{"id":"https://openalex.org/W3093962849","doi":"https://doi.org/10.1101/2020.10.20.346262","title":"Zebrafish studies on the vaccine candidate to COVID-19, the Spike protein: Production of antibody and adverse reaction","display_name":"Zebrafish studies on the vaccine candidate to COVID-19, the Spike protein: Production of antibody and adverse reaction","publication_year":2020,"publication_date":"2020-10-20","ids":{"openalex":"https://openalex.org/W3093962849","doi":"https://doi.org/10.1101/2020.10.20.346262","mag":"3093962849"},"language":"en","primary_location":{"id":"doi:10.1101/2020.10.20.346262","doi":"https://doi.org/10.1101/2020.10.20.346262","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.10.20.346262","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/10/20/2020.10.20.346262.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2020/10/20/2020.10.20.346262.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072496292","display_name":"Bianca Helena Ventura Fernandes","orcid":"https://orcid.org/0000-0002-2213-4355","observed_orcids":["https://orcid.org/0000-0002-2213-4355"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Bianca H Ventura Fernandes","raw_affiliation_strings":["Disciplina de endocrinologia do departamento de Clinica medica e Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular","Laborat\u00f3rio de Controle Gen\u00e9tico e Sanit\u00e1rio, Diretoria T\u00e9cnica de Apoio ao Ensino e Pesquisa, Faculdade de Medicina da Universidade de S\u00e3o Paulo","Disciplina de endocrinologia do departamento de Clinica medica e Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular, LIM 42"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Disciplina de endocrinologia do departamento de Clinica medica e Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular","institution_ids":[]},{"raw_affiliation_string":"Laborat\u00f3rio de Controle Gen\u00e9tico e Sanit\u00e1rio, Diretoria T\u00e9cnica de Apoio ao Ensino e Pesquisa, Faculdade de Medicina da Universidade de S\u00e3o Paulo","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Disciplina de endocrinologia do departamento de Clinica medica e Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular, LIM 42","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103024625","display_name":"Nat\u00e1lia Martins Feitosa","orcid":"https://orcid.org/0000-0001-9425-8018","observed_orcids":["https://orcid.org/0000-0001-9425-8018","https://orcid.org/0000-0002-1095-2588"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Nat\u00e1lia Martins Feitosa","raw_affiliation_strings":["Integrated Laboratory of Translational Bioscience (LIBT), Institute of Biodiversity and Sustainability (NUPEM), Federal University of Rio de Janeiro (UFRJ)-Maca\u00e9","Integrated Laboratory of Translational Bioscience (LIBT), Institute of Biodiversity and Sustainability (NUPEM), Federal University of Rio de Janeiro (UFRJ)-Maca\u00e9, RJ, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrated Laboratory of Translational Bioscience (LIBT), Institute of Biodiversity and Sustainability (NUPEM), Federal University of Rio de Janeiro (UFRJ)-Maca\u00e9","institution_ids":["https://openalex.org/I122140584"]},{"raw_affiliation_string":"Integrated Laboratory of Translational Bioscience (LIBT), Institute of Biodiversity and Sustainability (NUPEM), Federal University of Rio de Janeiro (UFRJ)-Maca\u00e9, RJ, Brazil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ana Paula Barbosa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ana Paula Barbosa","raw_affiliation_strings":["Department of Microbiology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo","Department of Microbiology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Department of Microbiology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090694653","display_name":"Camila Gasque Bomfim","orcid":"https://orcid.org/0000-0002-7367-2153","observed_orcids":["https://orcid.org/0000-0002-7367-2153"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Camila Gasque Bomfim","raw_affiliation_strings":["Department of Microbiology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo","Department of Microbiology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Department of Microbiology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084576390","display_name":"Anali M. B. Garnique","orcid":"https://orcid.org/0000-0001-6305-539X","observed_orcids":["https://orcid.org/0000-0001-6305-539X"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Anali M. B. Garnique","raw_affiliation_strings":["Department of Cell Biology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo","Department of Cell Biology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Department of Cell Biology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019431023","display_name":"Francisco Isaac Fernandes Gomes","orcid":"https://orcid.org/0000-0002-8843-2945","observed_orcids":["https://orcid.org/0000-0002-8843-2945"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Francisco I. F. Gomes","raw_affiliation_strings":["Center of Research in Inflammatory Diseases, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto","Department of Pharmacology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto","Center of Research in Inflammatory Diseases, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Research in Inflammatory Diseases, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Department of Pharmacology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Center of Research in Inflammatory Diseases, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009953835","display_name":"Rafael Takahiro Nakajima","orcid":"https://orcid.org/0000-0002-9931-1102","observed_orcids":["https://orcid.org/0000-0002-9931-1102"]},"institutions":[{"id":"https://openalex.org/I879563668","display_name":"Universidade Estadual Paulista (Unesp)","ror":"https://ror.org/00987cb86","country_code":"BR","type":"education","lineage":["https://openalex.org/I879563668"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rafael T. Nakajima","raw_affiliation_strings":["Reproductive and Molecular Biology Group, Department of Morphology, Institute of Biosciences, S\u00e3o Paulo State University, Botucatu","Reproductive and Molecular Biology Group, Department of Morphology, Institute of Biosciences, S\u00e3o Paulo State University, Botucatu, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive