{"id":"https://openalex.org/W3094046894","doi":"https://doi.org/10.14309/01.ajg.0000706892.59075.79","title":"S1211 The Associations Between Obesity and Early Onset Colorectal Cancer: A Propensity-Weighted Analysis of the National Health and Nutrition Examination Survey (NHANES)","display_name":"S1211 The Associations Between Obesity and Early Onset Colorectal Cancer: A Propensity-Weighted Analysis of the National Health and Nutrition Examination Survey (NHANES)","publication_year":2020,"publication_date":"2020-10-01","ids":{"openalex":"https://openalex.org/W3094046894","doi":"https://doi.org/10.14309/01.ajg.0000706892.59075.79","mag":"3094046894"},"language":"en","primary_location":{"id":"doi:10.14309/01.ajg.0000706892.59075.79","doi":"https://doi.org/10.14309/01.ajg.0000706892.59075.79","is_oa":false,"landing_page_url":"https://doi.org/10.14309/01.ajg.0000706892.59075.79","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063745071","display_name":"Hisham Hussan","orcid":"https://orcid.org/0000-0002-8646-8370","observed_orcids":["https://orcid.org/0000-0002-8646-8370"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hisham Hussan","raw_affiliation_strings":["The Ohio State University Wexner Medical Center, Columbus, OH;","The Ohio State University Wexner Medical Center, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Wexner Medical Center, Columbus, OH;","institution_ids":["https://openalex.org/I2802841970"]},{"raw_affiliation_string":"The Ohio State University Wexner Medical Center, Columbus, OH","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049335680","display_name":"Arsheya Patel","orcid":"https://orcid.org/0000-0003-4012-8167","observed_orcids":["https://orcid.org/0000-0003-4012-8167"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arsheya Patel","raw_affiliation_strings":["The Ohio State University Wexner Medical Center, Columbus, OH;","The Ohio State University Wexner Medical Center, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Wexner Medical Center, Columbus, OH;","institution_ids":["https://openalex.org/I2802841970"]},{"raw_affiliation_string":"The Ohio State University Wexner Medical Center, Columbus, OH","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091084441","display_name":"Alice M. Hinton","orcid":"https://orcid.org/0000-0003-4505-4021","observed_orcids":["https://orcid.org/0000-0003-4505-4021"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alice Hinton","raw_affiliation_strings":["The Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103047585","display_name":"Qin Ma","orcid":"https://orcid.org/0009-0007-2615-7312","observed_orcids":["https://orcid.org/0009-0007-2615-7312"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qin Ma","raw_affiliation_strings":["The Ohio State University Wexner Medical Center, Columbus, OH;","The Ohio State University Wexner Medical Center, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Wexner Medical Center, Columbus, OH;","institution_ids":["https://openalex.org/I2802841970"]},{"raw_affiliation_string":"The Ohio State University Wexner Medical Center, Columbus, OH","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068795037","display_name":"Fred K. Tabung","orcid":"https://orcid.org/0000-0001-8193-7150","observed_orcids":["https://orcid.org/0000-0001-8193-7150"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fred Tabung","raw_affiliation_strings":["The Ohio State University Wexner Medical Center, Columbus, OH;","The Ohio State University Wexner Medical Center, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Wexner Medical Center, Columbus, OH;","institution_ids":["https://openalex.org/I2802841970"]},{"raw_affiliation_string":"The Ohio State University Wexner Medical Center, Columbus, OH","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013392249","display_name":"Steven K. Clinton","orcid":"https://orcid.org/0000-0002-2840-5865","observed_orcids":["https://orcid.org/0000-0002-2840-5865"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Clinton","raw_affiliation_strings":["The Ohio State University Wexner Medical Center, Columbus, OH;","The Ohio State University