{"id":"https://openalex.org/W3095089412","doi":"https://doi.org/10.1182/blood-2020-138951","title":"Genomic and Transcriptomic Characterization of IgM Multiple Myeloma Identifies a Pre-Germinal Center Plasma Cell Disorder with Immature B-Cell Transcription-Factor Signature","display_name":"Genomic and Transcriptomic Characterization of IgM Multiple Myeloma Identifies a Pre-Germinal Center Plasma Cell Disorder with Immature B-Cell Transcription-Factor Signature","publication_year":2020,"publication_date":"2020-11-05","ids":{"openalex":"https://openalex.org/W3095089412","doi":"https://doi.org/10.1182/blood-2020-138951","mag":"3095089412"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2020-138951","doi":"https://doi.org/10.1182/blood-2020-138951","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2020-138951","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048162877","display_name":"Abdul Hamid Bazarbachi","orcid":"https://orcid.org/0000-0003-0243-4040","observed_orcids":["https://orcid.org/0000-0003-0243-4040"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abdul Hamid Bazarbachi","raw_affiliation_strings":["Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Paris, France","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063422967","display_name":"Herv\u00e9 Avet\u2010Loiseau","orcid":"https://orcid.org/0000-0002-3050-0140","observed_orcids":["https://orcid.org/0000-0002-3050-0140"]},"institutions":[{"id":"https://openalex.org/I4210098740","display_name":"Institut universitaire du cancer de Toulouse Oncopole","ror":"https://ror.org/014hxhm89","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017","https://openalex.org/I4210098740","https://openalex.org/I4210128666"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Herve Avet-Loiseau","raw_affiliation_strings":["Insititut Universitaire du Cancer, Unite de Genomique du Myelome, IUC-Oncopole, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Insititut Universitaire du Cancer, Unite de Genomique du Myelome, IUC-Oncopole, Toulouse, France","institution_ids":["https://openalex.org/I4210098740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026121534","display_name":"Zachary R. Hunter","orcid":"https://orcid.org/0000-0002-1689-1691","observed_orcids":["https://orcid.org/0000-0002-1689-1691"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zachary R Hunter","raw_affiliation_strings":["Bing Center for Waldenstrom's Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bing Center for Waldenstrom's Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055748047","display_name":"Raphael Elie Szalat","orcid":"https://orcid.org/0000-0002-6198-3405","observed_orcids":["https://orcid.org/0000-0002-6198-3405"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raphael Szalat","raw_affiliation_strings":["Boston University School of Medicine, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University School of Medicine, Boston, MA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071900604","display_name":"An\u0131l Akta\u015f-Samur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anil Aktas-Samur","raw_affiliation_strings":["Department of Data Science, Dana Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Data Science, Dana Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063099799","display_name":"Masood A. Shammas","orcid":"https://orcid.org/0000-0002-8932-6829","observed_orcids":["https://orcid.org/0000-0002-8932-6829"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masood A. Shammas","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030565933","display_name":"Jill Corre","orcid":"https://orcid.org/0000-0003-1580-6106","observed_orcids":["https://orcid.org/0000-0003-1580-6106"]},"institutions":[{"id":"https://openalex.org/I4210098740","display_name":"Institut universitaire du cancer de Toulouse Oncopole","ror":"https://ror.org/014hxhm89","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017","https://openalex.org/I4210098740","https://openalex.org/I4210128666"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jill Corre","raw_affiliation_strings":["Unite de Genomique du Myelome, IUC-T Oncopole, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unite de Genomique du Myelome, IUC-T