and Molecular Biology Group, Department of Morphology, Institute of Biosciences, S\u00e3o Paulo State University, Botucatu","institution_ids":["https://openalex.org/I879563668"]},{"raw_affiliation_string":"Reproductive and Molecular Biology Group, Department of Morphology, Institute of Biosciences, S\u00e3o Paulo State University, Botucatu, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I879563668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009650615","display_name":"Marco Ant\u00f4nio de Andrade Belo","orcid":"https://orcid.org/0000-0001-5845-3940","observed_orcids":["https://orcid.org/0000-0001-5845-3940","https://orcid.org/0000-0001-7708-3340"]},"institutions":[{"id":"https://openalex.org/I3019322962","display_name":"Universidade Brasil","ror":"https://ror.org/04031z735","country_code":"BR","type":"education","lineage":["https://openalex.org/I3019322962"]},{"id":"https://openalex.org/I879563668","display_name":"Universidade Estadual Paulista (Unesp)","ror":"https://ror.org/00987cb86","country_code":"BR","type":"education","lineage":["https://openalex.org/I879563668"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marco A. A. Belo","raw_affiliation_strings":["Department of Preventive Veterinary Medicine, S\u00e3o Paulo State University, Jaboticabal","Laboratory of Animal Pharmacology and Toxicology, Brasil University, Descalvado","Department of Preventive Veterinary Medicine, S\u00e3o Paulo State University, Jaboticabal, S\u00e3o Paulo, Brazil","Laboratory of Animal Pharmacology and Toxicology, Brasil University, Descalvado, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Veterinary Medicine, S\u00e3o Paulo State University, Jaboticabal","institution_ids":["https://openalex.org/I879563668"]},{"raw_affiliation_string":"Laboratory of Animal Pharmacology and Toxicology, Brasil University, Descalvado","institution_ids":[]},{"raw_affiliation_string":"Department of Preventive Veterinary Medicine, S\u00e3o Paulo State University, Jaboticabal, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I879563668"]},{"raw_affiliation_string":"Laboratory of Animal Pharmacology and Toxicology, Brasil University, Descalvado, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I3019322962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006277842","display_name":"Silas Fernandes Eto","orcid":"https://orcid.org/0000-0003-4796-9727","observed_orcids":["https://orcid.org/0000-0003-4796-9727"]},"institutions":[{"id":"https://openalex.org/I4210144834","display_name":"Universidade Federal de Roraima","ror":"https://ror.org/03ehp1h78","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210144834"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Silas Fernandes Eto","raw_affiliation_strings":["Postgraduate Program in Health Sciences - PROCISA, Federal University of Roraima","Postgraduate Program in Health Sciences - PROCISA, Federal University of Roraima, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Postgraduate Program in Health Sciences - PROCISA, Federal University of Roraima","institution_ids":["https://openalex.org/I4210144834"]},{"raw_affiliation_string":"Postgraduate Program in Health Sciences - PROCISA, Federal University of Roraima, Brazil","institution_ids":["https://openalex.org/I4210144834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053771248","display_name":"Dayanne Carla Fernandes","orcid":"https://orcid.org/0000-0003-2037-1397","observed_orcids":["https://orcid.org/0000-0003-2037-1397"]},"institutions":[{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Dayanne Carla Fernandes","raw_affiliation_strings":["Immunochemistry Laboratory, Butantan Institute","Immunochemistry Laboratory, Butantan Institute, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunochemistry Laboratory, Butantan Institute","institution_ids":["https://openalex.org/I2800423888"]},{"raw_affiliation_string":"Immunochemistry Laboratory, Butantan Institute, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I2800423888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074804419","display_name":"Guilherme Malafaia","orcid":"https://orcid.org/0000-0003-4773-7598","observed_orcids":["https://orcid.org/0000-0003-4773-7598"]},"institutions":[{"id":"https://openalex.org/I3020668385","display_name":"Instituto Federal Goiano","ror":"https://ror.org/0036c6m19","country_code":"BR","type":"education","lineage":["https://openalex.org/I3020668385"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Guilherme Malafaia","raw_affiliation_strings":["Biological Research Laboratory, Goiano Federal Institute \u2013 Uruta\u00ed Campus","Biological Research Laboratory, Goiano Federal Institute \u2013 Uruta\u00ed Campus, GO, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Research Laboratory, Goiano Federal Institute \u2013 Uruta\u00ed Campus","institution_ids":[]},{"raw_affiliation_string":"Biological Research Laboratory, Goiano Federal Institute \u2013 Uruta\u00ed Campus, GO, Brazil","institution_ids":["https://openalex.org/I3020668385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071023894","display_name":"Wilson G\u00f3mez Manrique","orcid":"https://orcid.org/0000-0003-3097-3770","observed_orcids":["https://orcid.org/0000-0003-3097-3770"]},"institutions":[{"id":"https://openalex.org/I123001628","display_name":"Universidade Federal de Rond\u00f4nia","ror":"https://ror.org/02842cb31","country_code":"BR","type":"education","lineage":["https://openalex.org/I123001628"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Wilson G. Manrique","raw_affiliation_strings":["Aquaculture Health Research and Extension Group - GRUPESA, Aquaculture Health Laboratory - LABSA, Department of Veterinary Medicine, Federal University of Rond\u00f4nia, Rolim de Moura campus","Aquaculture Health Research and Extension Group - GRUPESA, Aquaculture Health Laboratory - LABSA, Department of Veterinary Medicine, Federal University of Rond\u00f4nia, Rolim de Moura campus, Rond\u00f4nia, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aquaculture Health Research and Extension Group - GRUPESA, Aquaculture Health Laboratory - LABSA, Department of Veterinary Medicine, Federal University of Rond\u00f4nia, Rolim de Moura campus","institution_ids":["https://openalex.org/I123001628"]},{"raw_affiliation_string":"Aquaculture Health Research and Extension Group - GRUPESA, Aquaculture Health Laboratory - LABSA, Department of Veterinary Medicine, Federal University of Rond\u00f4nia, Rolim de Moura campus, Rond\u00f4nia, Brazil","institution_ids":["https://openalex.org/I123001628"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005386269","display_name":"Gabriel Conde","orcid":"https://orcid.org/0000-0002-2209-7793","observed_orcids":["https://orcid.org/0000-0002-2209-7793"]},"institutions":[{"id":"https://openalex.org/I879563668","display_name":"Universidade Estadual Paulista (Unesp)","ror":"https://ror.org/00987cb86","country_code":"BR","type":"education","lineage":["https://openalex.org/I879563668"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Gabriel Conde","raw_affiliation_strings":["Department of Preventive Veterinary Medicine, S\u00e3o Paulo State University, Jaboticabal","Department of Preventive Veterinary Medicine, S\u00e3o Paulo State University, Jaboticabal, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Veterinary Medicine, S\u00e3o Paulo State University, Jaboticabal","institution_ids":["https://openalex.org/I879563668"]},{"raw_affiliation_string":"Department of Preventive Veterinary Medicine, S\u00e3o Paulo State University, Jaboticabal, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I879563668"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Roberta R. C. Rosales","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Roberta R. C. Rosales","raw_affiliation_strings":["Department of Cell and Molecular Biology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto","Department of Cell and Molecular Biology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Department of Cell and Molecular Biology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012169338","display_name":"\u00cdris Todeschini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Iris Todeschini","raw_affiliation_strings":["Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo","Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085341462","display_name":"Ilo Rivero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170935008","display_name":"Pontif\u00edcia Universidade Cat\u00f3lica de Minas Gerais","ror":"https://ror.org/03j1rr444","country_code":"BR","type":"education","lineage":["https://openalex.org/I170935008"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ilo Rivero","raw_affiliation_strings":["Pontificia Universidade Catolica de Minas Gerais"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pontificia Universidade Catolica de Minas Gerais","institution_ids":["https://openalex.org/I170935008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071147948","display_name":"Edgar Enrique Llontop","orcid":"https://orcid.org/0000-0003-4910-9667","observed_orcids":["https://orcid.org/0000-0003-4910-9667"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Edgar Llontop","raw_affiliation_strings":["Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo","Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011982393","display_name":"Germ\u00e1n G. Sgro","orcid":"https://orcid.org/0000-0002-2831-7945","observed_orcids":["https://orcid.org/0000-0002-2831-7945"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"German G. Sgro","raw_affiliation_strings":["Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo","Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039125621","display_name":"Gabriel Umaji Oka","orcid":"https://orcid.org/0000-0002-1943-7259","observed_orcids":["https://orcid.org/0000-0002-1943-7259","https://orcid.org/0000-0003-3751-7102"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Gabriel Umaji Oka","raw_affiliation_strings":["Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo","Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005399662","display_name":"Natalia Fernanda Bueno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Natalia F Bueno","raw_affiliation_strings":["Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo","Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042854259","display_name":"Fausto Klabund Ferraris","orcid":"https://orcid.org/0000-0001-9434-3503","observed_orcids":["https://orcid.org/0000-0001-9434-3503"]},"institutions":[{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fausto K. Ferraris","raw_affiliation_strings":["Department of Pharmacology and Toxicology, Oswaldo Cruz Foundation - FIOCRUZ- Rio de Janeiro","Department of Pharmacology and Toxicology, Oswaldo Cruz Foundation - FIOCRUZ- Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Oswaldo Cruz Foundation - FIOCRUZ- Rio de Janeiro","institution_ids":["https://openalex.org/I52325"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Oswaldo Cruz Foundation - FIOCRUZ- Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017863285","display_name":"Mariana T. Q. de Magalh\u00e3es","orcid":"https://orcid.org/0000-0003-4912-0233","observed_orcids":["https://orcid.org/0000-0003-4912-0233"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Mariana T. Q. de Magalhaes","raw_affiliation_strings":["Department of Biochemistry and Immunology, Institute of Biological Sciences \u2013 ICB, Federal University of Minas Gerais","Department of Biochemistry and Immunology, Institute of Biological Sciences \u2013 ICB, Federal University of Minas Gerais, Belo Horizonte, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Immunology, Institute of Biological Sciences \u2013 ICB, Federal University of Minas Gerais","institution_ids":["https://openalex.org/I110200422"]},{"raw_affiliation_string":"Department of Biochemistry and Immunology, Institute of Biological Sciences \u2013 ICB, Federal University of Minas Gerais, Belo Horizonte, Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007497183","display_name":"Renata Jurema Medeiros","orcid":"https://orcid.org/0000-0003-2991-1265","observed_orcids":["https://orcid.org/0000-0003-2991-1265"]},"institutions":[{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Renata J. Medeiros","raw_affiliation_strings":["Laboratory of Physiology - Zebrafish INCQS/Fiocruz Facility, Department of Pharmacology and Toxicology \u2013 DFT, INCQS - National Institute for Quality Control in Health. Rio de Janeiro","Laboratory of Physiology - Zebrafish INCQS/Fiocruz Facility, Department of Pharmacology and Toxicology \u2013 DFT, INCQS - National Institute for Quality Control in Health. Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Physiology - Zebrafish INCQS/Fiocruz Facility, Department of Pharmacology and Toxicology \u2013 DFT, INCQS - National Institute for Quality Control in Health. Rio de Janeiro","institution_ids":["https://openalex.org/I52325"]},{"raw_affiliation_string":"Laboratory of Physiology - Zebrafish INCQS/Fiocruz Facility, Department of Pharmacology and Toxicology \u2013 DFT, INCQS - National Institute for Quality Control in Health. Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069663658","display_name":"Juliana Moreira Mendon\u00e7a-Gomes","orcid":"https://orcid.org/0000-0002-5444-5764","observed_orcids":["https://orcid.org/0000-0002-5444-5764"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Juliana M. M Gomes","raw_affiliation_strings":["Transplantation Immunobiology Lab, Department of Immunology, Institute of Biomedical Sciences, Universidade de S\u00e3o Paulo","Transplantation Immunobiology Lab, Department of Immunology, Institute of Biomedical Sciences, Universidade de S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplantation Immunobiology Lab, Department of Immunology, Institute of Biomedical Sciences, Universidade de S\u00e3o Paulo","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Transplantation Immunobiology Lab, Department of Immunology, Institute of Biomedical Sciences, Universidade de S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018528780","display_name":"Mara de Souza Junqueira","orcid":"https://orcid.org/0000-0002-2404-6543","observed_orcids":["https://orcid.org/0000-0002-2404-6543"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4210088998","display_name":"Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo","ror":"https://ror.org/005vqqr19","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210088998"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Mara de Souza Junqueira","raw_affiliation_strings":["Center for Translational Research in Oncology, Cancer Institute of the State of S\u00e3o Paulo, Faculty of Medicine, University of S\u00e3o Paulo","Center for Translational Research in Oncology, Cancer Institute of the State of S\u00e3o Paulo, Faculty of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo. Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Research in Oncology, Cancer Institute of the State of S\u00e3o Paulo, Faculty of Medicine, University of S\u00e3o Paulo","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210088998"]},{"raw_affiliation_string":"Center for Translational Research in Oncology, Cancer Institute of the State of S\u00e3o Paulo, Faculty of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo. Brazil","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210088998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010058926","display_name":"K\u00e1tia Concei\u00e7\u00e3o","orcid":"https://orcid.org/0000-0003-4506-4553","observed_orcids":["https://orcid.org/0000-0003-4506-4553"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Katia Concei\u00e7\u00e3o","raw_affiliation_strings":["Laboratory of Peptide Biochemistry, Federal University of S\u00e3o Paulo","Laboratory of Peptide Biochemistry, Federal University of S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Peptide Biochemistry, Federal University of S\u00e3o Paulo","institution_ids":["https://openalex.org/I88273585"]},{"raw_affiliation_string":"Laboratory of Peptide Biochemistry, Federal University of S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058101694","display_name":"Let\u00edcia Gomes de Pontes","orcid":"https://orcid.org/0000-0002-6648-3880","observed_orcids":["https://orcid.org/0000-0002-6648-3880"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Let\u00edcia G. Pontes","raw_affiliation_strings":["Laboratory of Human Immunology, Department Immunology, Institute Biomedical Sciences, University Sao Paulo","Laboratory of Human Immunology, Department Immunology, Institute Biomedical Sciences, University Sao Paulo, Sao Paulo \u2013 Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Human Immunology, Department Immunology, Institute Biomedical Sciences, University Sao Paulo","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Laboratory of Human Immunology, Department Immunology, Institute Biomedical Sciences, University Sao Paulo, Sao Paulo \u2013 Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090580248","display_name":"Ant\u00f4nio Condino\u2010Neto","orcid":"https://orcid.org/0000-0002-1069-3117","observed_orcids":["https://orcid.org/0000-0002-1069-3117"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Antonio Condino-Neto","raw_affiliation_strings":["Laboratory of Human Immunology, Department Immunology, Institute Biomedical Sciences, University Sao Paulo","Laboratory of Human Immunology, Department Immunology, Institute Biomedical Sciences, University Sao Paulo, Sao Paulo \u2013 Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Human Immunology, Department Immunology, Institute Biomedical Sciences, University Sao Paulo","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Laboratory of Human Immunology, Department Immunology, Institute Biomedical Sciences, University Sao Paulo, Sao Paulo \u2013 Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034755954","display_name":"Andrea Perez","orcid":"https://orcid.org/0000-0001-7424-8891","observed_orcids":["https://orcid.org/0000-0001-7424-8891"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Andrea C. Perez","raw_affiliation_strings":["Department of Pharmacology, Universidade Federal de Minas Gerais","Department of Pharmacology, Universidade Federal de Minas Gerais, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Universidade Federal de Minas Gerais","institution_ids":["https://openalex.org/I110200422"]},{"raw_affiliation_string":"Department of Pharmacology, Universidade Federal de Minas Gerais, Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078525425","display_name":"Leonardo Jos\u00e9 Gil Barcellos","orcid":"https://orcid.org/0000-0002-4637-3377","observed_orcids":["https://orcid.org/0000-0002-4637-3377"]},"institutions":[{"id":"https://openalex.org/I16371252","display_name":"Universidade de Passo Fundo","ror":"https://ror.org/01cwd8p12","country_code":"BR","type":"education","lineage":["https://openalex.org/I16371252"]},{"id":"https://openalex.org/I33501960","display_name":"Universidade Federal de Santa Maria","ror":"https://ror.org/01b78mz79","country_code":"BR","type":"education","lineage":["https://openalex.org/I33501960"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Leonardo