{"id":"https://openalex.org/W3094464202","doi":"https://doi.org/10.1016/j.mtbio.2020.100082","title":"Low dose novel PARP-PI3K inhibition via nanoformulation improves colorectal cancer immunoradiotherapy","display_name":"Low dose novel PARP-PI3K inhibition via nanoformulation improves colorectal cancer immunoradiotherapy","publication_year":2020,"publication_date":"2020-09-01","ids":{"openalex":"https://openalex.org/W3094464202","doi":"https://doi.org/10.1016/j.mtbio.2020.100082","mag":"3094464202","pmid":"https://pubmed.ncbi.nlm.nih.gov/33294836","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7689338"},"language":"en","primary_location":{"id":"doi:10.1016/j.mtbio.2020.100082","doi":"https://doi.org/10.1016/j.mtbio.2020.100082","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.mtbio.2020.100082","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2590006420300429/pdf","source":{"id":"https://openalex.org/S4210219546","display_name":"Materials Today Bio","issn_l":"2590-0064","issn":["2590-0064"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Materials Today Bio","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2590006420300429/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080249531","display_name":"Madeleine R. Landry","orcid":"https://orcid.org/0000-0002-4594-9426","observed_orcids":["https://orcid.org/0000-0002-4594-9426"]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.R. Landry","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, 97201, OR, USA"],"raw_orcid":"https://orcid.org/0000-0002-4594-9426","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, 97201, OR, USA","institution_ids":["https://openalex.org/I131249849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044202097","display_name":"Allison N. DuRoss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A.N. DuRoss","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, 97201, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, 97201, OR, USA","institution_ids":["https://openalex.org/I131249849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009965717","display_name":"Megan J. Neufeld","orcid":"https://orcid.org/0000-0003-0812-2208","observed_orcids":["https://orcid.org/0000-0003-0812-2208"]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.J. Neufeld","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, 97201, OR, USA"],"raw_orcid":"https://orcid.org/0000-0003-0812-2208","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, 97201, OR, USA","institution_ids":["https://openalex.org/I131249849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010196373","display_name":"Lukas Hahn","orcid":"https://orcid.org/0000-0002-3744-2000","observed_orcids":["https://orcid.org/0000-0002-3744-2000"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"L. Hahn","raw_affiliation_strings":["Department of Chemistry and Pharmacy, University W\u00fcrzburg, R\u00f6ntgenring 11, W\u00fcrzburg, 97070, Germany"],"raw_orcid":"https://orcid.org/0000-0002-3744-2000","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Pharmacy, University W\u00fcrzburg, R\u00f6ntgenring 11, W\u00fcrzburg, 97070, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073162135","display_name":"Gaurav Sahay","orcid":"https://orcid.org/0000-0003-1071-0500","observed_orcids":["https://orcid.org/0000-0003-1071-0500"]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]},{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Sahay","raw_affiliation_strings":["Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University, Portland, 97201, OR, USA","Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, 97201, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University, Portland, 97201, OR, USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, 97201, OR, USA","institution_ids":["https://openalex.org/I131249849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025070309","display_name":"Robert Luxenhofer","orcid":"https://orcid.org/0000-0001-5567-7404","observed_orcids":["https://orcid.org/0000-0001-5567-7404"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE","FI"],"is_corresponding":false,"raw_author_name":"R. Luxenhofer","raw_affiliation_strings":["Department of Chemistry and Pharmacy, University W\u00fcrzburg, R\u00f6ntgenring 11, W\u00fcrzburg, 97070, Germany","Soft Matter Chemistry, Department of Chemistry, University of Helsinki, Helsinki, 00014, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Pharmacy, University W\u00fcrzburg, R\u00f6ntgenring 11, W\u00fcrzburg, 97070, Germany","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"Soft Matter Chemistry, Department of Chemistry, University of Helsinki, Helsinki, 00014, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031164461","display_name":"Conroy Sun","orcid":"https://orcid.org/0000-0001-5193-6907","observed_orcids":["https://orcid.org/0000-0001-5193-6907"]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]},{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"C. Sun","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, 97201, OR, USA","Department of Radiation Medicine, School of Medicine, Oregon Health & Science University, Portland, 97239, OR, USA"],"raw_orcid":"https://orcid.org/0000-0001-5193-6907","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, 97201, OR, USA","institution_ids":["https://openalex.org/I131249849"]},{"raw_affiliation_string":"Department of Radiation Medicine, School of Medicine, Oregon Health & Science University, Portland, 