{"id":"https://openalex.org/W3094875604","doi":"https://doi.org/10.1210/jendso/bvaa168","title":"Overaccumulation of Fat Caused Rapid Reproductive Senescence but not Loss of Ovarian Reserve in ob/ob Mice","display_name":"Overaccumulation of Fat Caused Rapid Reproductive Senescence but not Loss of Ovarian Reserve in ob/ob Mice","publication_year":2020,"publication_date":"2020-11-05","ids":{"openalex":"https://openalex.org/W3094875604","doi":"https://doi.org/10.1210/jendso/bvaa168","mag":"3094875604","pmid":"https://pubmed.ncbi.nlm.nih.gov/33324862","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7722705"},"language":"en","primary_location":{"id":"doi:10.1210/jendso/bvaa168","doi":"https://doi.org/10.1210/jendso/bvaa168","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jendso/bvaa168","pdf_url":"https://academic.oup.com/jes/article-pdf/5/1/bvaa168/35098752/bvaa168.pdf","source":{"id":"https://openalex.org/S2735747656","display_name":"Journal of the Endocrine Society","issn_l":"2472-1972","issn":["2472-1972"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315851","host_organization_name":"Endocrine Society","host_organization_lineage":["https://openalex.org/P4310315851"],"host_organization_lineage_names":["Endocrine Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Endocrine Society","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/jes/article-pdf/5/1/bvaa168/35098752/bvaa168.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007404232","display_name":"Mohammad Lalmoddin Mollah","orcid":"https://orcid.org/0009-0001-3921-1310","observed_orcids":["https://orcid.org/0009-0001-3921-1310"]},"institutions":[{"id":"https://openalex.org/I165677929","display_name":"Sungshin Women's University","ror":"https://ror.org/0500xzf72","country_code":"KR","type":"education","lineage":["https://openalex.org/I165677929"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Mohammad Lalmoddin Mollah","raw_affiliation_strings":["Division of Development and Physiology, School of Bioscience and Chemistry, Sungshin Women University, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Development and Physiology, School of Bioscience and Chemistry, Sungshin Women University, Seoul, South Korea","institution_ids":["https://openalex.org/I165677929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049437810","display_name":"Hee-Seon Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165677929","display_name":"Sungshin Women's University","ror":"https://ror.org/0500xzf72","country_code":"KR","type":"education","lineage":["https://openalex.org/I165677929"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hee-Seon Yang","raw_affiliation_strings":["Division of Development and Physiology, School of Bioscience and Chemistry, Sungshin Women University, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Development and Physiology, School of Bioscience and Chemistry, Sungshin Women University, Seoul, South Korea","institution_ids":["https://openalex.org/I165677929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002795901","display_name":"SoRa Jeon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165677929","display_name":"Sungshin Women's University","ror":"https://ror.org/0500xzf72","country_code":"KR","type":"education","lineage":["https://openalex.org/I165677929"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"SoRa Jeon","raw_affiliation_strings":["Division of Development and Physiology, School of Bioscience and Chemistry, Sungshin Women University, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Development and Physiology, School of Bioscience and Chemistry, Sungshin Women University, Seoul, South Korea","institution_ids":["https://openalex.org/I165677929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050286398","display_name":"Kil\u2010Soo Kim","orcid":"https://orcid.org/0000-0001-7370-2685","observed_orcids":["https://orcid.org/0000-0001-7370-2685","https://orcid.org/0000-0003-1960-4464"]},"institutions":[{"id":"https://openalex.org/I31419693","display_name":"Kyungpook National University","ror":"https://ror.org/040c17130","country_code":"KR","type":"education","lineage":["https://openalex.org/I31419693"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"KilSoo Kim","raw_affiliation_strings":["College of Veterinary Medicine, Kyungpook National University, Daegu, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Kyungpook National University, Daegu, Korea","institution_ids":["https://openalex.org/I31419693"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074906627","display_name":"Yong\u2010Pil Cheon","orcid":"https://orcid.org/0000-0002-8497-9257","observed_orcids":["https://orcid.org/0000-0002-8497-9257"]},"institutions":[{"id":"https://openalex.org/I165677929","display_name":"Sungshin Women's University","ror":"https://ror.org/0500xzf72","country_code":"KR","type":"education","lineage":["https://openalex.org/I165677929"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Yong-Pil Cheon","raw_affiliation_strings":["Division of Development and Physiology, School of Bioscience and Chemistry, Sungshin Women University, Seoul, South Korea"],"raw_orcid":"https://orcid.org/0000-0002-8497-9257","affiliations":[{"raw_affiliation_string":"Division of Development and Physiology, School of Bioscience and Chemistry, Sungshin Women University, Seoul, South