{"id":"https://openalex.org/W3093563328","doi":"https://doi.org/10.1210/endocr/bqaa193","title":"Corticosterone Is Essential for Survival Through Frog Metamorphosis","display_name":"Corticosterone Is Essential for Survival Through Frog Metamorphosis","publication_year":2020,"publication_date":"2020-10-24","ids":{"openalex":"https://openalex.org/W3093563328","doi":"https://doi.org/10.1210/endocr/bqaa193","mag":"3093563328","pmid":"https://pubmed.ncbi.nlm.nih.gov/33099610"},"language":"en","primary_location":{"id":"doi:10.1210/endocr/bqaa193","doi":"https://doi.org/10.1210/endocr/bqaa193","is_oa":true,"landing_page_url":"https://doi.org/10.1210/endocr/bqaa193","pdf_url":"https://academic.oup.com/endo/article-pdf/161/12/bqaa193/41812721/bqaa193.pdf","source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/endo/article-pdf/161/12/bqaa193/41812721/bqaa193.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068019825","display_name":"Leena H. Shewade","orcid":"https://orcid.org/0000-0003-4316-0891","observed_orcids":["https://orcid.org/0000-0003-4316-0891"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Leena H Shewade","raw_affiliation_strings":["Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040422732","display_name":"Jamee A. Schoephoerster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jamee A Schoephoerster","raw_affiliation_strings":["Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077559959","display_name":"Matthew D. Patmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew D Patmann","raw_affiliation_strings":["Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001139520","display_name":"Saurabh S. Kulkarni","orcid":"https://orcid.org/0000-0002-0882-6478","observed_orcids":["https://orcid.org/0000-0002-0882-6478"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saurabh S Kulkarni","raw_affiliation_strings":["Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, Virginia","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084792810","display_name":"Daniel R. Buchholz","orcid":"https://orcid.org/0000-0003-2070-5684","observed_orcids":["https://orcid.org/0000-0003-2070-5684"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniel R Buchholz","raw_affiliation_strings":["Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio"],"raw_orcid":"https://orcid.org/0000-0003-2070-5684","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio","institution_ids":["https://openalex.org/I63135867"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5068019825","https://openalex.org/A5084792810"],"corresponding_institution_ids":["https://openalex.org/I63135867"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":1.4592,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.81623778,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"161","issue":"12","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.7519999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.7519999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11505","display_name":"Reproductive biology and impacts on aquatic species","score":0.06599999964237213,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.028300000354647636,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/corticosterone","display_name":"corticosterone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/frog-metamorphosis","display_name":"frog metamorphosis","score":0.9710000157356262},{"id":"https://openalex.org/keywords/proopiomelanocortin","display_name":"proopiomelanocortin","score":0.8939999938011169},{"id":"https://openalex.org/keywords/thyroid-hormone-signaling","display_name":"thyroid hormone signaling","score":0.7720000147819519},{"id":"https://openalex.org/keywords/xenopus-tropicalis","display_name":"Xenopus tropicalis","score":0.8259999752044678},{"id":"https://openalex.org/keywords/klf9","display_name":"KLF9","score":0.8840000033378601},{"id":"https://openalex.org/keywords/thyroid-hormone-receptor-beta","display_name":"thyroid hormone receptor beta","score":0.9449999928474426},{"id":"https://openalex.org/keywords/tail-resorption","display_name":"tail resorption","score":0.9470000267028809},{"id":"https://openalex.org/keywords/inanition","display_name":"inanition","score":0.8220000267028809}],"concepts":[{"id":"https://openalex.org/C136397037","wikidata":"https://www.wikidata.org/wiki/Q33753","display_name":"Metamorphosis","level":3,"score":0.919879674911499},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7891303300857544},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7692060470581055},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7387080788612366},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.6138990521430969},{"id":"https://openalex.org/C2780352252","wikidata":"https://www.wikidata.org/wiki/Q422543","display_name":"Corticosterone","level":3,"score":0.529244601726532},{"id":"https://openalex.org/C2779535977","wikidata":"https://www.wikidata.org/wiki/Q1342298","display_name":"Xenopus","level":3,"score":0.497421532869339},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.45717954635620117},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3914870619773865},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30850183963775635},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.2888666093349457},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14306384325027466},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0720163881778717},{"id":"https://openalex.org/C173758957","wikidata":"https://www.wikidata.org/wiki/Q129270","display_name":"Larva","level":2,"score":0.07100334763526917},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003345","descriptor_name":"Corticosterone","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D003345","descriptor_name":"Corticosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008675","descriptor_name":"Metamorphosis, Biological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011333","descriptor_name":"Pro-Opiomelanocortin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011333","descriptor_name":"Pro-Opiomelanocortin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013963","descriptor_name":"Thyroid