{"id":"https://openalex.org/W3095281986","doi":"https://doi.org/10.21873/anticanres.14628","title":"An Autocrine Role for CXCL1 in Progression of Hepatocellular Carcinoma","display_name":"An Autocrine Role for CXCL1 in Progression of Hepatocellular Carcinoma","publication_year":2020,"publication_date":"2020-10-27","ids":{"openalex":"https://openalex.org/W3095281986","doi":"https://doi.org/10.21873/anticanres.14628","mag":"3095281986","pmid":"https://pubmed.ncbi.nlm.nih.gov/33109545"},"language":"en","primary_location":{"id":"doi:10.21873/anticanres.14628","doi":"https://doi.org/10.21873/anticanres.14628","is_oa":false,"landing_page_url":"https://doi.org/10.21873/anticanres.14628","pdf_url":null,"source":{"id":"https://openalex.org/S157347057","display_name":"Anticancer Research","issn_l":"0250-7005","issn":["0250-7005","1791-7530"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4320800545","host_organization_name":"International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts","host_organization_lineage":["https://openalex.org/P4320800545"],"host_organization_lineage_names":["International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022700978","display_name":"Korbyn J.V. Dahlquist","orcid":"https://orcid.org/0000-0002-0415-1338","observed_orcids":["https://orcid.org/0000-0002-0415-1338"]},"institutions":[{"id":"https://openalex.org/I895819238","display_name":"Bethel University","ror":"https://ror.org/02faxbd19","country_code":"US","type":"education","lineage":["https://openalex.org/I895819238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"KORBYN J.V. DAHLQUIST","raw_affiliation_strings":["Department of Chemistry, Bethel University, Saint Paul, MN, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Bethel University, Saint Paul, MN, U.S.A","institution_ids":["https://openalex.org/I895819238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027812357","display_name":"LAURA C. VOTH","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I895819238","display_name":"Bethel University","ror":"https://ror.org/02faxbd19","country_code":"US","type":"education","lineage":["https://openalex.org/I895819238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LAURA C. VOTH","raw_affiliation_strings":["Department of Chemistry, Bethel University, Saint Paul, MN, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Bethel University, Saint Paul, MN, U.S.A","institution_ids":["https://openalex.org/I895819238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001302295","display_name":"AMANDA J. FEE","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I895819238","display_name":"Bethel University","ror":"https://ror.org/02faxbd19","country_code":"US","type":"education","lineage":["https://openalex.org/I895819238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"AMANDA J. FEE","raw_affiliation_strings":["Department of Chemistry, Bethel University, Saint Paul, MN, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Bethel University, Saint Paul, MN, U.S.A","institution_ids":["https://openalex.org/I895819238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049802441","display_name":"Angela K. Stoeckman","orcid":"https://orcid.org/0000-0002-2009-0424","observed_orcids":["https://orcid.org/0000-0002-2009-0424"]},"institutions":[{"id":"https://openalex.org/I895819238","display_name":"Bethel University","ror":"https://ror.org/02faxbd19","country_code":"US","type":"education","lineage":["https://openalex.org/I895819238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ANGELA K. STOECKMAN","raw_affiliation_strings":["Department of Chemistry, Bethel University, Saint Paul, MN, U.S.A. a-stoeckman@bethel.edu","Department of Chemistry, Bethel University, Saint Paul, MN, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Bethel University, Saint Paul, MN, U.S.A. a-stoeckman@bethel.edu","institution_ids":["https://openalex.org/I895819238"]},{"raw_affiliation_string":"Department of Chemistry, Bethel University, Saint Paul, MN, U.S.A","institution_ids":["https://openalex.org/I895819238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I895819238"],"apc_list":null,"apc_paid":null,"fwci":0.692,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.680428,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"40","issue":"11","first_page":"6075","last_page":"6081"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cxcl1","display_name":"CXCL1","score":0.875},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9819999933242798},{"id":"https://openalex.org/keywords/autocrine-signaling","display_name":"autocrine signaling","score":0.8510000109672546},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.7860000133514404},{"id":"https://openalex.org/keywords/palmitate","display_name":"palmitate","score":0.996999979019165},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6890000104904175},{"id":"https://openalex.org/keywords/cxcr2","display_name":"CXCR2","score":0.9700000286102295},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.7129999995231628},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7979999780654907}],"concepts":[{"id":"https://openalex.org/C96525457","wikidata":"https://www.wikidata.org/wiki/Q5014879","display_name":"CXCL1","level":4,"score":0.8770284652709961},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6847832202911377},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6370093822479248},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.619688868522644},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.5920008420944214},