{"id":"https://openalex.org/W3094123792","doi":"https://doi.org/10.1111/jcmm.15928","title":"Methylprednisolone alleviates multiple sclerosis by expanding myeloid\u2010derived suppressor cells via glucocorticoid receptor \u03b2 and S100A8/9 up\u2010regulation","display_name":"Methylprednisolone alleviates multiple sclerosis by expanding myeloid\u2010derived suppressor cells via glucocorticoid receptor \u03b2 and S100A8/9 up\u2010regulation","publication_year":2020,"publication_date":"2020-10-23","ids":{"openalex":"https://openalex.org/W3094123792","doi":"https://doi.org/10.1111/jcmm.15928","mag":"3094123792","pmid":"https://pubmed.ncbi.nlm.nih.gov/33094923","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7753844"},"language":"en","primary_location":{"id":"doi:10.1111/jcmm.15928","doi":"https://doi.org/10.1111/jcmm.15928","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jcmm.15928","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcmm.15928","source":{"id":"https://openalex.org/S76698325","display_name":"Journal of Cellular and Molecular Medicine","issn_l":"1582-1838","issn":["1582-1838","1582-4934"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular and Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcmm.15928","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Zhongkun Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhongkun Wang","raw_affiliation_strings":["Central Laboratory, The First Hospital of Jilin University, Changchun, China","Key Laboratory of Organ Regeneration and Transplantation, Ministry of Education, Changchun, China","Vasculocardiology Department, The Second Hospital of Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Laboratory, The First Hospital of Jilin University, Changchun, China","institution_ids":["https://openalex.org/I4210125137"]},{"raw_affiliation_string":"Key Laboratory of Organ Regeneration and Transplantation, Ministry of Education, Changchun, China","institution_ids":[]},{"raw_affiliation_string":"Vasculocardiology Department, The Second Hospital of Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ge Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ge Zheng","raw_affiliation_strings":["Hepatopancreatobiliary Surgery Department, The Second Hospital of Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hepatopancreatobiliary Surgery Department, The Second Hospital of Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055426416","display_name":"Guangjian Li","orcid":"https://orcid.org/0009-0007-5284-5602","observed_orcids":["https://orcid.org/0009-0007-5284-5602","https://orcid.org/0009-0006-2381-3081"]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guangjian Li","raw_affiliation_strings":["Neurology Department, The First Hospital of Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Department, The First Hospital of Jilin University, Changchun, China","institution_ids":["https://openalex.org/I4210125137"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mengkun Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengkun Wang","raw_affiliation_strings":["Pediatric Department, The First Hospital of Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Department, The First Hospital of Jilin University, Changchun, China","institution_ids":["https://openalex.org/I4210125137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050328119","display_name":"Zhanchuan Ma","orcid":"https://orcid.org/0000-0001-8420-6759","observed_orcids":["https://orcid.org/0000-0001-8420-6759"]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhanchuan Ma","raw_affiliation_strings":["Central Laboratory, The First Hospital of Jilin University, Changchun, China","Key Laboratory of Organ Regeneration and Transplantation, Ministry of Education, Changchun, China"],"raw_orcid":"https://orcid.org/0000-0001-8420-6759","affiliations":[{"raw_affiliation_string":"Central Laboratory, The First Hospital of Jilin University, Changchun, China","institution_ids":["https://openalex.org/I4210125137"]},{"raw_affiliation_string":"Key Laboratory of Organ Regeneration and Transplantation, Ministry of Education, Changchun, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100410833","display_name":"Huimin Li","orcid":"https://orcid.org/0009-0006-1394-327X","observed_orcids":["https://orcid.org/0009-0006-1394-327X"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huimin Li","raw_affiliation_strings":["Central Laboratory, The First Hospital of Jilin University, Changchun, China","Clinical Laboratory, The Second Hospital of Jilin University, Changchun, China","Key Laboratory of Organ Regeneration and Transplantation, Ministry of Education, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Laboratory, The First Hospital of Jilin University, Changchun, China","institution_ids":["https://openalex.org/I4210125137"]},{"raw_affiliation_string":"Clinical Laboratory, The Second Hospital of Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]},{"raw_affiliation_string":"Key Laboratory of Organ Regeneration and Transplantation, Ministry of Education, Changchun, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100755827","display_name":"Xiang\u2010Yang Wang","orcid":"https://orcid.org/0000-0003-2421-5367","observed_orcids":["https://orcid.org/0000-0003-2421-5367"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I4390039382","display_name":"VCU Massey Comprehensive Cancer Center","ror":"https://ror.org/0173y3036","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiang\u2010Yang Wang","raw_affiliation_strings":["Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA","Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102011509","display_name":"Huanfa