{"id":"https://openalex.org/W3094128751","doi":"https://doi.org/10.1097/md.0000000000021933","title":"The efficacy and safety of Chinese herbal compound combined with western medicine for amyotrophic lateral sclerosis","display_name":"The efficacy and safety of Chinese herbal compound combined with western medicine for amyotrophic lateral sclerosis","publication_year":2020,"publication_date":"2020-10-23","ids":{"openalex":"https://openalex.org/W3094128751","doi":"https://doi.org/10.1097/md.0000000000021933","mag":"3094128751","pmid":"https://pubmed.ncbi.nlm.nih.gov/33120727","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7581109"},"language":"en","primary_location":{"id":"doi:10.1097/md.0000000000021933","doi":"https://doi.org/10.1097/md.0000000000021933","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md.0000000000021933","pdf_url":null,"source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1097/md.0000000000021933","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101967651","display_name":"Lei Sun","orcid":"https://orcid.org/0000-0001-6373-2063","observed_orcids":["https://orcid.org/0000-0001-6373-2063","https://orcid.org/0009-0005-4437-3380"]},"institutions":[{"id":"https://openalex.org/I75920027","display_name":"Shaanxi University of Chinese Medicine","ror":"https://ror.org/021r98132","country_code":"CN","type":"education","lineage":["https://openalex.org/I75920027"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Sun","raw_affiliation_strings":["Shaanxi University of Chinese Medicine, Xixian New Area"],"raw_orcid":"https://orcid.org/0000-0001-6373-2063","affiliations":[{"raw_affiliation_string":"Shaanxi University of Chinese Medicine, Xixian New Area","institution_ids":["https://openalex.org/I75920027"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000561844","display_name":"Wenjuan Zhao","orcid":"https://orcid.org/0000-0003-2529-3404","observed_orcids":["https://orcid.org/0000-0003-2529-3404","https://orcid.org/0009-0007-7181-2400","https://orcid.org/0009-0002-5941-9378","https://orcid.org/0000-0002-3616-5347"]},"institutions":[{"id":"https://openalex.org/I4210136679","display_name":"Affiliated Hospital of Shaanxi University of Chinese Medicine","ror":"https://ror.org/041v5th48","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136679"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenjuan Zhao","raw_affiliation_strings":["Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang","institution_ids":["https://openalex.org/I4210136679"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mingliang Yan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mingliang Yan","raw_affiliation_strings":["Yan\u2019an Municipal Hospital of Traditional Chinese Medicine, Yan\u2019an, Shaanxi Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yan\u2019an Municipal Hospital of Traditional Chinese Medicine, Yan\u2019an, Shaanxi Province, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059823936","display_name":"Bin Yang","orcid":"https://orcid.org/0000-0003-4127-7260","observed_orcids":["https://orcid.org/0000-0003-4127-7260"]},"institutions":[{"id":"https://openalex.org/I4210136679","display_name":"Affiliated Hospital of Shaanxi University of Chinese Medicine","ror":"https://ror.org/041v5th48","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136679"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Yang","raw_affiliation_strings":["Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang","institution_ids":["https://openalex.org/I4210136679"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Peng Xiong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136679","display_name":"Affiliated Hospital of Shaanxi University of Chinese Medicine","ror":"https://ror.org/041v5th48","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136679"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Xiong","raw_affiliation_strings":["Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang","institution_ids":["https://openalex.org/I4210136679"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5115500968","display_name":"Shengjie Zhao","orcid":"https://orcid.org/0000-0003-0187-2049","observed_orcids":["https://orcid.org/0000-0003-0187-2049"]},"institutions":[{"id":"https://openalex.org/I4210136679","display_name":"Affiliated Hospital of Shaanxi University of Chinese Medicine","ror":"https://ror.org/041v5th48","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136679"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shengjie Zhao","raw_affiliation_strings":["Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang","institution_ids":["https://openalex.org/I4210136679"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5115500968"],"corresponding_institution_ids":["https://openalex.org/I4210136679"],"apc_list":{"value":1950,"currency":"USD","value_usd":1950},"apc_paid":{"value":1950,"currency":"USD","value_usd":1950},"fwci":0.1269,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.40841287,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"99","issue":"43","first_page":"e21933","last_page":"e21933"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.8008000254631042,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.8008000254631042,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13444","display_name":"Traditional Chinese Medicine Clinical Research","score":0.15950000286102295,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12647","display_name":"Traditional Chinese Medicine Studies","score":0.025299999862909317,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":1.0},{"id":"https://openalex.org/keywords/compound-chinese-herbal-medicine","display_name":"compound Chinese herbal medicine","score":0.8410000205039978},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.8410000205039978},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6800000071525574},{"id":"https://openalex.org/keywords/integrative-medicine","display_name":"integrative medicine","score":0.7160000205039978},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.7289999723434448},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.7099999785423279},{"id":"https://openalex.org/keywords/functional-rating-scale","display_name":"functional