{"id":"https://openalex.org/W3095031997","doi":"https://doi.org/10.1111/dth.14476","title":"Beyond Mohs surgery and excisions: A focused review of treatment options for subtypes of basal cell carcinoma","display_name":"Beyond Mohs surgery and excisions: A focused review of treatment options for subtypes of basal cell carcinoma","publication_year":2020,"publication_date":"2020-10-30","ids":{"openalex":"https://openalex.org/W3095031997","doi":"https://doi.org/10.1111/dth.14476","mag":"3095031997","pmid":"https://pubmed.ncbi.nlm.nih.gov/33125804"},"language":"en","primary_location":{"id":"doi:10.1111/dth.14476","doi":"https://doi.org/10.1111/dth.14476","is_oa":true,"landing_page_url":"https://doi.org/10.1111/dth.14476","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dth.14476","source":{"id":"https://openalex.org/S67424211","display_name":"Dermatologic Therapy","issn_l":"1396-0296","issn":["1396-0296","1529-8019"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dermatologic Therapy","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dth.14476","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031128436","display_name":"Ece Altun","orcid":"https://orcid.org/0000-0002-8118-3405","observed_orcids":["https://orcid.org/0000-0002-8118-3405"]},"institutions":[{"id":"https://openalex.org/I3125470973","display_name":"Istanbul Medipol University","ror":"https://ror.org/037jwzz50","country_code":"TR","type":"education","lineage":["https://openalex.org/I3125470973"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ece Altun","raw_affiliation_strings":["Department of Dermatology Medipol Mega University Hospital  \u0130stanbul Turkey"],"raw_orcid":"https://orcid.org/0000-0002-8118-3405","affiliations":[{"raw_affiliation_string":"Department of Dermatology Medipol Mega University Hospital  \u0130stanbul Turkey","institution_ids":["https://openalex.org/I3125470973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036482995","display_name":"Gabrielle H. Schwartzman","orcid":"https://orcid.org/0000-0002-3912-5527","observed_orcids":["https://orcid.org/0000-0002-3912-5527"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabrielle Schwartzman","raw_affiliation_strings":["Department of Dermatology, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067904788","display_name":"Alexander M. Cartron","orcid":"https://orcid.org/0000-0002-1711-7964","observed_orcids":["https://orcid.org/0000-0002-1711-7964"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander M. Cartron","raw_affiliation_strings":["Department of Dermatology, University of Maryland, Baltimore, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Maryland, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017611684","display_name":"Amor Khachemoune","orcid":"https://orcid.org/0000-0003-1622-1097","observed_orcids":["https://orcid.org/0000-0003-1622-1097"]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Amor Khachemoune","raw_affiliation_strings":["Department of Dermatology, State University of New York Downstate, Brooklyn, New York, USA","Department of Dermatology, Veterans Health Administration, Brooklyn, New York, USA"],"raw_orcid":"https://orcid.org/0000-0003-1622-1097","affiliations":[{"raw_affiliation_string":"Department of Dermatology, State University of New York Downstate, Brooklyn, New York, USA","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I181697535"]},{"raw_affiliation_string":"Department of Dermatology, Veterans Health Administration, Brooklyn, New York, USA","institution_ids":["https://openalex.org/I2799886695"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5017611684"],"corresponding_institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I181697535","https://openalex.org/I2799886695"],"apc_list":{"value":3100,"currency":"USD","value_usd":3100},"apc_paid":{"value":3100,"currency":"USD","value_usd":3100},"fwci":0.2102,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.24966533,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"34","issue":"1","first_page":"e14476","last_page":"e14476"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11868","display_name":"Cancer and Skin Lesions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/basal-cell-carcinoma","display_name":"basal cell carcinoma","score":1.0},{"id":"https://openalex.org/keywords/conservative-treatment","display_name":"conservative treatment","score":0.8539999723434448},{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.875},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.9010000228881836},{"id":"https://openalex.org/keywords/laser-therapy","display_name":"laser