Oncopole, Toulouse, France","institution_ids":["https://openalex.org/I4210098740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062468245","display_name":"Mariateresa Fulciniti","orcid":"https://orcid.org/0000-0002-1432-9742","observed_orcids":["https://orcid.org/0000-0002-1432-9742"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mariateresa Fulciniti","raw_affiliation_strings":["Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032464400","display_name":"Kenneth Carl Anderson","orcid":"https://orcid.org/0000-0002-6418-0886","observed_orcids":["https://orcid.org/0000-0002-6418-0886"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth Anderson","raw_affiliation_strings":["The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050977500","display_name":"Giovanni Parmigiani","orcid":"https://orcid.org/0000-0002-8783-5961","observed_orcids":["https://orcid.org/0000-0002-8783-5961"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Giovanni Parmigiani","raw_affiliation_strings":["Data Science, Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Data Science, Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081299017","display_name":"Steven Peter Treon","orcid":"https://orcid.org/0000-0001-6393-6154","observed_orcids":["https://orcid.org/0000-0001-6393-6154"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Treon","raw_affiliation_strings":["Bing Center for Waldenstrom Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bing Center for Waldenstrom Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020996390","display_name":"Mohamad Mohty","orcid":"https://orcid.org/0000-0002-7264-808X","observed_orcids":["https://orcid.org/0000-0002-7264-808X","https://orcid.org/0000-0001-8536-7781"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210102928","display_name":"H\u00f4pital Saint-Antoine","ror":"https://ror.org/01875pg84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]},{"id":"https://openalex.org/I4210162862","display_name":"European Society for Blood and Marrow Transplantation","ror":"https://ror.org/05gkev856","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210162862"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mohamad Mohty","raw_affiliation_strings":["Department of Haematology and EBMT Paris study office / CEREST-TC, Saint Antoine Hospital, INSERM UMR 938 and Universit\u00e9 Pierre et Marie Curie, Paris, France","Saint Antoine Hospital, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology and EBMT Paris study office / CEREST-TC, Saint Antoine Hospital, INSERM UMR 938 and Universit\u00e9 Pierre et Marie Curie, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210102928","https://openalex.org/I4210162862","https://openalex.org/I4405264447"]},{"raw_affiliation_string":"Saint Antoine Hospital, Paris, France","institution_ids":["https://openalex.org/I4210102928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041668980","display_name":"Mehmet Samur","orcid":"https://orcid.org/0000-0002-9978-5682","observed_orcids":["https://orcid.org/0000-0002-9978-5682"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mehmet K. Samur","raw_affiliation_strings":["Department of Data Science, Dana-Farber Cancer Institute, Harvard TH Chan School of Public Health, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Data Science, Dana-Farber Cancer Institute, Harvard TH Chan School of Public Health, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045740077","display_name":"Nikhil C. Munshi","orcid":"https://orcid.org/0000-0002-7344-9795","observed_orcids":["https://orcid.org/0000-0002-7344-9795","https://orcid.org/0000-0002-8397-100X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikhil C. Munshi","raw_affiliation_strings":["Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.16593847,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"136","issue":"Supplement 1","first_page":"7","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/waldenstrom-macroglobulinemia","display_name":"Waldenstr\u00f6m macroglobulinemia","score":0.9539999961853027},{"id":"https://openalex.org/keywords/class-switch-recombination","display_name":"class switch recombination","score":0.6899999976158142},{"id":"https://openalex.org/keywords/igh-translocation","display_name":"IGH