Korea","institution_ids":["https://openalex.org/I165677929"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5074906627"],"corresponding_institution_ids":["https://openalex.org/I165677929"],"apc_list":{"value":3255,"currency":"USD","value_usd":3255},"apc_paid":{"value":3255,"currency":"USD","value_usd":3255},"fwci":0.1871,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.57641726,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"5","issue":"1","first_page":"bvaa168","last_page":"bvaa168"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.8695999979972839,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.8695999979972839,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.12680000066757202,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1102","display_name":"Agronomy and Crop Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7440000176429749},{"id":"https://openalex.org/keywords/leptin-deficiency","display_name":"leptin deficiency","score":0.8479999899864197},{"id":"https://openalex.org/keywords/ob-ob-mice","display_name":"ob/ob mice","score":0.9760000109672546},{"id":"https://openalex.org/keywords/ovarian-reserve","display_name":"ovarian reserve","score":0.9869999885559082},{"id":"https://openalex.org/keywords/reproductive-aging","display_name":"reproductive aging","score":0.9100000262260437},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.4090000092983246},{"id":"https://openalex.org/keywords/estrous-cyclicity","display_name":"estrous cyclicity","score":0.7570000290870667},{"id":"https://openalex.org/keywords/follicular-atresia","display_name":"follicular atresia","score":0.7900000214576721},{"id":"https://openalex.org/keywords/primordial-follicles","display_name":"primordial follicles","score":0.8759999871253967},{"id":"https://openalex.org/keywords/sohlh1","display_name":"SOHLH1","score":0.8270000219345093},{"id":"https://openalex.org/keywords/anti-mullerian-hormone","display_name":"anti-M\u00fcllerian hormone","score":0.8460000157356262},{"id":"https://openalex.org/keywords/dazl","display_name":"DAZL","score":0.6140000224113464},{"id":"https://openalex.org/keywords/stra8","display_name":"Stra8","score":0.7940000295639038},{"id":"https://openalex.org/keywords/zp3","display_name":"ZP3","score":0.9120000004768372},{"id":"https://openalex.org/keywords/adipocytes","display_name":"adipocytes","score":0.492000013589859},{"id":"https://openalex.org/keywords/energy-balance","display_name":"energy balance","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C142773365","wikidata":"https://www.wikidata.org/wiki/Q3499793","display_name":"Antral follicle","level":3,"score":0.8001950979232788},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7821970582008362},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7732111811637878},{"id":"https://openalex.org/C2776600139","wikidata":"https://www.wikidata.org/wiki/Q7113253","display_name":"Ovarian reserve","level":4,"score":0.7540042400360107},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.6693875789642334},{"id":"https://openalex.org/C1998276","wikidata":"https://www.wikidata.org/wiki/Q388121","display_name":"Estrous cycle","level":2,"score":0.628302276134491},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5300887227058411},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.49052733182907104},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4794813096523285},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.47647973895072937},{"id":"https://openalex.org/C2778780466","wikidata":"https://www.wikidata.org/wiki/Q21108939","display_name":"Anti-M\u00fcllerian hormone","level":3,"score":0.4662700295448303},{"id":"https://openalex.org/C2777688143","wikidata":"https://www.wikidata.org/wiki/Q179399","display_name":"Infertility","level":3,"score":0.4276546239852905},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.31043893098831177},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2734440565109253},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.1181517243385315},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1210/jendso/bvaa168","doi":"https://doi.org/10.1210/jendso/bvaa168","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jendso/bvaa168","pdf_url":"https://academic.oup.com/jes/article-pdf/5/1/bvaa168/35098752/bvaa168.pdf","source":{"id":"https://openalex.org/S2735747656","display_name":"Journal of the Endocrine Society","issn_l":"2472-1972","issn":["2472-1972"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315851","host_organization_name":"Endocrine Society","host_organization_lineage":["https://openalex.org/P4310315851"],"host_organization_lineage_names":["Endocrine Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Endocrine Society","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7722705","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7722705","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Endocr Soc","raw_type":"Text"},{"id":"pmid:33324862","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33324862","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Endocrine Society","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1210/jendso/bvaa168","doi":"https://doi.org/10.1210/jendso/bvaa168","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jendso/bvaa168","pdf_url":"https://academic.oup.com/jes/article-pdf/5/1/bvaa168/35098752/bvaa168.pdf","source":{"id":"https://openalex.org/S2735747656","display_name":"Journal of the Endocrine Society","issn_l":"2472-1972","issn":["2472-1972"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315851","host_organization_name":"Endocrine