therapy","score":0.6570000052452087},{"id":"https://openalex.org/keywords/hedgehog-pathway-inhibitors","display_name":"Hedgehog pathway inhibitors","score":0.8360000252723694},{"id":"https://openalex.org/keywords/cryosurgery","display_name":"cryosurgery","score":0.949999988079071},{"id":"https://openalex.org/keywords/electrodessication","display_name":"electrodessication","score":0.9570000171661377},{"id":"https://openalex.org/keywords/topical-drugs","display_name":"topical drugs","score":0.515999972820282},{"id":"https://openalex.org/keywords/ultraviolet-radiation","display_name":"ultraviolet radiation","score":0.7689999938011169},{"id":"https://openalex.org/keywords/histological-subtypes","display_name":"histological subtypes","score":0.6549999713897705},{"id":"https://openalex.org/keywords/treatment-selection","display_name":"treatment selection","score":0.8190000057220459}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8867003917694092},{"id":"https://openalex.org/C2778804307","wikidata":"https://www.wikidata.org/wiki/Q809758","display_name":"Basal cell carcinoma","level":3,"score":0.8244971036911011},{"id":"https://openalex.org/C2777789703","wikidata":"https://www.wikidata.org/wiki/Q192102","display_name":"Skin cancer","level":3,"score":0.7413893938064575},{"id":"https://openalex.org/C2778334829","wikidata":"https://www.wikidata.org/wiki/Q1968950","display_name":"Mohs surgery","level":2,"score":0.6630611419677734},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.6180697679519653},{"id":"https://openalex.org/C2780106285","wikidata":"https://www.wikidata.org/wiki/Q2705075","display_name":"Cryosurgery","level":2,"score":0.5753955841064453},{"id":"https://openalex.org/C2779545874","wikidata":"https://www.wikidata.org/wiki/Q2070286","display_name":"Vismodegib","level":4,"score":0.5387782454490662},{"id":"https://openalex.org/C2779904257","wikidata":"https://www.wikidata.org/wiki/Q1428130","display_name":"Curettage","level":2,"score":0.5066414475440979},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4877663254737854},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.47591930627822876},{"id":"https://openalex.org/C2780943399","wikidata":"https://www.wikidata.org/wiki/Q5173994","display_name":"Cosmesis","level":2,"score":0.4407252371311188},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4064967930316925},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.40041184425354004},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.29748690128326416},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24396666884422302},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12911173701286316}],"mesh":[{"descriptor_ui":"D002280","descriptor_name":"Basal Cell Carcinoma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015580","descriptor_name":"Mohs Surgery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/dth.14476","doi":"https://doi.org/10.1111/dth.14476","is_oa":true,"landing_page_url":"https://doi.org/10.1111/dth.14476","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dth.14476","source":{"id":"https://openalex.org/S67424211","display_name":"Dermatologic Therapy","issn_l":"1396-0296","issn":["1396-0296","1529-8019"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dermatologic Therapy","raw_type":"journal-article"},{"id":"pmid:33125804","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33125804","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dermatologic therapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/dth.14476","doi":"https://doi.org/10.1111/dth.14476","is_oa":true,"landing_page_url":"https://doi.org/10.1111/dth.14476","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dth.14476","source":{"id":"https://openalex.org/S67424211","display_name":"Dermatologic Therapy","issn_l":"1396-0296","issn":["1396-0296","1529-8019"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dermatologic Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3095031997.pdf","grobid_xml":"https://content.openalex.org/works/W3095031997.