{"id":"https://openalex.org/W3093671722","doi":"https://doi.org/10.1016/j.neo.2020.09.005","title":"ONC201 and imipridones: Anti-cancer compounds with clinical efficacy","display_name":"ONC201 and imipridones: Anti-cancer compounds with clinical efficacy","publication_year":2020,"publication_date":"2020-10-23","ids":{"openalex":"https://openalex.org/W3093671722","doi":"https://doi.org/10.1016/j.neo.2020.09.005","mag":"3093671722","pmid":"https://pubmed.ncbi.nlm.nih.gov/33142238","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7588802"},"language":"en","primary_location":{"id":"doi:10.1016/j.neo.2020.09.005","doi":"https://doi.org/10.1016/j.neo.2020.09.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neo.2020.09.005","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1476558620301512/pdf","source":{"id":"https://openalex.org/S20008548","display_name":"Neoplasia","issn_l":"1476-5586","issn":["1476-5586","1522-8002"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasia","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S1476558620301512/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056800304","display_name":"Varun V. Prabhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128844","display_name":"Oncoceutics (United States)","ror":"https://ror.org/032rwz169","country_code":"US","type":"company","lineage":["https://openalex.org/I4210128844"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Varun Vijay Prabhu","raw_affiliation_strings":["Oncoceutics, Inc., 3675 Market St, Suite 200, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncoceutics, Inc., 3675 Market St, Suite 200, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I4210128844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103625130","display_name":"Sara N. Morrow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128844","display_name":"Oncoceutics (United States)","ror":"https://ror.org/032rwz169","country_code":"US","type":"company","lineage":["https://openalex.org/I4210128844"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara Morrow","raw_affiliation_strings":["Oncoceutics, Inc., 3675 Market St, Suite 200, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncoceutics, Inc., 3675 Market St, Suite 200, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I4210128844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005698070","display_name":"Abed Rahman Kawakibi","orcid":"https://orcid.org/0000-0001-6347-8974","observed_orcids":["https://orcid.org/0000-0001-6347-8974"]},"institutions":[{"id":"https://openalex.org/I4210128844","display_name":"Oncoceutics (United States)","ror":"https://ror.org/032rwz169","country_code":"US","type":"company","lineage":["https://openalex.org/I4210128844"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abed Rahman Kawakibi","raw_affiliation_strings":["Oncoceutics, Inc., 3675 Market St, Suite 200, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncoceutics, Inc., 3675 Market St, Suite 200, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I4210128844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100674993","display_name":"Lanlan Zhou","orcid":"https://orcid.org/0000-0001-9471-9099","observed_orcids":["https://orcid.org/0000-0001-9471-9099"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lanlan Zhou","raw_affiliation_strings":["Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039443199","display_name":"Marie D. Ralff","orcid":"https://orcid.org/0000-0003-2113-0974","observed_orcids":["https://orcid.org/0000-0003-2113-0974"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marie Ralff","raw_affiliation_strings":["Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104062798","display_name":"Jocelyn Ray","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jocelyn Ray","raw_affiliation_strings":["Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088284368","display_name":"Aakash Jhaveri","orcid":"https://orcid.org/0000-0003-3420-2332","observed_orcids":["https://orcid.org/0000-0003-3420-2332"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aakash Jhaveri","raw_affiliation_strings":["Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007303823","display_name":"Isacco Ferrarini","orcid":"https://orcid.org/0000-0001-9867-8335","observed_orcids":["https://orcid.org/0000-0001-9867-8335"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Isacco Ferrarini","raw_affiliation_strings":["Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100389568","display_name":"Young Lee","orcid":"https://orcid.org/0000-0001-9205-1785","observed_orcids":["https://orcid.org/0000-0001-9205-1785"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Young