rating scale","score":0.6589999794960022},{"id":"https://openalex.org/keywords/tcm-syndrome-score","display_name":"TCM syndrome score","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9824028611183167},{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.8817096948623657},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.46028369665145874},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3484914004802704},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.32435911893844604},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1051613986492157}],"mesh":[{"descriptor_ui":"D000078202","descriptor_name":"Systematic Reviews as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008516","descriptor_name":"Medicine, Chinese Traditional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015201","descriptor_name":"Meta-Analysis as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1097/md.0000000000021933","doi":"https://doi.org/10.1097/md.0000000000021933","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md.0000000000021933","pdf_url":null,"source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7581109","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7581109/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7581109/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine (Baltimore)","raw_type":"Text"},{"id":"pmid:33120727","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33120727","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1097/md.0000000000021933","doi":"https://doi.org/10.1097/md.0000000000021933","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md.0000000000021933","pdf_url":null,"source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320324173","display_name":"Natural Science Foundation of Shaanxi Province","ror":null},{"id":"https://openalex.org/F4320325627","display_name":"Education Department of Shaanxi Province","ror":"https://ror.org/00jb7xy46"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3094128751.pdf","grobid_xml":"https://content.openalex.org/works/W3094128751.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1997966685","https://openalex.org/W2001432662","https://openalex.org/W2026487992","https://openalex.org/W2108381339","https://openalex.org/W2155221045","https://openalex.org/W2163119148","https://openalex.org/W2532280078","https://openalex.org/W2597399186","https://openalex.org/W2767405902","https://openalex.org/W2778170101","https://openalex.org/W2885679472","https://openalex.org/W2896683815","https://openalex.org/W2902842923","https://openalex.org/W2912136011","https://openalex.org/W2913609543","https://openalex.org/W2971106694","https://openalex.org/W2991360048"],"related_works":["https://openalex.org/W6943981091","https://openalex.org/W4302773408","https://openalex.org/W2767405902","https://openalex.org/W6887877363","https://openalex.org/W7220902081","https://openalex.org/W3197650084","https://openalex.org/W4405923703","https://openalex.org/W4200171312","https://openalex.org/W4293740503","https://openalex.org/W4414190198"],"abstract_inverted_index":{"BACKGROUND:":[0],"Traditional":[1],"Chinese":[2,63,95,123,163,248],"medicine":[3,69,101,164,167,211,254],"(TCM)":[4],"compound":[5,65,97,162,250],"formulations":[6],"are":[7],"selected":[8],"according":[9],"to":[10,54,88,110,150],"different":[11],"populations,":[12],"with":[13,67,99,161,165,209,252],"strong":[14],"targeting":[15],"and":[16,46,92,122,130,141,175,186,204,232],"less":[17],"adverse":[18,233],"reactions.":[19],"As":[20],"a":[21],"complex":[22],"disease,":[23],"amyotrophic":[24],"lateral":[25],"sclerosis":[26],"(ALS)":[27],"has":[28,70],"limited":[29],"efficacy":[30,91,203],"in":[31,102,212,255],"the":[32,90,103,119,145,148,180,183,189,202,213,244,256],"use":[33],"of":[34,49,79,84,94,105,117,147,182,188,206,215,219,247,258],"conventional":[35],"treatment":[36,104,214,257],"regiments,":[37],"short":[38],"life":[39],"cycle,":[40],"high":[41],"cost,":[42],"many":[43],"side":[44],"effects,":[45],"low":[47],"quality":[48,177,181],"life.":[50],"It":[51],"is":[52,76],"urgent":[53],"seek":[55],"new":[56],"alternative":[57],"therapies.":[58],"Clinical":[59],"practice":[60],"shows":[61],"that":[62],"herbal":[64,96,249],"combined":[66,98,208,251],"western":[68,100,166,210,253],"certain":[71],"therapeutic":[72],"advantages,":[73],"but":[74],"there":[75],"no":[77],"evidence":[78,242],"evidence-based":[80],"medicine.":[81],"The":[82],"purpose":[83],"this":[85],"study":[86,157,200,238],"was":[87,192],"evaluate":[89],"safety":[93,205],"ALS.":[106],"METHODS:":[107],"Use":[108],"computer":[109],"retrieve":[111,138],"English":[112],"database":[113,124,149],"(PubMed,":[114],"Embase,":[115],"Web":[116],"Science,":[118],"Cochrane":[120],"Library)":[121],"(CNKI,":[125],"Wanfang":[126],"Database,":[127],"Weipu":[128],"database,":[129],"China":[131],"Biomedical":[132],"Literature":[133],"Service":[134],"System),":[135],"moreover":[136],"manually":[137],"Baidu":[139],"academic":[140,143],"Google":[142],"from":[144],"establishment":[146],"2020":[151],"July":[152],"for":[153,243],"randomized":[154],"controlled":[155],"clinical":[156,245],"on":[158,179],"ALS":[159,216,225],"treated":[160],"therapy,":[168],"2":[169],"researchers":[170],"independently":[171],"conducted":[172],"data":[173],"extraction":[174],"literature":[176,191],"evaluation":[178],"included":[184,190],"studies,":[185],"meta-analysis":[187],"carried":[193],"out":[194],"using":[195],"RevMan5.3":[196],"software.":[197],"RESULTS:":[198],"This":[199,237],"evaluated":[201],"TCM":[207,229],"by":[217],"means":[218],"effective":[220],"rate,":[221],"improved":[222],"Norris":[223],"scale,":[224],"Functional":[226],"Rating":[227],"Scale,":[228],"syndrome":[230],"score,":[231],"reaction":[234],"incidence.":[235],"CONCLUSION:":[236],"will":[239],"provide":[240],"reliable":[241],"application":[246],"ALS.OSF":[259],"registration":[260],"number:":[261],"DOI":[262],"10.17605/OSF.IO/R5XG4.":[263]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2020-10-29T00:00:00"}