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W92445081","https://openalex.org/W152590681","https://openalex.org/W182214322","https://openalex.org/W1533920571","https://openalex.org/W1788144888","https://openalex.org/W1840476868","https://openalex.org/W1869820893","https://openalex.org/W1950053141","https://openalex.org/W1964376876","https://openalex.org/W1965431780","https://openalex.org/W1965500674","https://openalex.org/W1966083301","https://openalex.org/W1967281628","https://openalex.org/W1967705561","https://openalex.org/W1984042712","https://openalex.org/W1985710911","https://openalex.org/W1998263769","https://openalex.org/W2018590090","https://openalex.org/W2023088479","https://openalex.org/W2025618385","https://openalex.org/W2025971695","https://openalex.org/W2026103783","https://openalex.org/W2038114233","https://openalex.org/W2053141040","https://openalex.org/W2054342443","https://openalex.org/W2064494154","https://openalex.org/W2069624304","https://openalex.org/W2076473714","https://openalex.org/W2083513345","https://openalex.org/W2093707221","https://openalex.org/W2122888213","https://openalex.org/W2129925282","https://openalex.org/W2139092752","https://openalex.org/W2143839627","https://openalex.org/W2155272579","https://openalex.org/W2159478438","https://openalex.org/W2161540365","https://openalex.org/W2167106546","https://openalex.org/W2170324110","https://openalex.org/W2170459272","https://openalex.org/W2278262184","https://openalex.org/W2317869702","https://openalex.org/W2336139814","https://openalex.org/W2341152357","https://openalex.org/W2389343900","https://openalex.org/W2422877605","https://openalex.org/W2488259342","https://openalex.org/W2507798609","https://openalex.org/W2610806920","https://openalex.org/W2765213795","https://openalex.org/W2767005502","https://openalex.org/W2783973185","https://openalex.org/W2794156118","https://openalex.org/W2799455932","https://openalex.org/W2808329747","https://openalex.org/W2852818958","https://openalex.org/W2890587253","https://openalex.org/W2901949882","https://openalex.org/W2943081846"],"related_works":["https://openalex.org/W4210755403","https://openalex.org/W2943081846","https://openalex.org/W28946803","https://openalex.org/W4307244304","https://openalex.org/W1981535154","https://openalex.org/W4242759765","https://openalex.org/W4289110089","https://openalex.org/W4283590210","https://openalex.org/W2488259342","https://openalex.org/W3030678619"],"abstract_inverted_index":{"Basal":[0],"cell":[1,19],"carcinoma":[2],"(BCC)":[3],"is":[4,42,46,72],"the":[5,17,22,26,31,48,75,88,99,103,116,160,198],"most":[6,35,140,161],"common":[7,162],"nonmelanoma":[8],"skin":[9],"cancer.":[10],"It":[11],"originates":[12],"from":[13,25],"undifferentiated":[14],"cells":[15],"in":[16,38,87],"basal":[18],"layer":[20],"of":[21,30,40,51,69,79,90,105,200],"epidermis":[23],"or":[24,150,181],"outer":[27],"root":[28],"sheath":[29],"hair":[32],"follicle.":[33],"The":[34,67,139],"important":[36],"factor":[37],"development":[39],"BCC":[41,173],"ultraviolet":[43],"radiation.":[44],"Surgery":[45],"considered":[47],"gold":[49],"standard":[50],"treatment":[52,104,199],"for":[53,60,65,98,102,159,166,172,197],"BCC.":[54,91,106,168,201],"However,":[55],"nonsurgical":[56,81,100,163,170],"options":[57,101],"are":[58,63,193],"available":[59],"individuals":[61],"who":[62],"unsuitable":[64],"surgery.":[66],"purpose":[68],"this":[70],"review":[71,95],"to":[73,115,119,155,222],"summarize":[74],"efficacy":[76],"and":[77,111,188,195,208,227],"indications":[78],"alternative,":[80],"treatments":[82,171],"that":[83],"can":[84],"be":[85,212,231],"used":[86,165],"management":[89],"An":[92],"extensive":[93],"literature":[94],"was":[96],"performed":[97],"Resources":[107],"searched":[108,123],"included":[109,124],"PubMed":[110],"Google":[112],"Scholars,":[113],"limited":[114],"years":[117],"1995":[118],"2020.":[120],"Key":[121],"words":[122],"BCC,":[125],"destructive":[126,175],"methods,":[127],"photodynamic":[128],"therapy":[129],"(PDT),":[130],"radiotherapy,":[131,186],"topical":[132,184],"medication,":[133],"laser,":[134,187],"hedgehog":[135],"pathway":[136],"inhibitors":[137],"(HPIs).":[138],"relevant":[141],"results":[142,226],"such":[143,203],"as":[144,204],"systematic":[145],"reviews,":[146],"randomized":[147],"controlled":[148],"trials,":[149],"comparative":[151],"studies":[152],"were":[153],"selected":[154],"provide":[156],"a":[157],"summary":[158],"methods":[164,176],"treating":[167],"Effective":[169],"include":[174],"(eg,":[177],"curettage":[178],"alone,":[179],"cryosurgery,":[180],"electrodessication),":[182],"PDT,":[183],"medications,":[185],"HPIs.":[189],"Nonsurgical":[190],"therapeutic":[191],"alternatives":[192],"safe":[194],"effective":[196],"Factors":[202],"tumor":[205],"location,":[206],"size,":[207],"histopathological":[209],"subtype":[210],"should":[211,230],"taken":[213],"into":[214],"consideration":[215],"when":[216],"selecting":[217],"optimal":[218],"treatment.":[219],"In":[220],"addition":[221],"clinical":[223],"factors,":[224],"cosmetic":[225],"patient":[228],"preference":[229],"considered.":[232]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-11-09T00:00:00"}