{"id":"https://openalex.org/W3093672866","doi":null,"title":"Targeting Casein Kinases in the Fungal Pathogen Candida albicans","display_name":"Targeting Casein Kinases in the Fungal Pathogen Candida albicans","publication_year":2020,"publication_date":"2020-06-01","ids":{"openalex":"https://openalex.org/W3093672866","mag":"3093672866"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/101072","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/101072","pdf_url":"https://utoronto.scholaris.ca/bitstreams/d7bb4b21-e784-49f1-ba3f-013a81e77066/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/d7bb4b21-e784-49f1-ba3f-013a81e77066/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025806374","display_name":"Sabrina Hyde","orcid":"https://orcid.org/0000-0003-3529-8647","observed_orcids":["https://orcid.org/0000-0003-3529-8647"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sabrina Hyde","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3529-8647","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5025806374"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.01860000006854534,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11900","display_name":"Fungal Plant Pathogen Control","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.921999990940094},{"id":"https://openalex.org/keywords/casein-kinase","display_name":"casein kinase","score":0.9419999718666077},{"id":"https://openalex.org/keywords/echinocandin-resistance","display_name":"echinocandin resistance","score":0.9369999766349792},{"id":"https://openalex.org/keywords/caspofungin","display_name":"caspofungin","score":0.9660000205039978},{"id":"https://openalex.org/keywords/protein-kinase-inhibitors","display_name":"protein kinase inhibitors","score":0.7889999747276306},{"id":"https://openalex.org/keywords/antifungal-resistance","display_name":"antifungal resistance","score":0.9300000071525574}],"concepts":[{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.8065255880355835},{"id":"https://openalex.org/C3019170707","wikidata":"https://www.wikidata.org/wiki/Q6471530","display_name":"Fungal pathogen","level":3,"score":0.6655223965644836},{"id":"https://openalex.org/C160110348","wikidata":"https://www.wikidata.org/wiki/Q5048387","display_name":"Casein kinase 1","level":4,"score":0.6135135889053345},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.5490199327468872},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5284469127655029},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.48626482486724854},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41373181343078613},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15930962562561035},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.10376110672950745}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/101072","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/101072","pdf_url":"https://utoronto.scholaris.ca/bitstreams/d7bb4b21-e784-49f1-ba3f-013a81e77066/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:3093672866","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/bitstream/1807/101072/1/Hyde_Sabrina_Claudia_202006_MSc_thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/101072","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/101072","pdf_url":"https://utoronto.scholaris.ca/bitstreams/d7bb4b21-e784-49f1-ba3f-013a81e77066/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3093672866.pdf","grobid_xml":"https://content.openalex.org/works/W3093672866.grobid-xml"},"referenced_works_count":171,"referenced_works":["https://openalex.org/W1182581869","https://openalex.org/W1494279257","https://openalex.org/W1503938960","https://openalex.org/W1608710587","https://openalex.org/W1755623111","https://openalex.org/W1773825673","https://openalex.org/W1803102843","https://openalex.org/W1888528915","https://openalex.org/W1889468485","https://openalex.org/W1905535572","https://openalex.org/W1918079945","https://openalex.org/W1929821956","https://openalex.org/W1965575582","https://openalex.org/W1970250905","https://openalex.org/W1971071885","https://openalex.org/W1972736746","https://openalex.org/W1976123775","https://openalex.org/W1977785594","https://openalex.org/W1979749196","https://openalex.org/W1981239770","https://openalex.org/W1981737096","https://openalex.org/W1985046929","https://openalex.org/W1986481314","https://openalex.org/W1987095367","https://openalex.org/W1987756781","https://openalex.org/W1988825409","https://openalex.org/W1991488616","https://openalex.org/W1992193993","https://openalex.org/W1993727333","https://openalex.org/W1994028261","https://openalex.org/W1994762541","https://openalex.org/W1995351663","https://openalex.org/W1995380559","https://openalex.org/W1995919293","https://openalex.org/W1999608828","https://openalex.org/W2002218888","https://openalex.org/W2003905487","https://openalex.org/W2008837893","https://openalex.org/W2012050459","https://openalex.org/W2014031830","https://openalex.org/W2021255160","https://openalex.org/W2021740841","https://openalex.org/W2021890674","https://openalex.org/W2025947534","https://openalex.org/W2028867134","https://openalex.org/W2030205108","https://openalex.org/W2031259765","https://openalex.org/W2032893561","https://openalex.org/W2034399479","https://openalex.org/W2037951556","https://openalex.org/W2045507047","https://openalex.org/W2050156567","https://openalex.org/W2051269276","https://openalex.org/W2051440750","https://openalex.org/W2063925951","https://openalex.org/W2064031122","https://openalex.org/W2064314272","https://openalex.org/W2064931183","https://openalex.org/W2073824980","https://openalex.org/W2074740152","https://openalex.org/W2077804275","https://openalex.org/W2078807391","https://openalex.org/W2079590574","https://openalex.org/W2081370923","https://openalex.org/W2082462656","https://openalex.org/W2082568641","https://