{"id":"https://openalex.org/W3093653404","doi":"https://doi.org/10.1016/j.jcmgh.2020.10.011","title":"Hepatic Autophagy Deficiency Remodels Gut Microbiota for Adaptive Protection via FGF15-FGFR4 Signaling","display_name":"Hepatic Autophagy Deficiency Remodels Gut Microbiota for Adaptive Protection via FGF15-FGFR4 Signaling","publication_year":2020,"publication_date":"2020-10-23","ids":{"openalex":"https://openalex.org/W3093653404","doi":"https://doi.org/10.1016/j.jcmgh.2020.10.011","mag":"3093653404","pmid":"https://pubmed.ncbi.nlm.nih.gov/33127558","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7898036"},"language":"en","primary_location":{"id":"doi:10.1016/j.jcmgh.2020.10.011","doi":"https://doi.org/10.1016/j.jcmgh.2020.10.011","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jcmgh.2020.10.011","pdf_url":"http://www.cmghjournal.org/article/S2352345X20301740/pdf","source":{"id":"https://openalex.org/S2764889447","display_name":"Cellular and Molecular Gastroenterology and Hepatology","issn_l":"2352-345X","issn":["2352-345X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Gastroenterology and Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cmghjournal.org/article/S2352345X20301740/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049804804","display_name":"Shengmin Yan","orcid":"https://orcid.org/0000-0003-4012-9557","observed_orcids":["https://orcid.org/0000-0003-4012-9557"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]},{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shengmin Yan","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana; Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana","Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana","Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana; Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana","institution_ids":["https://openalex.org/I114832834","https://openalex.org/I4388446366","https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091793236","display_name":"Bilon Khambu","orcid":"https://orcid.org/0000-0002-9432-2064","observed_orcids":["https://orcid.org/0000-0002-9432-2064"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]},{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bilon Khambu","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana; Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana","Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana","Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana; Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana","institution_ids":["https://openalex.org/I114832834","https://openalex.org/I4388446366","https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100702115","display_name":"Xiaoyun Chen","orcid":"https://orcid.org/0000-0002-2276-5392","observed_orcids":["https://orcid.org/0000-0002-2276-5392"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoyun Chen","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050155862","display_name":"Zheng Dong","orcid":"https://orcid.org/0000-0003-3538-8095","observed_orcids":["https://orcid.org/0000-0003-3538-8095"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]},{"id":"https://openalex.org/I2799702486","display_name":"Charlie Norwood VA Medical Center","ror":"https://ror.org/01ng1yh19","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799702486","https://openalex.org/I2799886695","https://openalex.org/I4210131075"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zheng Dong","raw_affiliation_strings":["Department of Cell Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia; Charlie Norwood VA Medical Center, Augusta, Georgia","Charlie Norwood VA Medical Center, Augusta, Georgia","Department of Cell Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia; Charlie Norwood VA Medical Center, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050","https://openalex.org/I2799702486"]},{"raw_affiliation_string":"Charlie Norwood VA Medical Center, Augusta, Georgia","institution_ids":["https://openalex.org/I2799702486"]},{"raw_affiliation_string":"Department of Cell Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079254452","display_name":"Grace Liejun Guo","orcid":"https://orcid.org/0000-0002-2666-0635","observed_orcids":["https://orcid.org/0000-0002-2666-0635"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grace Guo","raw_affiliation_strings":["Department of Pharmacology and Toxicology, Rutgers University, Piscataway, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Rutgers