{"id":"https://openalex.org/W3093666957","doi":"https://doi.org/10.3892/or.2020.7817","title":"Glycogen synthase kinase 3\u03b2 in tumorigenesis and oncotherapy (Review)","display_name":"Glycogen synthase kinase 3\u03b2 in tumorigenesis and oncotherapy (Review)","publication_year":2020,"publication_date":"2020-10-20","ids":{"openalex":"https://openalex.org/W3093666957","doi":"https://doi.org/10.3892/or.2020.7817","mag":"3093666957","pmid":"https://pubmed.ncbi.nlm.nih.gov/33125126"},"language":"en","primary_location":{"id":"doi:10.3892/or.2020.7817","doi":"https://doi.org/10.3892/or.2020.7817","is_oa":true,"landing_page_url":"https://doi.org/10.3892/or.2020.7817","pdf_url":"https://www.spandidos-publications.com/10.3892/or.2020.7817/download","source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.spandidos-publications.com/10.3892/or.2020.7817/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073712215","display_name":"Rui He","orcid":"https://orcid.org/0000-0002-8314-9155","observed_orcids":["https://orcid.org/0000-0002-8314-9155"]},"institutions":[{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui He","raw_affiliation_strings":["Department of Union, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Union, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, P.R. China","institution_ids":["https://openalex.org/I2800091995","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005669008","display_name":"Suya Du","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]},{"id":"https://openalex.org/I4210118556","display_name":"Sichuan Cancer Hospital","ror":"https://ror.org/029wq9x81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210118556"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Suya Du","raw_affiliation_strings":["Department of Clinical Pharmacy, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610041, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610041, P.R. China","institution_ids":["https://openalex.org/I150229711","https://openalex.org/I4210118556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102765414","display_name":"Tiantian Lei","orcid":"https://orcid.org/0009-0000-0249-4225","observed_orcids":["https://orcid.org/0009-0000-0249-4225"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tiantian Lei","raw_affiliation_strings":["Department of Pharmacy, Chongqing Health Center for Women and Children, Chongqing 400013, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Chongqing Health Center for Women and Children, Chongqing 400013, P.R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100723573","display_name":"Xiaofang Xie","orcid":"https://orcid.org/0000-0003-3010-8349","observed_orcids":["https://orcid.org/0000-0003-3010-8349","https://orcid.org/0000-0001-9892-1518"]},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaofang Xie","raw_affiliation_strings":["Department of Medicine, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610041, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610041, P.R. China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100364899","display_name":"Yi Wang","orcid":"https://orcid.org/0000-0001-9921-0304","observed_orcids":["https://orcid.org/0000-0001-9921-0304","https://orcid.org/0000-0002-9907-133X"]},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]},{"id":"https://openalex.org/I4210118397","display_name":"Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital","ror":"https://ror.org/01qh26a66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210118397"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Wang","raw_affiliation_strings":["Personalized Drug Therapy Key Laboratory of Sichuan Province, Department of Pharmacy, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610041, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Personalized Drug Therapy Key Laboratory of Sichuan Province, Department of Pharmacy, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610041, P.R. China","institution_ids":["https://openalex.org/I150229711","https://openalex.org/I4210118397"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6609,"has_fulltext":true,"cited_by_count":83,"citation_normalized_percentile":{"value":0.84435898,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"44","issue":"6","first_page":"2373","last_page":"2385"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glycogen-synthase-kinase-3beta","display_name":"glycogen synthase kinase-3\u03b2","score":0.9750000238418579},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.8960000276565552},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.9520000219345093},{"id":"https://openalex.org/keywords/tumor-suppression","display_name":"tumor suppression","score":0.6439999938011169},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.5979999899864197},{"id":"https://openalex.org/keywords/chemosensitivity","display_name":"chemosensitivity","score":0.7850000262260437},{"id":"https://openalex.org/keywords/kinase-regulation","display_name":"kinase regulation","score":0.5709999799728394},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5320000052452087},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5270000100135803},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8140000104904175},{"id":"https://openalex.org/keywords/glycogen-metabolism","display_name":"glycogen