{"id":"https://openalex.org/W3095068463","doi":"https://doi.org/10.1016/s0959-8049(20)31217-x","title":"Optimal therapeutic positioning of a selective bi-steric inhibitor of MTORC1 in genetically defined cancers","display_name":"Optimal therapeutic positioning of a selective bi-steric inhibitor of MTORC1 in genetically defined cancers","publication_year":2020,"publication_date":"2020-10-01","ids":{"openalex":"https://openalex.org/W3095068463","doi":"https://doi.org/10.1016/s0959-8049(20)31217-x","mag":"3095068463"},"language":"en","primary_location":{"id":"doi:10.1016/s0959-8049(20)31217-x","doi":"https://doi.org/10.1016/s0959-8049(20)31217-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0959-8049(20)31217-x","pdf_url":"http://www.ejcancer.com/article/S095980492031217X/pdf","source":{"id":"https://openalex.org/S16731738","display_name":"European Journal of Cancer","issn_l":"0959-8049","issn":["0959-8049","1879-0852"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.ejcancer.com/article/S095980492031217X/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101768843","display_name":"Jingjing Jiang","orcid":"https://orcid.org/0000-0002-5646-6040","observed_orcids":["https://orcid.org/0000-0002-5646-6040"]},"institutions":[{"id":"https://openalex.org/I4210100604","display_name":"Revolution Medicines (United States)","ror":"https://ror.org/00mny1y94","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100604"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Jiang","raw_affiliation_strings":["Revolution Medicines, Research and Development, Redwood City, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Revolution Medicines, Research and Development, Redwood City, USA","institution_ids":["https://openalex.org/I4210100604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020727899","display_name":"Yu Chi Yang","orcid":"https://orcid.org/0000-0001-8318-1174","observed_orcids":["https://orcid.org/0000-0001-8318-1174"]},"institutions":[{"id":"https://openalex.org/I4210100604","display_name":"Revolution Medicines (United States)","ror":"https://ror.org/00mny1y94","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100604"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y.C. Yang","raw_affiliation_strings":["Revolution Medicines, Research and Development, Redwood City, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Revolution Medicines, Research and Development, Redwood City, USA","institution_ids":["https://openalex.org/I4210100604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052945974","display_name":"Christopher J. Schulze","orcid":"https://orcid.org/0009-0005-6736-871X","observed_orcids":["https://orcid.org/0009-0005-6736-871X"]},"institutions":[{"id":"https://openalex.org/I4210100604","display_name":"Revolution Medicines (United States)","ror":"https://ror.org/00mny1y94","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100604"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C.J. Schulze","raw_affiliation_strings":["Revolution Medicines, Research and Development, Redwood City, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Revolution Medicines, Research and Development, Redwood City, USA","institution_ids":["https://openalex.org/I4210100604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029071777","display_name":"James Evans","orcid":"https://orcid.org/0009-0005-0401-6397","observed_orcids":["https://orcid.org/0009-0005-0401-6397"]},"institutions":[{"id":"https://openalex.org/I4210100604","display_name":"Revolution Medicines (United States)","ror":"https://ror.org/00mny1y94","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100604"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.W. Evans","raw_affiliation_strings":["Revolution Medicines, Research and Development, Redwood City, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Revolution Medicines, Research and Development, Redwood City, USA","institution_ids":["https://openalex.org/I4210100604"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Z.C. Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100604","display_name":"Revolution Medicines (United States)","ror":"https://ror.org/00mny1y94","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100604"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Z.C. Wang","raw_affiliation_strings":["Revolution Medicines, Research and Development, Redwood City, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Revolution Medicines, Research and Development, Redwood City, USA","institution_ids":["https://openalex.org/I4210100604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021673608","display_name":"B.J. Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100604","display_name":"Revolution Medicines (United States)","ror":"https://ror.org/00mny1y94","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100604"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B.J. Lee","raw_affiliation_strings":["Revolution Medicines, Research and Development, Redwood City, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Revolution Medicines, Research and Development, Redwood City, USA","institution_ids":["https://openalex.org/I4210100604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055494036","display_name":"Tiffany J. Choy","orcid":"https://orcid.org/0000-0001-6501-2123","observed_orcids":["https://orcid.org/0000-0001-6501-2123"]},"institutions":[{"id":"https://openalex.org/I4210100604","display_name":"Revolution Medicines (United States)","ror":"https://ror.org/00mny1y94","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100604"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T.J. Choy","raw_affiliation_strings":["Revolution Medicines, Research and Development, Redwood City, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Revolution