translocation","score":0.5659999847412109},{"id":"https://openalex.org/keywords/ccnd1","display_name":"CCND1","score":0.8510000109672546},{"id":"https://openalex.org/keywords/bcl11a","display_name":"BCL11A","score":0.4790000021457672},{"id":"https://openalex.org/keywords/bcl11b","display_name":"BCL11B","score":0.5529999732971191},{"id":"https://openalex.org/keywords/bcl11c","display_name":"BCL11C","score":0.5529999732971191},{"id":"https://openalex.org/keywords/bcl11d","display_name":"BCL11D","score":0.5590000152587891},{"id":"https://openalex.org/keywords/bcl11e","display_name":"BCL11E","score":0.6050000190734863},{"id":"https://openalex.org/keywords/bcl11f","display_name":"BCL11F","score":0.6840000152587891},{"id":"https://openalex.org/keywords/bcl11g","display_name":"BCL11G","score":0.6470000147819519},{"id":"https://openalex.org/keywords/bcl11h","display_name":"BCL11H","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C96926380","wikidata":"https://www.wikidata.org/wiki/Q1737968","display_name":"Germinal center","level":4,"score":0.7536900043487549},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7095378637313843},{"id":"https://openalex.org/C137756551","wikidata":"https://www.wikidata.org/wiki/Q2386881","display_name":"Immunoglobulin class switching","level":4,"score":0.7022212147712708},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.5802803039550781},{"id":"https://openalex.org/C2776396001","wikidata":"https://www.wikidata.org/wiki/Q250694","display_name":"Plasma cell","level":3,"score":0.5708470344543457},{"id":"https://openalex.org/C36394416","wikidata":"https://www.wikidata.org/wiki/Q949267","display_name":"Immunoglobulin light chain","level":3,"score":0.5271551012992859},{"id":"https://openalex.org/C2776553844","wikidata":"https://www.wikidata.org/wiki/Q79451","display_name":"Immunoglobulin M","level":4,"score":0.5011920928955078},{"id":"https://openalex.org/C48010095","wikidata":"https://www.wikidata.org/wiki/Q79447","display_name":"Immunoglobulin D","level":4,"score":0.4899977743625641},{"id":"https://openalex.org/C29447677","wikidata":"https://www.wikidata.org/wiki/Q18030356","display_name":"PAX5","level":4,"score":0.4885736405849457},{"id":"https://openalex.org/C96007430","wikidata":"https://www.wikidata.org/wiki/Q3776943","display_name":"Immunoglobulin heavy chain","level":3,"score":0.4813128709793091},{"id":"https://openalex.org/C2776391228","wikidata":"https://www.wikidata.org/wiki/Q4118092","display_name":"Macroglobulinemia","level":3,"score":0.47820115089416504},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4628109037876129},{"id":"https://openalex.org/C113646796","wikidata":"https://www.wikidata.org/wiki/Q50263283","display_name":"Recombination-activating gene","level":4,"score":0.4295824468135834},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4226928949356079},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.3871702253818512},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3087790012359619},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2838500142097473},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.23421910405158997},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23410183191299438},{"id":"https://openalex.org/C156695909","wikidata":"https://www.wikidata.org/wiki/Q3373825","display_name":"Recombination","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2020-138951","doi":"https://doi.org/10.1182/blood-2020-138951","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2020-138951","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3196948396","https://openalex.org/W2209053940","https://openalex.org/W1609171779","https://openalex.org/W1995732551","https://openalex.org/W4417004807","https://openalex.org/W2062776328","https://openalex.org/W2550399697","https://openalex.org/W2338762004","https://openalex.org/W4249236223","https://openalex.org/W4310108058"],"abstract_inverted_index":{"Multiple":[0],"myeloma":[1],"(MM)":[2],"is":[3,35,53,83,229,232,562],"a":[4,36,235,286,296,340,411,476,544,585],"proliferation":[5],"of":[6,198,237,239,242,325,332,351,360,369,373,425,431,496,507,534,546,575,591,623,634,645,658,669,680,692,820],"terminally":[7,402],"differentiated":[8,403],"plasma":[9],"cells":[10