{"id":"https://openalex.org/W3095015332","doi":"https://doi.org/10.1016/j.resuscitation.2020.10.028","title":"Translation from animal studies of novel pharmacological therapies to clinical trials in cardiac arrest: A systematic review","display_name":"Translation from animal studies of novel pharmacological therapies to clinical trials in cardiac arrest: A systematic review","publication_year":2020,"publication_date":"2020-11-02","ids":{"openalex":"https://openalex.org/W3095015332","doi":"https://doi.org/10.1016/j.resuscitation.2020.10.028","mag":"3095015332","pmid":"https://pubmed.ncbi.nlm.nih.gov/33147523"},"language":"en","primary_location":{"id":"doi:10.1016/j.resuscitation.2020.10.028","doi":"https://doi.org/10.1016/j.resuscitation.2020.10.028","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.resuscitation.2020.10.028","pdf_url":null,"source":{"id":"https://openalex.org/S128507546","display_name":"Resuscitation","issn_l":"0300-9572","issn":["0300-9572","1873-1570"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Resuscitation","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030354282","display_name":"P Lind","orcid":"https://orcid.org/0000-0002-6710-8011","observed_orcids":["https://orcid.org/0000-0002-6710-8011"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Peter Car\u00f8e Lind","raw_affiliation_strings":["Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035788378","display_name":"Cecilie Munch Johannsen","orcid":"https://orcid.org/0009-0002-6004-2571","observed_orcids":["https://orcid.org/0009-0002-6004-2571"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Cecilie Munch Johannsen","raw_affiliation_strings":["Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077526592","display_name":"Lauge Vammen","orcid":"https://orcid.org/0000-0002-5653-2992","observed_orcids":["https://orcid.org/0000-0002-5653-2992"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Lauge Vammen","raw_affiliation_strings":["Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Department of Intensive Care and Anesthesiology, Aarhus University Hospital, Aarhus, Denmark","Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","Department of Intensive Care and Anesthesiology, Aarhus University Hospital, Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Department of Intensive Care and Anesthesiology, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017","https://openalex.org/I2802335433"]},{"raw_affiliation_string":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Department of Intensive Care and Anesthesiology, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043502740","display_name":"Andreas Magnussen","orcid":"https://orcid.org/0000-0002-6620-5194","observed_orcids":["https://orcid.org/0000-0002-6620-5194"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Andreas Magnussen","raw_affiliation_strings":["Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-6620-5194","affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074537027","display_name":"Lars W. Andersen","orcid":"https://orcid.org/0000-0001-5752-8082","observed_orcids":["https://orcid.org/0000-0001-5752-8082"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]},{"id":"https://openalex.org/I4210115617","display_name":"Central Denmark Region","ror":"https://ror.org/0247ay475","country_code":"DK","type":"government","lineage":["https://openalex.org/I4210115617"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Lars W. Andersen","raw_affiliation_strings":["Department of Intensive Care and Anesthesiology, Aarhus University Hospital, Aarhus, Denmark; Research Center for Emergency Medicine, Department of Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark; Prehospital Emergency Medical Services, Central Denmark Region, Denmark","Department of Intensive Care and Anesthesiology, Aarhus University Hospital, Aarhus, Denmark","Prehospital Emergency Medical Services, Central Denmark Region, Denmark","Research Center for Emergency Medicine, Department of Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Intensive Care and Anesthesiology, Aarhus University Hospital, Aarhus, Denmark; Research Center for Emergency Medicine, Department of Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark; Prehospital Emergency Medical Services, Central Denmark Region, Denmark","institution_ids":["https://openalex.org/I204337017","https://openalex.org/I2802335433","https://openalex.org/I4210115617"]},{"raw_affiliation_string":"Department of Intensive Care and Anesthesiology, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]},{"raw_affiliation_string":"Prehospital Emergency Medical Services, Central Denmark Region, Denmark","institution_ids":["https://openalex.org/I4210115617"]},{"raw_affiliation_string":"Research Center for Emergency Medicine, Department of Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017","https://openalex.org/I2802335433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020337708","display_name":"Asger Granfeldt","orcid":"https://orcid.org/0000-0002-7241-6131","observed_orcids":["https://orcid.org/0000-0002-7241-6131"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]},{"id":"https://openalex.org/I4210153757","display_name":"Regional Hospital Randers","ror":"https://ror.org/05n00ke18","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I4210153757"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Asger Granfeldt","raw_affiliation_strings":["Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Department of Intensive Care and Anesthesiology, Aarhus University Hospital, Aarhus, Denmark; Department of Anesthesiology and Intensive Care Medicine, Randers Regional Hospital, Randers, Denmark. Electronic address: granfeldt@gmail.com","Department of Anesthesiology and Intensive Care Medicine, Randers Regional Hospital, Randers, Denmark","Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","Department of Intensive Care and Anesthesiology, Aarhus University Hospital, Aarhus, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-7241-6131","affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Department of Intensive Care and Anesthesiology, Aarhus University Hospital, Aarhus, Denmark; Department of Anesthesiology and Intensive Care Medicine, Randers Regional Hospital, Randers, Denmark. Electronic address: granfeldt@gmail.com","institution_ids":["https://openalex.org/I204337017","https://openalex.org/I2802335433","https://openalex.org/I4210153757"]},{"raw_affiliation_string":"Department of Anesthesiology and Intensive Care