"expression":[86],"complex":[88],"structures.":[89],"Here,":[90],"we":[91],"focus":[92],"on":[93],"that":[96,115],"have":[97],"approved":[99],"or":[100],"subject":[102],"clinical":[104,125],"trials":[105],"present":[107],"technologies":[109],"prepare":[111],"antigens":[114],"enable":[116],"isolation":[118],"proceed":[123],"toward":[124],"validation.":[126]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-11-09T00:00:00"}