{"id":"https://openalex.org/W3095178777","doi":null,"title":"Signalling mechanisms used by the orexin-1 receptor","display_name":"Signalling mechanisms used by the orexin-1 receptor","publication_year":2011,"publication_date":"2011-05-27","ids":{"openalex":"https://openalex.org/W3095178777","mag":"3095178777"},"language":"en","primary_location":{"id":"pmh:oai:erepo.uef.fi:123456789/10111","doi":null,"is_oa":true,"landing_page_url":"http://urn.fi/URN:ISBN:978-952-61-0436-2","pdf_url":"https://erepo.uef.fi/handle/123456789/10111","source":{"id":"https://openalex.org/S4306402418","display_name":"UEF eRepo (University of Eastern Finland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I175532246","host_organization_name":"University of Eastern Finland","host_organization_lineage":["https://openalex.org/I175532246"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://erepo.uef.fi/handle/123456789/10111","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019171076","display_name":"Hanna M. Peltonen","orcid":"https://orcid.org/0000-0002-1616-5948","observed_orcids":["https://orcid.org/0000-0002-1616-5948"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hanna Peltonen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1616-5948","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5019171076"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.5092999935150146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.5092999935150146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.17329999804496765,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.05869999900460243,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/orexin-1-receptor","display_name":"orexin-1 receptor","score":0.9800000190734863},{"id":"https://openalex.org/keywords/orexin-a","display_name":"orexin-A","score":0.8460000157356262},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.8510000109672546},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.6389999985694885},{"id":"https://openalex.org/keywords/store-operated-calcium-entry","display_name":"store-operated calcium entry","score":0.8629999756813049},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.7950000166893005},{"id":"https://openalex.org/keywords/trpc3-channels","display_name":"TRPC3 channels","score":0.8870000243186951},{"id":"https://openalex.org/keywords/diacylglycerol","display_name":"diacylglycerol","score":0.8730000257492065},{"id":"https://openalex.org/keywords/gq-11-protein","display_name":"Gq/11 protein","score":0.6940000057220459},{"id":"https://openalex.org/keywords/voltage-dependent-calcium-current","display_name":"voltage-dependent calcium current","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C39743133","wikidata":"https://www.wikidata.org/wiki/Q3262595","display_name":"Signalling","level":2,"score":0.7225342988967896},{"id":"https://openalex.org/C2779680196","wikidata":"https://www.wikidata.org/wiki/Q410857","display_name":"Orexin","level":4,"score":0.5339794158935547},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.518548309803009},{"id":"https://openalex.org/C2779605129","wikidata":"https://www.wikidata.org/wiki/Q24785218","display_name":"Orexin receptor","level":5,"score":0.4299094080924988},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.39077436923980713},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3427296280860901},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33928611874580383},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.33111321926116943},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3031313419342041},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.15001830458641052},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12460121512413025}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:erepo.uef.fi:123456789/10111","doi":null,"is_oa":true,"landing_page_url":"http://urn.fi/URN:ISBN:978-952-61-0436-2","pdf_url":"https://erepo.uef.fi/handle/123456789/10111","source":{"id":"https://openalex.org/S4306402418","display_name":"UEF eRepo (University of Eastern Finland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I175532246","host_organization_name":"University of Eastern Finland","host_organization_lineage":["https://openalex.org/I175532246"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:3095178777","doi":null,"is_oa":false,"landing_page_url":"https://erepo.uef.fi/bitstream/123456789/10111/1/urn_isbn_978-952-61-0436-2.