Medicine, Randers Regional Hospital, Randers, Denmark","institution_ids":["https://openalex.org/I4210153757"]},{"raw_affiliation_string":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Department of Intensive Care and Anesthesiology, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5020337708"],"corresponding_institution_ids":["https://openalex.org/I204337017","https://openalex.org/I2802335433","https://openalex.org/I4210153757"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":null,"fwci":0.5918,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.56399132,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"158","issue":null,"first_page":"258","last_page":"269"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10645","display_name":"Cardiac Arrest and Resuscitation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10645","display_name":"Cardiac Arrest and Resuscitation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-arrest","display_name":"cardiac arrest","score":0.9950000047683716},{"id":"https://openalex.org/keywords/drug-therapy","display_name":"pharmacotherapy","score":0.8159999847412109},{"id":"https://openalex.org/keywords/vasopressors","display_name":"vasopressors","score":0.9129999876022339},{"id":"https://openalex.org/keywords/anesthetic-agents","display_name":"anesthetic agents","score":0.8299999833106995},{"id":"https://openalex.org/keywords/molecular-targets","display_name":"molecular targets","score":0.6140000224113464},{"id":"https://openalex.org/keywords/clinical-trial-results","display_name":"clinical trial results","score":0.49300000071525574},{"id":"https://openalex.org/keywords/translational-research","display_name":"translational research","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.963417649269104},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5719545483589172},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5587283968925476},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.44856756925582886},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19342637062072754},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006323","descriptor_name":"Heart Arrest","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.resuscitation.2020.10.028","doi":"https://doi.org/10.1016/j.resuscitation.2020.10.028","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.resuscitation.2020.10.028","pdf_url":null,"source":{"id":"https://openalex.org/S128507546","display_name":"Resuscitation","issn_l":"0300-9572","issn":["0300-9572","1873-1570"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Resuscitation","raw_type":"journal-article"},{"id":"pmid:33147523","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33147523","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Resuscitation","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:publications/9c7749f6-9111-41b7-a162-66f35f1e22f7","doi":null,"is_oa":false,"landing_page_url":"https://pure.au.dk/portal/en/publications/9c7749f6-9111-41b7-a162-66f35f1e22f7","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Lind, P C, Munch Johannsen, C, Vammen, L, Magnussen, A, Andersen, L W & Granfeldt, A 2021, 'Translation from animal studies of novel pharmacological therapies to clinical trials in cardiac arrest : A systematic review', Resuscitation, vol. 158, pp. 258-269. https://doi.org/10.1016/j.resuscitation.2020.10.028","raw_type":"info:eu-repo/semantics/review"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W1546847154","https://openalex.org/W1984479490","https://openalex.org/W1994010728","https://openalex.org/W2007372190","https://openalex.org/W2014789843","https://openalex.org/W2020765940","https://openalex.org/W2022077299","https://openalex.org/W2022146490","https://openalex.org/W2032294879","https://openalex.org/W2033634023","https://openalex.org/W2042550742","https://openalex.org/W2047096257","https://openalex.org/W2050917505","https://openalex.org/W2057056526","https://openalex.org/W2070646568","https://openalex.org/W2077015042","https://openalex.org/W2089537280","https://openalex.org/W2099687485","https://openalex.org/W2104225141","https://openalex.org/W2104383304","https://openalex.org/W2109179624","https://openalex.org/W2110349079","https://openalex.org/W2110944531","https://openalex.org/W2113328186","https://openalex.org/W2113519449","https://openalex.org/W2122525165","https://openalex.org/W2130886643","https://openalex.org/W2136999581","https://openalex.org/W2140440432","https://openalex.org/W2152662651","https://openalex.org/W2157962981","https://openalex.org/W2159961127","https://openalex.org/W2160599473","https://openalex.org/W2170786978","https://openalex.org/W2171886225","https://openalex.org/W2172034710","https://openalex.org/W2172292061","https://openalex.org/W2174745877","https://openalex.org/W2296910921","https://openalex.org/W2330410310","https://openalex.org/W2334744999","https://openalex.org/W2406493898","https://openalex.org/W2409454139","https://openalex.org/W2465483907","https://openalex.org/W2472599713","https://openalex.org/W2554794172","https://openalex.org/W2588042060","https://openalex.org/W2597979791","https://openalex.org/W2733779494","https://openalex.org/W2756184018","https://openalex.org/W2763588040","https://openalex.org/W2766115192","https://openalex.org/W2766381943","https://openalex.org/W2767579528","https://openalex.org/W2769028546","https://openalex.org/W2770872189","https://openalex.org/W2783405732","https://openalex.org/W2789673685","https://openalex.org/W2789732111","https://openalex.org/W2800650179","https://openalex.org/W2807029594","https://openalex.org/W2883159984","https://openalex.org/W2889503006","https://openalex.org/W2917971741","https://openalex.org/W2922448987","https://openalex.org/W2924401090","https://openalex.org/W2939249589","https://openalex.org/W2939917650","https://openalex.org/W2990547384","https://openalex.org/W2990699751","https://openalex.org/W2996640392","https://openalex.org/W3009041599","https://openalex.org/W3012988264","https://openalex.org/W3017361368","https://openalex.org/W3029630545","https://openalex.org/W3142799958"],"related_works":["https://openalex.org/W3108011906","https://openalex.org/W2177686463","https://openalex.org/W4389356956","https://openalex.org/W4281897829","https://openalex.org/W2120865113","https://openalex.org/W4206159170","https://openalex.org/W2027257559","https://openalex.org/W2146685541","https://openalex.org/W4401058565","https://openalex.org/W2464255482"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2020-11-09T00:00:00"}