{"id":"https://openalex.org/W3095214746","doi":"https://doi.org/10.1016/j.ijpharm.2020.120028","title":"Optimization and evaluation of propolis liposomes as a promising therapeutic approach for COVID-19","display_name":"Optimization and evaluation of propolis liposomes as a promising therapeutic approach for COVID-19","publication_year":2020,"publication_date":"2020-11-06","ids":{"openalex":"https://openalex.org/W3095214746","doi":"https://doi.org/10.1016/j.ijpharm.2020.120028","mag":"3095214746","pmid":"https://pubmed.ncbi.nlm.nih.gov/33166584","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7647905"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijpharm.2020.120028","doi":"https://doi.org/10.1016/j.ijpharm.2020.120028","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijpharm.2020.120028","pdf_url":null,"source":{"id":"https://openalex.org/S131016564","display_name":"International Journal of Pharmaceutics","issn_l":"0378-5173","issn":["0378-5173","1873-3476"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7647905/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030265035","display_name":"Hesham Refaat","orcid":"https://orcid.org/0000-0002-1477-837X","observed_orcids":["https://orcid.org/0000-0002-1477-837X"]},"institutions":[{"id":"https://openalex.org/I4401727001","display_name":"Deraya University","ror":"https://ror.org/05252fg05","country_code":"EG","type":"education","lineage":["https://openalex.org/I4401727001"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Hesham Refaat","raw_affiliation_strings":["Department of Pharmaceutics, Faculty of Pharmacy, Deraya University, Minia, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Faculty of Pharmacy, Deraya University, Minia, Egypt","institution_ids":["https://openalex.org/I4401727001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036490274","display_name":"Fatma Mohammed Mady","orcid":"https://orcid.org/0000-0002-2865-145X","observed_orcids":["https://orcid.org/0000-0002-2865-145X"]},"institutions":[{"id":"https://openalex.org/I89466785","display_name":"Minia University","ror":"https://ror.org/02hcv4z63","country_code":"EG","type":"education","lineage":["https://openalex.org/I89466785"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Fatma M. Mady","raw_affiliation_strings":["Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt","institution_ids":["https://openalex.org/I89466785"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108664766","display_name":"Hatem A. Sarhan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89466785","display_name":"Minia University","ror":"https://ror.org/02hcv4z63","country_code":"EG","type":"education","lineage":["https://openalex.org/I89466785"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Hatem A. Sarhan","raw_affiliation_strings":["Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt","institution_ids":["https://openalex.org/I89466785"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023377021","display_name":"Heba S. Rateb","orcid":"https://orcid.org/0000-0002-6952-1790","observed_orcids":["https://orcid.org/0000-0002-6952-1790"]},"institutions":[{"id":"https://openalex.org/I154632036","display_name":"Misr University for Science and Technology","ror":"https://ror.org/05debfq75","country_code":"EG","type":"education","lineage":["https://openalex.org/I154632036"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Heba S. Rateb","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, College of Pharmaceutical Science and Drug Manufacturing, Misr University for Science and Technology, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, College of Pharmaceutical Science and Drug Manufacturing, Misr University for Science and Technology, Cairo, Egypt","institution_ids":["https://openalex.org/I154632036"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001091510","display_name":"Eman Alaaeldin","orcid":"https://orcid.org/0000-0002-8631-5315","observed_orcids":["https://orcid.org/0000-0002-8631-5315"]},"institutions":[{"id":"https://openalex.org/I4401727001","display_name":"Deraya University","ror":"https://ror.org/05252fg05","country_code":"EG","type":"education","lineage":["https://openalex.org/I4401727001"]},{"id":"https://openalex.org/I89466785","display_name":"Minia University","ror":"https://ror.org/02hcv4z63","country_code":"EG","type":"education","lineage":["https://openalex.org/I89466785"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Eman Alaaeldin","raw_affiliation_strings":["Department of Pharmaceutics, Faculty of Pharmacy, Deraya University, Minia, Egypt; Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt. Electronic address: Eman_alaa_eldin@yahoo.com","Department of Pharmaceutics, Faculty of Pharmacy, Deraya University, Minia, Egypt","Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Faculty of Pharmacy, Deraya University, Minia, Egypt; Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt. Electronic address: Eman_alaa_eldin@yahoo.com","institution_ids":["https://openalex.org/I4401727001","https://openalex.org/I89466785"]},{"raw_affiliation_string":"Department of Pharmaceutics, Faculty of Pharmacy, Deraya University, Minia, Egypt","institution_ids":["https://openalex.org/I4401727001"]},{"raw_affiliation_string":"Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt","institution_ids":["https://openalex.org/I89466785"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5001091510"],"corresponding_institution_ids":["https://openalex.org/I4401727001","https://openalex.org/I89466785"],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":null,"fwci":15.4892,"has_fulltext":true,"cited_by_count":122,"citation_normalized_percentile":{"value":0.99768709,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"592","issue":null,"first_page":"120028","last_page":"120028"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11386","display_name":"Bee Products Chemical Analysis","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11386","display_name":"Bee Products Chemical Analysis","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.020500000566244125,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/propolis","display_name":"propolis","score":0.949999988079071},{"id":"https://openalex.org/keywords/liposomes","display_name":"liposomes","score":0.8759999871253967},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9909999966621399},{"id":"https://openalex.org/keywords/main-protease","display_name":"main