{"id":"https://openalex.org/W3093744968","doi":"https://doi.org/10.1097/mph.0000000000001983","title":"Adjuvant Maintenance Larotrectinib Therapy in 2 Children With NTRK Fusion-positive High-grade Cancers","display_name":"Adjuvant Maintenance Larotrectinib Therapy in 2 Children With NTRK Fusion-positive High-grade Cancers","publication_year":2020,"publication_date":"2020-10-21","ids":{"openalex":"https://openalex.org/W3093744968","doi":"https://doi.org/10.1097/mph.0000000000001983","mag":"3093744968","pmid":"https://pubmed.ncbi.nlm.nih.gov/33093355"},"language":"en","primary_location":{"id":"doi:10.1097/mph.0000000000001983","doi":"https://doi.org/10.1097/mph.0000000000001983","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mph.0000000000001983","pdf_url":null,"source":{"id":"https://openalex.org/S15952725","display_name":"Journal of Pediatric Hematology/Oncology","issn_l":"1077-4114","issn":["1077-4114","1536-3678"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Hematology/Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020216132","display_name":"Maria Carter\u2010Febres","orcid":"https://orcid.org/0000-0003-4076-8615","observed_orcids":["https://orcid.org/0000-0003-4076-8615"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Maria Carter-Febres","raw_affiliation_strings":["Division of Pediatric Hematology-Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Hematology-Oncology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065127545","display_name":"Netta Schneller","orcid":"https://orcid.org/0000-0001-7299-3986","observed_orcids":["https://orcid.org/0000-0001-7299-3986"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Netta Schneller","raw_affiliation_strings":["Division of Pediatric Hematology-Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Hematology-Oncology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077879670","display_name":"Douglas Beaty Fair","orcid":"https://orcid.org/0000-0001-9742-4640","observed_orcids":["https://orcid.org/0000-0001-9742-4640"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Douglas Fair","raw_affiliation_strings":["Division of Pediatric Hematology-Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Hematology-Oncology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088179286","display_name":"David A. Solomon","orcid":"https://orcid.org/0000-0003-4571-7999","observed_orcids":["https://orcid.org/0000-0003-4571-7999"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Solomon","raw_affiliation_strings":["Department of Pathology, University of California San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of California San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052983963","display_name":"Arie Perry","orcid":"https://orcid.org/0000-0002-8300-7261","observed_orcids":["https://orcid.org/0000-0002-8300-7261"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arie Perry","raw_affiliation_strings":["Department of Pathology, University of California San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of California San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065741141","display_name":"Angshumoy Roy","orcid":"https://orcid.org/0000-0001-7248-8576","observed_orcids":["https://orcid.org/0000-0001-7248-8576"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210147586","display_name":"Texas Children's Hospital","ror":"https://ror.org/05cz92x43","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210147586"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angshumoy Roy","raw_affiliation_strings":["Department of Pathology, Baylor College of Medicine, Texas Children\u2019s Hospital, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Baylor College of Medicine, Texas Children\u2019s Hospital, Houston, TX","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210147586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051525450","display_name":"Luke L. Linscott","orcid":"https://orcid.org/0000-0001-6074-0789","observed_orcids":["https://orcid.org/0000-0001-6074-0789"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luke Linscott","raw_affiliation_strings":["Medical Imaging"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Imaging","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058704285","display_name":"Mouied Alashari","orcid":"https://orcid.org/0000-0001-5503-2024","observed_orcids":["https://orcid.org/0000-0001-5503-2024"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mouied Alashari","raw_affiliation_strings":["Pediatric Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Pathology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068202237","display_name":"John R. W. Kestle","orcid":"https://orcid.org/0000-0003-3634-2312","observed_orcids":["https://orcid.org/0000-0003-3634-2312"]},"institutions":[{"id":"https://openalex.org/I1324574813","display_name":"Primary Children's Hospital","ror":"https://ror.org/053hkmn05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I108785884","https://openalex.org/I1324574813"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John R. Kestle","raw_affiliation_strings":["Pediatric Neurosurgery, University of Utah School of Medicine and Primary Children\u2019s Hospital, Salt Lake City, UT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Neurosurgery, University of Utah School of Medicine and Primary Children\u2019s Hospital, Salt Lake City, UT","institution_ids":["https://openalex.org/I1324574813","https://openalex.org/I223532165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017658161","display_name":"Carol S. Bruggers","orcid":"https://orcid.org/0000-0002-6550-0941","observed_orcids":["https://orcid.org/0000-0002-6550-0941"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Carol S. Bruggers","raw_affiliation_strings":["Division of Pediatric Hematology-Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Hematology-Oncology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5017658161","https://openalex.org/A5020216132","https://openalex.org/A5065127545","https://openalex.org/A5077879670"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7029,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.73902971,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"43","issue":"7","first_page":"e987","last_page":"e990"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.8848000168800354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.8848000168800354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.02239999920129776,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.015200000256299973,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/larotrectinib","display_name":"larotrectinib","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ntrk-fusion","display_name":"NTRK