openalex.org/W2083982805","https://openalex.org/W2084207316","https://openalex.org/W2085708633","https://openalex.org/W2087273774","https://openalex.org/W2091902964","https://openalex.org/W2094349823","https://openalex.org/W2095869995","https://openalex.org/W2097290405","https://openalex.org/W2097666362","https://openalex.org/W2099735525","https://openalex.org/W2099951777","https://openalex.org/W2103503400","https://openalex.org/W2103685216","https://openalex.org/W2106064593","https://openalex.org/W2107794472","https://openalex.org/W2108543631","https://openalex.org/W2113522006","https://openalex.org/W2114409750","https://openalex.org/W2115346931","https://openalex.org/W2117206304","https://openalex.org/W2120365200","https://openalex.org/W2120771633","https://openalex.org/W2124026197","https://openalex.org/W2124557759","https://openalex.org/W2128003379","https://openalex.org/W2128207311","https://openalex.org/W2128575896","https://openalex.org/W2130437495","https://openalex.org/W2131321938","https://openalex.org/W2131635397","https://openalex.org/W2133183053","https://openalex.org/W2136493024","https://openalex.org/W2136685494","https://openalex.org/W2136881626","https://openalex.org/W2137037625","https://openalex.org/W2139307267","https://openalex.org/W2139472183","https://openalex.org/W2141563676","https://openalex.org/W2142427146","https://openalex.org/W2144035662","https://openalex.org/W2144149632","https://openalex.org/W2148709825","https://openalex.org/W2149579582","https://openalex.org/W2150428940","https://openalex.org/W2151188141","https://openalex.org/W2152745547","https://openalex.org/W2153898589","https://openalex.org/W2156217754","https://openalex.org/W2157058776","https://openalex.org/W2157428610","https://openalex.org/W2159940514","https://openalex.org/W2161465643","https://openalex.org/W2162171804","https://openalex.org/W2163811015","https://openalex.org/W2169687789","https://openalex.org/W2173151789","https://openalex.org/W2180229411","https://openalex.org/W2216117396","https://openalex.org/W2218047029","https://openalex.org/W2252911663","https://openalex.org/W2254560754","https://openalex.org/W2314754341","https://openalex.org/W2412706318","https://openalex.org/W2415657445","https://openalex.org/W2470291098","https://openalex.org/W2471236952","https://openalex.org/W2480552071","https://openalex.org/W2509038340","https://openalex.org/W2523840231","https://openalex.org/W2528150422","https://openalex.org/W2530414747","https://openalex.org/W2532305189","https://openalex.org/W2552182704","https://openalex.org/W2586214293","https://openalex.org/W2586557085","https://openalex.org/W2592596297","https://openalex.org/W2608385659","https://openalex.org/W2615277755","https://openalex.org/W2620457249","https://openalex.org/W2635415917","https://openalex.org/W2738438224","https://openalex.org/W2744246623","https://openalex.org/W2751938171","https://openalex.org/W2752509294","https://openalex.org/W2767885461","https://openalex.org/W2783191314","https://openalex.org/W2790047349","https://openalex.org/W2794593110","https://openalex.org/W2794930605","https://openalex.org/W2797453547","https://openalex.org/W2801204339","https://openalex.org/W2803225311","https://openalex.org/W2808956493","https://openalex.org/W2891298374","https://openalex.org/W2898801056","https://openalex.org/W2913687673","https://openalex.org/W2914131906","https://openalex.org/W2923923573","https://openalex.org/W2924886534","https://openalex.org/W2936120062","https://openalex.org/W2946533698","https://openalex.org/W2951867871","https://openalex.org/W2956222167","https://openalex.org/W2973294764","https://openalex.org/W4256093214"],"related_works":["https://openalex.org/W7168261974","https://openalex.org/W2999244147","https://openalex.org/W2922340825","https://openalex.org/W4406285404","https://openalex.org/W4280539175","https://openalex.org/W3006918168","https://openalex.org/W4401602700","https://openalex.org/W4412370543","https://openalex.org/W3129842662","https://openalex.org/W4403494557"],"abstract_inverted_index":{"Fungal":[0],"pathogens":[1],"are":[2],"a":[3,11],"major":[4],"public":[5],"health":[6],"burden.":[7],"We":[8],"previously":[9],"screened":[10],"library":[12],"of":[13,38,48,50,89,110,113,129],"over":[14],"700":[15],"protein":[16],"kinase":[17,61,92],"inhibitors":[18],"and":[19,55,64,71,77,104],"identified":[20],"compounds":[21],"with":[22,28,57,85,121],"potent":[23],"antifungal":[24,31],"activity":[25,98],"in":[26,90,115],"combination":[27],"the":[29,46,51,80,122,127],"echinocandin":[30,117],"drug":[32],"caspofungin,":[33],"against":[34],"an":[35,107,143],"echinocandin-resistant":[36],"isolate":[37],"Candida":[39],"albicans.":[40,150],"My":[41],"thesis":[42],"aimed":[43],"to":[44,146],"validate":[45],"interaction":[47],"two":[49],"top":[52],"compounds,":[53],"GW416484":[54],"SB-400868,":[56],"their":[58],"putative":[59],"casein":[60,139],"targets,":[62],"Yck2":[63,76,97],"Hrr25.":[65],"Genetic":[66],"analysis":[67],"suggested":[68],"that":[69,96,137],"GW461484":[70,103],"related":[72],"molecules":[73],"targeted":[74],"both":[75,102],"Hrr25,":[78],"whereas":[79],"SB-400868":[81,105],"scaffold":[82],"specifically":[83],"engaged":[84],"Yck2.":[86,132],"Through":[87],"use":[88],"vitro":[91],"assays":[93],"I":[94],"confirmed":[95],"is":[99],"inhibited":[100],"by":[101],"suggesting":[106],"important":[108],"role":[109],"this":[111,134],"family":[112],"kinases":[114,140],"governing":[116],"resistance.":[118],"In":[119],"collaboration":[120],"Savchenko":[123],"Lab,":[124],"we":[125],"solved":[126],"structure":[128],"C.":[130,149],"albicans":[131],"Overall,":[133],"work":[135],"reveals":[136],"targeting":[138],"may":[141],"be":[142],"effective":[144],"strategy":[145],"cripple":[147],"drug-resistant":[148]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-10-29T00:00:00"}