metabolism","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C182996813","wikidata":"https://www.wikidata.org/wiki/Q910847","display_name":"GSK-3","level":3,"score":0.848107099533081},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.8130364418029785},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6706851720809937},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5211246609687805},{"id":"https://openalex.org/C192118531","wikidata":"https://www.wikidata.org/wiki/Q86360001","display_name":"Glycogen synthase","level":3,"score":0.5022733211517334},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49947190284729004},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.4718998372554779},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.47071024775505066},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4622046947479248},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.43107423186302185},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41893136501312256},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3880079984664917},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.2245718240737915},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.21291321516036987},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17003464698791504},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08673441410064697}],"mesh":[{"descriptor_ui":"D000071679","descriptor_name":"Glycogen Synthase Kinase 3 beta","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000071679","descriptor_name":"Glycogen Synthase Kinase 3 beta","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000071679","descriptor_name":"Glycogen Synthase Kinase 3 beta","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000071679","descriptor_name":"Glycogen Synthase Kinase 3 beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000071679","descriptor_name":"Glycogen Synthase Kinase 3 beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000071679","descriptor_name":"Glycogen Synthase Kinase 3 beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000074322","descriptor_name":"Antineoplastic Agents, Immunological","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000074322","descriptor_name":"Antineoplastic Agents, Immunological","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000074322","descriptor_name":"Antineoplastic Agents, Immunological","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000074322","descriptor_name":"Antineoplastic Agents, Immunological","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000074322","descriptor_name":"Antineoplastic Agents, Immunological","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000074322","descriptor_name":"Antineoplastic Agents, Immunological","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3892/or.2020.7817","doi":"https://doi.org/10.3892/or.2020.7817","is_oa":true,"landing_page_url":"https://doi.org/10.3892/or.2020.7817","pdf_url":"https://www.spandidos-publications.com/10.3892/or.2020.7817/download","source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},{"id":"pmid:33125126","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33125126","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7610307","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7610307","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Oncol Rep","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3892/or.2020.7817","doi":"https://doi.org/10.3892/or.2020.7817","is_oa":true,"landing_page_url":"https://doi.org/10.3892/or.2020.7817","pdf_url":"https://www.spandidos-publications.com/10.3892/or.2020.7817/download","source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4179777627","display_name":null,"funder_award_id":"2020YFC2005500","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G43548690","display_name":null,"funder_award_id":"81802504","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3093666957.pdf","grobid_xml":"https://content.openalex.org/works/W3093666957.grobid-xml"},"referenced_works_count":146,"referenced_works":["https://openalex.org/W168615931","https://openalex.org/W409345335","https://openalex.org/W1246025851","https://openalex.org/W1481809543","https://openalex.org/W1487499403","https://openalex.org/W1489736060","https://openalex.org/W1496316111","https://openalex.org/W1546578130","https://openalex.org/W1568081373","https://openalex.org/W1836452880","https://openalex.org/W1955215720","https://openalex.org/W1964632863","https://openalex.org/W1966934989","https://openalex.org/W1971714772","https://openalex.org/W1972343960","https://openalex.org/W1973251504","https://openalex.org/W1975454216","https://openalex.org/W1976153058","https://openalex.org/W1978046076","https://openalex.org/W1980627480","https://openalex.org/W1982628692","https://openalex.org/W1982958012","https://openalex.org/W1983055247","https://openalex.org/W1984407262","https://openalex.org/W1987380441","https://openalex.org/W1988154493","https://openalex.org/W1990285976","https://openalex.org/W1991782850","https://openalex.org/W1994053097","https://openalex.org/W1994994301","https://openalex.org/W1997224330","https://openalex.org/W1998582734","https://openalex.org/W1999756074","https://openalex.org/W2000000814","https://openalex.org/W2003720538","https://openalex.org/W2007573950","https://openalex.org/W2009423916","https://openalex.org/W2019041110","https://openalex.org/W2024345380","https://openalex.org/W2024651104","https://openalex.org/W2028295337","https://openalex.org/W2029296770","https://openalex.org/W2031607563","https://openalex.org/W2031777771","https://openalex.org/W2036619542","https://openalex.org/W2037283794","https://openalex.org/W2038504801","https://openalex.org/W2039816570","https://openalex.org/W2040061273","https://openalex.org/W2040516248","https://openalex.org/W2046982257","https://openalex