97239, OR, USA","institution_ids":["https://openalex.org/I165690674"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5031164461"],"corresponding_institution_ids":["https://openalex.org/I131249849","https://openalex.org/I165690674"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":{"value":3300,"currency":"USD","value_usd":3300},"fwci":1.7152,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.86926114,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"8","issue":null,"first_page":"100082","last_page":"100082"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.5067999958992004,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.5067999958992004,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.22709999978542328,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.1103999987244606,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9909999966621399},{"id":"https://openalex.org/keywords/immunoradiotherapy","display_name":"immunoradiotherapy","score":0.9629999995231628},{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.7820000052452087},{"id":"https://openalex.org/keywords/pi3k-inhibitors","display_name":"PI3K inhibitors","score":0.9769999980926514},{"id":"https://openalex.org/keywords/niraparib","display_name":"niraparib","score":0.9929999709129333},{"id":"https://openalex.org/keywords/polymeric-micelles","display_name":"polymeric micelles","score":0.6650000214576721},{"id":"https://openalex.org/keywords/nanoformulations","display_name":"nanoformulations","score":0.8289999961853027},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.8119999766349792},{"id":"https://openalex.org/keywords/immunogenic-cell-death","display_name":"immunogenic cell death","score":0.9679999947547913},{"id":"https://openalex.org/keywords/anti-ctla-4-immunotherapy","display_name":"anti-CTLA-4 immunotherapy","score":0.9200000166893005},{"id":"https://openalex.org/keywords/dna-repair-inhibition","display_name":"DNA repair inhibition","score":0.7789999842643738},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.8560000061988831},{"id":"https://openalex.org/keywords/ct26-tumor-model","display_name":"CT26 tumor model","score":0.7200000286102295},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6556895971298218},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6041448712348938},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.603232204914093},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.592021107673645},{"id":"https://openalex.org/C2779138821","wikidata":"https://www.wikidata.org/wiki/Q7118227","display_name":"PARP inhibitor","level":5,"score":0.49421361088752747},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.49417927861213684},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4832075834274292},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4788617789745331},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.46982288360595703},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.4611506760120392},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.38073334097862244},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3333665132522583},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.2914241552352905},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2538191080093384},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2315157949924469},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18219751119613647},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.07374012470245361},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1016/j.mtbio.2020.100082","doi":"https://doi.org/10.1016/j.mtbio.2020.100082","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.mtbio.2020.100082","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2590006420300429/pdf","source":{"id":"https://openalex.org/S4210219546","display_name":"Materials Today Bio","issn_l":"2590-0064","issn":["2590-0064"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Materials Today Bio","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7689338","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7689338","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mater Today Bio","raw_type":"Text"},{"id":"pmid:33294836","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33294836","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Materials today. Bio","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:3035fe69034f428f987510110cd9325a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3035fe69034f428f987510110cd9325a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Materials Today Bio, Vol 8, Iss , Pp 100082- (2020)","raw_type":"article"},{"id":"pmh:oai:helda.helsinki.fi:10138/325044","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/325044","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1016/j.mtbio.2020.100082","doi":"https://doi.org/10.1016/j.mtbio.2020.100082","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.mtbio.2020.100082","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2590006420300429/pdf","source":{"id":"https://openalex.org/S4210219546","display_name":"Materials Today Bio","issn_l":"2590-0064","issn":["2590-0064"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Materials Today Bio","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1389014453","display_name":"StrukturEigenschaftsbeziehung von ultrahochbeladenen Wirkstoffnanoformulierungen auf der Basis von Poly(2oxazolin)/Poly(2oxazin) Amphiphilien","funder_award_id":"398461692","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2235679154","display_name":null,"funder_award_id":"TRR 225","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2323813215","display_name":null,"funder_award_id":"R35GM119839","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2936213625","display_name":"Mechanisms of Intracellular trafficking and endosomal escape of nanoparticles for mRNA delivery","funder_award_id":"R15EB021581","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G3658796857","display_name":null,"funder_award_id":"326 