University, Piscataway, New Jersey","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035051165","display_name":"Xiao\u2010Ming Yin","orcid":"https://orcid.org/0000-0002-8576-6093","observed_orcids":["https://orcid.org/0000-0002-8576-6093"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xiao-Ming Yin","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana; Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana. Electronic address: xmyin@tulane.edu","Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana","Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana"],"raw_orcid":"https://orcid.org/0000-0002-8576-6093","affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana; Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana. Electronic address: xmyin@tulane.edu","institution_ids":["https://openalex.org/I114832834","https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana","institution_ids":["https://openalex.org/I114832834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5035051165"],"corresponding_institution_ids":["https://openalex.org/I114832834","https://openalex.org/I4394709130"],"apc_list":{"value":2000,"currency":"USD","value_usd":2000},"apc_paid":{"value":2000,"currency":"USD","value_usd":2000},"fwci":1.4592,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.81622566,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"11","issue":"4","first_page":"973","last_page":"997"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9101999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9101999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.04129999876022339,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatic-autophagy","display_name":"hepatic autophagy","score":0.9739999771118164},{"id":"https://openalex.org/keywords/atg5","display_name":"ATG5","score":0.7860000133514404},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9629999995231628},{"id":"https://openalex.org/keywords/fgf15","display_name":"FGF15","score":0.8579999804496765},{"id":"https://openalex.org/keywords/fgfr4","display_name":"FGFR4","score":0.9440000057220459},{"id":"https://openalex.org/keywords/bile-acids","display_name":"bile acids","score":0.7900000214576721},{"id":"https://openalex.org/keywords/gut-liver-axis","display_name":"gut-liver axis","score":0.7699999809265137},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.8930000066757202},{"id":"https://openalex.org/keywords/antibiotic-associated-dysbiosis","display_name":"antibiotic-induced dysbiosis","score":0.6959999799728394},{"id":"https://openalex.org/keywords/cholestyramine","display_name":"cholestyramine","score":0.9620000123977661}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.8465594053268433},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5838263034820557},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.48365700244903564},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37305086851119995},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32607966661453247},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2091066837310791},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15776029229164124},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.11756113171577454}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000071187","descriptor_name":"Autophagy-Related Protein 5","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001647","descriptor_name":"Bile Acids and Salts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051499","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051499","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055371","descriptor_name":"Acute Lung Injury","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D055371","descriptor_name":"Acute Lung Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055371","descriptor_name":"Acute Lung Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D055371","descriptor_name":"Acute Lung Injury","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D064806","descriptor_name":"Dysbiosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1016/j.jcmgh.2020.10.011","doi":"https://doi.org/10.1016/j.jcmgh.2020.10.011","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jcmgh.2020.10.011","pdf_url":"http://www.cmghjournal.org/article/S2352345X20301740/pdf","source":{"id":"https://openalex.org/S2764889447","display_name":"Cellular and Molecular Gastroenterology and Hepatology","issn_l":"2352-345X","issn":["2352-345X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Gastroenterology and Hepatology","raw_type":"journal-article"},{"id":"doi:10.1101/2020.05.12.090613","doi":"https://doi.org/10.1101/2020.05.12.090613","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.05.12.090613","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/05/14/2020.05.12.090613.