Wexner Medical Center, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Wexner Medical Center, Columbus, OH;","institution_ids":["https://openalex.org/I2802841970"]},{"raw_affiliation_string":"The Ohio State University Wexner Medical Center, Columbus, OH","institution_ids":["https://openalex.org/I2802841970"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"115","issue":"1","first_page":"S595","last_page":"S595"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.5321999788284302,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.5321999788284302,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.45339998602867126,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10010","display_name":"Obesity, Physical Activity, Diet","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/early-onset-colorectal-cancer","display_name":"early-onset colorectal cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9589999914169312},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.9879999756813049},{"id":"https://openalex.org/keywords/colorectal-cancer-risk-factors","display_name":"colorectal cancer risk factors","score":0.7649999856948853},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.46700000762939453},{"id":"https://openalex.org/keywords/age-at-diabetes-diagnosis","display_name":"age at diabetes diagnosis","score":0.718999981880188},{"id":"https://openalex.org/keywords/reverse-causality","display_name":"reverse causality","score":0.7889999747276306},{"id":"https://openalex.org/keywords/cancer-prevention","display_name":"cancer prevention","score":0.5260000228881836},{"id":"https://openalex.org/keywords/nhanes","display_name":"NHANES","score":0.8019999861717224},{"id":"https://openalex.org/keywords/young-adults","display_name":"young adults","score":0.3970000147819519},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.5789999961853027},{"id":"https://openalex.org/keywords/colorectal-cancer-screening-guidelines","display_name":"colorectal cancer screening guidelines","score":0.4779999852180481},{"id":"https://openalex.org/keywords/colorectal-cancer-screening-intervals","display_name":"colorectal cancer screening intervals","score":0.40799999237060547}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.933687686920166},{"id":"https://openalex.org/C2779874844","wikidata":"https://www.wikidata.org/wiki/Q1967281","display_name":"National Health and Nutrition Examination Survey","level":3,"score":0.8686349391937256},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.7080562710762024},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6650962233543396},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.6002897024154663},{"id":"https://openalex.org/C2781179581","wikidata":"https://www.wikidata.org/wiki/Q2857712","display_name":"Family history","level":2,"score":0.5442748665809631},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5220924615859985},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.48284298181533813},{"id":"https://openalex.org/C2777767895","wikidata":"https://www.wikidata.org/wiki/Q4691924","display_name":"Age of onset","level":3,"score":0.48090600967407227},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.4359038770198822},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3982841670513153},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.39502638578414917},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2300739884376526},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.16590553522109985},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.08697524666786194},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14309/01.ajg.0000706892.59075.79","doi":"https://doi.org/10.14309/01.ajg.0000706892.59075.79","is_oa":false,"landing_page_url":"https://doi.org/10.14309/01.ajg.0000706892.59075.79","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Zero