fusion","score":0.8939999938011169},{"id":"https://openalex.org/keywords/pediatric-solid-tumors","display_name":"pediatric solid tumors","score":0.9200000166893005},{"id":"https://openalex.org/keywords/etv6-ntrk3-fusion","display_name":"ETV6-NTRK3 fusion","score":0.9259999990463257},{"id":"https://openalex.org/keywords/anaplastic-astrocytoma","display_name":"anaplastic astrocytoma","score":0.9700000286102295},{"id":"https://openalex.org/keywords/ntrk-inhibitors","display_name":"NTRK inhibitors","score":0.746999979019165},{"id":"https://openalex.org/keywords/treatment-related-morbidity","display_name":"treatment-related morbidity","score":0.8050000071525574}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9255455732345581},{"id":"https://openalex.org/C2779083369","wikidata":"https://www.wikidata.org/wiki/Q486092","display_name":"Anaplastic astrocytoma","level":4,"score":0.625480055809021},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5225205421447754},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.4867391586303711},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4780471920967102},{"id":"https://openalex.org/C2777982462","wikidata":"https://www.wikidata.org/wiki/Q2481887","display_name":"Adjuvant therapy","level":3,"score":0.46499812602996826},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.40061426162719727},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.30652666091918945},{"id":"https://openalex.org/C2778880634","wikidata":"https://www.wikidata.org/wiki/Q177755","display_name":"Astrocytoma","level":3,"score":0.21195504069328308},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.13558754324913025}],"mesh":[{"descriptor_ui":"D000097764","descriptor_name":"ETS Translocation Variant 6 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001254","descriptor_name":"Astrocytoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001254","descriptor_name":"Astrocytoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001254","descriptor_name":"Astrocytoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009373","descriptor_name":"Neoplasms, Germ Cell and Embryonal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009373","descriptor_name":"Neoplasms, Germ Cell and Embryonal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009373","descriptor_name":"Neoplasms, Germ Cell and Embryonal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015514","descriptor_name":"Oncogene Proteins, Fusion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020812","descriptor_name":"Receptor, trkC","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020813","descriptor_name":"Receptor, trkB","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060046","descriptor_name":"Maintenance Chemotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/mph.0000000000001983","doi":"https://doi.org/10.1097/mph.0000000000001983","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mph.0000000000001983","pdf_url":null,"source":{"id":"https://openalex.org/S15952725","display_name":"Journal of Pediatric Hematology/Oncology","issn_l":"1077-4114","issn":["1077-4114","1536-3678"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Hematology/Oncology","raw_type":"journal-article"},{"id":"pmid:33093355","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33093355","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pediatric hematology/oncology","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W2028785929","https://openalex.org/W2053349906","https://openalex.org/W2572335661","https://openalex.org/W2766312566","https://openalex.org/W2790254562","https://openalex.org/W2795040138","https://openalex.org/W2835158150","https://openalex.org/W2888845108","https://openalex.org/W2891473286","https://openalex.org/W2896424462","https://openalex.org/W2898404843","https://openalex.org/W2907142640","https://openalex.org/W2908270783","https://openalex.org/W2940697425","https://openalex.org/W2942512225","https://openalex.org/W2996574710","https://openalex.org/W3001529224","https://openalex.org/W3008107700","https://openalex.org/W7075602604"],"related_works":["https://openalex.org/W4386390714","https://openalex.org/W2891457886","https://openalex.org/W4281766686","https://openalex.org/W3000969831","https://openalex.org/W7162557218","https://openalex.org/W4405171435","https://openalex.org/W2947629987","https://openalex.org/W3166940707","https://openalex.org/W7123736187","https://openalex.org/W2988843746"],"abstract_inverted_index":{"Treatment-related":[0],"morbidity":[1],"drives":[2],"research":[3],"to":[4],"identify":[5],"targetable":[6],"lesions":[7],"in":[8,19,53,76,100],"children":[9,101],"with":[10,56,102,107],"cancer.":[11],"Neurotrophic":[12],"tropomyosin":[13],"receptor":[14],"kinase":[15],"(NTRK)":[16],"alterations":[17],"occur":[18],"~1%":[20],"of":[21,65],"pediatric":[22,27],"solid":[23],"tumors.":[24],"Early":[25],"phase":[26],"trials":[28],"involving":[29],"the":[30,44,66,88,95],"NTRK":[31,57,89,103],"inhibitor":[32,90],"treatment":[33,48,99],"for":[34],"progressive":[35],"NTRK-mutated":[36],"cancers":[37,105],"show":[38],"promising":[39],"results.":[40],"The":[41],"authors":[42],"describe":[43],"adjuvant":[45,96],"maintenance":[46,97],"larotrectinib":[47,82,98],"after":[49],"definitive":[50],"surgical":[51],"resection":[52],"2":[54],"toddlers":[55],"fusion-positive":[58,61,70,104],"malignancies":[59],"(ETV6-NTRK3":[60],"undifferentiated":[62],"embryonal":[63],"sarcoma":[64],"kidney":[67],"and":[68,80],"NACC2-NTRK2":[69],"anaplastic":[71],"astrocytoma).":[72],"Both":[73],"are":[74],"alive,":[75],"remission,":[77],"developing":[78],"normally":[79],"tolerating":[81],"15":[83],"months":[84],"later,":[85],"thus":[86],"extending":[87],"therapeutic":[91],"spectrum":[92],"by":[93],"describing":[94],"associated":[106],"high":[108],"recurrences.":[109]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-10-29T00:00:00"}