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:7898036","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7898036","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Mol Gastroenterol Hepatol","raw_type":"Text"},{"id":"pmid:33127558","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33127558","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and molecular gastroenterology and hepatology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:9952d7d39a7b42c587e6ef23bbe51ec2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9952d7d39a7b42c587e6ef23bbe51ec2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 973-997 (2021)","raw_type":"article"},{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/29603","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1805/29603","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1016/j.jcmgh.2020.10.011","doi":"https://doi.org/10.1016/j.jcmgh.2020.10.011","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jcmgh.2020.10.011","pdf_url":"http://www.cmghjournal.org/article/S2352345X20301740/pdf","source":{"id":"https://openalex.org/S2764889447","display_name":"Cellular and Molecular Gastroenterology and Hepatology","issn_l":"2352-345X","issn":["2352-345X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Gastroenterology and Hepatology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7300000190734863,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1470401036","display_name":"The Role of HMGB1 in autophagy deficiency-induced liver pathology","funder_award_id":"R01DK116605","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3093653404.pdf","grobid_xml":"https://content.openalex.org/works/W3093653404.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1514132913","https://openalex.org/W1555526329","https://openalex.org/W1945590693","https://openalex.org/W1969579498","https://openalex.org/W1975691929","https://openalex.org/W2002050129","https://openalex.org/W2012490955","https://openalex.org/W2012600855","https://openalex.org/W2037108200","https://openalex.org/W2039757379","https://openalex.org/W2065462174","https://openalex.org/W2071273298","https://openalex.org/W2093364415","https://openalex.org/W2102354517","https://openalex.org/W2116836791","https://openalex.org/W2119399459","https://openalex.org/W2126958442","https://openalex.org/W2130787560","https://openalex.org/W2134897177","https://openalex.org/W2134912211","https://openalex.org/W2150717198","https://openalex.org/W2168741168","https://openalex.org/W2408052000","https://openalex.org/W2428595929","https://openalex.org/W2549253162","https://openalex.org/W2581434358","https://openalex.org/W2586579187","https://openalex.org/W2619680342","https://openalex.org/W2621109592","https://openalex.org/W2734974018","https://openalex.org/W2761145411","https://openalex.org/W2764061533","https://openalex.org/W2766738477","https://openalex.org/W2770310782","https://openalex.org/W2788255593","https://openalex.org/W2794373470","https://openalex.org/W2797379250","https://openalex.org/W2797871134","https://openalex.org/W2801515643","https://openalex.org/W2803013275","https://openalex.org/W2803579602","https://openalex.org/W2904802960","https://openalex.org/W2909477364","https://openalex.org/W2911143260","https://openalex.org/W2921998529","https://openalex.org/W2924978408","https://openalex.org/W2941241726","https://openalex.org/W2946806894","https://openalex.org/W2949797783","https://openalex.org/W2950874120","https://openalex.org/W3034086154","https://openalex.org/W6739116729"],"related_works":["https://openalex.org/W3174362569","https://openalex.org/W2904802960","https://openalex.org/W7140963457","https://openalex.org/W3176137824","https://openalex.org/W2770310782","https://openalex.org/W4328025160","https://openalex.org/W2898366720","https://openalex.org/W4402012864","https://openalex.org/W2978988403","https://openalex.org/W7220708221"],"abstract_inverted_index":{"ABSTRACT":[0],"Objective":[1],"The":[2,117,150],"gut":[3,70,412],"microbiota":[4,77,264],"(GM)":[5,265],"can":[6,225,266,374,384,420],"have":[7,246],"complicated":[8],"and":[