Lee","raw_affiliation_strings":["Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062700121","display_name":"Cassandra Parker","orcid":"https://orcid.org/0000-0001-6464-4495","observed_orcids":["https://orcid.org/0000-0001-6464-4495"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cassandra Parker","raw_affiliation_strings":["Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100329234","display_name":"Yiqun Zhang","orcid":"https://orcid.org/0000-0002-0822-6384","observed_orcids":["https://orcid.org/0000-0002-0822-6384"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yiqun Zhang","raw_affiliation_strings":["Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062550497","display_name":"Robyn Borsuk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robyn Borsuk","raw_affiliation_strings":["Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068398828","display_name":"Wen-I Chang","orcid":"https://orcid.org/0000-0002-9376-1559","observed_orcids":["https://orcid.org/0000-0002-9376-1559"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wen-I Chang","raw_affiliation_strings":["Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024963174","display_name":"Joshua N. Honeyman","orcid":"https://orcid.org/0000-0002-9475-8263","observed_orcids":["https://orcid.org/0000-0002-9475-8263"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua N. Honeyman","raw_affiliation_strings":["Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091701598","display_name":"Fabio Rocha Fernandes Tavora","orcid":"https://orcid.org/0000-0003-2361-0613","observed_orcids":["https://orcid.org/0000-0003-2361-0613"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fabio Tavora","raw_affiliation_strings":["Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069923958","display_name":"Benedito A. Carneiro","orcid":"https://orcid.org/0000-0002-5468-1126","observed_orcids":["https://orcid.org/0000-0002-5468-1126"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benedito Carneiro","raw_affiliation_strings":["Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050792634","display_name":"Alexander Grenander Raufi","orcid":"https://orcid.org/0000-0001-5645-2629","observed_orcids":["https://orcid.org/0000-0001-5645-2629"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Raufi","raw_affiliation_strings":["Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029992402","display_name":"Kelsey E. Huntington","orcid":"https://orcid.org/0000-0002-5810-8220","observed_orcids":["https://orcid.org/0000-0002-5810-8220"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelsey Huntington","raw_affiliation_strings":["Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068051991","display_name":"Lindsey Carlsen","orcid":"https://orcid.org/0000-0003-0512-1760","observed_orcids":["https://orcid.org/0000-0003-0512-1760"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lindsey Carlsen","raw_affiliation_strings":["Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065299152","display_name":"Anna D. Louie","orcid":"https://orcid.org/0000-0001-8394-6106","observed_orcids":["https://orcid.org/0000-0001-8394-6106"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Louie","raw_affiliation_strings":["Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013039829","display_name":"Howard P. Safran","orcid":"https://orcid.org/0000-0002-6221-7147","observed_orcids":["https://orcid.org/0000-0002-6221-7147"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard Safran","raw_affiliation_strings":["Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008196559","display_name":"Attila A. Seyhan","orcid":"https://orcid.org/0000-0003-1276-8466","observed_orcids":["https://orcid.org/0000-0003-1276-8466"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Attila A. Seyhan","raw_affiliation_strings":["Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045679809","display_name":"Rohinton S. Tarapore","orcid":"https://orcid.org/0000-0002-8070-5646","observed_orcids":["https://orcid.org/0000-0002-8070-5646"]},"institutions":[{"id":"https://openalex.org/I4210128844","display_name":"Oncoceutics (United States)","ror":"https://ror.org/032rwz169","country_code":"US","type":"company","lineage":["https://openalex.org/I4210128844"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rohinton S. Tarapore","raw_affiliation_strings":["Oncoceutics, Inc., 3675 Market St, Suite 200, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncoceutics, Inc., 3675 Market St, Suite 200, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I4210128844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059799987","display_name":"Lee