J. G. Barcellos","raw_affiliation_strings":["Graduate Program of Pharmacology, Federal University of Santa Maria","Laboratory of Fish Physiology, Graduate Program of Bioexperimentation and of Environmental Sciences. University of Passo Fundo","Graduate Program of Pharmacology, Federal University of Santa Maria, Brazil","Laboratory of Fish Physiology, Graduate Program of Bioexperimentation and of Environmental Sciences. University of Passo Fundo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Program of Pharmacology, Federal University of Santa Maria","institution_ids":["https://openalex.org/I33501960"]},{"raw_affiliation_string":"Laboratory of Fish Physiology, Graduate Program of Bioexperimentation and of Environmental Sciences. University of Passo Fundo","institution_ids":["https://openalex.org/I16371252"]},{"raw_affiliation_string":"Graduate Program of Pharmacology, Federal University of Santa Maria, Brazil","institution_ids":["https://openalex.org/I33501960"]},{"raw_affiliation_string":"Laboratory of Fish Physiology, Graduate Program of Bioexperimentation and of Environmental Sciences. University of Passo Fundo, Brazil","institution_ids":["https://openalex.org/I16371252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044403678","display_name":"Jos\u00e9 Dias Corr\u00eaa","orcid":"https://orcid.org/0000-0002-8623-8524","observed_orcids":["https://orcid.org/0000-0002-8623-8524"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jose Dias Correa junior","raw_affiliation_strings":["Laboratorio do Estudo da Interacao Quimico Biologica e da Reproducao Animal, LIQBRA, Bloco O3,174, Departamento de Morfologia Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio do Estudo da Interacao Quimico Biologica e da Reproducao Animal, LIQBRA, Bloco O3,174, Departamento de Morfologia Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082066841","display_name":"Erick Gustavo Dorlass","orcid":"https://orcid.org/0000-0001-8169-3133","observed_orcids":["https://orcid.org/0000-0001-8169-3133"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Erick G. Dorlass","raw_affiliation_strings":["Department of Microbiology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo","Department of Microbiology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Department of Microbiology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063347657","display_name":"Niels Olsen Saraiva C\u00e2mara","orcid":"https://orcid.org/0000-0001-5436-1248","observed_orcids":["https://orcid.org/0000-0001-5436-1248"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Niels O. S Camara","raw_affiliation_strings":["Transplantation Immunobiology Lab, Department of Immunology, Institute of Biomedical Sciences, Universidade de S\u00e3o Paulo","Transplantation Immunobiology Lab, Department of Immunology, Institute of Biomedical Sciences, Universidade de S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplantation Immunobiology Lab, Department of Immunology, Institute of Biomedical Sciences, Universidade de S\u00e3o Paulo","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Transplantation Immunobiology Lab, Department of Immunology, Institute of Biomedical Sciences, Universidade de S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024090944","display_name":"Edison Lu\u00edz Durigon","orcid":"https://orcid.org/0000-0003-4898-6553","observed_orcids":["https://orcid.org/0000-0003-4898-6553"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Edison Luiz Durigon","raw_affiliation_strings":["Department of Microbiology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo","Department of Microbiology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Department of Microbiology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050684767","display_name":"Fernando Q. Cunha","orcid":"https://orcid.org/0000-0003-4755-1670","observed_orcids":["https://orcid.org/0000-0003-4755-1670"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fernando Q. Cunha","raw_affiliation_strings":["Center of Research in Inflammatory Diseases, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto","Department of Pharmacology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto","Center of Research in Inflammatory Diseases, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Research in Inflammatory Diseases, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Department of Pharmacology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Center of Research in Inflammatory Diseases, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091492354","display_name":"Rafael Henrique N\u00f3brega","orcid":"https://orcid.org/0000-0001-9796-5076","observed_orcids":["https://orcid.org/0000-0001-9796-5076"]},"institutions":[{"id":"https://openalex.org/I879563668","display_name":"Universidade Estadual Paulista (Unesp)","ror":"https://ror.org/00987cb86","country_code":"BR","type":"education","lineage":["https://openalex.org/I879563668"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rafael H. N\u00f3brega","raw_affiliation_strings":["Reproductive and Molecular Biology Group, Department of Morphology, Institute of Biosciences, S\u00e3o Paulo State University, Botucatu","Reproductive and Molecular Biology Group, Department of Morphology, Institute of Biosciences, S\u00e3o Paulo State University, Botucatu, S\u00e3o Paulo, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-9796-5076","affiliations":[{"raw_affiliation_string":"Reproductive and Molecular Biology Group, Department of Morphology, Institute of Biosciences, S\u00e3o Paulo State University, Botucatu","institution_ids":["https://openalex.org/I879563668"]},{"raw_affiliation_string":"Reproductive and Molecular Biology Group, Department of Morphology, Institute of Biosciences, S\u00e3o Paulo State University, Botucatu, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I879563668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036619623","display_name":"Gl\u00e1ucia Maria Machado\u2010Santelli","orcid":"https://orcid.org/0000-0003-2046-9693","observed_orcids":["https://orcid.org/0000-0003-2046-9693"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Glaucia M. Machado-Santelli","raw_affiliation_strings":["Department of Cell Biology, Institute of Biomedical Sciences, University of Sao Paulo","Department of Cell