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:erepo.uef.fi:123456789/10111","doi":null,"is_oa":true,"landing_page_url":"http://urn.fi/URN:ISBN:978-952-61-0436-2","pdf_url":"https://erepo.uef.fi/handle/123456789/10111","source":{"id":"https://openalex.org/S4306402418","display_name":"UEF eRepo (University of Eastern Finland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I175532246","host_organization_name":"University of Eastern Finland","host_organization_lineage":["https://openalex.org/I175532246"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3095178777.pdf","grobid_xml":"https://content.openalex.org/works/W3095178777.grobid-xml"},"referenced_works_count":320,"referenced_works":["https://openalex.org/W4221223","https://openalex.org/W27774160","https://openalex.org/W79052450","https://openalex.org/W182741536","https://openalex.org/W366582680","https://openalex.org/W1481198769","https://openalex.org/W1482441851","https://openalex.org/W1489654012","https://openalex.org/W1492894785","https://openalex.org/W1494239480","https://openalex.org/W1517501247","https://openalex.org/W1518153787","https://openalex.org/W1519232679","https://openalex.org/W1522789903","https://openalex.org/W1528325393","https://openalex.org/W1545579092","https://openalex.org/W1565496454","https://openalex.org/W1566391553","https://openalex.org/W1568965788","https://openalex.org/W1576671418","https://openalex.org/W1584157616","https://openalex.org/W1591707154","https://openalex.org/W1597385852","https://openalex.org/W1603199903","https://openalex.org/W1619312125","https://openalex.org/W1627229807","https://openalex.org/W1666469474","https://openalex.org/W1678757150","https://openalex.org/W1729732610","https://openalex.org/W1795554797","https://openalex.org/W1796558613","https://openalex.org/W1821976079","https://openalex.org/W1831184030","https://openalex.org/W1831949735","https://openalex.org/W1840002219","https://openalex.org/W1855586171","https://openalex.org/W1900979097","https://openalex.org/W1908186060","https://openalex.org/W1915837588","https://openalex.org/W1935851919","https://openalex.org/W1945000294","https://openalex.org/W1955207787","https://openalex.org/W1958742527","https://openalex.org/W1959892192","https://openalex.org/W1964628210","https://openalex.org/W1965055739","https://openalex.org/W1965263878","https://openalex.org/W1965531819","https://openalex.org/W1967578358","https://openalex.org/W1967866139","https://openalex.org/W1967936579","https://openalex.org/W1968099835","https://openalex.org/W1968399538","https://openalex.org/W1968682237","https://openalex.org/W1968925987","https://openalex.org/W1968973186","https://openalex.org/W1968974329","https://openalex.org/W1969458063","https://openalex.org/W1970493097","https://openalex.org/W1971473766","https://openalex.org/W1971565531","https://openalex.org/W1971886200","https://openalex.org/W1972076105","https://openalex.org/W1973109917","https://openalex.org/W1973237558","https://openalex.org/W1974342767","https://openalex.org/W1974354892","https://openalex.org/W1975001263","https://openalex.org/W1975042562","https://openalex.org/W1978634351","https://openalex.org/W1978887381","https://openalex.org/W1982092520","https://openalex.org/W1982350284","https://openalex.org/W1982728028","https://openalex.org/W1983298714","https://openalex.org/W1983933954","https://openalex.org/W1984212762","https://openalex.org/W1984311579","https://openalex.org/W1985579250","https://openalex.org/W1986447940","https://openalex.org/W1986626713","https://openalex.org/W1986633788","https://openalex.org/W1986674435","https://openalex.org/W1986876467","https://openalex.org/W1988097700","https://openalex.org/W1988336462","https://openalex.org/W1988612848","https://openalex.org/W1989051865","https://openalex.org/W1989347792","https://openalex.org/W1990350447","https://openalex.org/W1990452733","https://openalex.org/W1990538890","https://openalex.org/W1991277106","https://openalex.org/W1991747170","https://openalex.org/W1992054477","https://openalex.org/W1993204355","https://openalex.org/W1993481663","https://openalex.org/W1993582195","https://openalex.org/W1993886090","https://openalex.org/W1994915333","https://openalex.org/W1995221719","https://openalex.org/W1995515664","https://openalex.org/W1996084619","https://openalex.org/W1996164493","https://openalex.org/W1996305292","https://openalex.org/W1997463053","https://openalex.org/W1997508709","https://openalex.org/W1998390454","https://openalex.org/W1998969662","https://openalex.org/W1999433238","https://openalex.org/W1999591184","https://openalex.org/W1999633796","https://openalex.org/W1999934349","https://openalex.org/W2002393794","https://openalex.org/W2002613167","https://openalex.org/W2005626023","https://openalex.org/W2006027132","https://openalex.org/W2008408686","https://openalex.org/W2008870929","https://openalex.org/W2010230568","https://openalex.org/W2012578205","https://openalex.org/W2012943169","https://openalex.org/W2013655437","https://openalex.org/W2013962899","https://openalex.org/W2014028731","https://openalex.org/W2015023608","https://openalex.org/W2015251580","https://openalex.org/W2015264083","https://openalex.org/W2015637398","https://openalex.org/W2016429262","https://openalex.org/W2016536597","https://openalex.org/W2016729411","https://openalex.org/W2017384587","https://openalex.org/W2018297310","https://openalex.org/W2018800923","https://openalex.org/W2019040634","https://openalex.org/W2019097955","https://openalex.org/W2020526368","https://openalex.org/W2020674613","https://openalex.org/W2020708758","https://openalex.org/W2020803606","https://openalex.org/W2021094409","https://openalex.org/W2022037486","https://openalex.org/W2024348439","https://openalex.org/W2024400557","https://openalex.org/W2025976079","https://openalex.org/W2026781911","https://openalex.org/W2027721701","https://openalex.org/W2027740042","https://openalex.org/W2028175193","https://openalex.org/W2028344710","https://openalex.org/W2028676968","https://openalex.org/W2029301182","https://openalex.org/W2029525397","https://openalex.org/W2030721900","https://openalex.org/W2031943544","https://openalex.org/W2032007675","https://openalex.org/W2032825063","https://openalex.org/W2033663682","https://openalex.org/W2034915956","https://openalex.org/W2035053157","https://openalex.org/W2036287496","https://openalex.org/W2036325467","https://openalex.org/W2036385803","https://openalex.org/W2036507838","https://openalex.org/W2036910956","https://openalex.org/W2037945118","https://openalex.org/W2038404316","https://openalex.org/W2039599376","https://openalex.org/W2039896670","https://openalex.org/W2040012593","https://openalex.org/W2040700968","https://openalex.org/W2041731336","https://openalex.org/W2042388304","https://openalex.org/W2043029903","https://openalex.org/W2043217287","https://openalex.org/W2043875236","https://openalex.org/W2044056402","https://openalex.org/W2044775506","https://openalex.org/W2044995190","https://openalex.org/W2045139932","https://openalex.org/W2045471555","https://openalex.org/W2047067502","https://openalex.org/W2047362129","https://openalex.org/W2047385580","https://openalex.org/W2049082572","https://openalex.org/W2049088920","https://openalex.org/W2050209915","https://openalex.org/W2050947885","https://openalex.org/W2051408504","https://openalex.org/W2052039263","https://openalex.org/W2052482154","https://openalex.org/W2052877662","https://openalex.org/W2053209167","https://openalex.org/W2054088581","https://openalex.org/W2054158173","https://openalex.org/W2056656982","https://openalex.org/W2059180745","https://openalex.org/W2059883534","https://openalex.org/W2061432561","https://openalex.org/W2063535351","https://openalex.org/W2063544395","https://openalex.org/W2063987551","https://openalex.org/W2064442671","https://openalex.org/W2064514265","https://openalex.org/W2065638011","https://openalex.org/W2065664139","https://openalex.org/W2065899203","https://openalex.org/W2066577118","https://openalex.org/W2067369435","https://openalex.org/W2068973973","https://openalex.org/W2069066834","https://openalex.org/W2073881112","https://openalex.org/W2073909303","https://openalex.org/W2077257042","https://openalex.org/W2078184641","https://openalex.org/W2079071687","https://openalex.org/W2079636816","https://openalex.org/W2079839718","https://openalex