Schalop","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I4210128844","display_name":"Oncoceutics (United States)","ror":"https://ror.org/032rwz169","country_code":"US","type":"company","lineage":["https://openalex.org/I4210128844"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lee Schalop","raw_affiliation_strings":["Oncoceutics, Inc., 3675 Market St, Suite 200, Philadelphia, PA 19104, USA","Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncoceutics, Inc., 3675 Market St, Suite 200, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I4210128844"]},{"raw_affiliation_string":"Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055837818","display_name":"Martin Stogniew","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128844","display_name":"Oncoceutics (United States)","ror":"https://ror.org/032rwz169","country_code":"US","type":"company","lineage":["https://openalex.org/I4210128844"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin Stogniew","raw_affiliation_strings":["Oncoceutics, Inc., 3675 Market St, Suite 200, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncoceutics, Inc., 3675 Market St, Suite 200, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I4210128844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008547275","display_name":"Joshua E. Allen","orcid":"https://orcid.org/0000-0002-6835-1128","observed_orcids":["https://orcid.org/0000-0002-6835-1128"]},"institutions":[{"id":"https://openalex.org/I4210128844","display_name":"Oncoceutics (United States)","ror":"https://ror.org/032rwz169","country_code":"US","type":"company","lineage":["https://openalex.org/I4210128844"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joshua E. Allen","raw_affiliation_strings":["Oncoceutics, Inc., 3675 Market St, Suite 200, Philadelphia, PA 19104, USA. Electronic address: josh.allen@oncoceutics.com","Oncoceutics, Inc., 3675 Market St, Suite 200, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncoceutics, Inc., 3675 Market St, Suite 200, Philadelphia, PA 19104, USA. Electronic address: josh.allen@oncoceutics.com","institution_ids":["https://openalex.org/I4210128844"]},{"raw_affiliation_string":"Oncoceutics, Inc., 3675 Market St, Suite 200, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I4210128844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036916387","display_name":"Wolfgang Oster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128844","display_name":"Oncoceutics (United States)","ror":"https://ror.org/032rwz169","country_code":"US","type":"company","lineage":["https://openalex.org/I4210128844"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wolfgang Oster","raw_affiliation_strings":["Oncoceutics, Inc., 3675 Market St, Suite 200, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncoceutics, Inc., 3675 Market St, Suite 200, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I4210128844"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075201353","display_name":"Wafik S. El\u2010Deiry","orcid":"https://orcid.org/0000-0002-9577-8266","observed_orcids":["https://orcid.org/0000-0002-9577-8266"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wafik S. El-Deiry","raw_affiliation_strings":["Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA. Electronic address: wafik@brown.edu","Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA. Electronic address: wafik@brown.edu","institution_ids":["https://openalex.org/I27804330"]},{"raw_affiliation_string":"Warren Alpert Medical School, Brown University, 70 Ship Street, Room 537, Providence, RI 02912, USA","institution_ids":["https://openalex.org/I27804330"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5008547275","https://openalex.org/A5075201353"],"corresponding_institution_ids":["https://openalex.org/I27804330","https://openalex.org/I4210128844"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":{"value":2500,"currency":"USD","value_usd":2500},"fwci":2.1532,"has_fulltext":true,"cited_by_count":179,"citation_normalized_percentile":{"value":0.91114643,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"22","issue":"12","first_page":"725","last_page":"744"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.8676999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.8676999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.023099999874830246,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.02239999920129776,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/onc201","display_name":"ONC201","score":0.9990000128746033},{"id":"https://openalex.org/keywords/imipridone","display_name":"imipridone","score":0.9649999737739563},{"id":"https://openalex.org/keywords/trail","display_name":"TRAIL","score":0.8859999775886536},{"id":"https://openalex.org/keywords/drd2-antagonist","display_name":"DRD2 