Biology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Institute of Biomedical Sciences, University of Sao Paulo","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Department of Cell Biology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079193460","display_name":"Chuck S. Farah","orcid":"https://orcid.org/0000-0003-3110-6302","observed_orcids":["https://orcid.org/0000-0003-3110-6302"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Chuck Farah","raw_affiliation_strings":["Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo","Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036583809","display_name":"Flavio Protasio Veras","orcid":"https://orcid.org/0000-0002-6222-4064","observed_orcids":["https://orcid.org/0000-0002-6222-4064"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fl\u00e1vio P Veras","raw_affiliation_strings":["Center of Research in Inflammatory Diseases, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto","Department of Pharmacology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto","Center of Research in Inflammatory Diseases, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Research in Inflammatory Diseases, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Department of Pharmacology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Center of Research in Inflammatory Diseases, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027863333","display_name":"Jorge Galindo\u2010Villegas","orcid":"https://orcid.org/0000-0002-4250-2477","observed_orcids":["https://orcid.org/0000-0002-4250-2477"]},"institutions":[{"id":"https://openalex.org/I2802079931","display_name":"Nord University","ror":"https://ror.org/030mwrt98","country_code":"NO","type":"education","lineage":["https://openalex.org/I2802079931"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Jorge Galindo-Villegas","raw_affiliation_strings":["Faculty of Biosciences and Aquaculture, Nord University, 8049 Bod\u00f8","Faculty of Biosciences and Aquaculture, Nord University, 8049 Bod\u00f8, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Biosciences and Aquaculture, Nord University, 8049 Bod\u00f8","institution_ids":["https://openalex.org/I2802079931"]},{"raw_affiliation_string":"Faculty of Biosciences and Aquaculture, Nord University, 8049 Bod\u00f8, Norway","institution_ids":["https://openalex.org/I2802079931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088398854","display_name":"Let\u00edcia Veras Costa-Lotufo","orcid":"https://orcid.org/0000-0003-1861-5153","observed_orcids":["https://orcid.org/0000-0003-1861-5153"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Leticia Costa-Lotufo","raw_affiliation_strings":["Department of Pharmacology, Institute of Biomedical Sciences, Universidade de Sao Paulo","Department of Pharmacology, Institute of Biomedical Sciences, Universidade de Sao Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Institute of Biomedical Sciences, Universidade de Sao Paulo","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Department of Pharmacology, Institute of Biomedical Sciences, Universidade de Sao Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017615120","display_name":"Thiago M. Cunha","orcid":"https://orcid.org/0000-0003-1084-0065","observed_orcids":["https://orcid.org/0000-0003-1084-0065"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Thiago M. Cunha","raw_affiliation_strings":["Center of Research in Inflammatory Diseases, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto","Department of Pharmacology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto","Center of Research in Inflammatory Diseases, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Research in Inflammatory Diseases, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Department of Pharmacology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Center of Research in Inflammatory Diseases, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083692113","display_name":"Roger J. Chammas","orcid":"https://orcid.org/0000-0003-0342-8726","observed_orcids":["https://orcid.org/0000-0003-0342-8726"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4210088998","display_name":"Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo","ror":"https://ror.org/005vqqr19","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210088998"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Roger Chammas","raw_affiliation_strings":["Centro de Investiga\u00e7\u00e3o Translacional em Oncologia, Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo, Faculdade de Medicina da Universidade de S\u00e3o Paulo","Laborat\u00f3rio de Controle Gen\u00e9tico e Sanit\u00e1rio, Diretoria T\u00e9cnica de Apoio ao Ensino e Pesquisa, Faculdade de Medicina da Universidade de S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investiga\u00e7\u00e3o Translacional em Oncologia, Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo, Faculdade de Medicina da Universidade de S\u00e3o Paulo","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210088998"]},{"raw_affiliation_string":"Laborat\u00f3rio de Controle Gen\u00e9tico e Sanit\u00e1rio, Diretoria T\u00e9cnica de Apoio ao Ensino e Pesquisa, Faculdade de Medicina da Universidade de S\u00e3o Paulo","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108128545","display_name":"Cristiane Rodrigues Guzzo","orcid":"https://orcid.org/0000-0002-5664-8055","observed_orcids":["https://orcid.org/0000-0002-5664-8055","https://orcid.org/0000-0001-5994-3714"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Cristiane R. Guzzo","raw_affiliation_strings":["Department of Microbiology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo","Department of Microbiology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Department of Microbiology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000888722","display_name":"Luciani R. S. Carvalho","orcid":"https://orcid.org/0000-0002-7313-2130","observed_orcids":["https://orcid.org/0000-0002-7313-2130"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luciani R Carvalho","raw_affiliation_strings":["Disciplina de endocrinologia do departamento de Clinica medica e Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular","Laborat\u00f3rio de Controle Gen\u00e9tico e Sanit\u00e1rio, Diretoria T\u00e9cnica de Apoio ao Ensino e Pesquisa, Faculdade de Medicina da Universidade de S\u00e3o Paulo","Disciplina de endocrinologia do departamento