Society","host_organization_lineage":["https://openalex.org/P4310315851"],"host_organization_lineage_names":["Endocrine Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Endocrine Society","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4903955754","display_name":null,"funder_award_id":"2015M3A9D7067365","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G5008433131","display_name":null,"funder_award_id":"NRF-2015M3A9D7067365","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G6012226244","display_name":null,"funder_award_id":"H16C1085","funder_id":"https://openalex.org/F4320322107","funder_display_name":"Korea Health Industry Development Institute"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322107","display_name":"Korea Health Industry Development Institute","ror":"https://ror.org/00fdzyk40"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3094875604.pdf","grobid_xml":"https://content.openalex.org/works/W3094875604.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1855830668","https://openalex.org/W1868128271","https://openalex.org/W1969892925","https://openalex.org/W1978691222","https://openalex.org/W1988199281","https://openalex.org/W1994513698","https://openalex.org/W1997242064","https://openalex.org/W2018878975","https://openalex.org/W2019980431","https://openalex.org/W2032413234","https://openalex.org/W2033116750","https://openalex.org/W2055956383","https://openalex.org/W2060985350","https://openalex.org/W2076309235","https://openalex.org/W2086756948","https://openalex.org/W2087935210","https://openalex.org/W2111571951","https://openalex.org/W2122729366","https://openalex.org/W2140264607","https://openalex.org/W2141709586","https://openalex.org/W2157369555","https://openalex.org/W2163321855","https://openalex.org/W2164236895","https://openalex.org/W2228338492","https://openalex.org/W2271112859","https://openalex.org/W2345765523","https://openalex.org/W2396321838","https://openalex.org/W2416641010","https://openalex.org/W2482781689","https://openalex.org/W2501595964","https://openalex.org/W2553461544","https://openalex.org/W2605479022","https://openalex.org/W2607224904","https://openalex.org/W2765627102","https://openalex.org/W2770863902","https://openalex.org/W2800554476","https://openalex.org/W2805109865","https://openalex.org/W2942053059","https://openalex.org/W2980393509","https://openalex.org/W3009096598","https://openalex.org/W3010357781","https://openalex.org/W3016432471"],"related_works":["https://openalex.org/W1969892925","https://openalex.org/W2256737010","https://openalex.org/W2153184813","https://openalex.org/W2546357032","https://openalex.org/W1981109505","https://openalex.org/W4412646424","https://openalex.org/W2363776988","https://openalex.org/W2749355145","https://openalex.org/W4397016752","https://openalex.org/W2212754991"],"abstract_inverted_index":{"Abstract":[0],"Ovarian":[1],"reserve":[2,27,41,194],"and":[3,9,22,59,72,81,131,144,179,224],"fertility":[4,216],"are":[5],"reduced":[6],"by":[7],"aging":[8,23,39,76],"a":[10,45,218],"poor":[11],"energy":[12,20],"balance.":[13],"To":[14],"date,":[15],"the":[16,25,33,38,192,206,238],"relationships":[17],"of":[18,35,67,87,176,208],"high":[19],"accumulation":[21],"with":[24,61,75,156],"ovarian":[26,40,193,239],"have":[28],"not":[29,90],"been":[30],"elucidated.":[31],"Here,":[32],"effects":[34],"obesity":[36],"on":[37],"were":[42,77,107,125,134,147,165,183],"evaluated":[43],"in":[44,109,113,137,153,168,197,201,221,228,233],"leptin-deficient":[46],"(ob/ob)":[47],"mouse":[48],"model.":[49],"Abnormal":[50],"estrous":[51],"cyclicity":[52],"appeared":[53],"as":[54,56,232],"early":[55],"6":[57],"weeks":[58,152],"worsened":[60],"aging.":[62],"The":[63,84,174],"blood":[64,85],"level":[65,86],"patterns":[66],"17\u03b2-estradiol":[68],"(E2),":[69],"testosterone":[70],"(T),":[71],"progesterone":[73],"(P4)":[74],"similar":[78,95,126,184],"between":[79,127,185],"lean":[80,114,157,202],"ob/ob":[82,110,138,154,169,198,222,234],"mice.":[83,158],"E2":[88],"but":[89,103],"P4":[91],"or":[92,211],"T":[93],"was":[94],"at":[96,150,171,217],"24":[97,151,172],"weeks.":[98,142,173],"Many":[99],"more":[100],"atretic":[101],"follicles":[102,182],"fewer":[104],"corpora":[105],"lutea":[106],"observed":[108],"mice":[111,115,139,170,199,223],"than":[112,200],"within":[116],"all":[117],"age":[118,220],"groups.":[119],"Anti-M\u00fcllerian":[120],"hormone":[121],"(Amh)":[122],"mRNA":[123],"levels":[124],"genotypes.":[128,186],"Dazl,":[129],"Stra8,":[130],"ZP3":[132],"mRNAs":[133,146],"highly":[135,148],"expressed":[136,149],"after":[140],"12":[141],"Sohlh1":[143],"Ybx2":[145],"compared":[155],"In":[159],"addition,":[160],"SOHLH1-positive":[161],"primordial":[162],"follicle":[163],"counts":[164],"significantly":[166],"increased":[167],"proportions":[175],"AMH-positive":[177],"secondary":[178],"small":[180],"antral":[181],"Together,":[187],"these":[188],"results":[189],"show":[190],"that":[191,205,225],"lasts":[195],"longer":[196],"mice,":[203,235],"suggesting":[204],"loss":[207],"normal":[209],"physiological":[210],"physical":[212],"status":[213],"causes":[214],"decreased":[215],"young":[219],"an":[226],"increase":[227],"adipocytes":[229],"without":[230],"leptin,":[231],"can":[236,243],"improve":[237],"reserve.":[240],"Such":[241],"knowledge":[242],"be":[244],"applied":[245],"to":[246],"understanding":[247],"reproductive":[248],"dysfunction.":[249]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2020-11-09T00:00:00"}