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.5323354005813599},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48458755016326904},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.480785071849823},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.46002474427223206},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.4285629093647003},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40458717942237854},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40327584743499756},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4006032645702362},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3284667730331421},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26533597707748413},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2581140697002411},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.24825572967529297},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14513665437698364}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019308","descriptor_name":"Palmitic Acid","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D019898","descriptor_name":"Autocrine Communication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D023063","descriptor_name":"Receptors, Interleukin-8B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054360","descriptor_name":"Chemokine CXCL1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.21873/anticanres.14628","doi":"https://doi.org/10.21873/anticanres.14628","is_oa":false,"landing_page_url":"https://doi.org/10.21873/anticanres.14628","pdf_url":null,"source":{"id":"https://openalex.org/S157347057","display_name":"Anticancer Research","issn_l":"0250-7005","issn":["0250-7005","1791-7530"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4320800545","host_organization_name":"International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts","host_organization_lineage":["https://openalex.org/P4320800545"],"host_organization_lineage_names":["International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer Research","raw_type":"journal-article"},{"id":"pmid:33109545","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33109545","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1834481809","https://openalex.org/W1964083798","https://openalex.org/W1965712234","https://openalex.org/W1968128770","https://openalex.org/W1968782406","https://openalex.org/W1999238993","https://openalex.org/W2005562198","https://openalex.org/W2047438155","https://openalex.org/W2067184340","https://openalex.org/W2073168934","https://openalex.org/W2073751076","https://openalex.org/W2084776235","https://openalex.org/W2087129977","https://openalex.org/W2094884053","https://openalex.org/W2103563257","https://openalex.org/W2134785944","https://openalex.org/W2146206837","https://openalex.org/W2150942966","https://openalex.org/W2151172917","https://openalex.org/W2169333619","https://openalex.org/W2434791932","https://openalex.org/W2512939027","https://openalex.org/W2582817548","https://openalex.org/W2588082084","https://openalex.org/W2594158747","https://openalex.org/W2738457154","https://openalex.org/W2769288280","https://openalex.org/W2788261792","https://openalex.org/W2794942947","https://openalex.org/W2801929531","https://openalex.org/W2804509087","https://openalex.org/W2896280679","https://openalex.org/W2903155258","https://openalex.org/W2971877727","https://openalex.org/W3000870518","https://openalex.org/W4245403358"],"related_works":["https://openalex.org/W4408069911","https://openalex.org/W3003599806","https://openalex.org/W2152930674","https://openalex.org/W4401370283","https://openalex.org/W2512939027","https://openalex.org/W3049186058","https://openalex.org/W3135497466","https://openalex.org/W4395084632","https://openalex.org/W1522156216","https://openalex.org/W2063375774"],"abstract_inverted_index":{"BACKGROUND:":[0],"One":[1],"of":[2,7,23,55,70,86,106,117,142],"the":[3,24,53,115,140],"most":[4],"prevalent":[5],"causes":[6],"cancer":[8,143],"fatalities":[9],"is":[10],"hepatocellular":[11],"carcinoma":[12],"(HCC),":[13],"which":[14,76],"has":[15],"been":[16],"linked":[17],"to":[18,36,59,133],"metabolic":[19,32,134],"syndrome.":[20],"Circulating":[21],"levels":[22],"saturated":[25],"fatty":[26],"acid":[27],"palmitate":[28,60],"are":[29],"elevated":[30],"in":[31,68,114,131],"syndrome":[33,135],"and":[34,48,79,93,109,137],"lead":[35],"cellular":[37],"stress.":[38],"MATERIALS":[39],"AND":[40],"METHODS:":[41],"Using":[42],"enzyme-linked":[43],"immunosorbent":[44],"assay,":[45],"flow":[46],"cytometry,":[47],"migration":[49,105],"assays,":[50],"we":[51,103],"characterized":[52],"response":[54,132],"rat":[56],"hepatoma":[57,100,107],"cells":[58,108,119,128],"treatment.":[61],"RESULTS:":[62],"We":[63,83],"detected":[64],"a":[65,95,111],"60%":[66],"increase":[67,97,113],"secretion":[69],"C-X-C":[71,87],"motif":[72,88],"ligand":[73],"1":[74],"(CXCL1)":[75],"was":[77],"dose-dependent":[78],"coincided":[80],"with":[81],"apoptosis.":[82],"measured":[84],"expression":[85],"chemokine":[89],"receptor":[90],"2":[91],"(CXCR2)":[92],"observed":[94],"4.5-fold":[96],"on":[98],"apoptotic":[99],"cells.":[101],"Furthermore,":[102],"assayed":[104],"saw":[110],"2-fold":[112],"number":[116],"migrating":[118],"towards":[120],"CXCL1.":[121],"CONCLUSION:":[122],"These":[123],"findings":[124],"suggest":[125],"that":[126],"HCC":[127],"secrete":[129],"CXCL1":[130],"signals":[136],"may":[138],"promote":[139],"progression":[141],"through":[144],"apoptosis":[145],"recovery":[146],"or":[147],"metastasis.":[148]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-11-09T00:00:00"}