Medicines, Research and Development, Redwood City, USA","institution_ids":["https://openalex.org/I4210100604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112578026","display_name":"Denise F. Reyes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100604","display_name":"Revolution Medicines (United States)","ror":"https://ror.org/00mny1y94","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100604"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D.F. Reyes","raw_affiliation_strings":["Revolution Medicines, Research and Development, Redwood City, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Revolution Medicines, Research and Development, Redwood City, USA","institution_ids":["https://openalex.org/I4210100604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053584749","display_name":"Ren Zhao","orcid":"https://orcid.org/0000-0002-8127-8682","observed_orcids":["https://orcid.org/0000-0002-8127-8682"]},"institutions":[{"id":"https://openalex.org/I4210100604","display_name":"Revolution Medicines (United States)","ror":"https://ror.org/00mny1y94","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100604"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.P. Zhao","raw_affiliation_strings":["Revolution Medicines, Research and Development, Redwood City, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Revolution Medicines, Research and Development, Redwood City, USA","institution_ids":["https://openalex.org/I4210100604"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J.Y. Tao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.Y. Tao","raw_affiliation_strings":["University of Pittsburgh & University of Pittsburgh Medical Center, Department of Pathology & Pittsburgh Liver Research Center, Pittsburgh, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh & University of Pittsburgh Medical Center, Department of Pathology & Pittsburgh Liver Research Center, Pittsburgh, USA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024792267","display_name":"Heng Du","orcid":"https://orcid.org/0000-0001-9067-0910","observed_orcids":["https://orcid.org/0000-0001-9067-0910"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Du","raw_affiliation_strings":["Brigham & Women's Hospital, Division of Pulmonary & Critical Care Medicine, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham & Women's Hospital, Division of Pulmonary & Critical Care Medicine, Boston, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047028132","display_name":"Tomoko Ozawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210167126","display_name":"UCSF Helen Diller Family Comprehensive Cancer Center","ror":"https://ror.org/05yndxy10","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210110664","https://openalex.org/I4210167126"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Ozawa","raw_affiliation_strings":["University of California- San Francisco, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California- San Francisco, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, USA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038156337","display_name":"David P. Wildes","orcid":"https://orcid.org/0009-0009-3855-7270","observed_orcids":["https://orcid.org/0009-0009-3855-7270"]},"institutions":[{"id":"https://openalex.org/I4210100604","display_name":"Revolution Medicines (United States)","ror":"https://ror.org/00mny1y94","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100604"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D.P. Wildes","raw_affiliation_strings":["Revolution Medicines, Research and Development, Redwood City, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Revolution Medicines, Research and Development, Redwood City, USA","institution_ids":["https://openalex.org/I4210100604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007540843","display_name":"David Ronan Raleigh","orcid":"https://orcid.org/0000-0001-9299-8864","observed_orcids":["https://orcid.org/0000-0001-9299-8864"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210167126","display_name":"UCSF Helen Diller Family Comprehensive Cancer Center","ror":"https://ror.org/05yndxy10","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210110664","https://openalex.org/I4210167126"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D.R. Raleigh","raw_affiliation_strings":["University of California- San Francisco, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California- San Francisco, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, USA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057297846","display_name":"Z.P. Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100604","display_name":"Revolution Medicines (United States)","ror":"https://ror.org/00mny1y94","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100604"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Z.P. Wang","raw_affiliation_strings":["Revolution Medicines, Research and Development, Redwood City, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Revolution Medicines, Research and Development, Redwood City, USA","institution_ids":["https://openalex.org/I4210100604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045031054","display_name":"Satdarshan P. Monga","orcid":"https://orcid.org/0000-0002-8437-3378","observed_orcids":["https://orcid.org/0000-0002-8437-3378"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.P. Monga","raw_affiliation_strings":["University of Pittsburgh & University of Pittsburgh Medical Center, Department of Pathology & Pittsburgh Liver Research Center, Pittsburgh, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh & University of Pittsburgh Medical Center, Department of Pathology & Pittsburgh Liver Research Center, Pittsburgh, USA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100620133","display_name":"David