Hormones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014981","descriptor_name":"Xenopus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D030801","descriptor_name":"Animals, Genetically Modified","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037042","descriptor_name":"Thyroid Hormone Receptors beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/endocr/bqaa193","doi":"https://doi.org/10.1210/endocr/bqaa193","is_oa":true,"landing_page_url":"https://doi.org/10.1210/endocr/bqaa193","pdf_url":"https://academic.oup.com/endo/article-pdf/161/12/bqaa193/41812721/bqaa193.pdf","source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:33099610","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33099610","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1210/endocr/bqaa193","doi":"https://doi.org/10.1210/endocr/bqaa193","is_oa":true,"landing_page_url":"https://doi.org/10.1210/endocr/bqaa193","pdf_url":"https://academic.oup.com/endo/article-pdf/161/12/bqaa193/41812721/bqaa193.pdf","source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320310256","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320333740","display_name":"Department of Biological Sciences, University of Cincinnati","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3093563328.pdf","grobid_xml":"https://content.openalex.org/works/W3093563328.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W47184522","https://openalex.org/W145125954","https://openalex.org/W195983064","https://openalex.org/W1498791370","https://openalex.org/W1539401343","https://openalex.org/W1566898963","https://openalex.org/W1609773580","https://openalex.org/W1930053815","https://openalex.org/W1963956081","https://openalex.org/W1969481941","https://openalex.org/W1974218779","https://openalex.org/W1977927261","https://openalex.org/W1980748240","https://openalex.org/W1984634814","https://openalex.org/W1988613341","https://openalex.org/W1991593658","https://openalex.org/W2004502371","https://openalex.org/W2007786809","https://openalex.org/W2008205228","https://openalex.org/W2009639789","https://openalex.org/W2019673385","https://openalex.org/W2021932599","https://openalex.org/W2022321112","https://openalex.org/W2024298480","https://openalex.org/W2032905318","https://openalex.org/W2038311664","https://openalex.org/W2045217164","https://openalex.org/W2052178584","https://openalex.org/W2052410593","https://openalex.org/W2055326219","https://openalex.org/W2064489891","https://openalex.org/W2066300632","https://openalex.org/W2070365085","https://openalex.org/W2091815501","https://openalex.org/W2094481108","https://openalex.org/W2094828639","https://openalex.org/W2095953970","https://openalex.org/W2096860697","https://openalex.org/W2096891498","https://openalex.org/W2107277218","https://openalex.org/W2112367072","https://openalex.org/W2123617287","https://openalex.org/W2136942244","https://openalex.org/W2146031543","https://openalex.org/W2154045106","https://openalex.org/W2168245648","https://openalex.org/W2283127173","https://openalex.org/W2285947238","https://openalex.org/W2328269288","https://openalex.org/W2584976914","https://openalex.org/W2598717602","https://openalex.org/W2738712256","https://openalex.org/W2762689276","https://openalex.org/W2765537956","https://openalex.org/W2782969534","https://openalex.org/W2794829912","https://openalex.org/W2801835994","https://openalex.org/W2912060787","https://openalex.org/W2941778051","https://openalex.org/W2965928287","https://openalex.org/W2994993428","https://openalex.org/W3005345068"],"related_works":["https://openalex.org/W2944676299","https://openalex.org/W7160119286","https://openalex.org/W3005345068","https://openalex.org/W3212053746","https://openalex.org/W6996278835","https://openalex.org/W1988613341","https://openalex.org/W2102283751","https://openalex.org/W4318046954","https://openalex.org/W2045217164","https://openalex.org/W4309726368"],"abstract_inverted_index":{"Thyroid":[0],"hormone":[1],"(TH)":[2],"is":[3],"required":[4,174],"for":[5,21,175],"frog":[6],"metamorphosis,":[7],"and":[8,56,94,96,110,127],"corticosterone":[9],"(CORT)":[10],"increases":[11],"TH":[12,103,111,123,152,167],"signaling":[13,168],"to":[14,28,31,51,117,155,186],"accelerate":[15],"metamorphic":[16,184],"progression.":[17],"However,":[18],"a":[19,68],"requirement":[20],"CORT":[22,58,73,142],"in":[23,60,158,166],"metamorphosis":[24,75,178],"has":[25],"been":[26],"difficult":[27],"assess":[29],"prior":[30],"the":[32,81,163,182],"recent":[33],"development":[34,95],"of":[35,71,80,92,101,150],"gene-editing":[36],"technologies.":[37],"We":[38],"addressed":[39],"this":[40],"long-standing":[41],"question":[42],"using":[43],"transcription":[44],"activator-like":[45],"effector":[46],"nuclease":[47],"(TALEN)":[48],"gene":[49,83,125],"disruption":[50],"knock":[52],"out":[53],"proopiomelanocortin":[54],"(pomc)":[55],"disrupt":[57],"production":[59],"Xenopus":[61],"tropicalis.":[62],"As":[63],"expected,":[64],"mutant":[65],"tadpoles":[66],"had":[67,89,121],"reduced":[69,78,90,122],"peak":[70],"plasma":[72],"at":[74],"with":[76],"correspondingly":[77],"expression":[79,99],"CORT-response":[82],"Usher":[84],"syndrome":[85],"type-1G":[86],"(ush1g).":[87],"Mutants":[88],"rates":[91],"growth":[93],"exhibited":[97],"lower":[98],"levels":[100],"2":[102],"response":[104,116,124],"genes,":[105],"Kr\u00fcppel-like":[106],"factor":[107],"9":[108],"(klf9)":[109],"receptor":[112],"\u03b2":[113],"(thrb).":[114],"In":[115],"exogenous":[118,141,146,151],"TH,":[119],"mutants":[120,160],"induction":[126],"slower":[128],"morphological":[129],"change.":[130],"Importantly,":[131],"death":[132,157],"invariably":[133],"occurred":[134],"during":[135],"tail":[136],"resorption,":[137],"unless":[138],"rescued":[139],"by":[140,145,153],"and,":[143],"remarkably,":[144],"TH.":[147],"The":[148],"ability":[149],"itself":[154],"overcome":[156],"pomc":[159],"indicates":[161],"that":[162],"CORT-dependent":[164],"increase":[165],"may":[169,180],"ensure":[170],"functional":[171],"organ":[172],"transformation":[173],"survival":[176],"through":[177],"and/or":[179],"shorten":[181],"nonfeeding":[183],"transition":[185],"avoid":[187],"lethal":[188],"inanition.":[189]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-10-29T00:00:00"}