9,64,126,176,204,207,288,327,353,381],"often":[10],"undetermined":[11],"interactions":[12],"with":[13,51,80,157,191,347,445],"the":[14,20,32,38,56,67,111,184,219,234,240,251,283,294,301,319,342,360,377,405,415,429,454,460],"function":[15],"of":[16,28,34,58,69,83,120,152,161,173,180,195,242,298,305,313,321,331,350,356,417,431,463],"many":[17],"organs":[18],"in":[19,25,65,104,134,164,183,218,229,239,275,282,300,337,341,359,404,414,428,443],"body.":[21],"GM":[22,63,103,153,272,316,366,382],"is":[23,41,257,345],"altered":[24,215,268],"a":[26,141,158,170,177,310,328,387],"variety":[27],"liver":[29,39,48,73,202,216,227,243,284,302,378,390,418,435,446],"diseases,":[30],"but":[31],"significance":[33],"such":[35,59],"changes":[36,61],"on":[37,62,72,401],"disease":[40,419],"still":[42],"unclear.":[43],"Hepatic":[44],"autophagy":[45,299,338],"deficiency":[46,281],"causes":[47,289,303],"injury":[49,203,228,244,391],"accompanied":[50],"cholestasis.":[52],"Here,":[53],"we":[54],"investigated":[55],"impact":[57,400],"hepatic":[60,270],"turn":[66],"effect":[68,462],"dysbiosis":[71,224,413],"injury.":[74,291],"Design":[75],"Fecal":[76],"from":[78],"mice":[79,135,232],"liver-specific":[81],"loss":[82],"autophagy-related":[84],"gene":[85],"5":[86],"(":[87],"Atg5),":[88],"Atg5":[89,165,230],"\u0394hep":[90,166,231],"mice,":[91,167],"were":[92],"analyzed":[93],"by":[94],"16S":[95],"sequencing.":[96],"Antibiotics":[97,237],"(ABX)":[98],"was":[99,107,132,154],"used":[100,108,442],"to":[101,109,169,309,318,365,389,392,440,452,458],"modulate":[102,376],"mice.":[105,221],"Cholestyramine":[106],"reduce":[110],"enterohepatic":[112],"bile":[113,276],"acid":[114,277],"(BA)":[115,278],"level.":[116],"functional":[118],"role":[119],"fibroblast":[121,142,332],"growth":[122,143,333],"factor":[123,144,334],"15":[124,335],"(FGF15)":[125,336],"ileal":[127,189,322],"farnesoid":[128,323],"X":[129,324],"receptor":[130,145,325],"(FXR)":[131,326],"examined":[133],"over-expressing":[136],"FGF15":[137,209,213,372],"gene,":[138],"or":[139,198,371],"given":[140],"4":[146],"(FGFR4)":[147],"inhibitor.":[148],"Results":[149],"composition":[151],"significantly":[155],"changed":[156],"notable":[159],"increase":[160],"BA-metabolizing":[162,314],"bacteria":[163],"leading":[168],"lower":[171],"proportion":[172,179,312],"tauro-conjugated":[174],"BAs":[175,182,352,358],"higher":[178,311,329],"unconjugated":[181,357],"intestine,":[185],"which":[186,307,344],"markedly":[187],"activated":[188],"FXR":[190],"an":[192],"increased":[193,354],"expression":[194,330],"FGF15.":[196],"ABX":[197],"cholestyramine":[199],"treatment":[200],"exacerbated":[201],"ductular":[205],"reaction,":[206],"decreased":[208,348],"expression,":[210],"whereas":[211],"modulating":[212],"signaling":[214,373,457],"phenotypes":[217],"autophagy-deficient":[220],"Conclusion":[222],"Gut":[223,263],"remedy":[226],"through":[233],"FXR-FGF15":[235,455],"signaling.":[236],"use":[238,430],"condition":[241,340],"may":[245,449],"unexpected":[247],"adverse":[248],"consequences":[249],"via":[250],"gut-liver":[252],"axis.":[253],"SHORT":[254],"SUMMARY":[255],"What":[256,292],"already":[258],"known":[259],"about":[260],"this":[261],"subject?":[262],"be":[267,421,426,441,450],"during":[269,433],"pathogenesis.":[271],"are":[273,293],"involved":[274],"metabolism.":[279],"Autophagy":[280],"disrupts":[285],"BA":[286,369,380],"homeostasis":[287],"cholestatic":[290],"new":[295],"findings?":[296],"Deficiency":[297],"alteration":[304],"GM,":[306],"leads":[308],"bacteria.":[315],"contribute":[317],"activation":[320],"deficient":[339],"liver,":[343],"associated":[346],"levels":[349,355],"conjugated":[351],"intestine.":[361],"Manipulations":[362],"that":[363,411],"lead":[364],"alteration,":[367],"intestinal":[368],"signaling,":[370],"all":[375],"phenotype.":[379],"together":[383],"act":[385],"as":[386],"sensor":[388],"trigger":[393],"FGF15-mediated":[394],"protective":[395,461],"mechanism.":[396],"How":[397],"might":[398],"it":[399,448],"clinical":[402],"practice":[403],"foreseeable":[406],"future?":[407],"These":[408],"findings":[409],"indicate":[410],"scenario":[416],"beneficial,":[422],"suggesting":[423],"cautions":[424],"should":[425],"exercised":[427],"antibiotics":[432,438],"specific":[434],"diseases.":[436],"If":[437],"need":[439],"patients":[444],"diseases":[447],"beneficial":[451],"enhance":[453],"feedback":[456],"retain":[459],"GM.":[464]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-10-29T00:00:00"}