Yi","orcid":"https://orcid.org/0000-0003-3785-3691","observed_orcids":["https://orcid.org/0000-0003-3785-3691"]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huanfa Yi","raw_affiliation_strings":["Central Laboratory, The First Hospital of Jilin University, Changchun, China","Key Laboratory of Organ Regeneration and Transplantation, Ministry of Education, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Laboratory, The First Hospital of Jilin University, Changchun, China","institution_ids":["https://openalex.org/I4210125137"]},{"raw_affiliation_string":"Key Laboratory of Organ Regeneration and Transplantation, Ministry of Education, Changchun, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5102011509"],"corresponding_institution_ids":["https://openalex.org/I4210125137"],"apc_list":{"value":3080,"currency":"USD","value_usd":3080},"apc_paid":{"value":3080,"currency":"USD","value_usd":3080},"fwci":2.8981,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.91927177,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"24","issue":"23","first_page":"13703","last_page":"13714"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methylprednisolone","display_name":"methylprednisolone","score":0.9300000071525574},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glucocorticoid-receptor-beta","display_name":"glucocorticoid receptor beta","score":0.9800000190734863},{"id":"https://openalex.org/keywords/s100a8-a9","display_name":"S100A8/A9","score":0.8790000081062317},{"id":"https://openalex.org/keywords/arginase-1","display_name":"arginase-1","score":0.875},{"id":"https://openalex.org/keywords/experimental-autoimmune-encephalitis","display_name":"experimental autoimmune encephalitis","score":0.9190000295639038},{"id":"https://openalex.org/keywords/pulse-therapy","display_name":"pulse therapy","score":0.7289999723434448},{"id":"https://openalex.org/keywords/remission","display_name":"remission","score":0.7929999828338623},{"id":"https://openalex.org/keywords/relapsing-multiple-sclerosis","display_name":"relapsing multiple sclerosis","score":0.6700000166893005},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7440000176429749}],"concepts":[{"id":"https://openalex.org/C2780372218","wikidata":"https://www.wikidata.org/wiki/Q417222","display_name":"Methylprednisolone","level":2,"score":0.8015098571777344},{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.6676485538482666},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.6548063158988953},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.646088719367981},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.612309455871582},{"id":"https://openalex.org/C55721878","wikidata":"https://www.wikidata.org/wiki/Q15220362","display_name":"Myeloid-derived Suppressor Cell","level":4,"score":0.5333877205848694},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.5164511203765869},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5120499730110168},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47187748551368713},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.44493475556373596},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.42298823595046997},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4140404462814331},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.4101410508155823},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3444923460483551},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.340120792388916},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2719050645828247},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.20396876335144043},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1932808756828308},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.10268053412437439},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000072737","descriptor_name":"Myeloid-Derived Suppressor Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000072737","descriptor_name":"Myeloid-Derived Suppressor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001119","descriptor_name":"Arginase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004681","descriptor_name":"Encephalomyelitis, Autoimmune, Experimental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008775","descriptor_name":"Methylprednisolone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011965","descriptor_name":"Receptors, Glucocorticoid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040501","descriptor_name":"Calgranulin A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D040501","descriptor_name":"Calgranulin A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D040502","descriptor_name":"Calgranulin B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D040502","descriptor_name":"Calgranulin B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/jcmm.15928","doi":"https://doi.org/10.1111/jcmm.15928","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jcmm.15928","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcmm.15928","source":{"id":"https://openalex.org/S76698325","display_name":"Journal of Cellular and Molecular Medicine","issn_l":"1582-1838","issn":["1582-1838","1582-4934"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular and Molecular Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7753844","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7753844","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Mol Med","raw_type":"Text"},{"id":"pmid:33094923","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33094923","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular and molecular medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/jcmm.15928","doi":"https://doi.org/10.1111/jcmm.15928","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jcmm.15928","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcmm.15928","source":{"id":"https://openalex.org/S76698325","display_name":"Journal of Cellular and Molecular Medicine","issn_l":"1582-1838","issn":["1582-1838","1582-4934"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular and Molecular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3906916406","display_name":null,"funder_award_id":"20190201140JC","funder_id":"https://openalex.org/F4320327282","funder_display_name":"Department of Science and Technology of Jilin Province"},{"id":"https://openalex.org/G5143887133","display_name":null,"funder_award_id":"20190201140JC","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8946291282","display_name":null,"funder_award_id":"81671592","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322174","display_name":"People's Government of Jilin Province","ror":"https://ror.org/02fzqav45"},{"id":"https://openalex.org/F4320327282","display_name":"Department of Science and Technology of Jilin Province","ror":"https://ror.org/049x38272"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3094123792.pdf","grobid_xml":"https://content.openalex.org/works/W3094123792.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1515592753","https://openalex.org/W1536028944","https://openalex.org/W1558860870","https://openalex.org/W1645308222","https://openalex.org/W1728764802","https://openalex.org/W1828576284","https://openalex.org/W2000631468","https://openalex.org/W2001115904","https://openalex.org/W2004150448","https://openalex.org/W2013582179","https://openalex.org/W2018053716","https://openalex.org/W2022181071","https://openalex.org/W2030276683","https://openalex.org/W2037409902","https://openalex.org/W2042557504","https://openalex.org/W2052325011","https://openalex.org/W2071308799","https://openalex.org/W2089017130","https://openalex.org/W2102096789","https://openalex.org/W2107277218","https://openalex.org/W2114360920","https://openalex.org/W2118482193","https://openalex.org/W2119116867","https://openalex.org/W2145803099","https://openalex.org/W2149575935","https://openalex.org/W2150076493","https://openalex.org/W2155327161","https://openalex.org/W2171520885","https://openalex.org/W2191313711","https://openalex.org/W2304854632","https://openalex.org/W2326735612","https://openalex.org/W2428789477","https://openalex.org/W2516154060","https://openalex.org/W2526256829","https://openalex.org/W2549171424","https://openalex.org/W2566707319","https://openalex.org/W2573760796","https://openalex.org/W2596861603","https://openalex.org/W2790188328","https://openalex.org/W2791597969","https://openalex.org/W2905887661","https://openalex.org/W2909781225","https://openalex.org/W2969918848","https://openalex.org/W3159915152"],"related_works":["https://openalex.org/W2365820803","https://openalex.org/W7099399094","https://openalex.org/W4280554390","https://openalex.org/W2123554992","https://openalex.org/W1988098374","https://openalex.org/W2391633627","https://openalex.org/W2361497250","https://openalex.org/W2947976783","https://openalex.org/W2360634867","https://openalex.org/W2054314043"],"abstract_inverted_index":{"Methylprednisolone":[0],"is":[1,39],"an":[2,62],"effective":[3],"drug":[4],"in":[5,34,72,98,102,114,161,167],"the":[6,27,47,57,68,83,94,136,181],"treatment":[7,177],"of":[8,29,51,65,70,88,96,127,131,138,151,184,191],"autoimmune":[9],"disease,":[10],"such":[11],"as":[12],"multiple":[13],"sclerosis":[14],"(MS),":[15],"due":[16],"to":[17],"long-acting":[18],"anti-inflammatory,":[19],"antiallergic":[20],"and":[21,49,85,117,129,159,194],"immunosuppressant.":[22],"Previous":[23],"studies":[24],"have":[25],"noted":[26],"importance":[28],"myeloid-derived":[30],"suppressor":[31],"cells":[32],"(MDSC)":[33],"MS":[35,54,108,169,185],"progression.":[36],"However,":[37,93],"it":[38],"still":[40],"not":[41,81],"known":[42],"whether":[43],"methylprednisolone":[44,76],"could":[45],"influence":[46],"ratio":[48,64],"function":[50,87,160],"MDSC":[52,66,89,128,146,157,188],"during":[53,90,170],"treatment.":[55],"In":[56],"current":[58],"study,":[59],"we":[60],"found":[61],"increased":[63,101],"at":[67],"onset":[69],"EAE":[71,163],"mice":[73],"model;":[74],"but":[75],"pulse":[77],"therapy":[78],"(MPPT)":[79],"did":[80],"alter":[82],"percentage":[84,95],"suppressive":[86],"disease":[91,122],"attenuation.":[92],"G-MDSC":[97,118],"PBMC":[99],"significantly":[100],"patients":[103,109],"with":[104],"MS.":[105],"Surprisingly,":[106],"relapsing":[107],"showed":[110],"a":[111],"significant":[112],"increase":[113],"both":[115],"M-MDSC":[116],"after":[119],"MPPT.":[120,171],"The":[121],"remission":[123],"positively":[124],"correlated":[125],"expansion":[126],"expression":[130,137],"arginase-1.":[132],"Additionally,":[133],"MPPT":[134],"reduced":[135],"inhibitory":[139],"glucocorticoid":[140],"(GCs)":[141],"receptor":[142],"\u03b2":[143],"subunit":[144],"on":[145],"while":[147],"elevating":[148],"serum":[149],"levels":[150],"immune":[152],"regulatory":[153],"S100A8/A9":[154,195],"heterodimer.":[155],"Thus,":[156],"dynamics":[158],"mouse":[162],"differ":[164],"from":[165],"those":[166],"human":[168],"Our":[172],"study":[173],"suggested":[174],"that":[175],"GCs":[176],"may":[178],"help":[179],"relieve":[180],"acute":[182],"phase":[183],"by":[186],"expanding":[187],"through":[189],"up-regulating":[190],"GR":[192],"signalling":[193],"heterodimers.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-10-29T00:00:00"}