hunger","score":0.8299999833106995,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2002269994","https://openalex.org/W4301860395","https://openalex.org/W2067290261","https://openalex.org/W2762591723","https://openalex.org/W1681395393","https://openalex.org/W2087145054","https://openalex.org/W2349481434","https://openalex.org/W1963945637","https://openalex.org/W2084728497","https://openalex.org/W2132587658"],"abstract_inverted_index":{"INTRODUCTION:":[0],"The":[1],"rapid":[2],"rise":[3],"in":[4,12,45,183,194,320,332,355,367,388],"early-onset":[5,73,143,174,199,263,283,336,344,370,391],"colorectal":[6],"cancer":[7,125,229,352],"(CRC":[8],"diagnosed":[9,88],"<50":[10,110,350,377],"years)":[11],"the":[13,63,81,95,117,139,235,242,343,356],"U.S":[14],"has":[15],"stimulated":[16],"efforts":[17,328],"to":[18,76,135,212,215,223,269,334],"understand":[19],"risk":[20,31],"factors":[21],"and":[22,37,101,111,148,152,159,162,180,190,218,274,315,340,348,362,375,395],"define":[23],"preventive":[24],"strategies.":[25],"Obesity":[26],"is":[27,306],"likely":[28],"one":[29],"contributing":[30],"factor,":[32],"although":[33],"details":[34],"regarding":[35],"timing":[36],"associated":[38,308],"comorbidities":[39],"are":[40,193],"uncertain.":[41],"Of":[42],"course,":[43],"precision":[44],"defining":[46],"this":[47,184,254],"relationship":[48],"may":[49],"be":[50],"confounded":[51],"by":[52,240],"reverse":[53],"causality":[54],"(i.e.":[55],"CRC":[56,74,90,103,144,158,200,217,225,264,273,284,298,305],"induced":[57],"weight":[58],"loss).":[59],"Thus,":[60],"we":[61,256],"investigated":[62],"long-term":[64],"Body":[65],"Mass":[66],"Index":[67],"(BMI)":[68],"history":[69,123],"of":[70,94,109,119,124,260,271,276,288,318,342,364,383,400],"adults":[71,87,172,261,281,368,389],"with":[72,89,156,166,173,177,198,237,262,282,309,369,390],"compared":[75,155,165,214,222,268],"controls.":[77,129,167],"METHODS:":[78],"We":[79,98,169,232],"queried":[80],"1999\u20132018":[82],"NHANES":[83],"database":[84],"for":[85,296,301],"all":[86],"within":[91],"nine":[92],"years":[93,149,210,292],"survey":[96,153,213],"date.":[97],"classified":[99,127],"early-":[100],"later-onset":[102,157,216,224,272,297],"based":[104],"on":[105,145],"a":[106,122,202,321],"diagnosis":[107,151,290],"age":[108,118,206,287,317,363],"\u226550":[112],"years,":[113],"respectively.":[114],"Individuals":[115],"under":[116],"50":[120],"without":[121,228,278,351,378],"were":[126,265],"as":[128],"Propensity":[130],"weighted":[131],"analysis":[132,382,399],"was":[133],"used":[134],"compare":[136],"outcomes":[137],"between":[138,150],"groups":[140,354],"after":[141],"balancing":[142],"gender,":[146,188],"race,":[147],"when":[154,164],"age,":[160],"sex,":[161],"race":[163],"RESULTS:":[168],"included":[170],"133,008":[171],"CRC,":[175,179,345,347,371,374,392,394],"133,680":[176],"late-onset":[178,346,393],"133,009":[181],"controls":[182,227,277,349,376],"propensity-weighted":[185,357,381,398],"analyses.":[186],"Age,":[187],"racial":[189],"income":[191,341],"distributions":[192],"Table":[195],"1.":[196],"Participants":[197],"reported":[201,285],"higher":[203,219],"BMI":[204,221,245,361],"at":[205],"25":[207],"or":[208,226],"10":[209],"prior":[211,244,310],"greatest":[220,243],"(Table":[230],"2).":[231],"then":[233],"assessed":[234],"proportions":[236],"previous":[238],"obesity":[239,311,331,387],"dichotomizing":[241],"into":[246],"<30":[247],"vs.":[248,294,299],"\u226530":[249,313],"kg/m2":[250],"(Figure":[251],"1).":[252],"Using":[253],"method,":[255],"identified":[257],"that":[258],"100%":[259],"previously":[266],"obese":[267],"51.5%":[270],"46.1%":[275],"CRC.":[279],"Finally,":[280],"younger":[286],"diabetes":[289,319,365],"(37":[291],"old":[293],"58":[295],"46":[300],"controls).":[302],"CONCLUSION:":[303],"Early-onset":[304],"strongly":[307],"(BMI":[312],"kg/m2)":[314],"earlier":[316],"nationally":[322],"representative":[323],"sample.":[324],"This":[325],"data":[326],"support":[327],"targeting":[329],"early-age":[330],"order":[333],"prevent":[335],"CRC.Table":[337],"1.:":[338,385],"Demographics":[339],"control":[353],"modelTable":[358],"2.:":[359],"Historical":[360],"onset":[366],"late":[372],"-onset":[373],"cancer:":[379],"A":[380,397],"NHANESFigure":[384],"Prior":[386],"controls:":[396],"NHANES.":[401]},"counts_by_year":[{"year":2022,"cited_by_count":2}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}