antagonist","score":0.5979999899864197},{"id":"https://openalex.org/keywords/clpp","display_name":"ClpP","score":0.7710000276565552},{"id":"https://openalex.org/keywords/integrated-stress-response","display_name":"integrated stress response","score":0.8309999704360962},{"id":"https://openalex.org/keywords/dr5","display_name":"DR5","score":0.6230000257492065},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8809999823570251},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.8600000143051147},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9549999833106995},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.5149999856948853},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.7789999842643738},{"id":"https://openalex.org/keywords/high-grade-glioma","display_name":"high-grade glioma","score":0.6980000138282776},{"id":"https://openalex.org/keywords/mantle-cell-lymphoma","display_name":"mantle cell lymphoma","score":0.8970000147819519},{"id":"https://openalex.org/keywords/endometrial-cancer","display_name":"endometrial cancer","score":0.7960000038146973},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9300000071525574},{"id":"https://openalex.org/keywords/adrenal-tumors","display_name":"adrenal tumors","score":0.8159999847412109},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5389999747276306},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.4970000088214874},{"id":"https://openalex.org/keywords/oral-anticancer-drugs","display_name":"oral anticancer drugs","score":0.5569999814033508}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6683192253112793},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4864389896392822},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46720951795578003},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.450776070356369},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.43361443281173706},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.418582946062088},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37440866231918335},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3292333483695984},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18309670686721802},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10142451524734497}],"mesh":[{"descriptor_ui":"D000068456","descriptor_name":"Clinical Studies as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049071","descriptor_name":"Endopeptidase Clp","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049071","descriptor_name":"Endopeptidase Clp","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053221","descriptor_name":"TNF-Related Apoptosis-Inducing Ligand","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.neo.2020.09.005","doi":"https://doi.org/10.1016/j.neo.2020.09.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neo.2020.09.005","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1476558620301512/pdf","source":{"id":"https://openalex.org/S20008548","display_name":"Neoplasia","issn_l":"1476-5586","issn":["1476-5586","1522-8002"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasia","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7588802","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7588802","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasia","raw_type":"Text"},{"id":"pmid:33142238","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33142238","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasia (New York, N.Y.)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ab2136215d2b48418947dffdd2998a3e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ab2136215d2b48418947dffdd2998a3e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 12, Pp 725-744 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.neo.2020.09.005","doi":"https://doi.org/10.1016/j.neo.2020.09.