998 133 \u2013 TRR 225","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G3680569355","display_name":"Synergistic combination of nanotechnology and radiation in medicine","funder_award_id":"5r35gm119839-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4911582576","display_name":null,"funder_award_id":"subprojectA03","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5166090308","display_name":"TRR 225: Von den Grundlagen der Biofabrikation zu funktionalen Gewebemodellen","funder_award_id":"326998133","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6664376291","display_name":null,"funder_award_id":"1R35GM119839-01","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320311401","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3094464202.pdf","grobid_xml":"https://content.openalex.org/works/W3094464202.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1625062092","https://openalex.org/W1914776013","https://openalex.org/W1965762508","https://openalex.org/W1986412893","https://openalex.org/W1994323832","https://openalex.org/W2001539590","https://openalex.org/W2016445978","https://openalex.org/W2016612145","https://openalex.org/W2027018089","https://openalex.org/W2036431563","https://openalex.org/W2066299923","https://openalex.org/W2083710155","https://openalex.org/W2091103707","https://openalex.org/W2096439168","https://openalex.org/W2108821862","https://openalex.org/W2114095008","https://openalex.org/W2120806256","https://openalex.org/W2121209739","https://openalex.org/W2130084494","https://openalex.org/W2136447069","https://openalex.org/W2149964256","https://openalex.org/W2158794909","https://openalex.org/W2252550602","https://openalex.org/W2293998220","https://openalex.org/W2318913758","https://openalex.org/W2411685931","https://openalex.org/W2528021581","https://openalex.org/W2538816643","https://openalex.org/W2547204128","https://openalex.org/W2584824328","https://openalex.org/W2587235534","https://openalex.org/W2739484802","https://openalex.org/W2749055363","https://openalex.org/W2767551096","https://openalex.org/W2774282247","https://openalex.org/W2784868445","https://openalex.org/W2787221390","https://openalex.org/W2792801574","https://openalex.org/W2800256972","https://openalex.org/W2802054323","https://openalex.org/W2803156653","https://openalex.org/W2803757775","https://openalex.org/W2807377921","https://openalex.org/W2899192398","https://openalex.org/W2902367600","https://openalex.org/W2906334526","https://openalex.org/W2912626193","https://openalex.org/W2914850591","https://openalex.org/W2915645504","https://openalex.org/W2922407185","https://openalex.org/W2938158852","https://openalex.org/W2940036175","https://openalex.org/W2941897681","https://openalex.org/W2942052760","https://openalex.org/W2955669047","https://openalex.org/W2972535107","https://openalex.org/W2972762222","https://openalex.org/W2982419779","https://openalex.org/W2995977166","https://openalex.org/W2996516440","https://openalex.org/W3021349866","https://openalex.org/W3038795195","https://openalex.org/W6751182906","https://openalex.org/W6767828623"],"related_works":["https://openalex.org/W3093946962","https://openalex.org/W3004939197","https://openalex.org/W2953930235","https://openalex.org/W2902367600","https://openalex.org/W6922282572","https://openalex.org/W4294243636","https://openalex.org/W3120627169","https://openalex.org/W7165112279","https://openalex.org/W7164939873","https://openalex.org/W2908412431"],"abstract_inverted_index":{"Multimodal":[0],"therapy":[1],"is":[2],"often":[3],"used":[4],"in":[5,20,35,83,86,88,96,119,161],"oncology":[6],"to":[7,43,100,130,157],"overcome":[8,101],"dosing":[9],"limitations":[10,103],"and":[11,47,63,77,85,124,138],"chemoresistance.":[12],"Recently,":[13],"combination":[14,72,120,128],"immunoradiotherapy":[15],"has":[16],"shown":[17],"great":[18],"promise":[19],"a":[21,70,89,97,162],"select":[22],"subset":[23],"of":[24,51,149],"patients":[25],"with":[26,37,121,155],"colorectal":[27,111],"cancer":[28],"(CRC).":[29],"Furthermore,":[30],"molecularly":[31],"targeted":[32],"agents":[33],"delivered":[34],"tandem":[36],"immunotherapy":[38,160],"regimens":[39],"have":[40],"been":[41],"suggested":[42],"improve":[44],"treatment":[45],"outcomes":[46],"expand":[48],"the":[49,146],"population":[50],"responding":[52],"patients.":[53],"In":[54],"this":[55],"study,":[56],"radiation-sensitizing":[57],"small":[58],"molecules":[59],"niraparib":[60],"(PARP":[61],"inhibitor)":[62,66],"HS-173":[64],"(PI3K":[65],"are":[67],"identified":[68],"as":[69],"novel":[71],"that":[73],"synergistically":[74],"enhance":[75],"toxicity":[76],"induce":[78],"immunogenic":[79],"cell":[80],"death":[81],"both":[82],"vitro":[84],"vivo":[87],"CRC":[90,163],"model.":[91,164],"These":[92],"inhibitors":[93],"were":[94,114],"co-encapsulated":[95],"polymer":[98],"micelle":[99],"solubility":[102],"while":[104],"minimizing":[105],"off-target":[106],"toxicity.":[107],"Mice":[108],"bearing":[109],"syngeneic":[110],"tumors":[112],"(CT26)":[113],"administered":[115],"these":[116],"therapeutic":[117],"micelles":[118],"X-ray":[122],"irradiation":[123],"anti-CTLA-4":[125,159],"immunotherapy.":[126],"This":[127,143],"led":[129],"enhanced":[131],"efficacy":[132],"demonstrated":[133],"by":[134],"improved":[135],"tumor":[136,140],"control":[137],"increased":[139],"infiltrating":[141],"lymphocytes.":[142],"report":[144],"represents":[145],"first":[147],"investigation":[148],"DNA":[150],"damage":[151],"repair":[152],"inhibition":[153],"combined":[154],"radiation":[156],"potentiate":[158]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":8}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2020-10-29T00:00:00"}