.org/W2047197367","https://openalex.org/W2054340017","https://openalex.org/W2056081127","https://openalex.org/W2058138221","https://openalex.org/W2058783987","https://openalex.org/W2062118066","https://openalex.org/W2063770217","https://openalex.org/W2064913654","https://openalex.org/W2067671227","https://openalex.org/W2070208294","https://openalex.org/W2071570050","https://openalex.org/W2071642869","https://openalex.org/W2074883812","https://openalex.org/W2075334692","https://openalex.org/W2079718442","https://openalex.org/W2081040180","https://openalex.org/W2083308747","https://openalex.org/W2083993197","https://openalex.org/W2085174678","https://openalex.org/W2085663173","https://openalex.org/W2086320165","https://openalex.org/W2087204404","https://openalex.org/W2089034861","https://openalex.org/W2091605975","https://openalex.org/W2091683380","https://openalex.org/W2092613987","https://openalex.org/W2094093832","https://openalex.org/W2094390120","https://openalex.org/W2104492814","https://openalex.org/W2105170078","https://openalex.org/W2107958146","https://openalex.org/W2108958930","https://openalex.org/W2109519975","https://openalex.org/W2112578787","https://openalex.org/W2114594254","https://openalex.org/W2115094443","https://openalex.org/W2117133035","https://openalex.org/W2119958886","https://openalex.org/W2122159985","https://openalex.org/W2123851275","https://openalex.org/W2123861916","https://openalex.org/W2124321534","https://openalex.org/W2125675515","https://openalex.org/W2125904354","https://openalex.org/W2126244179","https://openalex.org/W2130979655","https://openalex.org/W2132557616","https://openalex.org/W2135794202","https://openalex.org/W2139908319","https://openalex.org/W2145808065","https://openalex.org/W2146669781","https://openalex.org/W2148636382","https://openalex.org/W2150622242","https://openalex.org/W2152710824","https://openalex.org/W2153696346","https://openalex.org/W2157020351","https://openalex.org/W2160276999","https://openalex.org/W2163205710","https://openalex.org/W2167028219","https://openalex.org/W2168060610","https://openalex.org/W2226515760","https://openalex.org/W2234610651","https://openalex.org/W2275963737","https://openalex.org/W2281537211","https://openalex.org/W2314202451","https://openalex.org/W2315201381","https://openalex.org/W2322487507","https://openalex.org/W2333341902","https://openalex.org/W2356489145","https://openalex.org/W2473912994","https://openalex.org/W2490441649","https://openalex.org/W2516432787","https://openalex.org/W2732730028","https://openalex.org/W2742755221","https://openalex.org/W2757437926","https://openalex.org/W2766366638","https://openalex.org/W2766962557","https://openalex.org/W2769000166","https://openalex.org/W2769630121","https://openalex.org/W2774108791","https://openalex.org/W2782213258","https://openalex.org/W2804975632","https://openalex.org/W2806089612","https://openalex.org/W2811419129","https://openalex.org/W2885110091","https://openalex.org/W2905264787","https://openalex.org/W2947764833","https://openalex.org/W2995558671","https://openalex.org/W2996612248","https://openalex.org/W2996959025","https://openalex.org/W3002292920","https://openalex.org/W3003100480","https://openalex.org/W3007959681","https://openalex.org/W3013537189","https://openalex.org/W4231263771"],"related_works":["https://openalex.org/W2078394421","https://openalex.org/W2418977330","https://openalex.org/W2327600894","https://openalex.org/W2385507499","https://openalex.org/W2500777475","https://openalex.org/W2073292164","https://openalex.org/W2349975776","https://openalex.org/W2344164921","https://openalex.org/W2193001123","https://openalex.org/W1997937533"],"abstract_inverted_index":{"Glycogen":[0],"synthase":[1],"kinase":[2],"3\u03b2":[3,40,63,72,90,112,132],"(GSK":[4],"3\u03b2),":[5],"a":[6,13,17,43],"multifunctional":[7],"serine":[8],"and":[9,26,33,54,68,83,117,135,137],"threonine":[10],"kinase,":[11],"plays":[12],"critical":[14],"role":[15],"in":[16,42,93,113,133,146],"variety":[18],"of":[19,38,46,80,88,110,130],"cellular":[20],"activities,":[21],"including":[22],"signaling":[23],"transduction,":[24],"protein":[25],"glycogen":[27],"metabolism,":[28],"cell":[29,31,101],"proliferation,":[30],"differentiation,":[32],"apoptosis.":[34],"Therefore,":[35],"aberrant":[36],"regulation":[37],"GSK":[39,62,71,89,111,131],"results":[41],"broad":[44],"range":[45],"human":[47],"diseases,":[48],"such":[49],"as":[50,142],"tumors,":[51],"diabetes,":[52],"inflammation":[53],"neurodegenerative":[55],"diseases.":[56],"Accumulating":[57],"evidence":[58],"has":[59],"suggested":[60],"that":[61],"is":[64,73,91],"correlated":[65],"with":[66],"tumorigenesis":[67,114,134],"progression.":[69],"However,":[70,105],"controversial":[74],"due":[75],"to":[76,99,103],"its":[77,140],"bifacial":[78],"roles":[79,129],"tumor":[81,94],"suppression":[82],"activation.":[84],"In":[85,122],"addition,":[86],"overexpression":[87],"involved":[92],"growth,":[95],"whereas":[96],"it":[97],"contributes":[98],"the":[100,106,128],"sensitivity":[102],"chemotherapy.":[104],"underlying":[107],"regulatory":[108],"mechanisms":[109],"remain":[115],"obscure":[116],"require":[118],"further":[119],"in\u2011depth":[120],"investigation.":[121],"this":[123],"review,":[124],"we":[125],"comprehensively":[126],"summarize":[127],"oncotherapy,":[136],"focus":[138],"on":[139],"potentials":[141],"an":[143],"available":[144],"target":[145],"oncotherapy.":[147]},"counts_by_year":[{"year":2026,"cited_by_count":19},{"year":2025,"cited_by_count":21},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2020-10-29T00:00:00"}