de Clinica medica e Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular, LIM 42"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Disciplina de endocrinologia do departamento de Clinica medica e Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular","institution_ids":[]},{"raw_affiliation_string":"Laborat\u00f3rio de Controle Gen\u00e9tico e Sanit\u00e1rio, Diretoria T\u00e9cnica de Apoio ao Ensino e Pesquisa, Faculdade de Medicina da Universidade de S\u00e3o Paulo","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Disciplina de endocrinologia do departamento de Clinica medica e Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular, LIM 42","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018497110","display_name":"Ives Charlie\u2010Silva","orcid":"https://orcid.org/0000-0002-7572-2767","observed_orcids":["https://orcid.org/0000-0002-7572-2767"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Ives Charlie-Silva","raw_affiliation_strings":["Department of Pharmacology, Institute of Biomedical Sciences, Universidade de Sao Paulo","Department of Pharmacology, Institute of Biomedical Sciences, Universidade de Sao Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Institute of Biomedical Sciences, Universidade de Sao Paulo","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Department of Pharmacology, Institute of Biomedical Sciences, Universidade de Sao Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":16,"corresponding_author_ids":["https://openalex.org/A5018497110"],"corresponding_institution_ids":["https://openalex.org/I17974374"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.8500999808311462,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.8500999808311462,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.13779999315738678,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10506","display_name":"Aquaculture disease management and microbiota","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.7549999952316284},{"id":"https://openalex.org/keywords/covid-19-vaccines","display_name":"COVID-19 vaccines","score":0.921999990940094},{"id":"https://openalex.org/keywords/sars-cov-2-spike-protein","display_name":"SARS-CoV-2 spike protein","score":0.9950000047683716},{"id":"https://openalex.org/keywords/vaccine-safety","display_name":"vaccine safety","score":0.7419999837875366},{"id":"https://openalex.org/keywords/humoral-immunity","display_name":"humoral immunity","score":0.9340000152587891},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7630000114440918},{"id":"https://openalex.org/keywords/angiotensin-converting-enzyme-2","display_name":"angiotensin-converting enzyme 2","score":0.9649999737739563},{"id":"https://openalex.org/keywords/toll-like-receptor-pathway","display_name":"Toll-like receptor pathway","score":0.9340000152587891},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.8119999766349792}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.7214429974555969},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.717247486114502},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6522887945175171},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6446361541748047},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.570270299911499},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5657914876937866},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.4821045696735382},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.47453773021698},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4458231031894684},{"id":"https://openalex.org/C2779261636","wikidata":"https://www.wikidata.org/wiki/Q7003054","display_name":"Neutralizing antibody","level":3,"score":0.4322482943534851},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3867797553539276},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15971478819847107},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09773647785186768}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1101/2020.10.20.346262","doi":"https://doi.org/10.1101/2020.10.20.346262","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.10.20.346262","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/10/20/2020.10.20.346262.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:arca.fiocruz.br:icict/45467","doi":null,"is_oa":true,"landing_page_url":"https://arca.fiocruz.br/handle/icict/45467","pdf_url":null,"source":{"id":"https://openalex.org/S7407055450","display_name":"Arca - Reposit\u00f3rio Institucional da Fiocruz","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"preprint"},{"id":"pmh:oai:www.arca.fiocruz.br:icict/45467","doi":null,"is_oa":true,"landing_page_url":"https://www.arca.fiocruz.br/handle/icict/45467","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da FIOCRUZ (ARCA)","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":{"id":"doi:10.1101/2020.10.20.346262","doi":"https://doi.org/10.1101/2020.10.20.346262","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.10.20.346262","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/10/20/2020.10.20.346262.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1020065205","display_name":null,"funder_award_id":"2014/04294-1","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G2286822848","display_name":null,"funder_award_id":"2018-0","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G295657101","display_name":null,"funder_award_id":"2019/","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G311168959","display_name":null,"funder_award_id":"303263/2018-0","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G356139876","display_name":null,"funder_award_id":"303,263/2018-0","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G3572101131","display_name":null,"funder_award_id":"2014/","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G4353328290","display_name":"Structure and function of bacterial secretion systems","funder_award_id":"17/17303-7","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G5121428398","display_name":null,"funder_award_id":"2017/173037","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G5502140171","display_name":"Effects of marine pharmaceuticals in zebrafish and ZFL cell line - emphasis","funder_award_id":"18/07098-0","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G5898989225","display_name":null,"funder_award_id":"2019/21739-0","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G5960408532","display_name":null,"funder_award_id":"2020/","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G757101492","display_name":null,"funder_award_id":"2019/12234\u20102","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G7688530525","display_name":"Design of different fragments of SARS-CoV-2 surface protein spike for the development of fast diagnostic test and vaccine","funder_award_id":"20/04680-0","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G7753071806","display_name":null,"funder_award_id":"2018/07098-0","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G7872602500","display_name":null,"funder_award_id":"2019/19939-1","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G8430152297","display_name":"Understanding the c-di-GMP signaling networks and the Type II secretion system present into the human pathogen Leptospira interrogans Copenhageni","funder_award_id":"19/00195-2","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"}],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3093962849.pdf","grobid_xml":"https://content.openalex.org/works/W3093962849.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W1527279107","https://openalex.org/W1559912818","https://openalex.org/W1588785067","https://openalex.org/W1615535881","https://openalex.org/W1960268259","https://openalex.org/W1964763138","https://openalex.org/W1965091685","https://openalex.org/W1975337336","https://openalex.org/W1977615011","https://openalex.org/W1980157773","https://openalex.org/W1981239255","https://openalex.org/W1984482049","https://openalex.org/W2038521663","https://openalex.org/W2043530968","https://openalex.org/W2046683160","https://openalex.org/W2046888375","https://openalex.org/W2060568978","https://openalex.org/W2065285343","https://openalex.org/W2073505294","https://openalex.org/W2074007592","https://openalex.org/W2084409051","https://openalex.org/W2100837269","https://openalex.org/W2101176145","https://openalex.org/W2113927019","https://openalex.org/W2125297253","https://openalex.org/W2126964023","https://openalex.org/W2135726036","https://openalex.org/W2141224543","https://openalex.org/W2146187773","https://openalex.org/W2159482845","https://openalex.org/W2469104897","https://openalex.org/W2552304730","https://openalex.org/W2617961123","https://openalex.org/W2750845696","https://openalex.org/W2790505494","https://openalex.org/W2918086501","https://openalex.org/W2987689554","https://openalex.org/W2999304916","https://openalex.org/W3000532606","https://openalex.org/W3007407747","https://openalex.org/W3007757493","https://openalex.org/W3007940623","https://openalex.org/W3010763499","https://openalex.org/W3012344554","https://openalex.org/W3013660050","https://openalex.org/W3013689008","https://openalex.org/W3015221761","https://openalex.org/W3015226680","https://openalex.org/W3016655508","https://openalex.org/W3021373025","https://openalex.org/W3021590963","https://openalex.org/W3022850953","https://openalex.org/W3026265675","https://openalex.org/W3027462748","https://openalex.org/W3031237995","https://openalex.org/W3033146751","https://openalex.org/W3034561954","https://openalex.org/W3038516322","https://openalex.org/W3038938150","https://openalex.org/W3040645987","https://openalex.org/W3043218917","https://openalex.org/W3043689353","https://openalex.org/W3044965497","https://openalex.org/W3046814626","https://openalex.org/W3048592349","https://openalex.org/W3048885045","https://openalex.org/W3049168646","https://openalex.org/W3069586704","https://openalex.org/W3071690528","https://openalex.org/W3081714253","https://openalex.org/W3082647175","https://openalex.org/W3087676301","https://openalex.org/W3088318008","https://openalex.org/W3088521725","https://openalex.org/W3090647840","https://openalex.org/W3112577032","https://openalex.org/W4255891627"],"related_works":["https://openalex.org/W4313453872","https://openalex.org/W4307977590","https://openalex.org/W4226158160","https://openalex.org/W3097142310","https://openalex.org/W4285591706","https://openalex.org/W7119315635","https://openalex.org/W4391746500","https://openalex.org/W4409689354","https://openalex.org/W4376959450","https://openalex.org/W3092953419"],"abstract_inverted_index":{"Summary":[0],"Establishing":[1],"new":[2],"experimental":[3],"animal":[4],"models":[5],"to":[6,13,44,54,88,100,158,196],"assess":[7],"the":[8,14,18,29,46,49,59,68,86,89,109,120,138,143,151,163,174,183,186,189,193,197],"safety":[9,47,184],"and":[10,53,72,84,96,111,115,142,166,188],"immune":[11,56,190],"response":[12,57,191],"antigen":[15],"used":[16],"in":[17,37,150,164,167],"development":[19],"of":[20,31,48,67,103,108,113,137,153,185,192],"COVID-19":[21],"vaccine":[22,51,187],"is":[23],"an":[24],"imperative":[25],"issue.":[26],"Based":[27,161],"on":[28,162],"advantages":[30],"using":[32],"zebrafish":[33,114,175],"as":[34,176],"a":[35,63,177],"model":[36,178],"research,":[38],"herein":[39],"we":[40,172],"suggest":[41],"doing":[42],"this":[43],"test":[45],"putative":[50],"candidates":[52],"study":[55],"against":[58],"virus.":[60,199],"We":[61],"produced":[62],"recombinant":[64],"N-terminal":[65],"fraction":[66],"Spike":[69,139],"SARS-CoV-2":[70,140,198],"protein":[71],"injected":[73],"it":[74],"into":[75,182],"adult":[76],"female":[77],"zebrafish.":[78],"The":[79,106],"specimens":[80],"generated":[81],"humoral":[82],"immunity":[83],"passed":[85],"antibodies":[87],"eggs.":[90],"However,":[91],"they":[92],"presented":[93,127,170],"adverse":[94],"reactions":[95],"inflammatory":[97],"responses":[98],"similar":[99],"severe":[101],"cases":[102],"human":[104,116,122],"COVID-19.":[105],"analysis":[107,133],"structure":[110],"function":[112],"Angiotensin-converting":[117],"enzyme":[118],"2,":[119],"main":[121],"receptor":[123,145],"for":[124,179],"virus":[125],"infection,":[126],"remarkable":[128],"sequence":[129],"similarities.":[130],"Moreover,":[131],"bioinformatic":[132],"predicted":[134],"protein-protein":[135],"interaction":[136],"fragment":[141],"Toll-like":[144],"pathway.":[146],"It":[147],"might":[148],"help":[149],"choice":[152],"future":[154],"therapeutic":[155],"pharmaceutical":[156],"drugs":[157],"be":[159],"studied.":[160],"vivo":[165],"silico":[168],"results":[169],"here,":[171],"propose":[173],"translational":[180],"research":[181],"vertebrate":[194],"organism":[195]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2020-10-29T00:00:00"}