.org/W2081434136","https://openalex.org/W2081490780","https://openalex.org/W2081666755","https://openalex.org/W2082094899","https://openalex.org/W2083021738","https://openalex.org/W2083310099","https://openalex.org/W2084264412","https://openalex.org/W2084675191","https://openalex.org/W2086076030","https://openalex.org/W2086126533","https://openalex.org/W2087564787","https://openalex.org/W2088041164","https://openalex.org/W2090575139","https://openalex.org/W2091887061","https://openalex.org/W2093069882","https://openalex.org/W2093266889","https://openalex.org/W2093661120","https://openalex.org/W2096549360","https://openalex.org/W2098318544","https://openalex.org/W2100149588","https://openalex.org/W2101674994","https://openalex.org/W2102220170","https://openalex.org/W2104554319","https://openalex.org/W2106376969","https://openalex.org/W2106988040","https://openalex.org/W2107370312","https://openalex.org/W2107391327","https://openalex.org/W2109152172","https://openalex.org/W2113440620","https://openalex.org/W2113921063","https://openalex.org/W2115902692","https://openalex.org/W2117029515","https://openalex.org/W2117519515","https://openalex.org/W2117917356","https://openalex.org/W2117954460","https://openalex.org/W2118950099","https://openalex.org/W2118988881","https://openalex.org/W2119084501","https://openalex.org/W2121147520","https://openalex.org/W2121192347","https://openalex.org/W2122196568","https://openalex.org/W2122782956","https://openalex.org/W2124158754","https://openalex.org/W2124674257","https://openalex.org/W2125145927","https://openalex.org/W2126469092","https://openalex.org/W2127230663","https://openalex.org/W2128002735","https://openalex.org/W2129647459","https://openalex.org/W2129684168","https://openalex.org/W2130717252","https://openalex.org/W2131486495","https://openalex.org/W2132372764","https://openalex.org/W2133533221","https://openalex.org/W2134333835","https://openalex.org/W2134922176","https://openalex.org/W2136672278","https://openalex.org/W2138262820","https://openalex.org/W2139287985","https://openalex.org/W2143609607","https://openalex.org/W2143934651","https://openalex.org/W2144249632","https://openalex.org/W2144950544","https://openalex.org/W2149487756","https://openalex.org/W2150091977","https://openalex.org/W2150132984","https://openalex.org/W2150515709","https://openalex.org/W2152630055","https://openalex.org/W2153283433","https://openalex.org/W2153671031","https://openalex.org/W2154275119","https://openalex.org/W2154675993","https://openalex.org/W2157584035","https://openalex.org/W2161440135","https://openalex.org/W2162014506","https://openalex.org/W2162054230","https://openalex.org/W2162970979","https://openalex.org/W2163094253","https://openalex.org/W2163162884","https://openalex.org/W2163650198","https://openalex.org/W2164662577","https://openalex.org/W2164675383","https://openalex.org/W2167591942","https://openalex.org/W2168909179","https://openalex.org/W2169378022","https://openalex.org/W2169412710","https://openalex.org/W2170390435","https://openalex.org/W2170617671","https://openalex.org/W2174190166","https://openalex.org/W2180588909","https://openalex.org/W2184997641","https://openalex.org/W2186073124","https://openalex.org/W2205652137","https://openalex.org/W2245778979","https://openalex.org/W2264168519","https://openalex.org/W2268409607","https://openalex.org/W2274419817","https://openalex.org/W2343154084","https://openalex.org/W2405794676","https://openalex.org/W2418742902","https://openalex.org/W4322388558"],"related_works":["https://openalex.org/W1764472238","https://openalex.org/W1918384039","https://openalex.org/W128496773","https://openalex.org/W2083977901","https://openalex.org/W1985579250","https://openalex.org/W214082660","https://openalex.org/W220103140","https://openalex.org/W1564519768","https://openalex.org/W2033547042","https://openalex.org/W2065214424"],"abstract_inverted_index":{"The":[0],"orexin-1":[1],"receptor":[2,281],"(OX1R)":[3],"is":[4,117,297,395],"a":[5,8,27,140,193,202,214,260,405],"member":[6],"of":[7,10,35,41,62,95,142,151,154,206,217,248,263,270,314,323,331,350,358,377,381,409],"superfamily":[9],"G-protein":[11],"coupled":[12],"receptors":[13],"(GPCRs).Two":[14],"hypothalamic":[15],"neuropeptides,":[16],"orexin-A/hypocretin-1":[17],"(Ox-A)":[18],"and":[19,23,26,46,49,67,71,86,104,132,171,181,213,236,273,300,318,326,341,354,383,412],"orexin-B/hypocretin-2,":[20],"bind":[21],"to":[22,58,84,93,113,158,170,200,246,258,321,329,336,372,384],"activate":[24],"OX1R":[25,55,168,351,382,410,418],"related":[28],"GPCR,":[29],"the":[30,36,52,63,75,99,105,118,160,167,178,207,267,271,274,286,293,298,312,332,374,389,393],"orexin-2":[31],"receptor.The":[32],"physiological":[33],"effects":[34],"orexin":[37],"system":[38],"include":[39],"regulation":[40],"feeding,":[42],"energy":[43],"metabolism,":[44],"endocrine":[45],"autonomic":[47],"systems,":[48],"sleep/wake":[50],"cycle.At":[51],"cellular":[53],"level,":[54],"stimulation":[56],"leads":[57],"neuronal":[59],"excitation,":[60],"activation":[61,353],"adenylyl":[64],"cyclase":[65],"pathway":[66,120],"several":[68],"protein":[69,342],"kinases,":[70],"an":[72,209],"increase":[73],"in":[74,186,292,311,388,403,413],"intracellular":[76,100],"Ca":[77,96,101,108,144,173,182,224,238,250,294,306,316,359,378],"2+":[78,81,97,102,109,145,174,183,219,225,239,251,295,307,317,360,379],"concentration":[79,197,240],"([Ca":[80],"]i).OX1R":[82],"couples":[83],"Gq/11-proteins":[85],"activates":[87],"phospholipase":[88,339],"C":[89,254],"(PLC":[90],"-pathway":[91],"leading":[92,169],"release":[94,150,325],"from":[98],"stores":[103],"subsequent":[106],"capacitative":[107],"entry":[110],"(CCE)":[111],"aiming":[112],"refill":[114],"depleted":[115],"stores.This":[116],"main":[119],"utilized":[121],"when":[122],"high":[123],"nanomolar":[124,195,365],"Ox-A":[125,196,229,304,366],"concentrations":[126,137,230],"are":[127],"evaluated,":[128],"but":[129],"at":[130,227],"lower,":[131],"probably":[133],"physiologically":[134],"more":[135,406],"relevant,":[136],"there":[138],"was":[139,157,198,221,256,370],"predominance":[141],"receptor-operated":[143,249],"influx":[146,296],"without":[147],"any":[148],"detectable":[149],"stores.The":[152],"aim":[153],"this":[155],"study":[156],"elucidate":[159],"poorly":[161],"characterized":[162],"signalling":[163,380,411],"mechanisms":[164],"used":[165],"by":[166,363,392],"regulating":[172],"responses.The":[175],"investigations":[176],"with":[177,276],"patch":[179],"clamp":[180],"imaging":[184],"techniques":[185],"recombinant":[187],"cell":[188],"models":[189],"demonstrated":[190],"that":[191,223,397],"even":[192],"low":[194,228,364],"able":[199],"evoke":[201],"highly":[203],"voltage-dependent":[204],"depolarization":[205],"membrane,":[208],"increased":[210],"ion":[211,289],"current,":[212],"robust":[215],"elevation":[216],"[Ca":[218],"]i.It":[220],"found":[222,257],"responses":[226,272,308],"were":[231,319,345],"acutely":[232],"dependent":[233],"on":[234,266],"voltage":[235],"extracellular":[237,315],"as":[241,243,347,355],"well":[242],"being":[244],"sensitive":[245,320],"blockers":[247],"entry.Protein":[252],"kinase":[253,343],"(PKC)":[255],"be":[259,401],"crucial":[261],"regulator":[262],"these":[264,398],"responses.Based":[265],"pharmacological":[268],"profile":[269],"experiments":[275],"dominant":[277],"negative":[278],"canonical":[279],"transient":[280],"potential":[282],"channel":[283,290],"(TRPC)":[284],"subtypes,":[285],"most":[287],"probable":[288],"involved":[291],"diacylglycerol-activated":[299],"PKC-regulated":[301],"TRPC3.At":[302],"higher":[303],"concentrations,":[305],"occurred":[309],"also":[310],"absence":[313],"inhibitors":[322],"store":[324],"CCE,":[327],"pointing":[328],"involvement":[330],"PLC":[333],"-pathway.In":[334],"addition":[335],"TRPC3":[337],"channel,":[338],"A2":[340],"D1/3":[344],"identified":[346],"novel":[348,386],"targets":[349],"mediated":[352],"prominent":[356],"modulators":[357],"oscillations":[361],"induced":[362],"concentrations.In":[367],"conclusion,":[368],"it":[369],"possible":[371],"confirm":[373],"present":[375],"view":[376],"identify":[385],"players":[387],"pathways":[390],"activated":[391],"receptor.It":[394],"hoped":[396],"results":[399],"will":[400],"useful":[402],"constructing":[404],"comprehensive":[407],"picture":[408],"developing":[414],"efficient":[415],"therapies":[416],"for":[417],"-related":[419],"disorders.":[420]},"counts_by_year":[],"updated_date":"2026-10-03T13:16:28.481748","created_date":"2020-11-09T00:00:00"}