protease","score":0.8309999704360962},{"id":"https://openalex.org/keywords/sars-cov-2-spike-protein","display_name":"SARS-CoV-2 spike protein","score":0.9020000100135803},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.8659999966621399},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.7829999923706055},{"id":"https://openalex.org/keywords/drug-release","display_name":"drug release","score":0.7680000066757202},{"id":"https://openalex.org/keywords/rutin","display_name":"rutin","score":0.7639999985694885},{"id":"https://openalex.org/keywords/caffeic-acid-phenethyl-ester","display_name":"caffeic acid phenethyl ester","score":0.9909999966621399},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.7820000052452087},{"id":"https://openalex.org/keywords/remdesivir","display_name":"remdesivir","score":0.8190000057220459},{"id":"https://openalex.org/keywords/hydroxychloroquine","display_name":"hydroxychloroquine","score":0.9789999723434448}],"concepts":[{"id":"https://openalex.org/C2780488879","wikidata":"https://www.wikidata.org/wiki/Q184398","display_name":"Propolis","level":2,"score":0.9750312566757202},{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.7827740907669067},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.6126842498779297},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.5831245183944702},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.573858916759491},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5085147619247437},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.4676157236099243},{"id":"https://openalex.org/C2778224086","wikidata":"https://www.wikidata.org/wiki/Q414116","display_name":"Caffeic acid","level":3,"score":0.45653778314590454},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.4418465793132782},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.40326663851737976},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2267911732196808},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19165855646133423},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.17854607105255127},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1682998538017273},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.16636168956756592},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.12771663069725037},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.10274985432624817},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.07691869139671326},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000086782","descriptor_name":"Coronavirus 3C Proteases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000087123","descriptor_name":"COVID-19 Nucleic Acid Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011429","descriptor_name":"Propolis","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011429","descriptor_name":"Propolis","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017063","descriptor_name":"Outcome Assessment, Health Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D064370","descriptor_name":"Spike Glycoprotein, Coronavirus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.ijpharm.2020.120028","doi":"https://doi.org/10.1016/j.ijpharm.2020.120028","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijpharm.2020.120028","pdf_url":null,"source":{"id":"https://openalex.org/S131016564","display_name":"International Journal of Pharmaceutics","issn_l":"0378-5173","issn":["0378-5173","1873-3476"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7647905","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7647905/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7647905/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Pharm","raw_type":"Text"},{"id":"pmid:33166584","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33166584","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of pharmaceutics","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7647905","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7647905/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7647905/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Pharm","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3095214746.pdf","grobid_xml":"https://content.openalex.org/works/W3095214746.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W163900819","https://openalex.org/W1528361538","https://openalex.org/W1551808017","https://openalex.org/W1583489850","https://openalex.org/W1963618232","https://openalex.org/W2003292735","https://openalex.org/W2011314829","https://openalex.org/W2027638447","https://openalex.org/W2030487072","https://openalex.org/W2056092093","https://openalex.org/W2064776678","https://openalex.org/W2077090690","https://openalex.org/W2078696617","https://openalex.org/W2081939621","https://openalex.org/W2086367918","https://openalex.org/W2095918019","https://openalex.org/W2113816263","https://openalex.org/W2132260239","https://openalex.org/W2284201926","https://openalex.org/W2320035351","https://openalex.org/W2489429113","https://openalex.org/W2606276626","https://openalex.org/W2831406633","https://openalex.org/W2890151713","https://openalex.org/W2905420437","https://openalex.org/W2981579389","https://openalex.org/W3001897055","https://openalex.org/W3004348779","https://openalex.org/W3006049090","https://openalex.org/W3006642361","https://openalex.org/W3007969569","https://openalex.org/W3012393736","https://openalex.org/W3013602382","https://openalex.org/W3014067025","https://openalex.org/W3015608194","https://openalex.org/W3016333236","https://openalex.org/W3022262124","https://openalex.org/W3025987322","https://openalex.org/W3035580728","https://openalex.org/W3047117796","https://openalex.org/W3158759799","https://openalex.org/W4313362220","https://openalex.org/W6775820635","https://openalex.org/W6775975991","https://openalex.org/W6779595696"],"related_works":["https://openalex.org/W2056092093","https://openalex.org/W4283838171","https://openalex.org/W4319991396","https://openalex.org/W2981579389","https://openalex.org/W6885429310","https://openalex.org/W4417289441","https://openalex.org/W2011157244","https://openalex.org/W3128154701","https://openalex.org/W3128343426","https://openalex.org/W7215212806"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":27},{"year":2022,"cited_by_count":35},{"year":2021,"cited_by_count":24}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2020-11-09T00:00:00"}