],"(PC)":[11],"producing":[12,46],"monoclonal":[13],"immunoglobulins":[14],"(Ig),":[15],"most":[16],"commonly":[17],"IgG":[18],"and":[19,22,25,32,40,59,73,78,102,106,120,178,205,257,276,327,329,355,357,362,371,429,450,468,512,522,536,551,564,588,597,604,686,694],"IgA":[20],"(50%":[21],"25%":[23],"respectively),":[24],"less":[26],"frequently,":[27],"light-chain":[28],"only":[29,314],"disease,":[30],"non-secretory,":[31],"IgD.":[33],"IgM-MM":[34,124,209,214,248,280,333,408,457,467,484,491,529],"rare":[37],"entity":[38],"(<0.5%),":[39],"its":[41,426,601],"differentiation":[42],"from":[43],"common":[44],"IgM":[45,95,111,511],"PC":[47,384],"disorders":[48],"like":[49],"Waldenstr\u00f6m's":[50],"macroglobulinemia":[51],"(WM)":[52],"essential":[54,390],"considering":[55],"their":[56],"distinct":[57],"treatments":[58],"prognoses.":[60],"Recent":[61],"advancements":[62],"in":[63,76,132,171,174,189,375,380,401,443,456,482,489,509,578,702,710,812,832],"molecular":[64,288],"techniques":[65],"have":[66],"shed":[67],"light":[68],"on":[69,93,109,619,630,641,654,665,676,816],"the":[70,110,145,185,190,279,306,310,335,349,358,397,421,483,572,606],"genomic":[71,587],"characteristics":[72],"unique":[74,297,341,586],"alterations":[75],"MM":[77,101,154,291,328],"WM,":[79,119,598],"however,":[80],"comprehensive":[81],"profiling":[82],"still":[84],"lacking":[85],"for":[86,299,304,391,480,519,556,608],"IgM-MM.":[87,580],"We":[88],"performed":[89],"deep":[90],"whole-genome":[91],"sequencing":[92,108],"five":[94],"samples":[96,112,125,155,281],"as":[97,99,113,115,487],"well":[98,114],"211":[100],"34":[103],"WM":[104,277,294,326,469],"samples,":[105],"transcriptome":[107],"30":[116],"MM,":[117],"35":[118],"3":[121],"PC.":[122,404],"All":[123,137],"harbored":[126],"t(11;14)":[127,307],"which":[128,227,231,418],"combines":[129],"super":[130],"enhancers":[131],"Ig":[133],"genes":[134,273],"with":[135,200,295,323,416,463,498],"CCND1.":[136],"translocations":[138,160,164,180],"involved":[139],"VHDHJH":[140,179],"regions":[141],"(Figure":[142,161,343],"1A)":[143],"at":[144,184],"immunoglobulin":[146],"heavy":[147],"chain":[148],"(IGH)":[149],"locus,":[150],"compared":[151,260,292,364,415,458,538,593],"to":[152,217,222,246,261,290,293,365,383,440,459,539,542,549,569,594],"IgG/IgA":[153],"that":[156,407,599],"had":[157,210,492,530],"predominantly":[158],"switch-region":[159,204],"1B/C).":[162],"Switch-region":[163],"are":[165,567],"generated":[166],"through":[167,396],"class-switch":[168],"recombination":[169,183],"(CSR)":[170],"mature":[172],"B-cells":[173,376],"germinal":[175],"centers":[176],"(GC),":[177],"occur":[181],"during":[182],"early":[186,392],"pro-B-cell":[187],"stage":[188],"bone":[191],"marrow":[192],"(BM).":[193],"While":[194],"IgG/IgA-MM":[195],"displayed":[196,250],"evidence":[197],"CSR":[199,228],"deletions":[201],"between":[202,274,466],"IGHM":[203],"IGHG/IGHA":[206],"switch":[207],"regions,":[208],"no":[211,464],"such":[212],"events.":[213,266],"therefore":[215,410,552],"appears":[216,406],"undergo":[218],"malignant":[219],"transformation":[220],"prior":[221],"late-stage":[223],"B-cell":[224,315,393],"maturation,":[225],"after":[226],"unlikely,":[230],"supported":[233],"by":[234,305],"lack":[236,430],"progression":[238,265],"IgM-monoclonal":[240],"gammopathy":[241],"undetermined":[243],"significance":[244],"(MGUS)":[245],"non-IgM-MM.":[247,283,366],"also":[249,338],"similar":[251,264,321],"copy":[252],"number":[253],"variation":[254],"(CNV)":[255],"patterns":[256],"driver":[258],"mutations":[259],"non-IgM-MM":[262,275,460,596],"suggesting":[263],"Unsupervised":[267],"hierarchical":[268],"clustering":[269,331],"using":[270,313,501],"differentially":[271],"expressed":[272],"separated":[278],"within":[282,334],"This":[284,473],"indicates":[285],"closer":[287],"homology":[289],"signature":[298,342],"this":[300],"group":[301],"not":[302,527],"accounted":[303],"translocation.":[308],"Running":[309],"same":[311],"analysis":[312],"specific":[316],"transcription":[317],"factors":[318],"(TFs)":[319],"yielded":[320],"results,":[322],"separation":[324],"preferential":[330],"latter":[336],"while":[337,386],"exhibiting":[339],"1D).":[344],"Some":[345],"noteworthy":[346],"examples":[347],"were":[348,438,514],"upregulation":[350,372],"PBX3,":[352],"PAX5,":[353],"BCL11A,":[354],"ATF2,":[356],"downregulation":[359],"PRDM1":[361,374],"BCL3":[363],"The":[367],"loss":[368],"PAX5":[370],"has":[377,409],"been":[378],"implicated":[379],"promoting":[381],"commitment":[382],"differentiation,":[385],"BCL11A":[387],"was":[388,453],"found":[389],"progenitor":[394],"development":[395],"GC":[398],"but":[399],"extinguished":[400],"It":[405],"more":[412,477],"immature":[413],"phenotype":[414],"non-IgM-MM,":[417],"further":[419,565],"supports":[420],"previously":[422],"discussed":[423],"findings":[424],"pre-GC":[427],"origin":[428,603],"terminal":[432],"development.":[433],"Three":[434],"clinically":[435],"relevant":[436],"targets":[437],"noted":[439],"be":[441,543],"upregulated":[442],"IgM-MM,":[444,592],"Bruton's":[445],"tyrosine":[446],"kinase":[447],"(BTK),":[448],"CD20":[449,497],"BCL-2.":[451],"BTK":[452],"significantly":[454],"higher":[455,547],"(log2fold=1.3;":[461],"FDR<10-3)":[462],"difference":[465],"(log2fold":[470],"=-0.4;":[471],"FDR>0.2).":[472],"could":[474],"elucidate":[475],"prominent":[478],"role":[479,574],"BTK-inhibition":[481],"subgroup.":[485],"Furthermore,":[486],"documented":[488],"t(11;14)-MM,":[490],"elevated":[493,505],"transcript":[494,532],"levels":[495,506,533],"possible":[499],"targeting":[500],"anti-CD20":[502],"antibodies.":[503],"Finally,":[504],"BCL-2":[508],"both":[510,520,595],"non-IgM-t(11;14)-MM":[513],"observed,":[515],"an":[516,553,620,631,642,655,666,677,817],"established":[517],"target":[518],"single-agent":[521],"combination":[523],"therapy.":[524],"Interestingly,":[525],"although":[526],"significant,":[528],"lower":[531],"BCL-XL":[535],"MCL-1":[537],"non-IgM-t(11;14)-MM,":[540],"believed":[541],"predictor":[545],"sensitivity":[548],"venetoclax,":[550],"important":[554],"guide":[555],"treatment":[557],"choice.":[558],"Clinical":[559],"data":[560],"however":[561],"lacking,":[563],"investigations":[566],"needed":[568],"fully":[570],"understand":[571],"potential":[573,609],"these":[576],"drugs":[577],"treating":[579],"In":[581],"summary":[582],"we":[583],"describe":[584],"transcriptomic":[589],"profile":[590],"describes":[600],"cellular":[602],"provides":[605],"rationale":[607],"therapeutic":[610],"intervention.":[611],"Disclosures":[612],"Fulciniti:":[613],"NIH:":[614],"Research":[615,726,730,735,742,749,756,763,771,778,785,792,799],"Funding.":[616,731],"Anderson:Gilead:":[617],"Membership":[618,629,640,653,664,675,815],"entity's":[621,632,643,656,667,678,818],"Board":[622,633,644,657,668,679,819],"Directors":[624,635,646,659,670,681,821],"or":[625,636,647,660,671,682,822],"advisory":[626,637,648,661,672,683,823],"committees;":[627,638,649,662,673,684],"Janssen:":[628,796,835],"Sanofi-Aventis:":[639],"Bristol":[650],"Myers":[651],"Squibb:":[652],"Celgene:":[663,739],"Millenium-Takeda:":[674],"Oncopep":[685,693],"C4":[687,695],"Therapeutics.:":[688],"Other:":[689,722],"Scientific":[690],"Founder":[691],"Therapeutics..":[696],"Parmigiani:Phaeno":[697],"Biotehnologies:":[698],"Current":[699,707,809,829],"equity":[700,708,810,830],"holder":[701,709,811,831],"publicly-traded":[703,711],"company;":[704,712,834],"CRA":[705],"Health:":[706],"Foundation":[713],"Medicine":[714],"Institute:":[715],"Consultancy;":[716,719,804,806,836,838,840,842,844],"Delphi":[717],"Diagnostics:":[718],"BayesMendel":[720],"Laboratory:":[721],"Co-lead.":[723],"Treon:Bristol-Meyer-Squibb:":[724],"Honoraria,":[725,729,734,741,748,755,762,770,777,784,791,798],"Funding;":[727],"Pharmacyclics:":[728],"Mohty:Novartis:":[732],"Consultancy,":[733,740,747,754,761,769,776,783,790,797,808],"Funding,":[736,743,750,757,764,772,779,786,793,800],"Speakers":[737,744,751,758,765,773,780,787,794,801],"Bureau;":[738,745,752,759,766,774,781,788,795],"GSK:":[746],"BMS:":[753,805],"Stemline:":[760],"Jazz":[767],"Pharmaceuticals:":[768],"Sanofi:":[775],"Takeda:":[782],"Amgen:":[789,841],"Bureau.":[802],"Munshi:Takeda:":[803],"OncoPep:":[807],"private":[813,833],"company,":[814],"committees,":[824],"Patents":[825],"&":[826],"Royalties;":[827],"C4:":[828],"Adaptive:":[837],"Legend:":[839],"Karyopharm:":[843],"AbbVie:":[845],"Consultancy.":[846]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2020-11-09T00:00:00"}