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neo.2020.09.005","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1476558620301512/pdf","source":{"id":"https://openalex.org/S20008548","display_name":"Neoplasia","issn_l":"1476-5586","issn":["1476-5586","1522-8002"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasia","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8299999833106995}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4511367935","display_name":"Adaptive Clinical Efficacy Evaluation of ONC201 in Recurrent High Grade Glioma","funder_award_id":"R44CA192427","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G460119355","display_name":"ONC201/TIC10 Anti-tumor Effect Through Regulation of the TRAIL pathway","funder_award_id":"R01CA173453","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4645388780","display_name":"TRAIL Upregulation by TIC10 Analogs","funder_award_id":"R43CA177002","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320307355","display_name":"Musella Foundation For Brain Tumor Research and Information","ror":"https://ror.org/0560cwj87"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3093671722.pdf","grobid_xml":"https://content.openalex.org/works/W3093671722.grobid-xml"},"referenced_works_count":137,"referenced_works":["https://openalex.org/W594682156","https://openalex.org/W1487834525","https://openalex.org/W1494874414","https://openalex.org/W1504508182","https://openalex.org/W1528349069","https://openalex.org/W1786514222","https://openalex.org/W1901896114","https://openalex.org/W1943336505","https://openalex.org/W1946314100","https://openalex.org/W1969845354","https://openalex.org/W1977362534","https://openalex.org/W1981468888","https://openalex.org/W1995733047","https://openalex.org/W1996967705","https://openalex.org/W1997729758","https://openalex.org/W2001267569","https://openalex.org/W2016670931","https://openalex.org/W2023544789","https://openalex.org/W2028643362","https://openalex.org/W2030315579","https://openalex.org/W2038709562","https://openalex.org/W2038809664","https://openalex.org/W2044217732","https://openalex.org/W2056920544","https://openalex.org/W2060211314","https://openalex.org/W2062062519","https://openalex.org/W2068812539","https://openalex.org/W2069776961","https://openalex.org/W2073955447","https://openalex.org/W2077399441","https://openalex.org/W2078431575","https://openalex.org/W2079167188","https://openalex.org/W2100299437","https://openalex.org/W2112171779","https://openalex.org/W2120393701","https://openalex.org/W2120806256","https://openalex.org/W2121232930","https://openalex.org/W2129077074","https://openalex.org/W2130084494","https://openalex.org/W2130632774","https://openalex.org/W2139161770","https://openalex.org/W2140580240","https://openalex.org/W2158233796","https://openalex.org/W2160374852","https://openalex.org/W2162606162","https://openalex.org/W2163013343","https://openalex.org/W2196159484","https://openalex.org/W2208581158","https://openalex.org/W2227783113","https://openalex.org/W2273498393","https://openalex.org/W2274682528","https://openalex.org/W2278250712","https://openalex.org/W2283948643","https://openalex.org/W2317040753","https://openalex.org/W2354094227","https://openalex.org/W2366536035","https://openalex.org/W2398546940","https://openalex.org/W2412718576","https://openalex.org/W2469642987","https://openalex.org/W2514974106","https://openalex.org/W2515779472","https://openalex.org/W2515940974","https://openalex.org/W2517931998","https://openalex.org/W2519635598","https://openalex.org/W2531876842","https://openalex.org/W2575704225","https://openalex.org/W2590156059","https://openalex.org/W2592743985","https://openalex.org/W2592958780","https://openalex.org/W2600944061","https://openalex.org/W2606094885","https://openalex.org/W2612676198","https://openalex.org/W2613790813","https://openalex.org/W2729207723","https://openalex.org/W2742158642","https://openalex.org/W2742224451","https://openalex.org/W2751652997","https://openalex.org/W2754353621","https://openalex.org/W2765153686","https://openalex.org/W2767037713","https://openalex.org/W2767517777","https://openalex.org/W2770901406","https://openalex.org/W2773577558","https://openalex.org/W2790751347","https://openalex.org/W2790779109","https://openalex.org/W2794978585","https://openalex.org/W2795439598","https://openalex.org/W2795707606","https://openalex.org/W2796059570","https://openalex.org/W2800465993","https://openalex.org/W2802016878","https://openalex.org/W2884482864","https://openalex.org/W2889905232","https://openalex.org/W2895957212","https://openalex.org/W2899003114","https://openalex.org/W2899944203","https://openalex.org/W2904387354","https://openalex.org/W2924177262","https://openalex.org/W2924419777","https://openalex.org/W2925940295","https://openalex.org/W2937030578","https://openalex.org/W2939341408","https://openalex.org/W2941632024","https://openalex.org/W2943151208","https://openalex.org/W2945196694","https://openalex.org/W2947518394","https://openalex.org/W2947736019","https://openalex.org/W2950749236","https://openalex.org/W2954376868","https://openalex.org/W2955333860","https://openalex.org/W2971333398","https://openalex.org/W2979839239","https://openalex.org/W2981427587","https://