J. Kwiatkowski","orcid":"https://orcid.org/0000-0002-5668-5219","observed_orcids":["https://orcid.org/0000-0002-5668-5219"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D.J. Kwiatkowski","raw_affiliation_strings":["Brigham & Women's Hospital, Division of Pulmonary & Critical Care Medicine, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham & Women's Hospital, Division of Pulmonary & Critical Care Medicine, Boston, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073603294","display_name":"William A. Weiss","orcid":"https://orcid.org/0000-0003-2230-9132","observed_orcids":["https://orcid.org/0000-0003-2230-9132"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210167126","display_name":"UCSF Helen Diller Family Comprehensive Cancer Center","ror":"https://ror.org/05yndxy10","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210110664","https://openalex.org/I4210167126"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W.A. Weiss","raw_affiliation_strings":["University of California- San Francisco, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California- San Francisco, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, USA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027330002","display_name":"Jacqueline A.M. Smith","orcid":"https://orcid.org/0000-0001-5028-8725","observed_orcids":["https://orcid.org/0000-0001-5028-8725"]},"institutions":[{"id":"https://openalex.org/I4210100604","display_name":"Revolution Medicines (United States)","ror":"https://ror.org/00mny1y94","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100604"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.A. Smith","raw_affiliation_strings":["Revolution Medicines, Research and Development, Redwood City, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Revolution Medicines, Research and Development, Redwood City, USA","institution_ids":["https://openalex.org/I4210100604"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057362852","display_name":"Mallika Singh","orcid":"https://orcid.org/0009-0003-0234-1589","observed_orcids":["https://orcid.org/0009-0003-0234-1589"]},"institutions":[{"id":"https://openalex.org/I4210100604","display_name":"Revolution Medicines (United States)","ror":"https://ror.org/00mny1y94","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100604"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Singh","raw_affiliation_strings":["Revolution Medicines, Research and Development, Redwood City, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Revolution Medicines, Research and Development, Redwood City, USA","institution_ids":["https://openalex.org/I4210100604"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":0.0811,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.36117192,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"138","issue":null,"first_page":"S53","last_page":"S53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mtorc1-inhibitors","display_name":"mTORC1 inhibitors","score":0.8619999885559082},{"id":"https://openalex.org/keywords/pi3k-mtor-pathway","display_name":"PI3K/mTOR pathway","score":0.8960000276565552},{"id":"https://openalex.org/keywords/s6k-phosphorylation","display_name":"S6K phosphorylation","score":0.8989999890327454},{"id":"https://openalex.org/keywords/translation-initiation","display_name":"translation initiation","score":0.6069999933242798},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.48100000619888306}],"concepts":[{"id":"https://openalex.org/C98490376","wikidata":"https://www.wikidata.org/wiki/Q14876060","display_name":"mTORC1","level":4,"score":0.9045248031616211},{"id":"https://openalex.org/C107846503","wikidata":"https://www.wikidata.org/wiki/Q14876061","display_name":"mTORC2","level":5,"score":0.8351646661758423},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.7455402612686157},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5641775131225586},{"id":"https://openalex.org/C104202773","wikidata":"https://www.wikidata.org/wiki/Q18031289","display_name":"P70-S6 Kinase 1","level":4,"score":0.48495104908943176},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4722530245780945},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34427183866500854},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3435286283493042},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26818275451660156},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.24053797125816345}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0959-8049(20)31217-x","doi":"https://doi.org/10.1016/s0959-8049(20)31217-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0959-8049(20)31217-x","pdf_url":"http://www.ejcancer.com/article/S095980492031217X/pdf","source":{"id":"https://openalex.org/S16731738","display_name":"European Journal of Cancer","issn_l":"0959-8049","issn":["0959-8049","1879-0852"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cancer","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/s0959-8049(20)31217-x","doi":"https://doi.org/10.1016/s0959-8049(20)31217-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0959-8049(20)31217-x","pdf_url":"http://www.ejcancer.com/article/S095980492031217X/pdf","source":{"id":"https://openalex.org/S16731738","display_name":"European Journal of Cancer","issn_l":"0959-8049","issn":["0959-8049","1879-0852"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4388041421","https://openalex.org/W4362594704","https://openalex.org/W3179566271","https://openalex.org/W3092023973","https://openalex.org/W3177289604","https://openalex.org/W3182932973","https://openalex.org/W4282968483","https://openalex.org/W4210499131","https://openalex.org/W2991322671","https://openalex.org/W2081690486"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2020-11-09T00:00:00"}