openalex.org/W2982747665","https://openalex.org/W2984632716","https://openalex.org/W2986669041","https://openalex.org/W2989611985","https://openalex.org/W2990218599","https://openalex.org/W3004949997","https://openalex.org/W3008637313","https://openalex.org/W3010239507","https://openalex.org/W3012638502","https://openalex.org/W3029218639","https://openalex.org/W3030334570","https://openalex.org/W3080869114","https://openalex.org/W3081299700","https://openalex.org/W3129398241","https://openalex.org/W4242937164","https://openalex.org/W4247617971","https://openalex.org/W4253043638","https://openalex.org/W4391694006","https://openalex.org/W6746760710","https://openalex.org/W6765619939","https://openalex.org/W6766927962","https://openalex.org/W6769768481","https://openalex.org/W6778287384","https://openalex.org/W6778655713"],"related_works":["https://openalex.org/W3083690945","https://openalex.org/W2514974106","https://openalex.org/W2739932201","https://openalex.org/W4399240212","https://openalex.org/W3133889778","https://openalex.org/W2887334374","https://openalex.org/W2740348896","https://openalex.org/W2773577558","https://openalex.org/W2738456364","https://openalex.org/W4414358381"],"abstract_inverted_index":{"ONC201":[0,12,47,96,123,149],"was":[1],"originally":[2],"discovered":[3],"as":[4,16,32],"TNF-Related":[5],"Apoptosis":[6],"Inducing":[7],"Ligand":[8],"(TRAIL)-inducing":[9],"compound":[10],"TIC10.":[11],"appears":[13],"to":[14,55,102,120,230],"act":[15],"a":[17,227],"selective":[18],"antagonist":[19],"of":[20,36,44,79,95,169,211],"the":[21,49,114,128,208,214],"G":[22],"protein":[23],"coupled":[24],"receptor":[25,28],"(GPCR)":[26],"dopamine":[27],"D2":[29],"(DRD2),":[30],"and":[31,66,110,133,146,179,188,197,237],"an":[33],"allosteric":[34],"agonist":[35],"mitochondrial":[37],"protease":[38,40],"caseinolytic":[39],"P":[41],"(ClpP).":[42],"Downstream":[43],"target":[45,232],"engagement,":[46],"activates":[48],"ATF4/CHOP-mediated":[50],"integrated":[51],"stress":[52],"response":[53],"leading":[54],"TRAIL/Death":[56],"Receptor":[57],"5":[58],"(DR5)":[59],"activation,":[60],"inhibits":[61],"oxidative":[62],"phosphorylation":[63],"via":[64],"c-myc,":[65],"inactivates":[67],"Akt/ERK":[68],"signaling":[69],"in":[70,76,137,140,155,194,201,241],"tumor":[71,80,100,115,156],"cells.":[72],"This":[73],"typically":[74],"results":[75],"DR5/TRAIL-mediated":[77],"apoptosis":[78],"cells;":[81],"however,":[82],"DR5/TRAIL-independent":[83],"apoptosis,":[84],"cell":[85,177],"cycle":[86],"arrest,":[87],"or":[88],"antiproliferative":[89],"effects":[90,94],"also":[91],"occur.":[92],"The":[93],"extend":[97],"beyond":[98],"bulk":[99],"cells":[101,112],"include":[103],"cancer":[104,107],"stem":[105],"cells,":[106],"associated":[108],"fibroblasts":[109],"immune":[111,239],"within":[113],"microenvironment":[116],"that":[117,158,221],"can":[118],"contribute":[119],"its":[121],"efficacy.":[122],"is":[124,134,198],"orally":[125],"administered,":[126],"crosses":[127],"intact":[129],"blood":[130],"brain":[131],"barrier,":[132],"under":[135],"evaluation":[136],"clinical":[138,153,202],"trials":[139],"patients":[141],"with":[142,183],"advanced":[143],"solid":[144],"tumors":[145],"hematological":[147],"malignancies.":[148],"has":[150,191],"single":[151],"agent":[152],"activity":[154],"types":[157],"are":[159,222],"enriched":[160],"for":[161],"DRD2":[162],"and/or":[163],"ClpP":[164],"expression":[165],"including":[166],"specific":[167],"subtypes":[168],"high-grade":[170],"glioma,":[171],"endometrial":[172],"cancer,":[173,175],"prostate":[174],"mantle":[176],"lymphoma,":[178],"adrenal":[180],"tumors.":[181],"Synergy":[182],"radiation,":[184],"chemotherapy,":[185],"targeted":[186],"therapy":[187],"immune-checkpoint":[189],"agents":[190],"been":[192],"identified":[193],"preclinical":[195],"models":[196],"being":[199,223],"evaluated":[200],"trials.":[203],"Structure-activity":[204],"relationships":[205],"based":[206],"on":[207],"core":[209],"pharmacophore":[210],"ONC201,":[212],"termed":[213],"imipridone":[215],"scaffold,":[216],"revealed":[217],"novel":[218,228],"potent":[219],"compounds":[220],"developed.":[224],"Imipridones":[225],"represent":[226],"approach":[229],"therapeutically":[231],"previously":[233],"undruggable":[234],"GPCRs,":[235],"ClpP,":[236],"innate":[238],"pathways":[240],"oncology.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":24},{"year":2025,"cited_by_count":31},{"year":2024,"cited_by_count":35},{"year":2023,"cited_by_count":34},{"year":2022,"cited_by_count":27},{"year":2021,"cited_by_count":26},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-10-29T00:00:00"}
